Information on EC 4.1.1.34 - dehydro-L-gulonate decarboxylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.1.34
-
RECOMMENDED NAME
GeneOntology No.
dehydro-L-gulonate decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-dehydro-L-gulonate = L-xylulose + CO2
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-glucuronate degradation I
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Metabolic pathways
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Pentose and glucuronate interconversions
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SYSTEMATIC NAME
IUBMB Comments
3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9024-67-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-Diketo-D-glucoheptonic acid
?
show the reaction diagram
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-
-
-
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2,3-Diketo-D-gluconic acid
?
show the reaction diagram
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-
-
-
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2,3-Diketo-D-gulonic acid
D-Xylulose + CO2
show the reaction diagram
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-
-
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2,3-Diketo-D-pentonic acid
?
show the reaction diagram
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-
-
-
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2,3-Diketo-L-gluconic acid
?
show the reaction diagram
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-
-
-
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2,3-Diketo-L-gulonic acid
?
show the reaction diagram
2,3-Diketo-L-gulonic acid
D-Xylonic acid + CO2
show the reaction diagram
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-
-
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2,3-Diketo-L-pentonic acid
?
show the reaction diagram
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-
-
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3-Dehydro-L-gulonate
L-Xylulose + CO2
show the reaction diagram
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2,3-Diketo-L-gulonic acid
?
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
restores activity after inhibition by 8-hydroxyquinoline
Mn2+
-
restores activity after inhibition by 8-hydroxyquinoline
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8-hydroxyquinoline
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Mn2+ or Mg2+ restore activity
diisopropylfluorophosphate
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Metal chelating agents
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monoiodoacetate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
65
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5 min, 90% loss of activity
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
instable in absence of Cys
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, partially purified enzyme, stable for months
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0°C, purified enzyme, stable for 1 week
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE