Information on EC 4.1.2.28 - 2-dehydro-3-deoxy-D-pentonate aldolase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.2.28
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RECOMMENDED NAME
GeneOntology No.
2-dehydro-3-deoxy-D-pentonate aldolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-Dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
condensation
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elimination
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of an aldehyde, C-C bond cleavage
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
ethylene glycol biosynthesis (engineered)
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Pentose and glucuronate interconversions
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xylose degradation IV
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SYSTEMATIC NAME
IUBMB Comments
2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase (pyruvate-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
55326-36-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-dehydro-3-deoxy-D-pentonate
?
show the reaction diagram
-
enzyme is involved in a new pathway of D-xylose metabolism
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2-dehydro-3-deoxy-D-pentonate
pyruvate + glycolaldehyde
show the reaction diagram
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r, specific for D-isomer
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-dehydro-3-deoxy-D-pentonate
?
show the reaction diagram
-
enzyme is involved in a new pathway of D-xylose metabolism
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.97
3-deoxy-D-pentonate acid
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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thermolabile
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
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biosynthesis route for ethylene glycol production from D-xylose, consisting of conversion steps D-xylose to D-xylonate to 2-dehydro-3-deoxy-D-pentonate to glycoaldehyde to ethylene glycol. Implementation of the respective enzymes, D-xylose dehydrogenase, D-xylonate dehydratase, 2-dehydro-3-deoxy-D-pentonate aldolase, and glycoaldehyde reductase, in a metabolically engineered Escherichia coli, in which the D-xylose to D-xylulose reaction is prevented by disrupting the D-xylose isomerase gene, leads to a construct producing 11.7 g/l of ethylene glycol from 40.0 g/l of D-xylose