Information on EC 4.1.1.80 - 4-hydroxyphenylpyruvate decarboxylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.1.80
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RECOMMENDED NAME
GeneOntology No.
4-hydroxyphenylpyruvate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(S)-reticuline biosynthesis I
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Biosynthesis of secondary metabolites
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Isoquinoline alkaloid biosynthesis
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L-tyrosine degradation III
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Tyrosine metabolism
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methionine metabolism
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tyrosine metabolism
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SYSTEMATIC NAME
IUBMB Comments
4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)
Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton.
CAS REGISTRY NUMBER
COMMENTARY hide
109300-96-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
produces large amounts of protoberberine alkaloids of the jatrorrhizine type
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Berberis regeliana
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Manually annotated by BRENDA team
Thalictrum dipterocarpum
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.67
4-hydroxyphenylpyruvate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30000
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HPLC gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
29fold partial purification
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