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IUBMB CommentsA pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
The taxonomic range for the selected organisms is: Manduca sexta
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dopa decarboxylase, aromatic l-amino acid decarboxylase, aromatic amino acid decarboxylase, tryptophan decarboxylase, l-dopa decarboxylase, l-aromatic amino acid decarboxylase, aromatic-l-amino-acid decarboxylase, l-amino-acid decarboxylase, 3,4-dihydroxyphenylalanine decarboxylase, aromatic l-aminoacid decarboxylase,
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3,4-Dihydroxyphenylalanine decarboxylase
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5-Hydroxy-L-tryptophan decarboxylase
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5-Hydroxytryptophan decarboxylase
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Aromatic amino acid decarboxylase
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Aromatic L-amino acid decarboxylase
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Decarboxylase, aromatic amino acid
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Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase
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DOPA-5-hydroxytryptophan decarboxylase
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Hydroxytryptophan decarboxylase
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L-3,4-Dihydroxyphenylalanine decarboxylase
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L-5-Hydroxytryptophan decarboxylase
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L-Aromatic amino acid decarboxylase
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L-DOPA decarboxylase
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L-Tryptophan decarboxylase
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Tryptophan decarboxylase
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Tyrosine/Dopa decarboxylase
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DDC
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DOPA decarboxylase
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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Aromatic-L-amino-acid carboxy-lyase
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
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3,4-Dihydroxyphenylalanine
Dopamine + CO2
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5-hydroxy-L-tryptophan
serotonin + CO2
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L-Dopa
dopamine + CO2
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pyridoxal 5'-phosphate
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SwissProt
brenda
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physiological function
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dopa decarboxylase is necessary for insect cuticular melanization
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DDC_MANSE
508
0
57892
Swiss-Prot
other Location (Reliability: 1)
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DEAE-cellulose chromatography
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both 20-hydroxyecdysone and juvenile hormone regulate DDC expression in the epidermis
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ecdysone cascades regulate DDC expression in the epidermis
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Hodgetts, R.B.; OKeefe, S.L.
Dopa decarboxylase: a model gene-enzyme system for studying development, behavior, and systematics
Annu. Rev. Entomol.
51
259-284
2006
Ceratitis capitata (O96937), Drosophila melanogaster (P05031), Manduca sexta (P48861), Aedes aegypti (Q16895), Mythimna separata (Q95YG8), Mamestra brassicae (Q95YG9), Bombyx mori (Q967Q9), Tenebrio molitor (Q9NL84)
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Hiruma, K.; Riddiford, L.M.
The molecular mechanisms of cuticular melanization: the ecdysone cascade leading to dopa decarboxylase expression in Manduca sexta
Insect Biochem. Mol. Biol.
39
245-253
2009
Manduca sexta
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