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Information on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase and Organism(s) Manduca sexta and UniProt Accession P48861

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.28 aromatic-L-amino-acid decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
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This record set is specific for:
Manduca sexta
UNIPROT: P48861
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Word Map
The taxonomic range for the selected organisms is: Manduca sexta
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dopa decarboxylase, aromatic l-amino acid decarboxylase, aromatic amino acid decarboxylase, tryptophan decarboxylase, l-dopa decarboxylase, l-aromatic amino acid decarboxylase, aromatic-l-amino-acid decarboxylase, l-amino-acid decarboxylase, 3,4-dihydroxyphenylalanine decarboxylase, aromatic l-aminoacid decarboxylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DOPA decarboxylase
-
EC 4.1.1.26
formerly
3,4-Dihydroxyphenylalanine decarboxylase
-
-
-
-
5-Hydroxy-L-tryptophan decarboxylase
-
-
-
-
5-Hydroxytryptophan decarboxylase
-
-
-
-
AADC
-
-
-
-
Aromatic amino acid decarboxylase
-
-
-
-
Aromatic L-amino acid decarboxylase
-
-
-
-
Decarboxylase, aromatic amino acid
-
-
-
-
Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase
-
-
-
-
DOPA DC
-
-
-
-
DOPA decarboxylase
DOPA-5-hydroxytryptophan decarboxylase
-
-
-
-
Hydroxytryptophan decarboxylase
-
-
-
-
L-3,4-Dihydroxyphenylalanine decarboxylase
-
-
-
-
L-5-Hydroxytryptophan decarboxylase
-
-
-
-
L-Aromatic amino acid decarboxylase
-
-
-
-
L-DOPA decarboxylase
-
-
-
-
L-Tryptophan decarboxylase
-
-
-
-
Tryptophan decarboxylase
-
-
-
-
TYDC
-
-
-
-
Tyrosine/Dopa decarboxylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Aromatic-L-amino-acid carboxy-lyase
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9042-64-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,4-Dihydroxyphenylalanine
Dopamine + CO2
show the reaction diagram
-
-
-
?
5-hydroxy-L-tryptophan
serotonin + CO2
show the reaction diagram
-
-
-
?
L-Dopa
dopamine + CO2
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
dopa decarboxylase is necessary for insect cuticular melanization
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DDC_MANSE
508
0
57892
Swiss-Prot
other Location (Reliability: 1)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DEAE-cellulose chromatography
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
both 20-hydroxyecdysone and juvenile hormone regulate DDC expression in the epidermis
-
ecdysone cascades regulate DDC expression in the epidermis
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hodgetts, R.B.; OKeefe, S.L.
Dopa decarboxylase: a model gene-enzyme system for studying development, behavior, and systematics
Annu. Rev. Entomol.
51
259-284
2006
Ceratitis capitata (O96937), Drosophila melanogaster (P05031), Manduca sexta (P48861), Aedes aegypti (Q16895), Mythimna separata (Q95YG8), Mamestra brassicae (Q95YG9), Bombyx mori (Q967Q9), Tenebrio molitor (Q9NL84)
Manually annotated by BRENDA team
Hiruma, K.; Riddiford, L.M.
The molecular mechanisms of cuticular melanization: the ecdysone cascade leading to dopa decarboxylase expression in Manduca sexta
Insect Biochem. Mol. Biol.
39
245-253
2009
Manduca sexta
Manually annotated by BRENDA team