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Information on EC 4.1.1.9 - malonyl-CoA decarboxylase and Organism(s) Homo sapiens and UniProt Accession O95822
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4.1.1.9 malonyl-CoA decarboxylaseIUBMB Comments
Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase.
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Word Map
- 4.1.1.9
- carnitine
-
malonic
-
amp-activated
- palmitoyltransferase
-
aciduria
- goose
-
uropygial
- methylmalonyl-coa
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methylmalonic
- medicine
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
malonyl-coa decarboxylase, malonyl coa decarboxylase, mlycd, malonyl-coenzyme a decarboxylase, malonyl coenzyme a decarboxylase, malonyl-coa decarboxylase/acetyltransferase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Acyl-CoA: malonate CoA transferase/malonyl-CoA decarboxylase
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Decarboxylase, malonyl coenzyme A
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Malonyl coenzyme A decarboxylase
Malonyl-CoA decarboxylase
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MCD
Malonyl coenzyme A decarboxylase
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MCD
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
malonyl-CoA = acetyl-CoA + CO2
half-of-the-sites reaction mechanism, overview
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
decarboxylation
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA carboxy-lyase (acetyl-CoA-forming)
Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase.
CAS REGISTRY NUMBER
COMMENTARY
9024-99-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Malonyl-CoA
Acetyl-CoA + CO2
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-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
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plays a critical role in fatty-acid metabolism, precursor hMCD plays a role in the regulation of the cytosolic malonyl-CoA level in cells
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?
additional information
?
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docking analysis of the enzyme onto peroxin 5. modeling, overview
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-
?
additional information
?
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docking analysis of the enzyme onto peroxin 5. modeling, overview
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-
?
additional information
?
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MCD expression plays a key reciprocal role in the balance between lipid and glucose metabolism, MCD silencing increases glucose uptake in myotubes
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
MCD expression plays a key reciprocal role in the balance between lipid and glucose metabolism, MCD silencing increases glucose uptake in myotubes
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
-
plays a critical role in fatty-acid metabolism, precursor hMCD plays a role in the regulation of the cytosolic malonyl-CoA level in cells
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(2,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(2,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(2,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-l]ethanone
-
1-[5-(3,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(3,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(4-hydroxyphenyl)-3-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
1-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
2-[3-(4-hydroxyphenyl)-5-(4-methoxy-2-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[3-(4-hydroxyphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(2,4-dinitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(3,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(3,5-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(4-bromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(4-nitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(furan-3-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(pyridin-2-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
-
-
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
-
((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
-
(2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enenitrile
-
-
(2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
-
-
(2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoic acid
-
-
(2Z)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-methyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-phenyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one oxime
-
-
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
-
-
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenyl)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
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1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
-
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1,1,1,3,3,3-hexafluoro-2-[4-[4-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-2-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(1-methylethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,3-bis(2-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1,3-diethyl-1-(8-hydroxyoctyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1,3-diethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-(4-hydroxybutyl)urea
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1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-(2-cyanoethyl)-3-ethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-(2-phenylethyl)urea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylurea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)butan-1-one
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1-benzyl-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]piperidinium
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1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyrrolidinium
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1-cyclohexyl-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)urea
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1-ethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3,3-dimethylurea
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1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
-
1-ethyl-3,3-dimethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-methoxy-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
-
1-methyl-3-phenyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]butan-1-ol
-
-
1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-1-methyl-3-phenylurea
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
-
-
2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-amino-3-[(2E)-but-2-en-1-yl]isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
-
-
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
-
-
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
2-methyl-N-(3-phenyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
-
-
2-methyl-N-(3-pyridin-4-yl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
-
-
2-methyl-N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanamide
-
-
2-methyl-N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
-
-
2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
-
2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl (1Z)-2-methyl-N-(1-methylethyl)propanimidoate
-
-
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-benzylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-butylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-ethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-furan-3-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-phenylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-pyridin-4-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
2-[4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(4-methoxyphenyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(ethoxymethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(trifluoromethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
-
3-(1-methylethyl)-1-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methyl]-1-(2-morpholin-4-ylethyl)urea
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propan-1-ol
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanoic acid
-
-
3-methyl-1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
3-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]propanoic acid
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
-
-
3-[[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]propanoic acid
-
-
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
-
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
-
-
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)phenol
-
-
4-carbamoyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholin-4-ium
-
-
4-cyano-N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
-
-
4-cyano-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]benzamide
-
-
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino]-pentanoic acid methyl ester
-
30% inhibition at 0.08 mg/ml, 50% inhibition at approximately 0.16 mg/ml
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
-
-
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoic acid
-
-
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoic acid
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
-
-
ethyl (2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enoate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-pyridin-4-yl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
ethyl 5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-3-carboxylate
-
-
ethyl [([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]acetate
-
-
ethyl [[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]acetate
-
-
methyl (2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]pentanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 4-methyl-2-(2-methylpropyl)-2-[2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl]pentanoate
-
-
methyl 4-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]butanoate
-
-
methyl 4-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]butanoate
-
-
methyl 5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)morpholine-4-carboxamido)pentanoate
-
-
methyl 5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoate
-
-
methyl N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycinate
-
-
methyl N-(morpholin-4-ylcarbonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-b-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycinate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)glycinate
-
-
methyl [(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetate
-
-
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
N,2-dimethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N,N-bis(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(1,5-dimethylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(1-methylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-phenylethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3,3-dimethylbutyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycine
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(4-cyanobutyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(4-cyanobutyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylpropanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)acetamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)hexanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)pyridine-4-carboxamide
-
-
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-benzyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-benzyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-butyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-butyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-cyclohexyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-cyclohexyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-ethyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyridine-4-carboxamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-heptyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-heptyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-hexyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
-
-
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
-
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-methyl-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-3-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-octyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-pentyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-[2-(dimethylamino)ethyl]-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-[2-(dimethylamino)ethyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]-2-phenylbutanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pentanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pyridine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-propylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenyl-N-(propan-2-yl)propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N,2-dimethylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-phenylethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alanine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-octylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-pentylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-propylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
tert-butyl (3R)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-b-alaninate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)phenylalaninate
-
-
[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetic acid
-
-
[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetic acid
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
AMP-activated potein kinase
-
AMP-activated potein kinase activates MCD by phosphorylation
-
additional information
-
there is an age-dependent increase in expression of MCD manifesting maturation of fatty acid metabolism in the newborn human heart
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.22
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant E302G, no H2O2
0.35
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.2 M H2O2
0.42
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.1 M H2O2
0.46
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.05 M H2O2
0.56
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, 0.2 M H2O2
0.58
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, no H2O2
0.68
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, 0.1 M H2O2
0.73
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, no H2O2
0.79
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, 0.2 M H2O2
0.8 - 1
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.2 M H2O2
0.83
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, no H2O2
0.99
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.1 M H2O2
1.04
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, 00.1 M H2O2
1.16
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, no H2O2
additional information
additional information
Michaelis-Menten steady-state kinetics, overview
-
additional information
additional information
-
Michaelis-Menten steady-state kinetics, overview
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
13.3
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant E302G, no H2O2
94.6
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, no H2O2
109.2
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.2 M H2O2
114.2
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, 0.2 M H2O2
117.1
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, no H2O2
128.3
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.05 M H2O2
135
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.1 M H2O2
137.5
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, 0.1 M H2O2
141.2
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, 00.1 M H2O2
141.2
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, no H2O2
162.5
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, no H2O2
167.1
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.2 M H2O2
175.4
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.1 M H2O2
208.3
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, 0.2 M H2O2
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00006
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant E302G, no H2O2
0.00014
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, 00.1 M H2O2
0.00014
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, no H2O2
0.00015
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, 0.2 M H2O2
0.00016
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S, no H2O2
0.00016
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, no H2O2
0.00017
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, no H2O2
0.00018
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.1 M H2O2
0.0002
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.2 M H2O2
0.0002
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, 0.1 M H2O2
0.00028
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.05 M H2O2
0.00031
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.2 M H2O2
0.00032
malonyl-CoA
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.1 M H2O2
0.00037
malonyl-CoA
pH 8.5, temperature not specified in the publication, mutant C243S, 0.2 M H2O2
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00633
1-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.0059
1-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00658
1-[5-(2,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00365
1-[5-(2,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00768
1-[5-(2,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-l]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00026
1-[5-(3,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00347
1-[5-(3,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00442
1-[5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.05
1-[5-(4-hydroxyphenyl)-3-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
IC50 above 0.05 mM, at pH 8.0 and 30°C
0.00697
1-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00225
2-[3-(4-hydroxyphenyl)-5-(4-methoxy-2-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00355
2-[3-(4-hydroxyphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.0016
2-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00203
2-[3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00765
2-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00204
2-[5-(2,4-dinitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00027
2-[5-(3,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00308
2-[5-(3,5-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00152
2-[5-(4-bromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00192
2-[5-(4-nitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.0001
2-[5-(furan-3-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00223
2-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00234
2-[5-(pyridin-2-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.000376
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000105
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00008
((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000627
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00045
1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00024 - 0.00032
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
0.000044
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000057
1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000037
1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000092
1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000036
1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000019
1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000087
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000046
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000012
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000081
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000076
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000059
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000089
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0006
1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000059
1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001564
1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000033
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000045
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.0000049
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000047
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000133
2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.006626
2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000017
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000032
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000079
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000027
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000051
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.004337
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000031
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000018
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000005
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000023
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000022
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000013
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000133
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000006
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000014
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000004
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000034
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000019
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000042
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00114
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000269
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001147
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000106
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00002
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00058
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000079
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000175
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000199
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00145
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00093
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000814
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000773
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00199
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000394
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001015
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00265
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00098
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00085
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000009
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.00024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00032
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
MCD mRNA and protein expression are detected at extremely elevated levels in the arcuate, dorsomedial, paraventricular and ventromedial hypothalamic nuclei
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
-
recombinant MCD lacking its mitochondrial and peroxisomal targeting sequences
-
enzyme may be targeted to mitochondria in addition to, or possibly instead of, peroxisomes
-
enzyme may be targeted to peroxisomes in addition to, or possibly instead of, mitochondria
additional information
intracellular mislocalization to the nucleus in M1K/H152N mutant patient, fluorescent immunohistochemic analysis, overview
-
additional information
-
full-length MCD contains a putative, N-terminal 39 amino acid mitochondria targeting sequence and a peroxisomal tageting sequence
-
additional information
-
MCD contains mitochondrial and peroxisomal targeting sequences
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
the MCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily, especially the curacin A polyketide synthase catalytic module, with a conserved His-Ser/Thr dyad important for catalysis
malfunction
physiological function
physiological function
-
malonyl-CoA is both a substrate for fatty acid synthase and an inhibitor of fatty acid oxidation acting as a metabolic switch between anabolic fatty acid synthesis and catabolic fatty acid oxidation
additional information
malfunction
impact of loss-of-function alleles in hereditary MCD deficiency
malfunction
MLYCD deficiency, OMIM 248360, also known as malonic aciduria, is a rare autosomal recessively inherited inborn error of fatty acid metabolism. A patient with this enzyme deficiency shows signs of neonatal hypoglycemia, mental retardation, developmental delay and rheumatoid arthritis. The brain shows patchy, symmetrical hyperintensity of the deep white matter with periventricular white matter and subcortical arcuate fibers being spared. Protein mislocalization to the nucleus is a characteristic feature of MLYCD deficiency in the patient. Phenotype, overview. The phenotype probably involves mutations H152N and M1K
physiological function
decarboxylation of malonyl-CoA to acetyl-CoA by malonyl-CoA decarboxylase is an essential facet in the regulation of fatty acid metabolism
physiological function
the enzyme provides a route for disposal of malonyl-CoA from mitochondria and peroxisomes, whereas in the cytosol the malonyl-CoA pool is regulated by the balance of th enzyme and acetyl-CoA carboxylase activities
additional information
catalytic domain structure and active site structure, with His-Ser/Thr dyad, comparisons, overview. The catalytic domain of MCD contains a central eight-stranded, mostly antiparallel etab sheet (beta1-beta8) that is surrounded by at least 11 alpha helices. The substrate can position its thioester carbonyl, bridging the carboxylate leaving group and CoA backbone, in the vicinity of Ser329 and His423
additional information
-
catalytic domain structure and active site structure, with His-Ser/Thr dyad, comparisons, overview. The catalytic domain of MCD contains a central eight-stranded, mostly antiparallel etab sheet (beta1-beta8) that is surrounded by at least 11 alpha helices. The substrate can position its thioester carbonyl, bridging the carboxylate leaving group and CoA backbone, in the vicinity of Ser329 and His423
additional information
structural asymmetry and disulfide bridges among subunits modulate the activity of the enzyme. The molecular organization of dimer of structural heterodimers, in which the two subunits present markedly different conformations, is consistent with half-of-the-sites reactivity. Interactions extend beyond the C-terminal targeting motif. Active site structure, overview
additional information
-
structural asymmetry and disulfide bridges among subunits modulate the activity of the enzyme. The molecular organization of dimer of structural heterodimers, in which the two subunits present markedly different conformations, is consistent with half-of-the-sites reactivity. Interactions extend beyond the C-terminal targeting motif. Active site structure, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). DCMC_HUMAN
493
0
55003
Swiss-Prot
Mitochondrion (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
tetramer
a dimer of structural heterodimers, in which the two subunits present markedly different conformations. Each subunit has an all-helix N-terminal domain and a catalytic C-terminal domain with an acetyltransferase fold. The N-terminal domain of each monomer, Met40-Trp189, contains eight alpha-helices organized as a bundle of four antiparallel helices (alpha1-alpha3 and alpha6) with two pairs of helices inserted (alpha4-alpha5 and alpha7-alpha8), a four-helix bundle variant. H2O2 oxidation is apparently cooperative in the sense that linked tetramers are formed preferentially to dimers
additional information
additional information
organization of the helical domains and the oligomeric states and intersubunit interfaces, secondary sequence comparisons, subunit structure and oligomeric architecture analysis and comparisons, overview. The MCD monomer contains an N-terminal helical domain and a C-terminal catalytic domain
additional information
-
organization of the helical domains and the oligomeric states and intersubunit interfaces, secondary sequence comparisons, subunit structure and oligomeric architecture analysis and comparisons, overview. The MCD monomer contains an N-terminal helical domain and a C-terminal catalytic domain
additional information
structure analysis, overview. Structural asymmetry and disulfide bridges among subunits modulate the activity of the enzyme. Intersubunit disulfide bridges, Cys206-Cys206 and Cys243-Cys243, can link the four subunits of the tetramer, imparting positive cooperativity to the catalytic process
additional information
-
structure analysis, overview. Structural asymmetry and disulfide bridges among subunits modulate the activity of the enzyme. Intersubunit disulfide bridges, Cys206-Cys206 and Cys243-Cys243, can link the four subunits of the tetramer, imparting positive cooperativity to the catalytic process
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
proteolytic modification
-
full-length MCD contains a putative, N-terminal 39 amino acid mitochondria targeting sequence and a peroxisomal tageting sequence
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant detagged enzyme, from 15% PEG 2000 monomethyl ether and 0.1 M sodium acetate, pH 4.5, and 10 mM sodium citrate, sitting drop vapor diffusion method, X-ray diffraction structure determination and analysis at 3.3-4.3 A resolution, molecular replacement
recombinant mutant E58A/K59A/E278A/E279A/K280A, sitting-drop vapor diffusion method, mixing of 10 mg/ml protein in HEPES, pH 7.5, 100 mM NaCl, 1% v/v glycerol, and 5 mM decanoyl-CoA. in a 2:1 ratio with a precipitant solution containing 10% w/v PEG 20000 and 0.1 M 2-(N-morpholino)ethanesulfonic acid, pH 6.0, at room temperature, X-ray diffraction structure determination and analysis at 2.8 A, by single isomorphous replacement with anomalous scattering
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
A69V
naturally occuring mutation in the N-terminal helical domain, the mutantion is involved in enzyme deficiency
E58A/K59A/E278A/E279A/K280A
site-directed mutagenesis, crystal structure determination. The mutant exhibits similar oligomeric and enzymatic properties as wild-typ, both alanine-substituted patches are located in surface-exposed regions: Glu58-Lys59 is found in the loop connecting helices alphaA and alphaB, while the loop containing residues 278-280, connecting strands beta3 and beta4, is disordered
G300V
naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
H152N
naturally occuring compound heterozygous MLYCD mutation at the N-terminal helical domain
H423N
site-directed mutagenesis, the mutant shows a 7fold loss in kcat compared to the wild-type enzyme
L161P
naturally occuring mutation in the N-terminal helical domain, the mutantion is involved in enzyme deficiency
L307R
naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
S290F
S329A
site-directed mutagenesis, the mutant shows a 110fold loss in kcat and 58fold loss in kcat/Km compared to the wild-type enzyme
S440I
naturally occuring mutation in the catalytic domain, the mutantion is involved in enzyme deficiency
S477F
naturally occuring mutation in the catalytic domain, the mutantion is involved in enzyme deficiency
W384C
naturally occuring mutation in the catalytic domain, the mutantion is involved in enzyme deficiency
Y456S
naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
additional information
-
genetic mutation causing malonic aciduria: a four nucleotide deletion at the 3-end of exon 2 of the gene, c.638-641delGTGA, that introduces a premature stop codon and deletes the 272 carboxy terminal amino acids of the protein
S290F
naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
S290F
site-directed mutagenesis, the mutant shows a 2fold decrease in kcat in vitro compared to the wild-type enzyme
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
the N-terminal region of hMCD plays a role in the folding process and conformation stability of enzyme
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant maltose-binding protein fusion wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by amylase affinity chromatography, fusion protein cleavage by tobacco etch virus protease, gel filtration, and anion exchange chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of wild-type and mutant enzymes as maltose-binding protein fusion proteins in Escherichia coli strain BL21(DE3) in minimal medium containing selenomethionine
gene MLYCD, localized on chromosome 16q24, DNA and amino acid sequence determination and analysis of the mutant enzyme, sequence comparison
expression in the human hepatoma cell line huh7, sequencing, located on chromosome 16q24
-
from heart, overexpression of full-length and N-terminal truncated hMCD in Escherichia coli BL21 (DE3), sequencing
-
overexpression of MCD lacking both its mitochondrial and peroxisomal targeting sequences in INS-1-derived 832/13 beta-cells, effect of MCD expression on glucose-stimulated insulin secretion
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
medicine
-
enzyme deficiency is associated with mild mental retardation, seizures, hypotonia, cardiomyopathie, vomiting, hypoglycemia, metabolic acidosis and malonic aciduria
medicine
-
enzyme deficiency is characterized by malonic aciduria, developmental delay, seizure disorder, and mental retardation
medicine
-
MCD is involved in regulating cardiac malonyl-CoA levels, inhibition of MCD can limit rates of fatty acid oxidation, leading to a secondary increase in glucose oxidation associated with an improvement in the functional recovery of the heart during ischaemia/reperfusion injury
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mulder, H.; Lu, D.; Finley IV, J.; An, J.; Cohen, J.; Antinozzi, P.A.; McGarry, J.D.; Newgard, C.B.
Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
J. Biol. Chem.
276
6479-6484
2001
Homo sapiens
Gao, J.; Waber, L.; Bennett, M.J.; Gibson, K.M.; Cohen, J.C.
Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase
J. Lipid Res.
40
178-182
1999
Homo sapiens
Zhou, D.; Yuen, P.; Chu, D.; Thon, V.; McConnell, S.; Brown, S.; Tsang, A.; Pena, M.; Russell, A.; Cheng, J.F.; Nadzan, A.M.; Barbosa, M.S.; Dyck, J.R.B.; Lopaschuk, G.D.; Yang, G.
Expression, purification, and characterization of human malonyl-CoA decarboxylase
Protein Expr. Purif.
34
261-269
2004
Homo sapiens
Kuhl, J.E.; Ruderman, N.B.; Musi, N.; Goodyear, L.J.; Patti, M.E.; Crunkhorn, S.; Dronamraju, D.; Thorell, A.; Nygren, J.; Ljungkvist, O.; Degerblad, M.; Stahle, A.; Brismar, T.B.; Andersen, K.L.; Saha, A.K.; Efendic, S.; Bavenholm, P.N.
Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle
Am. J. Physiol. Endocrinol. Metab.
290
E1296-E1303
2006
Homo sapiens
Cheng, J.F.; Chen, M.; Wallace, D.; Tith, S.; Haramura, M.; Liu, B.; Mak, C.C.; Arrhenius, T.; Reily, S.; Brown, S.; Thorn, V.; Harmon, C.; Barr, R.; Dyck, J.R.; Lopaschuk, G.D.; Nadzan, A.M.
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors
J. Med. Chem.
49
1517-1525
2006
Homo sapiens
Lo, M.C.; Wang, M.; Kim, K.W.; Busby, J.; Yamane, H.; Zondlo, J.; Yuan, C.; Young, S.W.; Xiao, S.H.
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase
Anal. Biochem.
376
122-130
2008
Homo sapiens
Saggerson, D.
Malonyl-CoA, a key signaling molecule in mammalian cells
Annu. Rev. Nutr.
28
253-272
2008
Homo sapiens
Ussher, J.R.; Lopaschuk, G.D.
The malonyl CoA axis as a potential target for treating ischaemic heart disease
Cardiovasc. Res.
79
259-268
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Lopez, M.; Vidal-Puig, A.
Brain lipogenesis and regulation of energy metabolism
Curr. Opin. Clin. Nutr. Metab. Care
11
483-490
2008
Homo sapiens
Bouzakri, K.; Austin, R.; Rune, A.; Lassman, M.E.; Garcia-Roves, P.M.; Berger, J.P.; Krook, A.; Chibalin, A.V.; Zhang, B.B.; Zierath, J.R.
Malonyl coenzyme A decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
Diabetes
57
1508-1516
2008
Homo sapiens
Li, J.; Lei, B.; Liu, H.; Li, S.; Yao, X.; Liu, M.; Gramatica, P.
QSAR study of malonyl-CoA decarboxylase inhibitors using GA-MLR and a new strategy of consensus modeling
J. Comput. Chem.
29
2636-2647
2008
Homo sapiens
Yatscoff, M.A.; Jaswal, J.S.; Grant, M.R.; Greenwood, R.; Lukat, T.; Beker, D.L.; Rebeyka, I.M.; Lopaschuk, G.D.
Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart
Pediatr. Res.
64
643-647
2008
Homo sapiens
Singh, P.; Kumar, R.; Sharma, B.; Prabhakar, Y.
Topological descriptors in modeling malonyl coenzyme A decarboxylase inhibitory activity: N-alkyl-N-(1,1,1,3,3,3-hexafluoro-2-hydroxypropylphenyl) amide derivatives
J. Enzyme Inhib. Med. Chem.
24
77-85
2009
Homo sapiens
Zhou, W.; Tu, Y.; Simpson, P.J.; Kuhajda, F.P.
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells
Oncogene
28
2979-2987
2009
Homo sapiens
Tang, H.; Yan, Y.; Feng, Z.; de Jesus, R.K.; Yang, L.; Levorse, D.A.; Owens, K.A.; Akiyama, T.E.; Bergeron, R.; Castriota, G.A.; Doebber, T.W.; Ellsworth, K.P.; Lassman, M.E.; Li, C.; Wu, M.S.; Zhang, B.B.; Chapman, K.T.; Mills, S.G.; Berger, J.P.; Pasternak, A.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities
Bioorg. Med. Chem. Lett.
20
6088-6092
2010
Homo sapiens
Polinati, P.P.; Valanne, L.; Tyni, T.
Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations
Brain Dev.
37
107-113
2015
Homo sapiens (O95822)
Aparicio, D.; Perez-Luque, R.; Carpena, X.; Diaz, M.; Ferrer, J.C.; Loewen, P.C.; Fita, I.
Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase
J. Biol. Chem.
288
11907-11919
2013
Homo sapiens (O95822), Homo sapiens
Froese, D.S.; Forouhar, F.; Tran, T.H.; Vollmar, M.; Kim, Y.S.; Lew, S.; Neely, H.; Seetharaman, J.; Shen, Y.; Xiao, R.; Acton, T.B.; Everett, J.K.; Cannone, G.; Puranik, S.; Savitsky, P.; Krojer, T.; Pilka, E.S.; Kiyani, W.; Lee, W.H.; Marsden, B.D.; von Delft, F.; Allerston, C.K.; Spagnolo, L.; Gileadi, O.; , M.
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations
Structure
21
1182-1192
2013
Agrobacterium vitis (B9K0V9), Agrobacterium vitis, Cupriavidus metallidurans (Q1LJK6), Cupriavidus metallidurans, Cupriavidus metallidurans CH34 (Q1LJK6), Homo sapiens (O95822), Homo sapiens, Rhodopseudomonas palustris
Hwang, I.W.; Makishima, Y.; Suzuki, T.; Kato, T.; Park, S.; Terzic, A.; Chung, S.K.; Park, E.Y.
Phosphorylation of Ser-204 and Tyr-405 in human malonyl-CoA decarboxylase expressed in silkworm Bombyx mori regulates catalytic decarboxylase activity
Appl. Microbiol. Biotechnol.
99
8977-8986
2015
Homo sapiens (O95822), Homo sapiens
Jagdale, D.; Ramaa, C.
Design, synthesis and in vitro evaluation of some small molecules malonyl CoA decarboxylase inhibitors containing pyrazoline scaffold and study of their binding interactions with malonyl CoA decarboxylase via preliminary docking simulation
Med. Chem. Res.
26
2127-2140
2017
Homo sapiens (O95822)
-
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