Information on EC 4.1.1.60 - stipitatonate decarboxylase

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The expected taxonomic range for this enzyme is: Talaromyces stipitatus

EC NUMBER
COMMENTARY hide
4.1.1.60
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RECOMMENDED NAME
GeneOntology No.
stipitatonate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
stipitatonate = stipitatate + CO2
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
stipitatate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
37290-52-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Puberulonic acid
?
show the reaction diagram
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Stipitatonate
Stipitate + CO2
show the reaction diagram
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additional information
?
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no activity with: tropolone-3,4-dicarboxylic acid, 5-, 6-, 7-hydroxy derivatives of tropolone-3,4-dicarboxylic acid
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
-
restores activity after dialysis
Zn2+
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restores activity after dialysis
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-Hydroxytropolone-3,4-dicarboxylic acid
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6-Hydroxytropolone-3,4-dicarboxylic acid
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7-Hydroxytropolone-3,4-dicarboxylic acid
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Mn2+
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slightly
Tropolone-3,4-dicarboxylic acid
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.6 - 7
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about 65% of maximal activity at pH 5.6 and at pH 7.0
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
loss of activity after dialysis. Mn2+ and Zn2+ restore activity
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
stable for several months in frozen state
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE