Information on EC 4.1.1.58 - Orsellinate decarboxylase

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The expected taxonomic range for this enzyme is: leotiomyceta

EC NUMBER
COMMENTARY
4.1.1.58
-
RECOMMENDED NAME
GeneOntology No.
Orsellinate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
orsellinate = orcinol + CO2
show the reaction diagram
mechanism
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
2,4-dihydroxy-6-methylbenzoate carboxy-lyase (orcinol-forming)
-
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Decarboxylase, orsellinate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9076-58-8
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-Dihydroxy-5,6-dimethylbenzoic acid
?
show the reaction diagram
-
-
-
-
-
2,4-Dihydroxy-6-ethyl benzoic acid
Orcinol monoethylether
show the reaction diagram
-
-
-
-
2,4-Dihydroxy-6-methylbenzoate
1,3-Dihydroxy-5-methylbenzene + CO2
show the reaction diagram
-
-
-
-
2,4-Dihydroxy-6-methylbenzoate
1,3-Dihydroxy-5-methylbenzene + CO2
show the reaction diagram
-
i.e. orsellinic acid, , ir
-
-
-
3-Chloro-2,4-dihydroxy-6-methylbenzoate
?
show the reaction diagram
-
-
-
-
-
4-Methoxy-2-hydroxy-6-methyl benzoic acid
Homoorcinol
show the reaction diagram
-
-
-
-
5-Chloro-2,4-dihydroxy-6-methylbenzoate
?
show the reaction diagram
-
-
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
no requirement
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2,3-Dihydroxybenzoate
-
-
2,4-Dihydroxybenzoate
-
-
2,4-Dihydroxybenzoate
-
-
2,5-Dihydroxybenzoate
-
-
2-Hydroxy-6-methylbenzoate
-
-
2-Hydroxybenzoate
-
-
Salicylic acid derivatives
-
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaN3
-
0.01 M, activates
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.211
2,4-dihydroxy-6-methylbenzoate
-
-
0.26
2,4-dihydroxy-6-methylbenzoate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
3.5 - 9
-
-
7.5
-
activity decreases above pH 7.5
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
90000
-
gel filtration
4726
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
-
1 * 72000, SDS-PAGE
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
3
-
complete loss of activity after 30 min
4727
7.5
-
remains stable at
4726
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
22
-
2 weeks, stable
4727
25
-
inactivated after several h
4726
55
-
no loss of activity after 10 min, up to 55°C
4727
65
-
rapidly inactivated above
4727
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
no loss of activity after dialysis
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15°C, little loss of activity after several months
-
no loss of activity when stored frozen for several months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE