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Information on EC 4.1.1.15 - glutamate decarboxylase and Organism(s) Drosophila melanogaster and UniProt Accession P20228

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.15 glutamate decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: P20228
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
glutamic acid decarboxylase, gad65, gad67, glutamate decarboxylase, glutamic acid decarboxylase 65, glutamic acid decarboxylase 67, gad-65, gad-67, glutamate decarboxylase 67, l-glutamate decarboxylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L-glutamate 1-carboxylyase
-
65 kDa glutamic acid decarboxylase
-
-
-
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67 kDa glutamic acid decarboxylase
-
-
-
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Aspartate 1-decarboxylase
-
-
-
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Aspartic alpha-decarboxylase
-
-
-
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Cysteic acid decarboxylase
-
-
-
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Decarboxylase, glutamate
-
-
-
-
ERT D1
-
-
-
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GAD
-
-
-
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GAD-65
-
-
-
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GAD-67
-
-
-
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GAD-alpha
-
-
-
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GAD-beta
-
-
-
-
GAD-gamma
-
-
-
-
GADCase
-
-
-
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gamma-Glutamate decarboxylase
-
-
-
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GDCase
-
-
-
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Glutamic acid decarboxylase
-
-
-
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Glutamic decarboxylase
-
-
-
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L-Aspartate-alpha-decarboxylase
-
-
-
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L-Glutamate alpha-decarboxylase
-
-
-
-
L-Glutamate decarboxylase
-
-
-
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L-Glutamic acid decarboxylase
-
-
-
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L-Glutamic decarboxylase
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-
-
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MGAD
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-58-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-glutamate
4-aminobutanoate + CO2
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-glutamate
4-aminobutanoate + CO2
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine
-
(5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one
-
1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside
-
1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde
-
10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
-
2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol
-
2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione
-
2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
-
2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione
-
2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one
-
2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid
-
2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile
-
3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole)
-
3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid
-
3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
-
3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
-
4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one]
-
4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one)
-
4-(morpholin-4-yl)naphthalene-1,2-dione
-
4-(piperidin-1-yl)naphthalene-1,2-dione
-
4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole
-
4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole
-
4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid
-
5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol
-
5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
-
5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one
-
5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium
-
9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
-
biphenyl-3,3'-dicarbaldehyde
-
carboxymethoxylamine
-
methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate
-
methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate
-
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide
-
N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
-
N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
-
naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione
-
[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
10.1
L-glutamate
pH 8.0, 37°C, recombinant enzyme
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03
(4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0033
(5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0038
1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0076
1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.002
10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.1
2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol
Drosophila melanogaster
above, pH 8.0, 37°C, recombinant enzyme
0.0089
2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0284
2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0047
2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.014
2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0714
2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0138
2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0212
3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole)
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.1
3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid
Drosophila melanogaster
above, pH 8.0, 37°C, recombinant enzyme
0.0109
3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0269
4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one]
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0188
4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one)
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.003
4-(morpholin-4-yl)naphthalene-1,2-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.003
4-(piperidin-1-yl)naphthalene-1,2-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0209
4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0981
4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0067
4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0037
5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0077
5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0066
5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0122
5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0022
6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0089
9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0063
biphenyl-3,3'-dicarbaldehyde
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0004
carboxymethoxylamine
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0014
methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.005
methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0105
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.001
N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0013
N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0037
naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
0.0244
[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid
Drosophila melanogaster
pH 8.0, 37°C, recombinant enzyme
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene gad
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DCE_DROME
510
0
57819
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene gad, expression of enzyme as maltose-bindig protein fusion protein in Escherichia coli strain TB1
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ilg, T.; Berger, M.; Noack, S.; Rohwer, A.; Gassel, M.
Glutamate decarboxylase of the parasitic arthropods Ctenocephalides felis and Rhipicephalus microplus: gene identification, cloning, expression, assay development, identification of inhibitors by high throughput screening and comparison with the orthologs
Insect Biochem. Mol. Biol.
43
162-177
2013
Ctenocephalides felis (K7WYY0), Ctenocephalides felis, Rhipicephalus microplus (K7XPX5), Rhipicephalus microplus, Drosophila melanogaster (P20228), Drosophila melanogaster, Mus musculus (P48318), Mus musculus (P48320), Mus musculus
Manually annotated by BRENDA team