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Information on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase and Organism(s) Anopheles gambiae and UniProt Accession O61718

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.28 aromatic-L-amino-acid decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
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Select one or more organisms in this record: ?
This record set is specific for:
Anopheles gambiae
UNIPROT: O61718
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Word Map
The taxonomic range for the selected organisms is: Anopheles gambiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dopa decarboxylase, aromatic l-amino acid decarboxylase, aromatic amino acid decarboxylase, tryptophan decarboxylase, l-dopa decarboxylase, l-aromatic amino acid decarboxylase, aromatic-l-amino-acid decarboxylase, l-amino-acid decarboxylase, 3,4-dihydroxyphenylalanine decarboxylase, aromatic l-aminoacid decarboxylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DOPA decarboxylase
-
3,4-Dihydroxyphenylalanine decarboxylase
-
-
-
-
5-Hydroxy-L-tryptophan decarboxylase
-
-
-
-
5-Hydroxytryptophan decarboxylase
-
-
-
-
AADC
-
-
-
-
Aromatic amino acid decarboxylase
-
-
-
-
Aromatic L-amino acid decarboxylase
-
-
-
-
Decarboxylase, aromatic amino acid
-
-
-
-
Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase
-
-
-
-
DOPA DC
-
-
-
-
DOPA decarboxylase
DOPA-5-hydroxytryptophan decarboxylase
-
-
-
-
Hydroxytryptophan decarboxylase
-
-
-
-
L-3,4-Dihydroxyphenylalanine decarboxylase
-
-
-
-
L-5-Hydroxytryptophan decarboxylase
-
-
-
-
L-Aromatic amino acid decarboxylase
-
-
-
-
L-DOPA decarboxylase
-
-
-
-
L-Tryptophan decarboxylase
-
-
-
-
Tryptophan decarboxylase
-
-
-
-
TYDC
-
-
-
-
Tyrosine/Dopa decarboxylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
SYSTEMATIC NAME
IUBMB Comments
Aromatic-L-amino-acid carboxy-lyase
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9042-64-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-Dopa
dopamine + CO2
show the reaction diagram
-
dopamine can serve as the catecholamine substrate for melanin production
-
?
L-Dopa
dopamine + CO2
show the reaction diagram
-
dopamine can serve as the catecholamine substrate for melanin production
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-Dopa
dopamine + CO2
show the reaction diagram
-
dopamine can serve as the catecholamine substrate for melanin production
-
?
L-Dopa
dopamine + CO2
show the reaction diagram
-
dopamine can serve as the catecholamine substrate for melanin production
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform 2, descended from accession number AF063021; strain G3, the strain has the ability to melanize malaria parasites
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
O61718_ANOGA
484
0
54669
TrEMBL
other Location (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
knockdown (silencing) of gene expression (RNA interference) results in a significant reduction of melanization of Sephadex beads at 24 h after injection. The average proportion of mosquitoes that completely melanized beads is 28% compared with 64% when the control green fluorescent protein is injected
knockdown (silencing) of gene expression (RNA interference) results in a significant reduction of melanization of Sephadex beads at 24 h after injection. The average proportion of mosquitoes that completely melanized beads is 28% compared with 64% when the control green fluorescent protein is injected
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Paskewitz, S.M.; Andreev, O.
Silencing the genes for dopa decarboxylase or dopachrome conversion enzyme reduces melanization of foreign targets in Anopheles gambiae
Comp. Biochem. Physiol. B
150
403-408
2008
Anopheles gambiae (O61717), Anopheles gambiae (O61718), Anopheles gambiae
Manually annotated by BRENDA team