Information on EC 4.1.2.B6 - aromatic (R)-hydroxynitrile lyase

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The expected taxonomic range for this enzyme is: Vicia sativa

EC NUMBER
COMMENTARY hide
4.1.2.B6
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
aromatic (R)-hydroxynitrile lyase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-mandelonitrile = cyanide + benzaldehyde
show the reaction diagram
SYSTEMATIC NAME
IUBMB Comments
(R)-mandelonitrile benzaldehyde lyase (cyanide and aromatic aldehyde-forming)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cyanide + 1,3-benzodioxole-5-carbaldehyde
(2R)-hydroxy(pyridin-3-yl)ethanenitrile
show the reaction diagram
-
-
71% yield, 3% enantiomeric excess
-
?
cyanide + 1,3-benzodioxole-5-carbaldehyde
(2S)-1,3-benzodioxol-5-yl(hydroxy)ethanenitrile
show the reaction diagram
-
-
93% yield, 88% enantiomeric excess
-
?
cyanide + 4-fluorobenzaldehyde
(2R)-(4-fluorophenyl)(hydroxy)ethanenitrile
show the reaction diagram
-
-
97% yield, 91% enantiomeric excess
-
?
cyanide + 4-methoxybenzaldehyde
(2R)-hydroxy(4-methoxyphenyl)ethanenitrile
show the reaction diagram
-
-
52% yield, 94% enantiomeric excess
-
?
cyanide + benzaldehyde
(R)-mandelonitrile
show the reaction diagram
-
-
100% yield, 99% enantiomeric excess
-
?
cyanide + furan-2-carbaldehyde
(2S)-furan-2-yl(hydroxy)ethanenitrile
show the reaction diagram
-
-
96% yield, 97% enantiomeric excess. (S)-configuration is due to the Cahn-Ingold-Prelog rules
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?
additional information
?
-
-
no activity with heptanal
-
-
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
defatted meal
Manually annotated by BRENDA team