Information on EC 4.1.1.9 - Malonyl-CoA decarboxylase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
4.1.1.9
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RECOMMENDED NAME
GeneOntology No.
Malonyl-CoA decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
malonyl-CoA = acetyl-CoA + CO2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetylation
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N-acetylation
decarboxylation
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
acetyl CoA biosynthesis
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beta-Alanine metabolism
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Metabolic pathways
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Propanoate metabolism
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SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA carboxy-lyase (acetyl-CoA-forming)
Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-99-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzyme has malonyl-CoA:acetate CoA transferase activity, acetylCoA:malonate CoA transferase and malonyl-CoA decarboxylase activity
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Anser domesticus
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain H37Ra
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Malonyl-CoA
?
show the reaction diagram
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
methylmalonyl-CoA
propionyl-CoA + CO2
show the reaction diagram
N-hydroxy-L-ornithine + malonyl-CoA
delta-N-acetyl-delta-N-hydroxy-L-ornithine + coenzyme A + CO2
show the reaction diagram
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acetylation of the delta-amino functionality of N-hydroxy-L-ornithine is mediated by the bifunctional malonyl-CoA decarboxylase/acetyltransferase Mcd
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Malonyl-CoA
?
show the reaction diagram
Malonyl-CoA
Acetyl-CoA + CO2
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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no cofactor requirement
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
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((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
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((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
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(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile
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(2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enenitrile
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(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile
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(2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
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(2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoic acid
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(2Z)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
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(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
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(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-methyloxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-phenyloxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one oxime
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(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
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(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
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1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenyl)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
1,1,1,3,3,3-hexafluoro-2-[4-[4-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-2-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(1-methylethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
1,3-bis(2-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1,3-diethyl-1-(8-hydroxyoctyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1,3-diethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-(4-hydroxybutyl)urea
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1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
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1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
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1-(2-cyanoethyl)-3-ethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-(2-phenylethyl)urea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylurea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)butan-1-one
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1-benzyl-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]piperidinium
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1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyrrolidinium
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1-cyclohexyl-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)urea
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1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
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1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
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1-ethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3,3-dimethylurea
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1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-ethyl-3,3-dimethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
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1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
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1-methoxy-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-methyl-3-phenyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-phenyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]butan-1-ol
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1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-1-methyl-3-phenylurea
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1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylurea
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
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2,2'-dipyridyl
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2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
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2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-amino-3-[(2E)-but-2-en-1-yl]isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-[(butylamino)methyl]-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
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2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
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2-methyl-N-(3-phenyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
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2-methyl-N-(3-pyridin-4-yl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
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2-methyl-N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanamide
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2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide
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2-methyl-N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
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2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
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2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
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2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
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2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
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2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
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2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl (1Z)-2-methyl-N-(1-methylethyl)propanimidoate
-
-
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone
-
-
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
2-[4-(5-amino-3-benzylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-butylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-ethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-furan-3-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-phenylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-pyridin-4-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
2-[4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(4-methoxyphenyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(ethoxymethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(trifluoromethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
3-(1-methylethyl)-1-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methyl]-1-(2-morpholin-4-ylethyl)urea
-
-
3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propan-1-ol
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanoic acid
-
-
3-Bromopyruvate
3-methyl-1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
-
-
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
3-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]propanoic acid
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
-
-
3-[[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]propanoic acid
-
-
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
-
-
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)phenol
-
-
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
-
-
4-carbamoyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholin-4-ium
-
-
4-cyano-N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
4-cyano-N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
-
-
4-cyano-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]benzamide
-
-
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
-
-
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1 trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide
-
-
5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino]-pentanoic acid methyl ester
-
30% inhibition at 0.08 mg/ml, 50% inhibition at approximately 0.16 mg/ml
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoic acid
-
-
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoic acid
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
Acetic anhydride
-
0.01 mg MCD is incubated with the 3fold excess of acetic anhydride leading to 70% loss of activity after 30 min
acetyl-CoA
ADP
-
inhibition at 2 mM
Avidin
CBM-301940
-
0.01 mM, 85% inhibition
diisopropylfluorophosphate
-
-
EDTA
-
1 mM, 15% inhibition
ethyl (2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enoate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
ethyl 2-pyridin-4-yl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
ethyl 5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-3-carboxylate
-
-
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
-
-
ethyl [([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]acetate
-
-
ethyl [[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]acetate
-
-
iodoacetamide
-
1 mM, 16% inhibition
L-Malate
-
-
methyl (2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]pentanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
methyl 4-methyl-2-(2-methylpropyl)-2-[2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl]pentanoate
-
-
methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate
-
-
methyl 4-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]butanoate
-
-
methyl 4-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]butanoate
-
-
methyl 5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)morpholine-4-carboxamido)pentanoate
-
-
methyl 5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoate
-
-
methyl N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycinate
-
-
methyl N-(morpholin-4-ylcarbonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-b-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycinate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)glycinate
-
-
methyl [(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetate
-
-
methyl-5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) phenyl)morpholine-4-carboxamido)pentanoate
-
i.e. CBM-301106, specific inhibitor of the enzyme
methylmalonyl-CoA
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
N,2-dimethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N,N-bis(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N,N-diethyl-4-(trifluoroacetyl)benzamide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
N,N-dipropyl-4-(trifluoroacetyl)benzamide
-
-
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1,5-dimethylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
-
-
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
-
-
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-phenylethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(3,3-dimethylbutyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
-
-
N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycine
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
N-(4-cyanobutyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(4-cyanobutyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(4-cyanophenyl)-2-methyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)propanamide
-
-
N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylpropanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)acetamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)hexanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)pyridine-4-carboxamide
-
-
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
-
-
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
-
-
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-benzyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-benzyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-butyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide
-
-
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-butyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
N-cyclohexyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-cyclohexyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-ethyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyridine-4-carboxamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-ethylmaleimide
-
1 mM, 47% inhibition
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-heptyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-heptyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-hexyl-4-(trifluoroacetyl)benzamide
-
-
N-hexyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
-
-
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
-
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
-
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide
-
-
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-3-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-octyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-pentyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
-
-
N-[2-(dimethylamino)ethyl]-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-[2-(dimethylamino)ethyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]-2-phenylbutanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pentanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pyridine-4-carboxamide
-
-
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-propylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenyl-N-(propan-2-yl)propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N,2-dimethylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-phenylethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alanine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-octylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-pentylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-propylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
-
-
NAD+
-
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
palmitoyl-CoA
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
propionyl-CoA
pyridoxal 5'-phosphate
-
partly competitive
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
SO42-
-
reversible
succinyl-CoA
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
-
i.e. CBM-301940
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-b-alaninate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)phenylalaninate
-
-
Vanillin
-
-
[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetic acid
-
-
[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetic acid
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
-
AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A
Alkaline phosphatase
-
treatment with alkaline phosphatase enhances MCD activity suggesting phosphorylation-related control of enzyme
-
AMP-activated potein kinase
-
AMP-activated potein kinase activates MCD by phosphorylation
-
DL-carnitine
-
stimulates
fatty acid
-
increases MCD expression in heart and skeletal muscle
fenofibrate
-
increases hepatic mRNA expression and MCD activity
iodoacetamide
palmitate
-
the activity of MCD elicits a dose-dependent increase (between 25% and 60%) in cells exposed to increasing concentrations of palmitate (0.1-0.8 mM)
phosphate
-
activates
WY-14643
-
specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0087 - 1.16
malonyl-CoA
0.025
N-hydroxy-L-ornithine
-
in 20 mM Tris, 100 mM NaCl, pH 7.2, at 25C
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
13 - 208.3
malonyl-CoA
0.038
N-hydroxy-L-ornithine
Saccharopolyspora erythraea
-
in 20 mM Tris, 100 mM NaCl, pH 7.2, at 25C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00006 - 0.00037
malonyl-CoA
1.53
N-hydroxy-L-ornithine
Saccharopolyspora erythraea
-
in 20 mM Tris, 100 mM NaCl, pH 7.2, at 25C
41713
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000376
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000105
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00008
((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00029
(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile
Rattus norvegicus
-
-
0.00014
(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile
Rattus norvegicus
-
-
0.000118
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
Rattus norvegicus
-
-
0.000152
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime
Rattus norvegicus
-
-
0.00035
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
Rattus norvegicus
-
-
0.000044
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
Rattus norvegicus
-
-
0.000627
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00045
1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00024 - 0.00032
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
0.000044
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000057
1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000209
1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000149
1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000274
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000114
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000465
1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000037
1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000092
1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000036
1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000019
1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000087
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000046
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000012
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000081
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000076
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000059
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000089
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0006
1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000155
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
Rattus norvegicus
-
-
0.000116
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
Rattus norvegicus
-
-
0.00034
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
Rattus norvegicus
-
-
0.00006
1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000037
1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.00009
1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
Rattus norvegicus
-
-
0.000005
1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000007
1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
Rattus norvegicus
-
-
0.000059
1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00006
1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
Rattus norvegicus
-
-
0.000059
1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
Rattus norvegicus
-
-
0.001564
1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000033
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000045
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.0000049
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000047
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00328
2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
Rattus norvegicus
-
-
0.0000133
2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00046
2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Rattus norvegicus
-
-
0.000303
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Rattus norvegicus
-
-
0.0002
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
Rattus norvegicus
-
-
0.000059
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
Rattus norvegicus
-
-
0.000225
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
Rattus norvegicus
-
-
0.000042
2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide
Rattus norvegicus
-
-
0.00545
2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
Rattus norvegicus
-
-
0.006626
2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0015
2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
Rattus norvegicus
-
-
0.0000017
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000074
2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone
Rattus norvegicus
-
-
0.000011
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000032
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000079
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000027
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00041
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Rattus norvegicus
-
-
0.0000051
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
0.00034
3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.00042
3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.0028
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
Rattus norvegicus
-
-
0.00008
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.004337
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000031
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000018
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000239
3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
Rattus norvegicus
-
-
0.000163
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
Rattus norvegicus
-
-
0.0000005
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000023
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000022
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000013
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
0.0000133
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000006
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000014
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000507
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
Rattus norvegicus
-
-
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
0.0049
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
Rattus norvegicus
-
-
0.0000004
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000034
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000019
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000042
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
0.00002 - 0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
0.00039
5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000107
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
Rattus norvegicus
-
-
0.000168
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
Rattus norvegicus
-
-
0.000318
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate
Rattus norvegicus
-
-
0.000037
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
Rattus norvegicus
-
-
0.000191
ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate
Rattus norvegicus
-
-
0.000463
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
Rattus norvegicus
-
-
0.000421
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.001767
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
Rattus norvegicus
-
-
4.1
L-Malate
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000088
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate
Rattus norvegicus
-
-
0.000065
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
Rattus norvegicus
-
-
0.000041
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
Rattus norvegicus
-
-
0.000054
methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate
Rattus norvegicus
-
-
0.00114
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000269
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000073
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001619
N,N-diethyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
0.000153
N,N-dipropyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000242
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00025
N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.003361
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000801
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000137
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.001731
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000115
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
0.000214
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000155
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001147
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000106
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000304
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000068
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001531
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000566
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.002753
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000489
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.001351
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000028
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.00002
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.00039
N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.001739
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000028
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000304 - 0.002298
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
0.000117
N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
Rattus norvegicus
-
-
0.002034
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00058
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000079
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000177
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide
Rattus norvegicus
-
-
0.000111
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide
Rattus norvegicus
-
-
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
0.000175
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000399
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001105
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
0.00006
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000679
N-hexyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000199
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00145
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00093
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0045
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
Rattus norvegicus
-
-
0.000814
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000773
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000676
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000953
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000394
N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide
Rattus norvegicus
-
-
0.00199
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.000394
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001015
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00265
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.005011
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000654
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000017
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.0172
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
Rattus norvegicus
-
-
2.2
NAD+
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.00098
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00085
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000168
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.00001
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000045
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
Rattus norvegicus
-
-
0.000005
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000136
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000007
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000009
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000015
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
Rattus norvegicus
-
-
0.000023
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000031
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
Rattus norvegicus
-
-
0.00003
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
Rattus norvegicus
-
-
0.000113
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
Rattus norvegicus
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43.4
-
pH 7, recombinant MCD
206
-
-
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5
-
-
8.3
-
brain
8.5
-
assay at
8.5 - 10
-
-
8.5 - 9
-
-
9.5
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.2 - 8.2
-
about 30% of maximal activity at pH 3.2 and pH 8.2
4.5 - 10
-
pH 4.5: about 40% of maximal activity, pH 8.5-10: optimum, less than 10% of maximal activity at pH 10.5
5 - 9
-
2 optima at pH 5 and at pH 9, minimal activity at pH 6-7
5.5 - 8
-
pH 5.5: about 80% of maximal activity, pH 8: about 40% of maximal activity
7.7
-
pH 7.7: 90% of the maximum activity measured at pH 8-9.5, assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
-
theoretical pI, N-terminal truncated apo-hMCD
9.1
-
theoretical pI, wild-type hMCD
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
neonatal
Manually annotated by BRENDA team
-
peritoneal
Manually annotated by BRENDA team
LOCALIZATION