Information on EC 4.1.1.99 - phosphomevalonate decarboxylase

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The expected taxonomic range for this enzyme is: Haloferax volcanii

EC NUMBER
COMMENTARY hide
4.1.1.99
-
RECOMMENDED NAME
GeneOntology No.
phosphomevalonate decarboxylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2
show the reaction diagram
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
-
mevalonate pathway II (archaea)
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-
Terpenoid backbone biosynthesis
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mevalonate metabolism
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SYSTEMATIC NAME
IUBMB Comments
ATP:phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
The enzyme is part of the mevalonate pathway in archaea.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + mevalonate 5-phosphate
ADP + phosphate + isopentenyl phosphate + CO2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + mevalonate 5-phosphate
ADP + phosphate + isopentenyl phosphate + CO2
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
KCl
activity is not strongly dependent on KCl over a 0 to 4 M range
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-fluoromevalonate 5'-phosphate
negligible inhibition by 6-fluoromevalonate diphosphate (a potent inhibitor of the classical mevalonate pathway), reinforcing its selectivity for monophosphorylated ligands
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.289
ATP
pH 7.5, 30°C
0.075
mevalonate 5-phosphate
pH 7.5, 30°C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.016
6-fluoromevalonate 5'-phosphate
Haloferax volcanii
D4GXZ3
pH 7.5, 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37328
x * 37328, His-tagged enzyme, matrix-assisted laser desorption ionization-time of flight mass spectrometry
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Haloferax volcanii H1209