Information on EC 4.1.2.54 - L-threo-3-deoxy-hexylosonate aldolase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.2.54
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RECOMMENDED NAME
GeneOntology No.
L-threo-3-deoxy-hexylosonate aldolase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-galacturonate degradation III
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Metabolic pathways
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Pentose and glucuronate interconversions
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degradation of sugar acids
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SYSTEMATIC NAME
IUBMB Comments
2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the deletion of the gene results in a strain unable to grow on D-galacturonate and accumulating L-threo-3-deoxy-hexulosonate
physiological function
the enzyme is induced during growth on D-galacturonate
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-dehydro-3-deoxy-L-galactonate
pyruvate + L-glyceraldehyde
show the reaction diagram
pyruvate + glycolaldehyde
?
show the reaction diagram
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?
pyruvate + L-glyceraldehyde
2-dehydro-3-deoxy-L-galactonate
show the reaction diagram
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r
pyruvate + methylglyoxal
?
show the reaction diagram
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?
additional information
?
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the reaction with D-glyceraldehyde, dihydroxyacetone, diacetyl, acetone, glyoxal, acetaldehyde or formaldehyde plus pyruvate is below the detection limit
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-dehydro-3-deoxy-L-galactonate
pyruvate + L-glyceraldehyde
show the reaction diagram
A6Y9S5
the enzyme is part of the fungal pathway of D-galacturonate degradation
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r
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-glyceraldehyde
inhibits reverse reaction with pyruvate and L-glyceraldehyde
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.5
2-dehydro-3-deoxy-L-galactonate
pH 7.0, 30°C
1.2
L-Glyceraldehyde
pH 7.0, 30°C
0.5
pyruvate
pH 7.0, 30°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
the L-threo-3-deoxy-hexulosonate aldolase activity is induced during growth on D-galacturonate
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33407
x * 33407, calculated from sequence
37000
x * 37000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 33407, calculated from sequence; x * 37000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae as a histidine-tagged protein
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
induced in Hypocrea jecorina during growth on D-galacturonate