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Information on EC 4.1.1.49 - phosphoenolpyruvate carboxykinase (ATP) and Organism(s) Thermus thermophilus and UniProt Accession Q5SLL5

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
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This record set is specific for:
Thermus thermophilus
UNIPROT: Q5SLL5 not found.
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Word Map
The taxonomic range for the selected organisms is: Thermus thermophilus
The enzyme appears in selected viruses and cellular organisms
Synonyms
pepc kinase, protein p60, phosphoenolpyruvate carboxylase kinase, pepk, atp-dependent phosphoenolpyruvate carboxykinase, pep carboxylase kinase, osppck3, pfpepck, osppck1, pepck (atp), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Carboxykinase, phosphopyruvate (adenosine triphosphate)
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Glycosomal protein P60
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PEP carboxykinase
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PEP carboxylase
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PEPCK
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PEPCK (ATP)
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PEPK
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phosphoenolpyruvate carboxykinase
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Phosphoenolpyruvate carboxylase
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Phosphoenolpyruvate carboxylase (ATP)
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phosphoenolpyruvic carboxykinase
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Phosphoenolpyruvic carboxylase
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phosphopyruvate carboxykinase
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Phosphopyruvate carboxykinase (adenosine triphosphate)
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Protein p60
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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SYSTEMATIC NAME
IUBMB Comments
ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9073-94-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
show the reaction diagram
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?
ATP + oxaloacetate
?
show the reaction diagram
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the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
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?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + oxaloacetate
?
show the reaction diagram
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the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
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?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04
ADP
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0.08
ATP
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0.03
oxaloacetate
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0.04
phosphoenolpyruvate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5
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phosphoenolpyruvate formation, imidazole-HCl buffer
7.5
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phosphoenolpyruvate formation, Tris-HCl buffer
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
oil-microbatch method, the unliganded form crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 64.7, b = 129.91 A, c = 173.39 A. The ATP-liganded crystals are nearly isomorphous to the unliganded crystals. They belong to space group P2(1)2(1)2(1), with unit cell parameters a = 64.07 A, b = 130.55 A, c = 174.2 A
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
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50 min, stable
90
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about 50% loss of activity after 20 min, about 90% loss of activity after 45 min
97
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complete inactivation after 5 min
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yoshizaki, F.; Imahori, K.
Properties of phosphoenolpyruvate carboxykinase of an extreme thermophile, Thermus thermophilus HB8
Agric. Biol. Chem.
43
397-399
1979
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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Manually annotated by BRENDA team
Sugahara, M.; Ohshima, N.; Ukita, Y.; Kunishima, N.
Structure of ATP-dependent phosphoenolpyruvate carboxykinase from Thermus thermophilus HB8 showing the structural basis of induced fit and thermostability
Acta Crystallogr. Sect. D
61
1500-1507
2005
Thermus thermophilus (Q5SLL5), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SLL5)
Manually annotated by BRENDA team