Information on EC 4.1.1.B4 - UDP-N-acetylglucosaminuronate decarboxylase

for references in articles please use BRENDA:EC4.1.1.B4
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The expected taxonomic range for this enzyme is: Bacillus cytotoxicus NVH 391-98

EC NUMBER
COMMENTARY hide
4.1.1.B4
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
UDP-N-acetylglucosaminuronate decarboxylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetylglucosaminuronic acid = UDP-N-acetylxylosamine + CO2
show the reaction diagram
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetylglucosaminuronic acid decarboxylase (UDP-N-acetyl-D-xylosamine-forming)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Bacillus cereus subsp. cytotoxis
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UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetylglucosaminuronic acid
UDP-N-acetylxylosamine + CO2
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
Bacillus cereus subsp. cytotoxis
exogenous NAD+ required. The enzyme-bound NAD+ is not released as NADH during the C-4 oxidation/reduction cycle
additional information
Bacillus cereus subsp. cytotoxis
NADP+ cannot substitute for NAD+
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
Bacillus cereus subsp. cytotoxis
0.5 mM, presence of 0.5 mM NAD+, no residual activity
NADPH
Bacillus cereus subsp. cytotoxis
0.5 mM, presence of 0.5 mM NAD+, 92% residual activity
UDP
Bacillus cereus subsp. cytotoxis
0.5 mM, presence of 0.5 mM NAD+, 48% residual activity
UDP-glucuronic acid
Bacillus cereus subsp. cytotoxis
0.5 mM, presence of 0.5 mM NAD+, 70% residual activity
UMP
Bacillus cereus subsp. cytotoxis
0.5 mM, presence of 0.5 mM NAD+, 93% residual activity
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.067
UDP-N-acetylglucosaminuronic acid
Bacillus cereus subsp. cytotoxis
pH 8.2, 37°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.47
UDP-N-acetylglucosaminuronic acid
Bacillus cereus subsp. cytotoxis
pH 8.2, 37°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7
UDP-N-acetylglucosaminuronic acid
Bacillus cereus subsp. cytotoxis
pH 8.2, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.2
Bacillus cereus subsp. cytotoxis
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4
Bacillus cereus subsp. cytotoxis
no activity below
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
Bacillus cereus subsp. cytotoxis
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
Bacillus cereus subsp. cytotoxis
x * 35000, SDS-PAGE
70200
Bacillus cereus subsp. cytotoxis
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant protein
Bacillus cereus subsp. cytotoxis
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
Bacillus cereus subsp. cytotoxis