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EC Tree
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Synonyms
pdc-e2, pepck-c, pep carboxykinase, p-enolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (gtp), pepck-m, pep-carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxykinase, gtp:oxaloacetate carboxy-lyase,
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GTP:oxaloacetate carboxy-lyase
transphosphorylating, interacts also with ATP, EC 4.1.1.49
phosphoenolpyruvate carboxykinase
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carboxykinase, phosphopyruvate (guanosine triphosphate)
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oxaloacetate kinase (decarboxylating, GDP)
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P-enolpyruvate carboxykinase
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PEP carboxykinase
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phosphoenolpyruvate carboxykinase
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Phosphoenolpyruvate carboxylase
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phosphoenolpyruvate carboxylase (GTP)
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phosphoenolpyruvic carboxykinase
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phosphoenolpyruvic carboxykinase (GTP)
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phosphoenolpyruvic carboxykinase (inosine triphosphate)
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Phosphoenolpyruvic carboxylase
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phosphoenolpyruvic carboxylase (GTP)
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phosphoenolpyruvic carboxylase (inosine triphosphate)
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phosphopyruvate carboxykinase
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phosphopyruvate carboxylase
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phosphopyruvate carboxylase (GTP)
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GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2
two-step mechanism: phosphorylation followed by decarboxylation, transition state with carbocationic character
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GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
ITP can act as phosphate donor.
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GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
interacts also with ATP, EC 4.1.1.49
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GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
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UniProt
brenda
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43000
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2 * 43000, SDS-PAGE
80000
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non-denaturing PAGE
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dimer
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2 * 43000, SDS-PAGE
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S252A
side directed mutagenesis
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mutant plasmid is transformed into the PEP carboxykinase-deficient yeast strain PUK-3B (MATalpha pck ura3)
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Dhe-Paganon, S.; Magrath, J.; Abeles, R.H.
Mechanism of mevalonate pyrophosphate decarboxylase: evidence for a carbocationic transition state
Biochemistry
33
13355-13362
1994
Saccharomyces cerevisiae
brenda
Castillo, D.; Sepulveda, C.; Cardemil, E.; Jabalquinto, A.M.
Functional evaluation of serine 252 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase
Biochimie
91
295-299
2008
Saccharomyces cerevisiae (P10963)
brenda