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Information on EC 4.1.2.13 - fructose-bisphosphate aldolase and Organism(s) Synechocystis sp. and UniProt Accession Q55664
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4.1.2.13 fructose-bisphosphate aldolaseIUBMB Comments
Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
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Word Map
- 4.1.2.13
- creatine
-
phosphofructokinase
- enolase
- hexokinase
- isozyme
- isoenzymes
- dihydroxyacetone
- glucose-6-phosphate
- erythrocyte
- phosphoglycerate
- aminotransferase
- albumin
- transaminase
- malate
- intolerance
- gapdh
- hereditary
- muscular
-
phosphokinase
- glycogen
- pentose
- myopathy
- plasmodium
-
gluconeogenesis
-
schiff
- falciparum
- transketolase
- phosphoglucomutase
-
purkinje
- dermatomyositis
- mutase
-
phosphoglucose
-
entner-doudoroff
- dhap
- myositis
- 6-phosphogluconate
-
gluconeogenic
-
calvin
- myoglobin
- myalgia
- fructose-1,6-bisphosphatase
- tpi
- rhabdomyolysis
- polymyositis
- fbpase
- fructokinase
- medicine
-
electromyography
- glycosomal
-
parasagittal
-
glutamic-oxalacetic
- molecular biology
- drug development
- diagnostics
- food industry
- agriculture
- synthesis
The taxonomic range for the selected organisms is: Synechocystis sp.
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
aldolase, aldolase a, aldolase b, aldolase c, aldoa, fructose-1,6-bisphosphate aldolase, fructose-bisphosphate aldolase, aldob, fructose bisphosphate aldolase, fructose 1,6-bisphosphate aldolase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,6-Diphosphofructose aldolase
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-
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37 kDa major allergen
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41 kDa antigen
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-
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aldolase
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-
-
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aldolase, fructose diphosphate
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-
-
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ALDP
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-
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Brain-type aldolase
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-
-
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CE1
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-
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CE2
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Diphosphofructose aldolase
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-
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FBP aldolase
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Fru-P2A
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-
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Fructoaldolase
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-
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Fructose 1,6-bisphosphate aldolase
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Fructose 1,6-diphosphate aldolase
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Fructose 1-monophosphate aldolase
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-
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Fructose 1-phosphate aldolase
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-
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Fructose bisphosphate aldolase
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-
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Fructose diphosphate aldolase
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-
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Fructose-1,6-bisphosphate triosephosphate-lyase
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-
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IgE-binding allergen
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-
-
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ketose 1-phosphate aldolase
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Liver-type aldolase
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-
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Muscle-type aldolase
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Phosphofructoaldolase
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SMALDO
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zymohexase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
condensation
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
-
-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
CAS REGISTRY NUMBER
COMMENTARY
9024-52-6
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-fructose 1,6-bisphosphate
glycerone phosphate + D-glyceraldehyde 3-phosphate
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-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-fructose 1,6-bisphosphate
glycerone phosphate + D-glyceraldehyde 3-phosphate
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-
-
r
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.007
D-fructose 1,6-bisphosphate
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pH 8, class I aldolase, recombinant enzyme
0.008
D-fructose 1,6-bisphosphate
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pH 7.5, class II aldolase, purified enzyme
0.008
D-fructose 1,6-bisphosphate
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pH 7.5, class II aldolase, recombinant enzyme
0.009
D-fructose 1,6-bisphosphate
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pH 8, class I aldolase, purified enzyme
0.008
sedoheptulose 1,7-bisphosphate
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pH 7.5, class II aldolase, recombinant enzyme
0.047
sedoheptulose 1,7-bisphosphate
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pH 8, class I aldolase, recombinant enzyme
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.12
D-ribulose 1,5-bisphosphate
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pH 7.5, class II aldolase, purified enzyme
0.37
D-ribulose 1,5-bisphosphate
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pH 8, class I aldolase, recombinant enzyme
0.59
D-ribulose 1,5-bisphosphate
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pH 7.5, class II aldolase, recombinant enzyme
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
EXTERNAL LINKS (specific for EC-Number 4.1.2.13)
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