Information on EC 4.1.2.35 - propioin synthase

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The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

EC NUMBER
COMMENTARY
4.1.2.35
-
RECOMMENDED NAME
GeneOntology No.
propioin synthase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
4-hydroxy-3-hexanone = 2 propanal
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
reversal of an aldol condensation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
4-hydroxy-3-hexanone propanal-lyase (propanal-forming)
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4-hydroxy-3-hexanone aldolase
-
-
-
-
synthase, propioin
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
114189-86-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
baker's yeast
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
propanal + propanal
4-hydroxy-3-hexanone
show the reaction diagram
-
-
-
?
propionaldehyde + propionaldehyde
propioin
show the reaction diagram
-
-
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
propionaldehyde + propionaldehyde
propioin
show the reaction diagram
-
-
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
thiamine diphosphate
-
10% stimulation at 0.16 mM, 65% stimulation at 0.4 mM
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
23% stimulation at 0.32 mM
Fe2+
-
58% stimulation at 0.08 mM, 145% stimulation at 0.16 mM
Mg2+
-
37% stimulation at 0.08 mM, 47% stimulation at 0.16 mM
Mn2+
-
55% stimulation at 0.5 mM, 125% stimulation at 1.6 mM
Na+
-
12% stimulation at 0.16 mM
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(CH3COO)2Pb
-
44% inhibition at 1.08 mM, complete inhibition at 32 mM
(NH4)2SO4
-
62% inhibition at 80.6 mM, complete inhibition at 806 mM
AgNO3
-
5% inhibition at 0.32 mM, complete inhibition at 3.2 mM
Cu2+
-
73% inhibition at 0.81 mM, complete inhibition at 8.06 mM
EDTA
-
5% inhibition at 0.24 mM, 45% inhibition at 9.68 mM
Fe3+
-
23% inhibition at 0.16 mM, complete inhibition at 32 mM
-
Hg2+
-
86% inhibition at 1.08 mM, complete inhibition at 10.8 mM
iodoacetic acid
-
68% inhibition at 16 mM, complete inhibition at 35 mM
Na2SO4
-
38% inhibition at 0.16 mM, 57% inhibition at 0.86 mM
NH4Cl
-
21% inhibition at 1.7 mM, complete inhibition at 968 mM
Sn2+
-
47% inhibition at 8.69 mM, complete inhibition at 16 mM
Zn2+
-
63% inhibition at 1.08 mM, complete inhibition at 16 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
stimulation at 3.05 and 6.1 mM
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6
10
-
18% activity t pH 6, 30% activity at pH 10
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
96000
-
-
equilibrium centrifugation
100000
-
-
gel filtration
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3
-
-
complete inactivation
7
8
-
most stable
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
45
-
5 min, pH 6.8, about 90% of maximum activity
50
-
-
5 min, pH 6.8, about 40% of maximum activity
55
-
-
5 min, pH 6.8, about 5% of maximum activity
60
-
-
5 min, pH 6.8, complete inactivation
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE