Information on EC 4.1.1.9 - Malonyl-CoA decarboxylase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
4.1.1.9
-
RECOMMENDED NAME
GeneOntology No.
Malonyl-CoA decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
malonyl-CoA = acetyl-CoA + CO2
show the reaction diagram
stereospecific reaction, replacement of the carboxyl group by hydrogen occurs with retention of configuration
-
malonyl-CoA = acetyl-CoA + CO2
show the reaction diagram
half-of-the-sites reaction mechanism, overview
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
acetylation
-
N-acetylation
decarboxylation
-
-
-
-
decarboxylation
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
acetyl CoA biosynthesis
-
-
beta-Alanine metabolism
-
-
Metabolic pathways
-
-
Propanoate metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA carboxy-lyase (acetyl-CoA-forming)
Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl-CoA: malonate CoA transferase/malonyl-CoA decarboxylase
-
-
-
-
Decarboxylase, malonyl coenzyme A
-
-
-
-
hMCD
-
-
malonyl CoA decarboxylase
-
-
Malonyl coenzyme A decarboxylase
-
-
-
-
Malonyl coenzyme A decarboxylase
-
-
Malonyl coenzyme A decarboxylase
-
-
Malonyl-CoA decarboxylase
-
-
-
-
malonyl-CoA decarboxylase/acetyltransferase
-
bifunctional enzyme
malonyl-coenzyme A decarboxylase
B9K0V9
-
malonyl-coenzyme A decarboxylase
Q1LJK6
-
malonyl-coenzyme A decarboxylase
O95822
-
malonyl-coenzyme A decarboxylase
-
-
MCD
-
-
-
-
MCD
O95822
-
MCD
-
bifunctional enzyme
MLYCD
O95822
gene name
CAS REGISTRY NUMBER
COMMENTARY
9024-99-1
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzyme has malonyl-CoA:acetate CoA transferase activity, acetylCoA:malonate CoA transferase and malonyl-CoA decarboxylase activity
-
-
Manually annotated by BRENDA team
Anser domesticus
-
-
-
Manually annotated by BRENDA team
gene MLYCD
Uniprot
Manually annotated by BRENDA team
male, normal and with malonic aciduria
-
-
Manually annotated by BRENDA team
mice lacking peroxisome proliferator-activated receptor alpha and age-matched wild-type Sv/129 mice
-
-
Manually annotated by BRENDA team
bifunctional enzyme
-
-
Manually annotated by BRENDA team
fenofibrate-fed Otsuka Long-Evans Tokushima fatty rats
-
-
Manually annotated by BRENDA team
male 6-months-old Fisher 344 rats
-
-
Manually annotated by BRENDA team
male Harlan Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Sprague-Dawley rats, dietary manipulated
-
-
Manually annotated by BRENDA team
male Sprague-Dawley rats, streptozotocin diabetic rats perfused in the presence or absence of insulin, under either diabetic or control conditions
-
-
Manually annotated by BRENDA team
Wistar rat
-
-
Manually annotated by BRENDA team
bv. trifolii
GenBank
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
-
the MCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily, especially the curacin A polyketide synthase catalytic module, with a conserved His-Ser/Thr dyad important for catalysis
evolution
B9K0V9
the MCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily, especially the curacin A polyketide synthase catalytic module, with a conserved His-Ser/Thr dyad important for catalysis
evolution
Q1LJK6
the MCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily, especially the curacin A polyketide synthase catalytic module, with a conserved His-Ser/Thr dyad important for catalysis
malfunction
-
impact of loss-of-function alleles in hereditary MCD deficiency
malfunction
O95822
MLYCD deficiency, OMIM 248360, also known as malonic aciduria, is a rare autosomal recessively inherited inborn error of fatty acid metabolism. A patient with this enzyme deficiency shows signs of neonatal hypoglycemia, mental retardation, developmental delay and rheumatoid arthritis. The brain shows patchy, symmetrical hyperintensity of the deep white matter with periventricular white matter and subcortical arcuate fibers being spared. Protein mislocalization to the nucleus is a characteristic feature of MLYCD deficiency in the patient. Phenotype, overview. The phenotype probably involves mutations H152N and M1K
physiological function
-
malonyl-CoA is both a substrate for fatty acid synthase and an inhibitor of fatty acid oxidation acting as a metabolic switch between anabolic fatty acid synthesis and catabolic fatty acid oxidation
physiological function
-
decarboxylation of malonyl-CoA to acetyl-CoA by malonyl-CoA decarboxylase is an essential facet in the regulation of fatty acid metabolism
physiological function
-
malonyl-CoA decarboxylase regulates fatty acid oxidation
physiological function
O95822
the enzyme provides a route for disposal of malonyl-CoA from mitochondria and peroxisomes, whereas in the cytosol the malonyl-CoA pool is regulated by the balance of th enzyme and acetyl-CoA carboxylase activities
malfunction
-
pharmacological inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance. Additionally, inhibition of MCD strongly diminishes lipopolysaccharide-induced activation of palmitate oxidation and prevents lipopolysaccharide-induced collapse of total cellular antioxidant capacity and prevents increases in the level of ceramide in cardiomyocytes and macrophages while also ameliorating LPS-initiated decreases in PPAR binding. Genetic inactivation of malonyl-CoA decarboxylase protects mice against high-fat diet-induced insulin resistance
additional information
-
catalytic domain structure and active site structure comparisons, overview
additional information
B9K0V9
catalytic domain structure and active site structure comparisons, overview
additional information
Q1LJK6
catalytic domain structure and active site structure comparisons, overview
additional information
-
catalytic domain structure and active site structure, with His-Ser/Thr dyad, comparisons, overview. The catalytic domain of MCD contains a central eight-stranded, mostly antiparallel etab sheet (beta1-beta8) that is surrounded by at least 11 alpha helices. The substrate can position its thioester carbonyl, bridging the carboxylate leaving group and CoA backbone, in the vicinity of Ser329 and His423
additional information
-
structural asymmetry and disulfide bridges among subunits modulate the activity of the enzyme. The molecular organization of dimer of structural heterodimers, in which the two subunits present markedly different conformations, is consistent with half-of-the-sites reactivity. Interactions extend beyond the C-terminal targeting motif. Active site structure, overview
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
ir
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
r
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
Q9ZIP6
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
O95822
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
B9K0V9
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
Q1LJK6
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
high affinity for malonyl-CoA
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
primary substrate, higher specific activity than with methylmalonyl-CoA as substrate, Cys-214 is located at or near the active site and plays a critical role in catalysis
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
control of malonyl-CoA concentration
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
Q9ZIP6
fatty-acid metabolism
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
important role in regulating fatty acid metabolism, involved in the control of cellular malonyl-CoA levels, may play an essential role in regulating energy utilization in the liver by regulating malonyl-CoA levels in response to various nutritional or pathological states, MCD regulation from liver
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
involved in the control of fatty acid oxidation, contributes to the high fatty acid oxidation rates in the diabetic heart
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
main route for the disposal of malonyl-CoA, the key metabolite in the regulation of mitochondrial fatty acid oxidation
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
malonate metabolism
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
malonyl-CoA degradation, transcriptional control of MCD by peroxisome proliferator-activated receptor alpha, involved in the regulation of fatty acid oxidation
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
may be implicated in the regulation of lipid metabolism and other cellular functions, involved in the regulation of the cellular malonyl-CoA level, may play an essential role in regulating energy utilization in response to various nutritional changes and/or pathological states
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
plays a critical role in fatty-acid metabolism, precursor hMCD plays a role in the regulation of the cytosolic malonyl-CoA level in cells
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
MCD degrades the natural CPT1 inhibitor malonyl-CoA and thereby facilitates fatty acid import into mitochondria
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
Pseudomonas putida IAM 1177
-
-
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
decarboxylates malonyl-CoA generated by propionyl-CoA carboxylase and thus protects mitochondrial enzymes susceptible to inhibition by malonyl-CoA
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
discussion of the probable role of the enzyme in the regulation of lipid metabolism, especially branched-chain fatty acid synthesis
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
the decarboxylase gene transcript levels show the developmental changes expected from the proposed role for this enzyme in the production of the secretory lipid of the uropygial glands
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
the main physiological role is thought to be the stabilization of malonyl-CoA levels which change very little with brain growth
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
heart enzyme has an important role in regulating fatty acid oxidation rates
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
decarboxylase provides propionyl-CoA for erythromycin synthesis probably via decarboxylation of methylmalonyl-CoA derived from succinyl-CoA
-
-
-
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
-
-
-
-
-
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
-
no reaction
-
-
-
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
-
at less than 7% of the activity with malonyl-CoA
-
-
-
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
-
the (R)-isomer is decarboxylated at 3% of the rate observed with malonyl-CoA, the (S)-isomer is not a substrate
-
-
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
-
at 5% of the activity with malonyl-CoA
-
-
-
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
-
specific activity is 0.1% that of malonyl-CoA decarboxylation
-
?
N-hydroxy-L-ornithine + malonyl-CoA
delta-N-acetyl-delta-N-hydroxy-L-ornithine + coenzyme A + CO2
show the reaction diagram
-
acetylation of the delta-amino functionality of N-hydroxy-L-ornithine is mediated by the bifunctional malonyl-CoA decarboxylase/acetyltransferase Mcd
-
-
?
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
Pseudomonas putida IAM 1177
-
-
-
-
-
additional information
?
-
-
MCD expression plays a key reciprocal role in the balance between lipid and glucose metabolism, MCD silencing increases glucose uptake in myotubes
-
-
-
additional information
?
-
-
MCD is an inhibitor of carnitine palmitoyl-CoA transferase-1
-
-
-
additional information
?
-
O95822
docking analysis of the enzyme onto peroxin 5. modeling, overview
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
O95822
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
control of malonyl-CoA concentration
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
Q9ZIP6
fatty-acid metabolism
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
important role in regulating fatty acid metabolism, involved in the control of cellular malonyl-CoA levels, may play an essential role in regulating energy utilization in the liver by regulating malonyl-CoA levels in response to various nutritional or pathological states, MCD regulation from liver
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
involved in the control of fatty acid oxidation, contributes to the high fatty acid oxidation rates in the diabetic heart
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
main route for the disposal of malonyl-CoA, the key metabolite in the regulation of mitochondrial fatty acid oxidation
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
malonate metabolism
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
malonyl-CoA degradation, transcriptional control of MCD by peroxisome proliferator-activated receptor alpha, involved in the regulation of fatty acid oxidation
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
may be implicated in the regulation of lipid metabolism and other cellular functions, involved in the regulation of the cellular malonyl-CoA level, may play an essential role in regulating energy utilization in response to various nutritional changes and/or pathological states
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
plays a critical role in fatty-acid metabolism, precursor hMCD plays a role in the regulation of the cytosolic malonyl-CoA level in cells
-
?
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
-
role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release
-
?
Malonyl-CoA
?
show the reaction diagram
-
-
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
decarboxylates malonyl-CoA generated by propionyl-CoA carboxylase and thus protects mitochondrial enzymes susceptible to inhibition by malonyl-CoA
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
discussion of the probable role of the enzyme in the regulation of lipid metabolism, especially branched-chain fatty acid synthesis
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
the decarboxylase gene transcript levels show the developmental changes expected from the proposed role for this enzyme in the production of the secretory lipid of the uropygial glands
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
the main physiological role is thought to be the stabilization of malonyl-CoA levels which change very little with brain growth
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
heart enzyme has an important role in regulating fatty acid oxidation rates
-
-
-
Malonyl-CoA
?
show the reaction diagram
-
decarboxylase provides propionyl-CoA for erythromycin synthesis probably via decarboxylation of methylmalonyl-CoA derived from succinyl-CoA
-
-
-
additional information
?
-
-
MCD expression plays a key reciprocal role in the balance between lipid and glucose metabolism, MCD silencing increases glucose uptake in myotubes
-
-
-
additional information
?
-
-
MCD is an inhibitor of carnitine palmitoyl-CoA transferase-1
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no cofactor requirement
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
no metal ion participation
additional information
-
no requirement of divalent metal ions
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
-
-
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
-
((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
-
(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile
-
-
(2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enenitrile
-
-
(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile
-
-
(2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
-
-
(2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoic acid
-
-
(2Z)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
-
-
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
-
-
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-methyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-phenyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one oxime
-
-
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
-
-
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
-
1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenyl)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[4-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-2-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(1-methylethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,3-bis(2-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1,3-diethyl-1-(8-hydroxyoctyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1,3-diethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-(4-hydroxybutyl)urea
-
-
1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
-
1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
-
-
1-(2-cyanoethyl)-3-ethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-(2-phenylethyl)urea
-
-
1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylurea
-
-
1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)butan-1-one
-
-
1-benzyl-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]piperidinium
-
-
1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyrrolidinium
-
-
1-cyclohexyl-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)urea
-
-
1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
-
-
1-ethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3,3-dimethylurea
-
-
1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
-
1-ethyl-3,3-dimethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
-
-
1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
-
-
1-methoxy-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
-
1-methyl-3-phenyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
1-phenyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
-
1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]butan-1-ol
-
-
1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-1-methyl-3-phenylurea
-
-
1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylurea
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
-
-
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
-
-
2,2'-dipyridyl
-
-
2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
-
-
2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-amino-3-[(2E)-but-2-en-1-yl]isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
-
-
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
-
-
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
-
-
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
-
-
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
2-methyl-N-(3-phenyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
-
-
2-methyl-N-(3-pyridin-4-yl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
-
-
2-methyl-N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanamide
-
-
2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide
-
-
2-methyl-N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
-
-
2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
-
-
2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
-
2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
-
2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl (1Z)-2-methyl-N-(1-methylethyl)propanimidoate
-
-
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone
-
-
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-benzylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-butylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-ethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-furan-3-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-phenylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-pyridin-4-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
2-[4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(4-methoxyphenyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(ethoxymethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(trifluoromethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
-
3-(1-methylethyl)-1-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methyl]-1-(2-morpholin-4-ylethyl)urea
-
-
3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propan-1-ol
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanoic acid
-
-
3-Bromopyruvate
-
-
3-Bromopyruvate
-
weak
3-methyl-1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
-
-
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
3-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]propanoic acid
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
-
-
3-[[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]propanoic acid
-
-
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
-
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
-
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
-
-
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)phenol
-
-
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
-
-
4-carbamoyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholin-4-ium
-
-
4-cyano-N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
-
-
4-cyano-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]benzamide
-
-
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
-
-
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1 trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide
-
-
5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino]-pentanoic acid methyl ester
-
30% inhibition at 0.08 mg/ml, 50% inhibition at approximately 0.16 mg/ml
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
-
-
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
-
-
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoic acid
-
-
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoic acid
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
-
-
Acetic anhydride
-
0.01 mg MCD is incubated with the 3fold excess of acetic anhydride leading to 70% loss of activity after 30 min
acetyl-CoA
-
-
acetyl-CoA
-
insensitive
acetyl-CoA
-
-
acetyl-CoA
-
-
acetyl-CoA
-
-
ADP
-
inhibition at 2 mM
Avidin
-
0.6 mg/ml, 11% inhibition
-
Avidin
-
no inhibition
-
Avidin
-
no inhibition
-
CBM-301940
-
0.01 mM, 85% inhibition
CoA
-
-
diisopropylfluorophosphate
-
-
EDTA
-
1 mM, 15% inhibition
ethyl (2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enoate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
ethyl 2-pyridin-4-yl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
ethyl 5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-3-carboxylate
-
-
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
-
-
ethyl [([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]acetate
-
-
ethyl [[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]acetate
-
-
iodoacetamide
-
1 mM, 16% inhibition
L-Malate
-
-
methyl (2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]pentanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
methyl 4-methyl-2-(2-methylpropyl)-2-[2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl]pentanoate
-
-
methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate
-
-
methyl 4-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]butanoate
-
-
methyl 4-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]butanoate
-
-
methyl 5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)morpholine-4-carboxamido)pentanoate
-
-
methyl 5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoate
-
-
methyl N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycinate
-
-
methyl N-(morpholin-4-ylcarbonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-b-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycinate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)glycinate
-
-
methyl [(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetate
-
-
methyl-5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) phenyl)morpholine-4-carboxamido)pentanoate
-
i.e. CBM-301106, specific inhibitor of the enzyme
methylmalonyl-CoA
-
competitive
methylmalonyl-CoA
-
-
methylmalonyl-CoA
-
-
methylmalonyl-CoA
-
-
methylmalonyl-CoA
-
-
methylmalonyl-CoA
-
-
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
N,2-dimethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N,N-bis(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N,N-diethyl-4-(trifluoroacetyl)benzamide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N,N-dipropyl-4-(trifluoroacetyl)benzamide
-
-
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1,5-dimethylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
-
-
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
-
-
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-phenylethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(3,3-dimethylbutyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
-
-
N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycine
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(4-cyanobutyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(4-cyanobutyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(4-cyanophenyl)-2-methyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)propanamide
-
-
N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylpropanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)acetamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)hexanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)pyridine-4-carboxamide
-
-
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
-
-
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
-
-
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-benzyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-benzyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-butyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide
-
-
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-butyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-cyclohexyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-cyclohexyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-ethyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyridine-4-carboxamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-ethylmaleimide
-
1 mM, 47% inhibition
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-heptyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-heptyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-hexyl-4-(trifluoroacetyl)benzamide
-
-
N-hexyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
-
-
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
-
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
-
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide
-
-
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-3-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-octyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-pentyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
-
-
N-[2-(dimethylamino)ethyl]-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-[2-(dimethylamino)ethyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]-2-phenylbutanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pentanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pyridine-4-carboxamide
-
-
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-propylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenyl-N-(propan-2-yl)propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N,2-dimethylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-phenylethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alanine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-octylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-pentylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-propylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
-
-
NAD+
-
-
NEM
-
-
NEM
-
inhibits iodoacetamide-induced malonyl-CoA decarboxylase activity
NEM
-
no inhibition
NEM
-
no inhibition
NEM
-
enzyme with malonyl-CoA:acetate CoA transferase activity, acetylCoA:malonate CoA transferase and malonyl-CoA decarboxylase activity completely loses its malonate decarboxylase activity by treatment with NEM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
0.1 mM, 95.5% inhibition
p-hydroxymercuribenzoate
-
insensitive
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
insensitive
p-hydroxymercuribenzoate
-
insensitive
palmitoyl-CoA
-
-
palmitoyl-CoA
-
noncompetitive
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
propionyl-CoA
-
-
propionyl-CoA
-
insensitive
propionyl-CoA
-
-
propionyl-CoA
-
-
pyridoxal 5'-phosphate
-
partly competitive
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
SO42-
-
reversible
succinyl-CoA
-
-
succinyl-CoA
-
-
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
-
i.e. CBM-301940
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-b-alaninate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)phenylalaninate
-
-
Vanillin
-
-
[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetic acid
-
-
[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetic acid
-
-
methylmalonyl-CoA
-
-
additional information
-
cerulenin has no effect in the iodoacetamide-treated enzyme
-
additional information
-
high ionic strength inhibits
-
additional information
-
troglitazone, a specific peroxisome proliferator-activated receptor-gamma agonist, decreases MCD expression, no effect on MCD activity
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
-
AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A
Alkaline phosphatase
-
treatment with alkaline phosphatase enhances MCD activity suggesting phosphorylation-related control of enzyme
-
AMP-activated potein kinase
-
AMP-activated potein kinase activates MCD by phosphorylation
-
DL-carnitine
-
stimulates
fatty acid
-
increases MCD expression in heart and skeletal muscle
fenofibrate
-
increases hepatic mRNA expression and MCD activity
iodoacetamide
-
malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide
palmitate
-
the activity of MCD elicits a dose-dependent increase (between 25% and 60%) in cells exposed to increasing concentrations of palmitate (0.1-0.8 mM)
phosphate
-
activates
WY-14643
-
specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle
iodoacetamide
-
treatment of fatty acid synthetase with iodoacetamide induces malonyl-CoA decarboxylase activity and impairs the synthetase activity
additional information
-
high-fat feeding, fasting and streptozotocin-induced diabetes increase the plasma concentration of nonesterified fatty acids, with a concomitant increase in both heart and skeletal muscle MCD mRNA
-
additional information
-
MCD activity is elevated under conditions in which hepatic fatty acid oxidation is known to increase, such as streptozotocin-induced diabetes or following a 48 h fast, 2fold increase in expression in streptozotocin-diabetic rats compared with controls
-
additional information
-
peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression
-
additional information
-
gastrocnemius contraction activates MCD, reversed by protein phosphatase A or by omitting phosphatase inhibitors from assay mixture, increase of MCD activity after skeletal muscle contraction is likely due to its phosphorylation by AMP-activated protein kinase
-
additional information
-
there is an age-dependent increase in expression of MCD manifesting maturation of fatty acid metabolism in the newborn human heart
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0087
malonyl-CoA
-
-
0.032
malonyl-CoA
-
-
0.033
malonyl-CoA
-
-
0.042
malonyl-CoA
-
-
0.05
malonyl-CoA
-
-
0.054
malonyl-CoA
-
-
0.065
malonyl-CoA
-
in presence of 150 mM PO43-
0.066
malonyl-CoA
-
-
0.068
malonyl-CoA
-
pH 7, recombinant MCD
0.1
malonyl-CoA
-
-
0.1
malonyl-CoA
Anser domesticus, Branta leucopsis
-
-
0.119
malonyl-CoA
-
gastrocnemius after 5 min of contraction
0.143
malonyl-CoA
-
-
0.146
malonyl-CoA
-
in presence of 40 mM PO43-
0.15
malonyl-CoA
-
-
0.19
malonyl-CoA
-
gastrocnemius, relaxed
0.2
malonyl-CoA
-
-
0.202
malonyl-CoA
-
in 100 mM potassium phosphate buffer (pH 8.5) and 1 mM thiophenol, at 60C
0.22
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant E302G, no H2O2
0.33 - 0.52
malonyl-CoA
-
full-length and N-terminal truncated apo-hMCD
0.33
malonyl-CoA
-
-
0.35
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.2 M H2O2
0.42
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.1 M H2O2
0.46
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.05 M H2O2
0.47
malonyl-CoA
-
-
0.5
malonyl-CoA
-
-
0.56
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, 0.2 M H2O2
0.58
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, no H2O2
0.68
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, 0.1 M H2O2
0.73
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, no H2O2
0.79
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, 0.2 M H2O2
0.8 - 1
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.2 M H2O2
0.83
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, no H2O2
0.99
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.1 M H2O2
1.04
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, 00.1 M H2O2
0.025
N-hydroxy-L-ornithine
-
in 20 mM Tris, 100 mM NaCl, pH 7.2, at 25C
1.16
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, no H2O2
additional information
additional information
-
-
-
additional information
additional information
-
Michaelis-Menten steady-state kinetics, overview
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
13 - 28
malonyl-CoA
-
full-length and N-terminal truncated apo-hMCD
13.3
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant E302G, no H2O2
47.3
malonyl-CoA
-
-
94.6
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, no H2O2
109.2
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.2 M H2O2
114.2
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, 0.2 M H2O2
117.1
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, no H2O2
128.3
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.05 M H2O2
135
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.1 M H2O2
137.5
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, 0.1 M H2O2
141.2
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, 00.1 M H2O2; pH 8.5, temperature not specified in the publication, wild-type enzyme, no H2O2
162.5
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, no H2O2
167.1
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.2 M H2O2
175.4
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.1 M H2O2
208.3
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, 0.2 M H2O2
0.038
N-hydroxy-L-ornithine
-
in 20 mM Tris, 100 mM NaCl, pH 7.2, at 25C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00006
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant E302G, no H2O2
76
0.00014
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, 00.1 M H2O2; pH 8.5, temperature not specified in the publication, mutant C206S/C243S, no H2O2
76
0.00015
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, 0.2 M H2O2
76
0.00016
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S, no H2O2; pH 8.5, temperature not specified in the publication, mutant C243S, no H2O2
76
0.00017
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, no H2O2
76
0.00018
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.1 M H2O2
76
0.0002
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C206S/C243S, 0.2 M H2O2; pH 8.5, temperature not specified in the publication, mutant C243S, 0.1 M H2O2
76
0.00028
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.05 M H2O2
76
0.00031
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.2 M H2O2
76
0.00032
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, wild-type enzyme, 0.1 M H2O2
76
0.00037
malonyl-CoA
-
pH 8.5, temperature not specified in the publication, mutant C243S, 0.2 M H2O2
76
1.53
N-hydroxy-L-ornithine
-
in 20 mM Tris, 100 mM NaCl, pH 7.2, at 25C
41713
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000376
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000105
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00008
((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00029
(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile
-
-
0.00014
(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile
-
-
0.000118
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
-
-
0.000152
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime
-
-
0.00035
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
-
-
0.000044
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
-
-
0.000627
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00045
1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.000024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.00024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.00032
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.000044
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.00011
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.0000057
1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
-
pH and temperature not specified in the publication
0.000209
1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
0.000149
1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
0.000274
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
0.000114
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
0.000465
1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
-
-
0.000037
1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.00002
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000013
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000092
1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000036
1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000019
1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.0000087
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000011
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000046
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000012
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.0000081
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000076
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.000059
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.0000089
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
-
pH and temperature not specified in the publication
0.0006
1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
-
pH and temperature not specified in the publication
0.000155
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
0.000116
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
0.00034
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
0.00006
1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000037
1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
0.00009
1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
-
-
0.000005
1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
0.000007
1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
-
-
0.000059
1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00006
1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
-
-
0.000059
1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
-
-
0.001564
1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000033
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
-
pH and temperature not specified in the publication
0.0000045
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
-
pH and temperature not specified in the publication
0.000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
-
pH and temperature not specified in the publication
0.0000049
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
-
pH and temperature not specified in the publication
0.0000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
-
pH and temperature not specified in the publication
0.0000009
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
-
pH and temperature not specified in the publication
0.0000047
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
-
pH and temperature not specified in the publication
0.00328
2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
-
-
0.0000133
2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
pH and temperature not specified in the publication
0.00046
2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
0.000303
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
0.0002
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
-
-
0.000059
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
-
-
0.000225
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
0.000042
2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide
-
-
0.00545
2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
-
-
0.006626
2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0015
2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
-
0.0000017
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
pH and temperature not specified in the publication
0.000074
2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone
-
-
0.000011
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
pH and temperature not specified in the publication
0.0000032
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
pH and temperature not specified in the publication
0.000079
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
pH and temperature not specified in the publication
0.0000027
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
pH and temperature not specified in the publication
0.00041
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
0.0000051
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
pH and temperature not specified in the publication
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
-
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
-
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00034
3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
0.00042
3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
0.0028
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
-
-
0.00008
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
-
-
0.004337
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000031
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
-
pH and temperature not specified in the publication
0.0000018
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
-
pH and temperature not specified in the publication
0.0000009
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
pH and temperature not specified in the publication
0.000239
3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
0.000163
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
0.0000005
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
pH and temperature not specified in the publication
0.0000023
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
-
pH and temperature not specified in the publication
0.0000022
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
-
pH and temperature not specified in the publication
0.0000013
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
pH and temperature not specified in the publication
0.000016
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
pH and temperature not specified in the publication
0.000014
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
-
pH and temperature not specified in the publication
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
-
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000133
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
-
pH and temperature not specified in the publication
0.0000006
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
pH and temperature not specified in the publication
0.0000014
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
pH and temperature not specified in the publication
0.000507
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
-
-
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
-
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0049
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
-
-
0.0000004
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
pH and temperature not specified in the publication
0.0000034
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
pH and temperature not specified in the publication
0.000004
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
pH and temperature not specified in the publication
0.000019
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
pH and temperature not specified in the publication
0.000042
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
pH and temperature not specified in the publication
0.000014
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00002
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00039
5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide
-
-
0.000107
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
-
-
0.000168
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
-
-
0.000318
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
0.000037
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
0.000191
ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
0.000463
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
0.000421
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
0.001767
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
-
-
4.1
L-Malate
-
in 40 mM Tris, pH 8.0
0.000088
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate
-
-
0.000065
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
0.000041
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
0.000054
methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate
-
-
0.00114
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000269
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000073
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
0.001619
N,N-diethyl-4-(trifluoroacetyl)benzamide
-
-
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000153
N,N-dipropyl-4-(trifluoroacetyl)benzamide
-
-
0.000242
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
0.00025
N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
0.003361
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
-
-
0.000801
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.000137
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.001731
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
-
-
0.000115
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
-
-
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000214
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
-
-
0.000155
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
-
-
0.001147
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000106
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000304
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
-
-
0.000068
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
-
-
0.001531
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
0.000566
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
0.002753
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
0.000489
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.001351
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
-
-
0.000028
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.00002
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00002
N-(4-cyanophenyl)-2-methyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)propanamide
-
-
0.00039
N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
0.001739
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
-
-
0.000028
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.000304
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
-
-
0.002298
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
-
-
0.000117
N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
-
-
0.002034
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
-
-
0.00058
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000079
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000177
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide
-
-
0.000111
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide
-
-
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000175
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000399
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
0.001105
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00006
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.000679
N-hexyl-4-(trifluoroacetyl)benzamide
-
-
0.000199
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00145
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00093
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0045
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
-
0.000814
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
in 40 mM Tris, pH 8.0
0.000773
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000676
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.000953
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
0.000394
N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide
-
-
0.00199
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000394
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001015
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00265
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.005011
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
-
-
0.000654
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
-
-
0.000017
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0172
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
-
-
2.2
NAD+
-
in 40 mM Tris, pH 8.0
0.00098
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00085
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.000168
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.00001
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.000045
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
0.000005
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.000136
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.000007
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.000009
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
in 40 mM Tris, pH 8.0
0.000015
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
0.000023
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
0.000031
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
0.00003
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
0.000113
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
43.4
-
pH 7, recombinant MCD
206
-
-
additional information
-
-
additional information
-
-
additional information
-
-
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5
-
2 optima: pH 5 and pH 9
6.5
-
-
7
-
assay at
7.5
B9K0V9
assay at
7.5
Q1LJK6
assay at
8.3
-
brain
8.5 - 10
-
-
8.5 - 9
-
-
8.5
-
assay at
9
-
2 optima: pH 5 and pH 9
9.5
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
3.2 - 8.2
-
about 30% of maximal activity at pH 3.2 and pH 8.2
4.5 - 10
-
pH 4.5: about 40% of maximal activity, pH 8.5-10: optimum, less than 10% of maximal activity at pH 10.5
5 - 9
-
2 optima at pH 5 and at pH 9, minimal activity at pH 6-7
5.5 - 8
-
pH 5.5: about 80% of maximal activity, pH 8: about 40% of maximal activity
7.7
-
pH 7.7: 90% of the maximum activity measured at pH 8-9.5, assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8
-
theoretical pI, N-terminal truncated apo-hMCD
9.1
-
theoretical pI, wild-type hMCD
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
nerve cells of the cerebral cortex, microglia, Golgi epithelial cells, Bergmann glia cells. Activity in brain is low, but steadily increases after birth. No activity in neurons of the cerebellar cortex
Manually annotated by BRENDA team
-
contains less than 1% of the malonyl-CoA decarboxylase mRNA in the gland
Manually annotated by BRENDA team
O95822
high expression level
Manually annotated by BRENDA team
-
MCD mRNA and protein expression are detected at extremely elevated levels in the arcuate, dorsomedial, paraventricular and ventromedial hypothalamic nuclei
Manually annotated by BRENDA team
-
contains less than 1% of the malonyl-CoA decarboxylase mRNA in the gland
Manually annotated by BRENDA team
-
contains less than 1% of the malonyl-CoA decarboxylase mRNA in the gland
Manually annotated by BRENDA team
-
of lactating animals
Manually annotated by BRENDA team
O95822
high expression level
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
enzyme of the uropygial gland
Manually annotated by BRENDA team
-
mainly located in cytoplasm
Manually annotated by BRENDA team
-
recombinant MCD lacking its mitochondrial and peroxisomal targeting sequences
Manually annotated by BRENDA team
-
INS-1 MCD, expression most likely in, contains an N-terminal mitochondrial targeting sequence
Manually annotated by BRENDA team
-
intramitochondrial distribution
Manually annotated by BRENDA team
-
a small portion is present in mitochondria
Manually annotated by BRENDA team
-
enzyme from liver
Manually annotated by BRENDA team
-
50% of MCD activity in heart and 65% in skeletal muscle is localized to mitochondria, while 50% and 35% is extramitochondrial
Manually annotated by BRENDA team
-
enzyme may be targeted to peroxisomes in addition to, or possibly instead of, mitochondria
Manually annotated by BRENDA team
-
INS-1 MCD, expression most likely inside, the C-terminal part of enzyme ends with a peroxisomal targeting motif
Manually annotated by BRENDA team
-
recombinant MCD, expression in a soluble and an insoluble form
-
Manually annotated by BRENDA team
-
enzyme may be targeted to mitochondria in addition to, or possibly instead of, peroxisomes
Manually annotated by BRENDA team
additional information
-
subcellular distribution
-
Manually annotated by BRENDA team
additional information
-
expression of recombinant MCD in a soluble and an insoluble form, the N-terminal 38 amino acids represents a putative mitochondrial targeting sequence, the last 3 amino acid sequences, SKL, represent peroxisomal targeting ones
-
Manually annotated by BRENDA team
additional information
-
full-length MCD contains a putative, N-terminal 39 amino acid mitochondria targeting sequence and a peroxisomal tageting sequence
-
Manually annotated by BRENDA team
additional information
-
MCD contains mitochondrial and peroxisomal targeting sequences
-
Manually annotated by BRENDA team
additional information
O95822
intracellular mislocalization to the nucleus in M1K/H152N mutant patient, fluorescent immunohistochemic analysis, overview
-
Manually annotated by BRENDA team
additional information
-
multiple intracellular locations of the enzyme
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
44000
-
gel filtration
4852, 4854
54000
-
Sephadex G-25 gel filtration
681625
56000
-
gel filtration
4852
93000
-
gel filtration
4856
130000
-
inactive enzyme form, gel filtration
4866
160000
-
gel filtration
4849, 4854
165000
-
active enzyme form, gel filtration
4866
170000
-
gel filtration
4851
170000
-
gel filtration
4864
186000
-
equilibrium sedimentation
4847
190000
-
gel filtration
4850
208000
-
field flow fractionation
651816
250000
-
gel filtration
4845
500000
-
gel filtration
4863
additional information
-
-
4843
additional information
-
malonyl-CoA decarboxylase is not a proteolysis product of fatty acid synthetase
4851
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 50000, SDS-PAGE
?
O95822
x * 55000
?
-
x * 30000 + x * 40000 + x * 70000, SDS-PAGE
?
-
x * 50000, about, wild-type apo-hMCD, SDS-PAGE
?
-
x * 50700, liver isoform, MCD exists in 2 isoforms of 50.7 kDa and 54.7 kDa, SDS-PAGE, Western blot analysis
?
-
x * 54000, SDS-PAGE, x * 54610, full-length MCD, calculated from the amino acid sequence
?
-
x * 54700, recombinant INS-1 MCD, enzyme might multimerize in vivo, calculated from the amino acid sequence
?
Pseudomonas putida IAM 1177
-
x * 30000 + x * 40000 + x * 70000, SDS-PAGE
-
dimer
-
2 * 45000, SDS-PAGE
dimer
-
2 * 250000, SDS-PAGE
pentamer
-
1 * 60000, alpha, + 1 * 33000, beta, + 1 * 28000, gamma, + 1 * 13000, delta, + 1 * epsilon, 30000, active enzyme form, SDS-PAGE
tetramer
-
4 * 47000, SDS-PAGE
tetramer
-
4 * 47000, SDS-PAGE
tetramer
-
1 * 60000, alpha, + 1 * 33000, beta, + 1 * 28000, gamma, + 1 * 13000, delta, inactive enzyme form, SDS-PAGE
tetramer
-
a dimer of structural heterodimers, in which the two subunits present markedly different conformations. Each subunit has an all-helix N-terminal domain and a catalytic C-terminal domain with an acetyltransferase fold. The N-terminal domain of each monomer, Met40-Trp189, contains eight alpha-helices organized as a bundle of four antiparallel helices (alpha1-alpha3 and alpha6) with two pairs of helices inserted (alpha4-alpha5 and alpha7-alpha8), a four-helix bundle variant. H2O2 oxidation is apparently cooperative in the sense that linked tetramers are formed preferentially to dimers
homotetramer
-
4 * 53000, SDS-PAGE, 4 * 51000, calculated from the amino acid sequence
additional information
-
organization of the helical domains and the oligomeric states and intersubunit interfaces, secondary sequence comparisons, subunit structure and oligomeric architecture analysis and comparisons, overview. The MCD monomer contains an N-terminal helical domain and a C-terminal catalytic domain
additional information
B9K0V9
organization of the helical domains and the oligomeric states and intersubunit interfaces, secondary sequence comparisons, subunit structure and oligomeric architecture analysis and comparisons, overview. The MCD monomer contains an N-terminal helical domain and a C-terminal catalytic domain
additional information
Q1LJK6
organization of the helical domains and the oligomeric states and intersubunit interfaces, secondary sequence comparisons, subunit structure and oligomeric architecture analysis and comparisons, overview. The MCD monomer contains an N-terminal helical domain and a C-terminal catalytic domain
additional information
-
structure analysis, overview. Structural asymmetry and disulfide bridges among subunits modulate the activity of the enzyme. Intersubunit disulfide bridges, Cys206-Cys206 and Cys243-Cys243, can link the four subunits of the tetramer, imparting positive cooperativity to the catalytic process
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
activation of AMP-activated protein kinase during muscle contraction leads to phosphorylation of MCD and an increase in its activity
proteolytic modification
-
the 50.7 kDa isoform may be generated from the 54.7 kDa isoform by posttranslational processing, probably by N-terminal cleavage
proteolytic modification
-
the N-terminal 38 amino acids represents a putative mitochondrial targeting sequence, the last 3 amino acid sequences, SKL, represent peroxisomal targeting ones
proteolytic modification
-
full-length MCD contains a putative, N-terminal 39 amino acid mitochondria targeting sequence and a peroxisomal tageting sequence
additional information
-
INS-1 MCD, sequence shows multiple possible sites of phosphorylation by casein kinase II and protein kinase C, no acylation sites
additional information
-
recombinant MCD has a different degree or lack of glycosylation from the original rat enzyme
additional information
-
the enzyme is phosphorylated at seven seryl/threonyl residues, and is acetylated at 11 lysyl residues
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
purified recombinant enzyme, microbatch method, 0.002 ml of the protein solution containing 10 mM Tris, pH 7.5, 100 mM NaCl, 5 mM DTT, and 0.02% NaN3 are mixed with 0.002 ml of the precipitant solution consisting of 200 mM ammonium sulfate, and 20% w/v PEG3350, 18C, X-ray diffraction structure determination and analysis at 2.3-3.1 A, selenomethionyl single-wavelength anomalous diffraction method, molecular replacement
B9K0V9
purified recombinant enzyme, microbatch method, mixingof 0.002 ml of protein in 20 mM Tris, pH 7.0, 250 mM NaCl, 5% v/v glycerol, and 3 mM malonyl-CoA with crystallization solution containing 160 mM magnesium chloride, 80 mM Tris, pH 8.5, 24% w/v PEG 4000, 20% v/v glycerol, and 3% v/v ethanol, 18C, X-ray diffraction structure determination and analysis at 2.3-3.1 A, selenomethionyl single-wavelength anomalous diffraction method, molecular replacement
Q1LJK6
purified recombinant detagged enzyme, from 15% PEG 2000 monomethyl ether and 0.1 M sodium acetate, pH 4.5, and 10 mM sodium citrate, sitting drop vapor diffusion method, X-ray diffraction structure determination and analysis at 3.3-4.3 A resolution, molecular replacement
-
recombinant mutant E58A/K59A/E278A/E279A/K280A, sitting-drop vapor diffusion method, mixing of 10 mg/ml protein in HEPES, pH 7.5, 100 mM NaCl, 1% v/v glycerol, and 5 mM decanoyl-CoA. in a 2:1 ratio with a precipitant solution containing 10% w/v PEG 20000 and 0.1 M 2-(N-morpholino)ethanesulfonic acid, pH 6.0, at room temperature, X-ray diffraction structure determination and analysis at 2.8 A, by single isomorphous replacement with anomalous scattering
-
hanging drop vapour-diffusion method, X-ray analysis
Q9ZIP6
purified recombinant enzyme, microbatch method, 0.002 ml of the protein solution containing 10 mM Tris, pH 7.5, 100 mM NaCl, 5 mM DTT, and 0.02% NaN3 are mixed with 0.002 ml of the precipitant solution consisting of 0.1 M magnesium nitrate, 100 mM Tris, pH 8.5, and 33% v/v PEG 400, 18C, X-ray diffraction structure determination and analysis at 2.3-3.1 A, selenomethionyl single-wavelength anomalous diffraction method, molecular replacement
-
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
49
-
50% loss of activity after 2 min
4845
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
the N-terminal region of hMCD plays a role in the folding process and conformation stability of enzyme
-
acetylated MCD activity reveals a time-dependent loss of specific activity, whereby 70% is lost by 30 min
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20C, one-third of the enzyme activity disappears after 4 months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
copurification of fatty acid synthetase and malonyl-CoA decarboxylase
-
recombinant full-length and N-terminal truncated apoenzymes
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recombinant maltose-binding protein fusion wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by amylase affinity chromatography, fusion protein cleavage by tobacco etch virus protease, gel filtration, and anion exchange chromatography
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Talon metal affinity resin chromatography, SP Sepharose column chromatography
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50.7 kDa isoform from liver, 1269fold
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glutathione Sepharose 4 Fast Flow column chromatography
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partial, from liver
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recombinant MCD
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recombinant enzyme
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Ni-NTA column chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cytoplasmic enzyme from uropygial gland and mitochondrial enzyme from liver
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single copy gene
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expressed in Escherichia coli strain BL21
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expression in the human hepatoma cell line huh7, sequencing, located on chromosome 16q24
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expression of wild-type and mutant enzymes as maltose-binding protein fusion proteins in Escherichia coli strain BL21(DE3) in minimal medium containing selenomethionine
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from heart, overexpression of full-length and N-terminal truncated hMCD in Escherichia coli BL21 (DE3), sequencing
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gene MLYCD, localized on chromosome 16q24, DNA and amino acid sequence determination and analysis of the mutant enzyme, sequence comparison
O95822
overexpression of MCD lacking both its mitochondrial and peroxisomal targeting sequences in INS-1-derived 832/13 beta-cells, effect of MCD expression on glucose-stimulated insulin secretion
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expressed in Escherichia coli BL21 cells
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from brain, expression in Escherichia coli BL21, sequencing
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from liver, expression in COS-7 cells as 50.7 kDa and 54.7 kDa MCD isoforms, sequencing
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from pancreatic beta cell line INS-1, expression in human kidney 293 cells, sequencing
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expression in Escherichia coli
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overexpression in Escherichia coli BL21 (DE3)
Q9ZIP6
expressed in Escherichia coli BL21(DE3) cells
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expression in Escherichia coli
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
A69V
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naturally occuring mutation in the N-terminal helical domain, the mutantion is involved in enzyme deficiency
C206S
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site-directed mutagenesis
C206S/C243S
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site-directed mutagenesis
C243S
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site-directed mutagenesis
E302G
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site-directed mutagenesis
E58A/K59A/E278A/E279A/K280A
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site-directed mutagenesis, crystal structure determination. The mutant exhibits similar oligomeric and enzymatic properties as wild-typ, both alanine-substituted patches are located in surface-exposed regions: Glu58-Lys59 is found in the loop connecting helices alphaA and alphaB, while the loop containing residues 278-280, connecting strands beta3 and beta4, is disordered
G300V
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naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
H152N
O95822
naturally occuring compound heterozygous MLYCD mutation at the N-terminal helical domain
H423N
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site-directed mutagenesis, the mutant shows a 7fold loss in kcat compared to the wild-type enzyme
L161P
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naturally occuring mutation in the N-terminal helical domain, the mutantion is involved in enzyme deficiency
L307R
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naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
S290F
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naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency, site-directed mutagenesis, the mutant shows a 2fold decrease in kcat in vitro compared to the wild-type enzyme
S329A
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site-directed mutagenesis, the mutant shows a 110fold loss in kcat and 58fold loss in kcat/Km compared to the wild-type enzyme
S440I
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naturally occuring mutation in the catalytic domain, the mutantion is involved in enzyme deficiency
S477F
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naturally occuring mutation in the catalytic domain, the mutantion is involved in enzyme deficiency
W384C
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naturally occuring mutation in the catalytic domain, the mutantion is involved in enzyme deficiency
Y456S
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naturally occuring mutation in the GNAT core, the mutantion is involved in enzyme deficiency
K210M
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completely inactive
K308M
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retains 60% of the wild type enzyme activity
K388M
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retains 60% of the wild type enzyme activity
M1K
O95822
naturally occuring heterozygous mutation without direct phenotype
additional information
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genetic mutation causing malonic aciduria: a four nucleotide deletion at the 3-end of exon 2 of the gene, c.638-641delGTGA, that introduces a premature stop codon and deletes the 272 carboxy terminal amino acids of the protein
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
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enzyme deficiency is associated with mild mental retardation, seizures, hypotonia, cardiomyopathie, vomiting, hypoglycemia, metabolic acidosis and malonic aciduria
medicine
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enzyme deficiency is characterized by malonic aciduria, developmental delay, seizure disorder, and mental retardation
medicine
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MCD is involved in regulating cardiac malonyl-CoA levels, inhibition of MCD can limit rates of fatty acid oxidation, leading to a secondary increase in glucose oxidation associated with an improvement in the functional recovery of the heart during ischaemia/reperfusion injury
medicine
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MCD is a potential novel target for cancer treatment
medicine
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MCD is involved in regulating cardiac malonyl-CoA levels, inhibition of MCD can limit rates of fatty acid oxidation, leading to a secondary increase in glucose oxidation associated with an improvement in the functional recovery of the heart during ischaemia/reperfusion injury