Information on EC 4.1.1.40 - hydroxypyruvate decarboxylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.1.40
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RECOMMENDED NAME
GeneOntology No.
hydroxypyruvate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydroxypyruvate = glycolaldehyde + CO2
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glyoxylate and dicarboxylate metabolism
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SYSTEMATIC NAME
IUBMB Comments
hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
37289-43-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Hydroxypyruvate
Glycolaldehyde + CO2
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
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metal ion required, Co2+ is most effective
Mg2+
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can replace Co2+ in activation
Mn2+
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can replace Co2+ in activation
Ni2+
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can replace Co2+ in activation
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-aminobutanoate
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activates
D-Glu
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activates
ethanolamine
-
activates
Galactosamine
-
activates
glucosamine
-
activates
glutathione
-
activates
L-Asp
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activates
L-Gln
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activates
L-Glu
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activates
L-Lys
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activates
L-Ser
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activates
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.083
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-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 7.4
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-
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
25% of the enzyme activity
Manually annotated by BRENDA team
-
75% of the enzyme activity
Manually annotated by BRENDA team
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
unaffected by detergents
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unaffected by freezing and thawing
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE