Information on EC 4.1.2.41 - vanillin synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.2.41
-
RECOMMENDED NAME
GeneOntology No.
vanillin synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA
show the reaction diagram
involved, together with EC 4.2.1.101 trans-feruloyl-CoA hydratase, in the production of vanillin from trans-ferulic acid. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
reversal of an aldol condensation
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
-
capsaicin biosynthesis
-
-
ferulate degradation
-
-
Phenylalanine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)
Involved, together with EC 4.2.1.101 trans-feruloyl-CoA hydratase, in the production of vanillin from trans-ferulic acid. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase.
CAS REGISTRY NUMBER
COMMENTARY hide
197462-63-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA
4-hydroxy-3-methoxybenzaldehyde + acetyl-CoA
show the reaction diagram
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA
vanillin + acetyl-CoA
show the reaction diagram
4-hydroxy-3-methoxy-phenyl-beta-hydroxypropionyl-CoA + H2O
vanillin + acetylCoA + feruloylCoA
show the reaction diagram
-
-
-
?
feruloyl-CoA + H2O
vanillin + acetyl-CoA
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA
vanillin + acetyl-CoA
show the reaction diagram
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
31000
-
gel filtration
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene encoding an enoyl-SCoA hydratase/lyase isolated, cloned and heterologously expressed in Escherichia coli JM109
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis