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Acute Lung Injury
Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase.
Acute Lung Injury
Protection of LPS-Induced Murine Acute Lung Injury by Sphingosine-1-Phosphate Lyase Suppression.
Addison Disease
A Sphingosine-1-Phosphate Lyase Mutation Associated With Congenital Nephrotic Syndrome and Multiple Endocrinopathy.
Addison Disease
Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency.
Addison Disease
Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1.
Addison Disease
SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
Addison Disease
Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction.
Addison Disease
Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
Adenocarcinoma
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Adrenal Insufficiency
A novel mutation in sphingosine-1-phosphate lyase causing congenital brain malformation.
Adrenal Insufficiency
Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency.
Adrenal Insufficiency
MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome.
Adrenal Insufficiency
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Adrenal Insufficiency
Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1.
Adrenocortical Carcinoma
Identification of novel lipid metabolic biomarkers associated with poor adrenocortical carcinoma prognosis using integrated bioinformatics.
Alzheimer Disease
Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.
Arthritis, Rheumatoid
Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice.
Arthritis, Rheumatoid
Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors.
Arthritis, Rheumatoid
Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI).
Arthritis, Rheumatoid
Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).
Arthritis, Rheumatoid
Pharmacology of the sphingosine-1-phosphate signalling system.
Arthritis, Rheumatoid
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Atherosclerosis
Fabrication of 3D continuous-flow reverse-transcription polymerase chain reaction microdevice integrated with on-chip fluorescence detection for semi-quantitative assessment of gene expression.
Atherosclerosis
Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.
Autoimmune Diseases
Creation of a S1P Lyase bacterial surrogate for structure-based drug design.
Autoimmune Diseases
Pharmacology of the sphingosine-1-phosphate signalling system.
Autoimmune Diseases
Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
Autoimmune Diseases
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Bone Diseases, Metabolic
Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss.
Breast Neoplasms
First evidence of SGPL1 expression in the cell membrane silencing the extracellular S1P siren in mammary epithelial cells.
Carcinogenesis
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.
Carcinogenesis
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
Carcinoma
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Carcinoma
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Carcinoma
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis.
Carcinoma, Embryonal
Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm.
Carcinoma, Hepatocellular
Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.
Carcinoma, Hepatocellular
Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.
Carcinoma, Neuroendocrine
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.
Carcinoma, Squamous Cell
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Charcot-Marie-Tooth Disease
Peripheral neuropathies: Atypical Charcot-Marie-Tooth disease linked to sphingosine 1-phosphate lyase deficiency.
Colitis
Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor.
Colitis
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Colitis
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
Colonic Neoplasms
Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P
Colonic Neoplasms
S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
Colonic Neoplasms
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.
Colorectal Neoplasms
Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
Colorectal Neoplasms
S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
Colorectal Neoplasms
S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells.
Cystic Fibrosis
Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.
Diabetic Retinopathy
Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy.
Diabetic Retinopathy
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Encephalomyelitis
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
Endometriosis
Expression and significance of ER? and TrkB in endometriosis.
Glaucoma
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Glomerulonephritis
Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases.
Heart Arrest
Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.
Huntington Disease
Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy.
Huntington Disease
Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.
Hydrops Fetalis
A novel mutation in sphingosine-1-phosphate lyase causing congenital brain malformation.
Hyperglycemia
Pharmacological inhibition of sphingosine-1-phosphate lyase partially reverses spatial memory impairment in streptozotocin-diabetic rats.
Hypertension, Pulmonary
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Hypogonadism
Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.
Ichthyosis
MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction.
Ichthyosis
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Ileitis
Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn's-Like Ileitis by Suppressing Thymocyte Maturation.
Infections
The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages.
Inflammatory Bowel Diseases
Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor.
Inflammatory Bowel Diseases
Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors.
Influenza, Human
Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?
Influenza, Human
Emerging Connections of S1P-Metabolizing Enzymes with Host Defense and Immunity During Virus Infections.
Influenza, Human
Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response.
Influenza, Human
Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.
Influenza, Human
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Insulinoma
4-deoxypyridoxine improves the viability of isolated pancreatic islets ex vivo.
Kidney Diseases
SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
Liver Diseases
Sphingosine-1-phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Lung Injury
Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats.
Lung Injury
Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium.
Lung Injury
Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase.
Lung Neoplasms
Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines.
Lung Neoplasms
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.
Lymphopenia
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Lymphopenia
Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition.
Lymphopenia
Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia.
Lymphopenia
Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.
Macular Degeneration
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Microcephaly
MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome.
Multiple Sclerosis
Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency.
Multiple Sclerosis
Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors.
Multiple Sclerosis
Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.
Multiple Sclerosis
Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.
Multiple Sclerosis
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Multiple Sclerosis
The first sphingosine 1-phosphate lyase inhibitors against multiple sclerosis: a successful drug discovery tale.
Neoplasm Metastasis
First evidence of SGPL1 expression in the cell membrane silencing the extracellular S1P siren in mammary epithelial cells.
Neoplasm Metastasis
SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma.
Neoplasms
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Neoplasms
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Neoplasms
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.
Neoplasms
Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P
Neoplasms
Fabrication of 3D continuous-flow reverse-transcription polymerase chain reaction microdevice integrated with on-chip fluorescence detection for semi-quantitative assessment of gene expression.
Neoplasms
First evidence of SGPL1 expression in the cell membrane silencing the extracellular S1P siren in mammary epithelial cells.
Neoplasms
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
Neoplasms
Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
Neoplasms
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Neoplasms
Influence of a leptin deficiency on testicular morphology, germ cell apoptosis, and expression levels of apoptosis-related genes in the mouse.
Neoplasms
New perspectives on the role of sphingosine 1-phosphate in cancer.
Neoplasms
Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening.
Neoplasms
Recent advances in the role of sphingosine 1-phosphate in cancer.
Neoplasms
Regulation of cell death by sphingosine 1-phosphate lyase.
Neoplasms
S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells.
Neoplasms
SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma.
Neoplasms
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
Neoplasms
Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren.
Neoplasms
Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
Neoplasms
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Nephrosis
Fifty years of lyase and a moment of truth: Sphingosine phosphate lyase from discovery to disease.
Nephrosis
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Nephrotic Syndrome
A novel mutation in sphingosine-1-phosphate lyase causing congenital brain malformation.
Nephrotic Syndrome
A Sphingosine-1-Phosphate Lyase Mutation Associated With Congenital Nephrotic Syndrome and Multiple Endocrinopathy.
Nephrotic Syndrome
Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency.
Nephrotic Syndrome
Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.
Nephrotic Syndrome
Disarranged Sphingolipid Metabolism From Sphingosine-1-Phosphate Lyase Deficiency Leads to Congenital Nephrotic Syndrome.
Nephrotic Syndrome
MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction.
Nephrotic Syndrome
MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome.
Nephrotic Syndrome
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Nephrotic Syndrome
Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1.
Nephrotic Syndrome
SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
Nephrotic Syndrome
Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction.
Nephrotic Syndrome
Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
Neurodegenerative Diseases
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
Osteoporosis
Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice.
Osteoporosis
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Osteosarcoma
Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation.
Peripheral Nervous System Diseases
Peripheral neuropathies: Atypical Charcot-Marie-Tooth disease linked to sphingosine 1-phosphate lyase deficiency.
Pneumonia
Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.
Pneumonia
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
Pneumonia
Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase.
Pre-Eclampsia
miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1.
Prostatic Neoplasms
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
Proteinuria
Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
Psoriasis
Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice.
Pulmonary Disease, Chronic Obstructive
Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).
Pulmonary Fibrosis
Sphingolipids in pulmonary fibrosis.
Pulmonary Fibrosis
Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.
Rhabdomyosarcoma, Alveolar
SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma.
Sepsis
Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis.
Sepsis
S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis.
sphinganine-1-phosphate aldolase deficiency
Disarranged Sphingolipid Metabolism From Sphingosine-1-Phosphate Lyase Deficiency Leads to Congenital Nephrotic Syndrome.
sphinganine-1-phosphate aldolase deficiency
Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.
sphinganine-1-phosphate aldolase deficiency
Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation.
sphinganine-1-phosphate aldolase deficiency
Peripheral neuropathies: Atypical Charcot-Marie-Tooth disease linked to sphingosine 1-phosphate lyase deficiency.
sphinganine-1-phosphate aldolase deficiency
Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
sphinganine-1-phosphate aldolase deficiency
S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.
sphinganine-1-phosphate aldolase deficiency
S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.
sphinganine-1-phosphate aldolase deficiency
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
sphinganine-1-phosphate aldolase deficiency
SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
sphinganine-1-phosphate aldolase deficiency
Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy.
sphinganine-1-phosphate aldolase deficiency
Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
sphinganine-1-phosphate aldolase deficiency
Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.
sphinganine-1-phosphate aldolase deficiency
Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction.
sphinganine-1-phosphate aldolase deficiency
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
Sphingolipidoses
A Sphingosine-1-Phosphate Lyase Mutation Associated With Congenital Nephrotic Syndrome and Multiple Endocrinopathy.
Sphingolipidoses
SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
Sphingolipidoses
Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism.
Squamous Cell Carcinoma of Head and Neck
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Triple Negative Breast Neoplasms
An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.
Ventilator-Induced Lung Injury
Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase.
Virus Diseases
Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.
Vitamin B 6 Deficiency
Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.
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4.1.2.27 sphinganine-1-phosphate aldolase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
