Information on EC 4.1.1.75 - 5-guanidino-2-oxopentanoate decarboxylase

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The expected taxonomic range for this enzyme is: Pseudomonas

EC NUMBER
COMMENTARY hide
4.1.1.75
-
RECOMMENDED NAME
GeneOntology No.
5-guanidino-2-oxopentanoate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Arginine and proline metabolism
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-
L-arginine degradation IX (arginine:pyruvate transaminase pathway)
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L-arginine degradation VIII (arginine oxidase pathway)
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L-arginine degradation XII
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Metabolic pathways
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arginine metabolism
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SYSTEMATIC NAME
IUBMB Comments
5-guanidino-2-oxo-pentanoate carboxy-lyase (4-guanidinobutanal-forming)
Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.
CAS REGISTRY NUMBER
COMMENTARY hide
56831-67-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain P2
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-Guanidino-2-oxopentanoate
4-Guanidinobutyraldehyde + CO2
show the reaction diagram
5-Guanidino-2-oxopentanoate
?
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5-Guanidino-2-oxopentanoate
?
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
-
required
thiamine diphosphate
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required
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
activates, half-maximal activity at 0.6 mM
Co2+
-
activates, half-maximal activity at 0.3 mM
Mg2+
-
activates, half-maximal activity at 0.3 mM
Mn2+
-
activates, half-maximal activity at 0.03 mM
Ni2+
-
activates
Zn2+
-
activates
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha-Hydroxy-delta-guanidino-N-pentanoate
-
weak
delta-Guanidinopentanoate
-
-
epsilon-Guanidinohexanoate
-
-
Ethylguanidine
-
-
gamma-Guanidinobutanoate
-
weak
gamma-Guanidinobutyraldehyde
-
-
Guanidinoacetate
-
weak
Hexylguanidine
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-
L-Arg
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weak
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
167
5-guanidino-2-oxopentanoate
Pseudomonas putida
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
-
30 min, stable
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli DH5alpha cells
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