Reference on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Murray, M.G.; Ross, C.
Molecular weight estimations of some pyrimidine-metabolizing enzymes from pea cotyledons by gel filtration
Phytochemistry
10
2645-2648
1971
Pisum sativum
-
Fyfe, J.A.; Miller, R.L.; Krenitsky, T.A.
Kinetic properties and inhibition of orotidine 5'-phosphate decarboxylase. Effects of some allopurinol metabolites on the enzyme
J. Biol. Chem.
248
3801-3809
1973
Saccharomyces cerevisiae
Shoaf, W.T.; Jones, M.E.
Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of six biosynthetic enzymes
Biochemistry
12
4039-4051
1973
Mus musculus
Brown, G.K.; Fox, R.M.; O'Sullivan, W.J.
Interconversion of different molecular weight forms of human erythrocyte orotidylate decarboxylase
J. Biol. Chem.
250
7352-7358
1975
Homo sapiens
Yoshimoto, A.; Umezu, K.; Kobayashi, K.; Tomita, K.
Orotidylate decarboxylase (yeast)
Methods Enzymol.
51
74-79
1978
Saccharomyces cerevisiae
Brody, R.S.; Westheimer, F.H.
The purification of orotidine-5'-phosphate decarboxylase from yeast by affinity chromatography
J. Biol. Chem.
254
4238-4244
1979
Saccharomyces cerevisiae
Oakley, B.R.; Rinehart, J.E.; Mitchell, B.L.; Oakley, C.E.; Carmona, C.; Gray, G.L.; May, G.S.
Cloning, mapping and molecular analysis of the pyrG (orotidine-5'-phosphate decarboxylase) gene of Aspergillus nidulans
Gene
61
385-399
1987
Aspergillus nidulans
Langdon, S.D.; Jones, M.E.
Study of the kinetic and physical properties of the orotidine-5'-monophosphate decarboxylase domain from mouse UMP synthase produced in Saccharomyces cerevisiae
J. Biol. Chem.
262
13359-13365
1987
Mus musculus
Reiter, S.; Grbner, W.
Orotidine-5'-phosphate decarboxylase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
4
338-346
1984
Saccharomyces cerevisiae, Mus musculus, Rattus norvegicus
-
Pragobpol, S.; Gero, A.M.; Lee, C.S.; O'Sullivan, W.J.
Orotate phosphoribosyltransferase and orotidylate decarboxylase from Crithidia luciliae: subcellular location of the enzymes and a study of substrate chanelling
Arch. Biochem. Biophys.
230
285-293
1984
Crithidia luciliae
Donovan, W.P.; Kushner, S.R.
Purification and characterization of orotidine-5'-phosphate decarboxylase from Escherichia coli K-12
J. Bacteriol.
156
620-624
1983
Escherichia coli
Levine, H.L.; Brody, R.S.; Westheimer, F.H.
Inhibition of orotidine-5'-phosphate decarboxylase by 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid, 6-azauridine 5'-phosphate and uridine 5'-phosphate
Biochemistry
19
4993-3999
1980
Saccharomyces cerevisiae
Floyd, E.E.; Jones, M.E.
Isolation and characterization of the orotidine 5'-monophosphate decarboxylase domain of the multifunctional protein uridine 5'-monophosphate synthase
J. Biol. Chem.
260
9443-9451
1985
Mus musculus
Smiley, J.A.; Paneth, P.; O'Leary, M.H.; Bell, J.B.; Jones, M.E.
Investigation of the enzymatic mechanism of yeast orotidine-5'-monophosphate decarboxylase using 13C kinetic isotope effects
Biochemistry
25
6216-6223
1991
Saccharomyces cerevisiae
Acheson, S.A.; Bell, J.B.; Jones, M.E.; Wolfenden, R.
Orotidine-5'-monophosphate decarboxylase catalysis: kinetic isotope effects and the state of hybridization of a bound transition-state analogue
Biochemistry
29
3198-3202
1990
Saccharomyces cerevisiae, Saccharomyces cerevisiae 15C
Smiley, J.A.; Jones, M.E.
A unique catalytic and inhibitor-binding role of Lys93 of yeast orotidylate decarboxylase
Biochemistry
31
12162-12168
1992
Mus musculus
Miller, B.G.; Traut, T.W.; Wolfenden, R.
A role for zinc in OMP decarboxylase, an unusually proficient enzyme
J. Am. Chem. Soc.
120
2666-2667
1998
Saccharomyces cerevisiae
-
Shostak, K.; Jones, E.
Orotidylate decarboxylase: insights into the catalytic mechanism from substrate specificity studies
Biochemistry
31
12155-12161
1992
Saccharomyces cerevisiae
Jones, M.E.
Orotidylate decarboxylase of yeast and man
Curr. Top. Cell. Regul.
33
331-342
1992
Saccharomyces cerevisiae, Homo sapiens, Mus musculus
Yablonski, M.J.; Pasek, D.A.; Han, B.D.; Jones, M.E.; Traut, T.W.
Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase
J. Biol. Chem.
271
10704-10708
1996
Homo sapiens
Bell, J.B.; Jones, M.E.
Purification and characterization of yeast orotidine 5'-monophosphate decarboxylase overexpressed from plasmid PGU2
J. Biol. Chem.
266
12662-12667
1991
Saccharomyces cerevisiae, Saccharomyces cerevisiae 15C
Strych, U.; Wohlfarth, S.; Winkler, U.K.
Orotidine-5'-monophate decarboxylase from Pseudomonas aeruginosa PAO1: cloning, overexpression, and enzyme characterization
Curr. Microbiol.
29
353-359
1994
Pseudomonas aeruginosa
Bell, J.B.; Jones, M.E.; Carter, C.W.
Crystallization and yeast orotidine 5'-monophosphate decarboxylase complexed with 1-(5'-phospho-beta-D-ribofuranosyl) barbituric acid
Proteins Struct. Funct. Genet.
9
143-151
1991
Saccharomyces cerevisiae
Wu, N.; Christendat, D.; Dharamsi, A.; Pai, E.F.
Purification, crystallization and preliminary X-ray study of orotidine 5'-monophosphate decarboxylase
Acta Crystallogr. Sect. D
56
912-914
2000
Methanothermobacter thermautotrophicus
-
Miller, B.G.; Wolfenden, R.
Catalytic proficiency: the unusual case of OMP decarboxylase
Annu. Rev. Biochem.
71
847-885
2002
Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli
Smiley, J.A.; DelFraino, B.J.; Simpson, B.A.
Hydrogen isotope tracing in the reaction of orotidine-5'-monophosphate decarboxylase
Arch. Biochem. Biophys.
412
267-271
2003
Saccharomyces cerevisiae
Cui, W.; DeWitt, J.G.; Miller, S.M.; Wu, W.
No metal cofactor in orotidine 5'-monophosphate decarboxylase
Biochem. Biophys. Res. Commun.
259
133-135
1999
Saccharomyces cerevisiae, Saccharomyces cerevisiae BJ5464
Porter, D.J.T.; Short, S.A.
Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation
Biochemistry
39
11788-11800
2000
Saccharomyces cerevisiae
Harris, P.; Poulsen, J.C.N.; Jensen, K.F.; Larsen, S.
Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase
Biochemistry
39
4217-4224
2000
Escherichia coli
Rishavy, M.A.; Cleland, W.W.
Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects
Biochemistry
39
4569-4574
2000
Saccharomyces cerevisiae
Miller, B.G.; Butterfoss, G.L.; Short, S.A.; Wolfenden, R.
Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization?
Biochemistry
40
6227-6232
2001
Saccharomyces cerevisiae (P03962), Saccharomyces cerevisiae
Wise, E.; Yew, W.S.; Babbitt, P.C.; Gerlt, J.A.; Rayment, I.
Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase
Biochemistry
41
3861-3869
2002
Bacillus subtilis
Wu, N.; Gillon, W.; Pai, E.F.
Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography
Biochemistry
41
4002-4011
2002
Methanothermobacter thermautotrophicus
Smiley, J.A.; Saleh, L.
Active site probes for yeast OMP decarboxylase: inhibition constants of UMP and thio-substituted UMP analogues and greatly reduced activity toward CMP-6-carboxylate
Bioorg. Chem.
27
297-306
1999
Saccharomyces cerevisiae, Saccharomyces cerevisiae BJ5424
-
Gao, J.
Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase
Curr. Opin. Struct. Biol.
13
184-192
2003
Methanothermobacter thermautotrophicus
Maiorano, J.N.; Grogan, D.W.
Extremely thermostable orotidine-5'-monophosphate decarboxylase from the archaeon Sulfolobus acidocaldarius
FEMS Microbiol. Lett.
174
81-87
1999
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DG6 / ATCC 49426
-
Quiles-Rosillo, M.D.; Ruiz-Vazquez, R.M.; Torres-Martinez, S.; Garre, V.
Cloning, characterization and heterologous expression of the Blakeslea trispora gene encoding orotidine-5'-monophosphate decarboxylase
FEMS Microbiol. Lett.
222
229-236
2003
Blakeslea trispora (Q870M2), Blakeslea trispora, Blakeslea trispora NRRL2895(+) (Q870M2)
Lee, T.S.; Chong, L.T.; Chodera, J.D.; Kollman, P.A.
An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase
J. Am. Chem. Soc.
123
12837-12848
2001
Methanothermobacter thermautotrophicus
Miller, B.G.; Smiley, J.A.; Short, S.A.; Wolfenden, R.
Activity of yeast orotidine-5'-phosphate decarboxylase in the absence of metals
J. Biol. Chem.
274
23841-23843
1999
Saccharomyces cerevisiae, Saccharomyces cerevisiae BJ5424
Miller, B.G.; Snider, M.J.; Wolfenden, R.; Short, S.A.
Dissecting a charged network at the active site of orotidine-5'-phosphate decarboxylase
J. Biol. Chem.
276
15174-15176
2001
Saccharomyces cerevisiae
Harris, P.; Poulsen, J.C.N.; Jensen, K.F.; Larsen, S.
Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase
J. Mol. Biol.
318
1019-1029
2002
Escherichia coli
Appleby, T.C.; Kinsland, C.; Begley, T.P.; Ealick, S.E.
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
Proc. Natl. Acad. Sci. USA
97
2005-2010
2000
Bacillus subtilis (P25971), Bacillus subtilis
Wu, N.; Mo, Y.; Gao, J.; Pai, E.F.
Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase
Proc. Natl. Acad. Sci. USA
97
2017-2022
2000
Methanothermobacter thermautotrophicus
Krungkrai, S.R.; Prapunwattana, P.; Horii, T.; Krungkrai, J.
Orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum
Biochem. Biophys. Res. Commun.
318
1012-1018
2004
Plasmodium falciparum
Krungkrai, S.R.; DelFraino, B.J.; Smiley, J.A.; Prapunwattana, P.; Mitamura, T.; Horii, T.; Krungkrai, J.
A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization
Biochemistry
44
1643-1652
2005
Plasmodium falciparum (Q8T6J6), Plasmodium falciparum
Sievers, A.; Wolfenden, R.
The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase
Bioorg. Chem.
33
45-52
2005
Saccharomyces cerevisiae
Callahan, B.P.; Bell, A.F.; Tonge, P.J.; Wolfenden, R.
A Raman-active competitive inhibitor of OMP decarboxylase
Bioorg. Chem.
34
59-65
2006
Saccharomyces cerevisiae
Amyes, T.L.; Richard, J.P.; Tait, J.J.
Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts
J. Am. Chem. Soc.
127
15708-15709
2005
Saccharomyces cerevisiae
Phillips, L.M.; Lee, J.K.
Theoretical studies of the effect of thio substitution on orotidine monophosphate decarboxylase substrates
J. Org. Chem.
70
1211-1221
2005
Bacillus subtilis (P25971)
Reinoso, C.; Sorais, F.; Nino-Vega, G.A.; Ferminan, E.; San-Blas, G.; Dominguez, A.
Cloning and functional analysis of the orotidine-5'-phosphate decarboxylase gene (PbrURA3) of the pathogenic fungus Paracoccidioides brasiliensis
Yeast
22
739-743
2005
Paracoccidioides brasiliensis (Q9C131), Paracoccidioides brasiliensis
Wittmann, J.G.; Rudolph, M.G.
Pseudo-merohedral twinning in monoclinic crystals of human orotidine-5-monophosphate decarboxylase
Acta Crystallogr. Sect. D
63
744-749
2007
Homo sapiens (P11172), Homo sapiens
Krungkrai, S.R.; Tokuoka, K.; Kusakari, Y.; Inoue, T.; Adachi, H.; Matsumura, H.; Takano, K.; Murakami, S.; Mori, Y.; Kai, Y.; Krungkrai, J.; Horii, T.
Crystallization and preliminary crystallographic analysis of orotidine 5-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum
Acta Crystallogr. Sect. F
F62
542-545
2006
Plasmodium falciparum
Lewis, C.A.; Wolfenden, R.
Indiscriminate binding by orotidine 5-phosphate decarboxylase of uridine 5-phosphate derivatives with bulky anionic c6 substituents
Biochemistry
46
13331-13343
2007
Saccharomyces cerevisiae
Callahan, B.P.; Miller, B.G.
OMP decarboxylase - An enigma persists
Bioorg. Chem.
35
465-469
2007
Saccharomyces cerevisiae
De Maeseneire, S.L.; De Groeve, M.R.; Dauvrin, T.; De Mey, M.; Soetaert, W.; Vandamme, E.J.
Cloning, sequence analysis and heterologous expression of the Myrothecium gramineum orotidine-5-monophosphate decarboxylase gene
FEMS Microbiol. Lett.
261
262-271
2006
Myrothecium gramineum (Q2HZ31), Myrothecium gramineum
Capone, R.F.; Ning, Y.; Pakulis, N.; Alhazzazi, T.; Fenno, J.C.
Characterization of Treponema denticola pyrF encoding orotidine-5-monophosphate decarboxylase
FEMS Microbiol. Lett.
268
261-267
2007
no activity in Treponema pallidum, Treponema denticola
Tokuoka, K.; Kusakari, Y.; Krungkrai, S.R.; Matsumura, H.; Krungkrai, J.; Horii, T.; Inoue, T.
Structural basis for the decarboxylation of orotidine 5-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase
J. Biochem.
143
69-78
2008
Plasmodium falciparum
Poduch, E.; Bello, A.M.; Tang, S.; Fujihashi, M.; Pai, E.F.; Kotra, L.P.
Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics
J. Med. Chem.
49
4937-4945
2006
Methanothermobacter thermautotrophicus
Bello, A.M.; Poduch, E.; Fujihashi, M.; Amani, M.; Li, Y.; Crandall, I.; Hui, R.; Lee, P.I.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
A potent, covalent inhibitor of orotidine 5-monophosphate decarboxylase with antimalarial activity
J. Med. Chem.
50
915-921
2007
Methanothermobacter thermautotrophicus, Plasmodium falciparum (Q8IJH3), Plasmodium falciparum
Wong, F.M.; Capule, C.C.; Wu, W.
Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5-monophosphate decarboxylase
Org. Lett.
8
6019-6022
2006
Saccharomyces cerevisiae
Langley, D.B.; Shojaei, M.; Chan, C.; Lok, H.C.; Mackay, J.P.; Traut, T.W.; Guss, J.M.; Christopherson, R.I.
Structure and inhibition of orotidine 5-monophosphate decarboxylase from Plasmodium falciparum
Biochemistry
47
3842-3854
2008
Plasmodium falciparum (Q8T6J6), Plasmodium falciparum
Barnett, S.A.; Amyes, T.L.; Wood, B.M.; Gerlt, J.A.; Richard, J.P.
Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5-monophosphate decarboxylase: a two-part substrate approach
Biochemistry
47
7785-7787
2008
Saccharomyces cerevisiae (P03962), Saccharomyces cerevisiae
Van Vleet, J.L.; Reinhardt, L.A.; Miller, B.G.; Sievers, A.; Wallace Cleland, W.
Carbon isotope effect study on orotidine 5-monophosphate decarboxylase: Support for an anionic intermediate
Biochemistry
47
798-803
2008
Saccharomyces cerevisiae
Hu, H.; Boone, A.; Yang, W.
Mechanism of OMP decarboxylation in orotidine 5-monophosphate decarboxylase
J. Am. Chem. Soc.
130
14493-14503
2008
Methanothermobacter thermautotrophicus
Amyes, T.L.; Wood, B.M.; Chan, K.; Gerlt, J.A.; Richard, J.P.
Formation and stability of a vinyl carbanion at the active site of orotidine 5-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP
J. Am. Chem. Soc.
130
1574-1575
2008
Saccharomyces cerevisiae
Poduch, E.; Wei, L.; Pai, E.F.; Kotra, L.P.
Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase
J. Med. Chem.
51
432-438
2008
Homo sapiens, Methanothermobacter thermautotrophicus (O26232), Methanothermobacter thermautotrophicus, Plasmodium falciparum (Q8IJH3), Plasmodium falciparum
Bello, A.M.; Poduch, E.; Liu, Y.; Wei, L.; Crandall, I.; Wang, X.; Dyanand, C.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase
J. Med. Chem.
51
439-448
2008
Methanothermobacter thermautotrophicus, Plasmodium falciparum (Q8IJH3), Plasmodium falciparum
Meza-Avina, M.E.; Wei, L.; Buhendwa, M.G.; Poduch, E.; Bello, A.M.; Pai, E.F.; Kotra, L.P.
Inhibition of orotidine 5-monophosphate decarboxylase and its therapeutic potential
Mini Rev. Med. Chem.
8
239-247
2008
Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Plasmodium falciparum, Plasmodium vivax, Methanococcus thermoautotrophicum
Chien, T.C.; Jen, C.H.; Wu, Y.J.; Liao, C.C.
Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5-monophosphate catalyzed by orotidine 5-monophosphate decarboxylase
Nucleic Acids Symp. Ser.
52
297-298
2008
Methanothermobacter thermautotrophicus (O26232)
Kotra, L.P.; Pai, E.F.
Inhibition of orotidine-5-monophosphate decarboxylase--discoveries and lessons
Nucleic Acids Symp. Ser.
52
85-86
2008
Helicobacter pylori, Homo sapiens, Staphylococcus aureus, Plasmodium falciparum, Methanothermobacter thermautotrophicus (O26232)
Wepukhulu, W.O.; Smiley, V.L.; Vemulapalli, B.; Smiley, J.A.; Phillips, L.M.; Lee, J.K.
A substantial oxygen isotope effect at O2 in the OMP decarboxylase reaction: mechanistic implications
Org. Biomol. Chem.
6
4533-4541
2008
Escherichia coli
Wittmann, J.G.; Heinrich, D.; Gasow, K.; Frey, A.; Diederichsen, U.; Rudolph, M.G.
Structures of the human orotidine-5-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
Structure
16
82-92
2008
Homo sapiens (P11172), Homo sapiens
Yang, F.; Zhang, S.; Tang, W.; Zhao, Z.K.
Identification of the orotidine-5-monophosphate decarboxylase gene of the oleaginous yeast Rhodosporidium toruloides
Yeast
25
623-630
2008
Rhodotorula toruloides (B3GF12), Rhodotorula toruloides
Meza-Avina, M.E.; Wei, L.; Liu, Y.; Poduch, E.; Bello, A.M.; Mishra, R.K.; Pai, E.F.; Kotra, L.P.
Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase
Bioorg. Med. Chem.
18
4032-4041
2010
Saccharomyces cerevisiae, Helicobacter pylori, Homo sapiens, Methanothermobacter thermautotrophicus, Staphylococcus aureus, Plasmodium falciparum
Wu, Y.J.; Liao, C.C.; Jen, C.H.; Shih, Y.C.; Chien, T.C.
Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase
Chem. Commun. (Camb. )
46
4821-4823
2010
Methanothermobacter thermautotrophicus
Lewis, M.; Meza-Avina, M.E.; Wei, L.; Crandall, I.E.; Bello, A.M.; Poduch, E.; Liu, Y.; Paige, C.J.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase
J. Med. Chem.
54
2891-2901
2011
Homo sapiens, Methanothermobacter thermautotrophicus
Huang, S.; Wong, F.M.; Gassner, G.T.; Wu, W.
Accelerated hydrolysis of alpha-halo and alpha-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMP
Tetrahedron Lett.
52
3960-3962
2011
Homo sapiens
Iiams, V.; Desai, B.J.; Fedorov, A.A.; Fedorov, E.V.; Almo, S.C.; Gerlt, J.A.
Mechanism of the orotidine 5-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site
Biochemistry
50
8497-8507
2011
Methanobacterium thermoautotrophicus (O26232), Methanobacterium thermoautotrophicus DSM 1053 (O26232)
Amyes, T.L.; Ming, S.A.; Goldman, L.M.; Wood, B.M.; Desai, B.J.; Gerlt, J.A.; Richard, J.P.
Orotidine 5-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions
Biochemistry
51
4630-4632
2012
Saccharomyces cerevisiae
Desai, B.J.; Wood, B.M.; Fedorov, A.A.; Fedorov, E.V.; Goryanova, B.; Amyes, T.L.; Richard, J.P.; Almo, S.C.; Gerlt, J.A.
Conformational changes in orotidine 5-monophosphate decarboxylase: a structure-based explanation for how the 5-phosphate group activates the enzyme
Biochemistry
51
8665-8678
2012
Methanothermobacter thermautotrophicus (O26232), Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DSM 1053 (O26232)
Vardi-Kilshtain, A.; Doron, D.; Major, D.T.
Quantum and classical simulations of orotidine monophosphate decarboxylase: support for a direct decarboxylation mechanism
Biochemistry
52
4382-4390
2013
Methanobacterium thermoautotrophicus (O26232), Methanobacterium thermoautotrophicus DSM 1053 (O26232)
Goryanova, B.; Spong, K.; Amyes, T.L.; Richard, J.P.
Catalysis by orotidine 5-monophosphate decarboxylase: effect of 5-fluoro and 4-substituents on the decarboxylation of two-part substrates
Biochemistry
52
537-546
2013
Saccharomyces cerevisiae
Goryanova, B.; Goldman, L.M.; Amyes, T.L.; Gerlt, J.A.; Richard, J.P.
Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5-phosphate decarboxylase-catalyzed reactions
Biochemistry
52
7500-7511
2013
Saccharomyces cerevisiae
Tsang, W.Y.; Wood, B.M.; Wong, F.M.; Wu, W.; Gerlt, J.A.; Amyes, T.L.; Richard, J.P.
Proton transfer from C-6 of uridine 5-monophosphate catalyzed by orotidine 5-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent
J. Am. Chem. Soc.
134
14580-14594
2012
Saccharomyces cerevisiae
Fujihashi, M.; Ishida, T.; Kuroda, S.; Kotra, L.P.; Pai, E.F.; Miki, K.
Substrate distortion contributes to the catalysis of orotidine 5-monophosphate decarboxylase
J. Am. Chem. Soc.
135
17432-17443
2013
Methanothermobacter thermautotrophicus (O26232), Methanothermobacter thermautotrophicus DSM 1053 (O26232)
Takashima, Y.; Mizohata, E.; Krungkrai, S.R.; Fukunishi, Y.; Kinoshita, T.; Sakata, T.; Matsumura, H.; Krungkrai, J.; Horii, T.; Inoue, T.
The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5-monophosphate decarboxylase
J. Biochem.
152
133-138
2012
Plasmodium falciparum (Q8T6J6), Plasmodium falciparum
Jamshidi, S.; Jalili, S.; Rafii-Tabar, H.
Study of orotidine 5-monophosphate decarboxylase in complex with the top three OMP, BMP, and PMP ligands by molecular dynamics simulation
J. Biomol. Struct. Dyn.
33
404-417
2015
Saccharomyces cerevisiae
Purohit, M.K.; Poduch, E.; Wei, L.W.; Crandall, I.E.; To, T.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
Novel cytidine-based orotidine-5-monophosphate decarboxylase inhibitors with an unusual twist
J. Med. Chem.
55
9988-9997
2012
Homo sapiens (P11172), Plasmodium falciparum (Q8IJH3), Plasmodium falciparum
Yuan, J.; Cardenas, A.M.; Gilbert, H.F.; Palzkill, T.
Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase
Protein Sci.
20
1891-1906
2011
Escherichia coli
Richard, J.P.; Amyes, T.L.; Reyes, A.C.
Orotidine 5'-monophosphate decarboxylase probing the limits of the possible for enzyme catalysis
Acc. Chem. Res.
51
960-969
2018
Saccharomyces cerevisiae (P03962), Saccharomyces cerevisiae ATCC 204508 / S288c (P03962)
Imprasittichail, W.; Roytrakul, S.; Krungkrai, S.R.; Krungkrail, J.
A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5-monophosphate decarboxylase
Asian Pac. J. Trop. Med.
7
184-192
2014
Plasmodium falciparum (A0A1D3TG46), Plasmodium falciparum
Yaoi, T.; Laksanalamai, P.; Jiemjit, A.; Kagawa, H.; Alton, T.; Trent, J.
Cloning and characterization of ftsZ and pyrF from the archaeon Thermoplasma acidophilum
Biochem. Biophys. Res. Commun.
275
936-945
2000
Thermoplasma acidophilum (O74110), Thermoplasma acidophilum
Goryanova, B.; Goldman, L.M.; Ming, S.; Amyes, T.L.; Gerlt, J.A.; Richard, J.P.
Rate and equilibrium constants for an enzyme conformational change during catalysis by orotidine 5'-monophosphate decarboxylase
Biochemistry
54
4555-4564
2015
Saccharomyces cerevisiae (P03962), Saccharomyces cerevisiae ATCC 204508 / S288c (P03962)
Chen, L.; Wei, D.; Zhang, Q.; Yu, X.; Wang, Y.; Zhu, X.
Orotidine 5'-phosphate decarboxylase-based reusable in situ genetic editing system Development and application in taxol-producing Pestalotiopsis microspora
Eng. Life Sci.
15
542-549
2015
Pestalotiopsis microspora (A0A0A0WDU2), Pestalotiopsis microspora NK17 (A0A0A0WDU2)
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Goldman, L.M.; Amyes, T.L.; Goryanova, B.; Gerlt, J.A.; Richard, J.P.
Enzyme architecture deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase
J. Am. Chem. Soc.
136
10156-10165
2014
Saccharomyces cerevisiae (P03962), Saccharomyces cerevisiae ATCC 204508 / S288c (P03962)
Reyes, A.C.; Amyes, T.L.; Richard, J.P.
Enzyme architecture Erection of active orotidine 5'-monophosphate decarboxylase by substrate-induced conformational changes
J. Am. Chem. Soc.
139
16048-16051
2017
Saccharomyces cerevisiae (P03962), Saccharomyces cerevisiae ATCC 204508 / S288c (P03962)
Paojinda, P.; Imprasittichai, W.; Krungkrai, S.R.; Palacpac, N.M.Q.; Horii, T.; Krungkrai, J.
Bifunctional activity of fused Plasmodium falciparum orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase
Parasitol. Int.
67
79-84
2018
Plasmodium falciparum (Q8T6J6), Plasmodium falciparum
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