Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 4.1.1.36 - phosphopantothenoylcysteine decarboxylase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9SWE5

for references in articles please use BRENDA:EC4.1.1.36
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.36 phosphopantothenoylcysteine decarboxylase
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9SWE5 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
athal3a, ppcdc, coabc, phosphopantothenoylcysteine decarboxylase, ppc-dc, hal3a, 4'-phosphopantothenoylcysteine decarboxylase, ppc decarboxylase, nthal3, 4'-phosphopantothenoyl-l-cysteine decarboxylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4'-phosphopantothenoyl-cysteine decarboxylase
-
decarboxylase AtHAL3a
-
flavoprotein AtHal3a
-
PPC decarboxylase
-
4'-Phospho-N-(D-pantothenoyl)-L-cysteine carboxy-lyase
-
-
-
-
4'-Phosphopantothenoyl-L-cysteine decarboxylase
-
-
-
-
4'-Phosphopantotheoylcysteine decarboxylase
-
-
-
-
Decarboxylase, phosphopantothenoylcysteine
-
-
-
-
N-((R)-4-phosphopantothenoyl)-L-cysteine carboxy-lyase
-
-
-
-
P-PaCysSH decarboxylase
-
-
-
-
Phosphopantothenoylcysteine decarboxylase
-
-
-
-
PPC-decarboxylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9024-69-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
pantotheine 4'-phosphate + CO2
show the reaction diagram
D-pantothenoylcysteine
pantotheine + CO2
show the reaction diagram
-
pantothenoylaminoethenethiol is the intermediate in decarboxylation
-
?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
pantotheine 4'-phosphate + CO2
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
pantotheine 4'-phosphate + CO2
show the reaction diagram
D-pantothenoylcysteine
pantotheine + CO2
show the reaction diagram
-
pantothenoylaminoethenethiol is the intermediate in decarboxylation
-
?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
pantotheine 4'-phosphate + CO2
show the reaction diagram
-
key step in coenzyme A biosynthesis
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
flavin
flavin
-
flavoprotein
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HAL3A_ARATH
209
0
23355
Swiss-Prot
other Location (Reliability: 4)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of mutant C175S in complex with reaction intermediate pantotheoylaminoethenethiol and FMNH(2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C175S
active site mutant
H90N
exchange leads to complete inactivation of the enzyme
A174S
-
site-directed mutagenesis
A174V
-
site-directed mutagenesis
C175S
-
site-directed mutagenesis
D177N
-
site-directed mutagenesis
G179A
-
site-directed mutagenesis
R95Q
-
site-directed mutagenesis
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 (DE3)
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kupke, T.; Hernandez-Acosta, P.; Steinbacher, S.; Culianez-Macia, F.A.
Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis
J. Biol. Chem.
276
19190-19196
2001
Arabidopsis thaliana (Q9SWE5), Arabidopsis thaliana, Escherichia coli
Manually annotated by BRENDA team
Hernandez-Acosta, P.; Schmid, D.G.; Jung, G.; Culianez-Macia, F.A.; Kupke, T.
Molecular characterization of the Arabidopsis thaliana flavoprotein AtHAL3a reveals the general reaction mechanism of 4'-phosphopantothenoylcysteine decarboxylases
J. Biol. Chem.
277
20490-20498
2002
Arabidopsis thaliana
Manually annotated by BRENDA team
Steinbacher, S.; Hernandez-Acosta, P.; Bieseler, B.; Blaesse, M.; Huber, R.; Culianez-Macia, F.A.; Kupke, T.
Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate
J. Mol. Biol.
327
193-202
2003
Arabidopsis thaliana (Q9SWE5), Arabidopsis thaliana
Manually annotated by BRENDA team
Rubio, S.; Larson, T.R.; Gonzalez-Guzman, M.; Alejandro, S.; Graham, I.A.; Serrano, R.; Rodriguez, P.L.
An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment
Plant Physiol.
140
830-843
2006
Arabidopsis thaliana (Q9SWE5)
Manually annotated by BRENDA team