Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.7.1.8 - 2,6-dioxo-6-phenylhexa-3-enoate hydrolase and Organism(s) Comamonas testosteroni and UniProt Accession Q59324

for references in articles please use BRENDA:EC3.7.1.8
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.7 Acting on carbon-carbon bonds
             3.7.1 In ketonic substances
                3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
IUBMB Comments
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Comamonas testosteroni
UNIPROT: Q59324
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Comamonas testosteroni
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
meta-cleavage product hydrolase, mcp hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, bphd enzyme, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase
-
-
-
-
HOHPDA hydrolase
-
-
-
-
HOPD hydrolase
-
-
-
-
hydrolase, 2,6-dioxo-6-phenylhexa-3-enoate
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate
show the reaction diagram
mechanism may involve an Asp-Ser-His catalytic triad
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of C-C bonds in ketonic substances
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.
CAS REGISTRY NUMBER
COMMENTARY hide
102925-38-2
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
PMSF
inhibition of semipurified enzyme
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BPHD_COMTE
286
0
31951
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S112A
inactive enzyme
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ahmad, S.; Fraser, J.; Sylvestre, M.; Larose, A.; Khan, A.; Bergeron, J.; Juteau, J.M.; Sondossi, M.
Sequence of the bphD gene encoding 2-hydroxy-6-oxo-(phenylchlorophenyl) hexa-2,4-dienoic acid (HOP/cPCA) hydrolase involved in the biphenyl/polychlorinated biphenyl degradation pathway in Comamonas testosteroni: evidence suggesting involvement of Ser112 in catalytic activity
Gene
156
69-74
1995
Comamonas testosteroni (Q59324)
Manually annotated by BRENDA team