Information on EC 4.1.1.58 - Orsellinate decarboxylase

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The expected taxonomic range for this enzyme is: leotiomyceta

EC NUMBER
COMMENTARY
4.1.1.58
-
RECOMMENDED NAME
GeneOntology No.
Orsellinate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
orsellinate = orcinol + CO2
show the reaction diagram
-
-
-
-
orsellinate = orcinol + CO2
show the reaction diagram
mechanism
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
2,4-dihydroxy-6-methylbenzoate carboxy-lyase (orcinol-forming)
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Decarboxylase, orsellinate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9076-58-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-Dihydroxy-5,6-dimethylbenzoic acid
?
show the reaction diagram
-
-
-
-
-
2,4-Dihydroxy-6-ethyl benzoic acid
Orcinol monoethylether
show the reaction diagram
-
-
-
-
2,4-Dihydroxy-6-methylbenzoate
1,3-Dihydroxy-5-methylbenzene + CO2
show the reaction diagram
-
-
-
-
2,4-Dihydroxy-6-methylbenzoate
1,3-Dihydroxy-5-methylbenzene + CO2
show the reaction diagram
-
i.e. orsellinic acid, , ir
-
-
-
3-Chloro-2,4-dihydroxy-6-methylbenzoate
?
show the reaction diagram
-
-
-
-
-
4-Methoxy-2-hydroxy-6-methyl benzoic acid
Homoorcinol
show the reaction diagram
-
-
-
-
5-Chloro-2,4-dihydroxy-6-methylbenzoate
?
show the reaction diagram
-
-
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
no requirement
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2,3-Dihydroxybenzoate
-
-
2,4-Dihydroxybenzoate
-
-
2,4-Dihydroxybenzoate
-
-
2,5-Dihydroxybenzoate
-
-
2-Hydroxy-6-methylbenzoate
-
-
2-Hydroxybenzoate
-
-
Salicylic acid derivatives
-
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NaN3
-
0.01 M, activates
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.211
-
2,4-dihydroxy-6-methylbenzoate
-
-
0.26
-
2,4-dihydroxy-6-methylbenzoate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.5
-
-
activity decreases above pH 7.5
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
90000
-
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
monomer
-
1 * 72000, SDS-PAGE
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3
-
-
complete loss of activity after 30 min
7.5
-
-
remains stable at
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
22
-
-
2 weeks, stable
25
-
-
inactivated after several h
55
-
-
no loss of activity after 10 min, up to 55°C
65
-
-
rapidly inactivated above
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
no loss of activity after dialysis
-
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-15°C, little loss of activity after several months
-
no loss of activity when stored frozen for several months
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE