Information on EC 4.1.1.66 - uracil-5-carboxylate decarboxylase

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The expected taxonomic range for this enzyme is: Neurospora crassa

EC NUMBER
COMMENTARY hide
4.1.1.66
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RECOMMENDED NAME
GeneOntology No.
uracil-5-carboxylate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
uracil 5-carboxylate = uracil + CO2
show the reaction diagram
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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-
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SYSTEMATIC NAME
IUBMB Comments
uracil-5-carboxylate carboxy-lyase (uracil-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
59299-01-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Uracil-5-carboxylate
?
show the reaction diagram
-
enzyme is involved in thymidine metabolism
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-
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Uracil-5-carboxylate
Uracil + CO2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Uracil-5-carboxylate
?
show the reaction diagram
-
enzyme is involved in thymidine metabolism
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
no cofactor requirement
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.2 - 10
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activity reduced at pH 5.2 and 10.0
PDB
SCOP
CATH
ORGANISM
UNIPROT
Cordyceps militaris (strain CM01)
Cordyceps militaris (strain CM01)
Cordyceps militaris (strain CM01)
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
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inactivation after 3 min
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-30°C, overnight storage, 80% loss of activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE