Information on EC 4.1.2.12 - 2-dehydropantoate aldolase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
4.1.2.12
-
RECOMMENDED NAME
GeneOntology No.
2-dehydropantoate aldolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
condensation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9024-51-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-Oxo-3-methylbutanoate + formaldehyde
2-Dehydropantoate
show the reaction diagram
-
reverse reaction not detected
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-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
activates
Fe2+
-
slight activation
Mg2+
-
slight activation
Mn2+
-
activates
Ni2+
-
activates
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
glycerol phosphate
-
-
glycylglycine
-
-
potassium phosphate
-
-
Tris(hydroxymethyl)aminomethane
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8 - 8.9
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 8.5
-
low activity below pH 6.5 and above pH 8.5
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE