Information on EC 4.1.1.48 - indole-3-glycerol-phosphate synthase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
4.1.1.48
-
RECOMMENDED NAME
GeneOntology No.
indole-3-glycerol-phosphate synthase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
decarboxylation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Metabolic pathways
-
Phenylalanine, tyrosine and tryptophan biosynthesis
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tryptophan biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(indol-3-yl)glycerol-3-phosphate-forming]
In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
eIGPS
-
-
-
-
IGP synthase
-
-
IGPS
-
-
-
-
IGPS
Mycobacterium tuberculosis Rv3246c
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-
-
IGPS
Q06121
-
-
IGPS
Vitis vinifera x Vitis riparia, Vitis vinifera x Vitis vinifera
-
-
indole-3-glycerol phosphate synthase
-
-
-
-
indole-3-glycerol phosphate synthase
-
-
indole-3-glycerol phosphate synthase
A1KJ27
-
indole-3-glycerol phosphate synthase
-
-
indole-3-glycerol phosphate synthase
A5U2W7
-
indole-3-glycerol phosphate synthase
P0A632
-
indole-3-glycerol phosphate synthase
Mycobacterium tuberculosis Rv3246c
-
-
-
indole-3-glycerol phosphate synthase
-
-
indole-3-glycerol phosphate synthase
Q06121
-
indole-3-glycerol phosphate synthase
Vitis vinifera x Vitis riparia, Vitis vinifera x Vitis vinifera
-
-
Indole-3-glycerol phosphate synthetase
-
-
-
-
Indole-3-glycerol-phosphate synthase
-
-
-
-
indole-3-glycerolphosphate synthase
Q9YGB5
-
Indole-3-glycerophosphate synthase
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-
-
-
Indoleglycerol phosphate synthase
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-
-
-
Indoleglycerol phosphate synthase
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Indoleglycerol phosphate synthetase
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-
-
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Indoleglycerolphosphate synthetase
-
-
-
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InGP synthase
-
-
-
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InGP synthetase
-
-
-
-
InGPS
-
-
-
-
Phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase
-
-
-
-
Pk-trpC
Q9YGB5
gene name
PRAI
-
-
-
-
PRAI-InGPS
-
-
-
-
sIGPS
-
-
-
-
sIGPS
Q06121
-
-
Synthase, indole-3-glycerol phosphate
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-
-
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TrpC
Mycobacterium tuberculosis Rv3246c
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-
-
TrpC
-
gene name
CAS REGISTRY NUMBER
COMMENTARY
9031-60-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
possibly forms a bifunctional enzyme with phosphoribosylanthranilate isomerase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
Enterobacter liquefaciens
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
strain W3110
-
-
Manually annotated by BRENDA team
Escherichia coli W3110
strain W3110
-
-
Manually annotated by BRENDA team
multifunctional enzyme with the activities of Ec 4.1.4.27, Ec 4.2.2.18, Ec 4.1.1.48 and Ec 4.2.1.20
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
strain H37Rv (ATCC 93009)
-
-
Manually annotated by BRENDA team
Mycobacterium tuberculosis Rv3246c
-
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
strain X2180-1A wild-type, strain RH 375 (Ndr), RH 558 (Cdr)
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
-
Manually annotated by BRENDA team
wild-type strain 655 and mutant strains
-
-
Manually annotated by BRENDA team
recombinant enzyme, expression in Escherichia coli
-
-
Manually annotated by BRENDA team
Vitis vinifera x Vitis riparia
-
-
-
Manually annotated by BRENDA team
Vitis vinifera x Vitis vinifera
-
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Brucella abortus (strain 2308)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)