Information on EC 4.1.1.3 - Oxaloacetate decarboxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY
4.1.1.3
-
RECOMMENDED NAME
GeneOntology No.
Oxaloacetate decarboxylase
PATHWAY
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
Metabolic pathways
-
methylgallate degradation
-
protocatechuate degradation I (meta-cleavage pathway)
-
Pyruvate metabolism
-
syringate degradation
-
SYSTEMATIC NAME
IUBMB Comments
oxaloacetate carboxy-lyase (pyruvate-forming)
The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Cg1458 protein
-
-
OAD-1
Q6A1G0
-
OAD-1
Vibrio cholerae O395-N1
Q6A1G0
-
-
OAD-2
Q6A1F6
-
OAD-2
Vibrio cholerae O395-N1
Q6A1F6
-
-
Oxalacetate decarboxylase
-
-
-
-
Oxalacetic acid decarboxylase
-
-
-
-
Oxalacetic beta-decarboxylase
-
-
-
-
Oxalacetic carboxylase
-
-
-
-
Oxalate beta-decarboxylase
-
-
-
-
oxaloacetate carboxylase Na+ pump
-
membrane-bound multiprotein complex that couples oxaloacetate decarboxylation to sodium ion transport across the membrane
Oxaloacetate carboxylyase
-
-
-
-
oxaloacetate decarboxylase
-
-
oxaloacetate decarboxylase Na+ pump
Q6A1F6, Q6A1G0
-
oxaloacetate decarboxylase Na+ pump
Vibrio cholerae O395-N1
Q6A1F6, Q6A1G0
-
-
oxaloacetate decarboxylase Na+ pump OAD-1
-
-
oxaloacetate decarboxylase Na+ pump OAD-2
-
-
oxaloacetate decarboxylase OAD-1
Q6A1G0
-
oxaloacetate decarboxylase OAD-1
Vibrio cholerae O395-N1
Q6A1G0
-
-
oxaloacetate decarboxylase OAD-2
Q6A1F6
-
oxaloacetate decarboxylase OAD-2
Vibrio cholerae O395-N1
Q6A1F6
-
-
PA4872
-
member of the PEP mutase/isocitrate lyase superfamily
CAS REGISTRY NUMBER
COMMENTARY
9024-98-0
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
guinea pig
-
-
Manually annotated by BRENDA team
strain ATCC 13032
-
-
Manually annotated by BRENDA team
strain ATCC 29212
-
-
Manually annotated by BRENDA team
Gluconacetobacter xylinus
-
-
-
Manually annotated by BRENDA team
sunflower
-
-
Manually annotated by BRENDA team
subspecies Lactococcus lactis lactis, strain IL1403
-
-
Manually annotated by BRENDA team
Lactococcus lactis CRL264
CRL264
-
-
Manually annotated by BRENDA team
formerly Micrococcus lysodeiktikus
-
-
Manually annotated by BRENDA team
pig
-
-
Manually annotated by BRENDA team
oxaloacetate decarboxylase OAD-1, alpha subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
oxaloacetate decarboxylase OAD-1, beta subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
oxaloacetate decarboxylase OAD-1, gamma subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
oxaloacetate decarboxylase OAD-2, alpha subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
oxaloacetate decarboxylase OAD-2, beta subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
oxaloacetate decarboxylase OAD-2, gamma subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
Vibrio cholerae O395-N1
oxaloacetate decarboxylase OAD-1, alpha subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
Vibrio cholerae O395-N1
oxaloacetate decarboxylase OAD-1, beta subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
Vibrio cholerae O395-N1
oxaloacetate decarboxylase OAD-1, gamma subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
Vibrio cholerae O395-N1
oxaloacetate decarboxylase OAD-2, alpha subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
Vibrio cholerae O395-N1
oxaloacetate decarboxylase OAD-2, beta subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
Vibrio cholerae O395-N1
oxaloacetate decarboxylase OAD-2, gamma subunit; O395-N1
SwissProt
Manually annotated by BRENDA team
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
citrate
-
expression is induced by citrate
EDTA
-
activating below 5 mM
NaCl
-
highest activity with 1-1.4 mM
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
22.3
-
oxaloacetate
Q82YW6
calculated value at pH 4.5, temperature not specified in the publication
14857
PDB
SCOP
CATH
ORGANISM
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
very instable, protease-sensitive, 50% loss of activity after 4 min at 4C
-
buffer-dependent, mercaptoethanol stabilises
-
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
4C, Tris-HCl buffer, pH 7.5, 2 month, 40% loss of activity
-
frozen, Tris-HCl buffer, pH 7.5, 1 month, 25% loss of activity
-
-20C, potassium phosphate buffer, pH 7, 50% glycerol, 2 month
-
4C, glycerol, 2 months
Gluconacetobacter xylinus
-
25C, 50 mM triethanolamine/HCl, pH 7.0, 5 days, almost complete inactivation, presence of 1 mM Mn2+ and 50% v/v glycerol stabilize
-
4C, phosphate buffer or arsenate buffer, pH 7, with mercaptoethanol, N2-atmosphere, 2 months
-
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
synthesis
-
optimization of oxaloacetate may increase lysine productivity of commercially used strains