Information on EC 4.1.1.14 - valine decarboxylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
4.1.1.14
-
RECOMMENDED NAME
GeneOntology No.
valine decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-valine = 2-methylpropanamine + CO2
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-valine carboxy-lyase (2-methylpropanamine-forming)
A pyridoxal-phosphate protein. Also acts on L-leucine.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-16-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Furcellaria fastigiata
-
-
-
Manually annotated by BRENDA team
no activity in Bangia fuscopurpurea
-
-
-
Manually annotated by BRENDA team
no activity in Hildenbrandia prototypus
-
-
-
Manually annotated by BRENDA team
no activity in Lemanea torulosa
-
-
-
Manually annotated by BRENDA team
no activity in Porphyra umbilicalis
-
-
-
Manually annotated by BRENDA team
no activity in Porphyridium purpureum
-
-
-
Manually annotated by BRENDA team
no activity in Porphyridium violaceum
-
-
-
Manually annotated by BRENDA team
no activity in Rhodochorton purpureum
-
-
-
Manually annotated by BRENDA team
Phyllophora brodiaei
-
-
-
Manually annotated by BRENDA team
Phyllophora membranifolia
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Polysiphonia nigrescens
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Trailliella intricata
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala
Ethylamine + CO2
show the reaction diagram
-
-
-
-
-
D,L-Homocysteine
?
show the reaction diagram
L-2-Aminobutanoate
n-Propylamine + CO2
show the reaction diagram
L-Cys
?
show the reaction diagram
L-Ile
2-Methylbutylamine + CO2
show the reaction diagram
L-Leu
3-Methylbutylamine + CO2
show the reaction diagram
L-Met
3-Methylmercaptopropylamine + CO2
show the reaction diagram
L-Norleucine
Pentylamine + CO2
show the reaction diagram
L-Norvaline
n-Butylamine + CO2
show the reaction diagram
L-Phe
2-phenylethylamine + CO2
show the reaction diagram
L-valine
i-butylamine + CO2
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hydroxylamine
-
-
iodoacetate
Isobutylamine
-
-
Isopentanoate
-
-
Penicillamine
-
-
Semicarbazide
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal
-
weak activation
pyridoxal phosphate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 6
Furcellaria fastigiata
-
-
7.7 - 7.9
-
Val, Leu or Met
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
highest activity in very young cultures, decreases rapidly in the early exponential phase of growth
Manually annotated by BRENDA team
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70
-
10 min, 85% loss of activity
80
-
10 min, complete inactivation
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE