Information on EC 4.1.2.24 - dimethylaniline-N-oxide aldolase

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The expected taxonomic range for this enzyme is: Sus scrofa

EC NUMBER
COMMENTARY hide
4.1.2.24
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RECOMMENDED NAME
GeneOntology No.
dimethylaniline-N-oxide aldolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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of an aldehyde, C-C bond cleavage
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SYSTEMATIC NAME
IUBMB Comments
N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)
Acts on various N,N-dialkylarylamides.
CAS REGISTRY NUMBER
COMMENTARY hide
37290-58-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N,N-Dimethyl-p-toluidine N-oxide
?
show the reaction diagram
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-
-
-
-
N,N-Dimethyl1-naphthylamine N-oxide
N-Methylaniline + formaldehyde
show the reaction diagram
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-
-
-
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N,N-Dimethylaniline N-oxide
?
show the reaction diagram
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-
-
-
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N-Ethyl-N-methylaniline N-oxide
?
show the reaction diagram
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weak activity
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-
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p-Chlorodimethylaniline N-oxide
?
show the reaction diagram
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-
-
-
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additional information
?
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no activity with N-oxide derivatives of trialkylamines, morphine N-ethyl derivatives of aniline N-oxide are dealkylated at a slower rate than methyl derivatives
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha-Phenyl-alpha-propyl-benzeneacetic acid 2-(diethylamino) ethyl ester
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SKF-525A
CO
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Pyridine
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
15 - 20
N,N-Dimethyl-p-toluidine N-oxide
33 - 80
N,N-Dimethylaniline N-oxide
6 - 7
N,N-dimethylnaphthylamine N-oxide
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 7
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
-
-
Manually annotated by BRENDA team