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Information on EC 3.7.1.28 - 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase

for references in articles please use BRENDA:EC3.7.1.28
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EC Tree
IUBMB Comments
The enzyme, which belongs to the RuBisCO-like-protein (RLP) superfamily, has been characterized from several bacterial species. It participates in the degradation of D-apionate. The reaction is initiated by decarboxylation to generate a stabilized enediolate intermediate, with the sequestered CO2 carboxylating the adjacent enediolate carbon atom. The resulting 3-ketose-1-phosphate intermediate is hydrolysed, as in the authentic RuBisCO-catalysed reaction, to generate glycolate and 3-phospho-D-glycerate. Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined.
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The expected taxonomic range for this enzyme is: Xanthobacter autotrophicus
Reaction Schemes
Synonyms
oiaT, RLP transcarboxylase/hydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-oxoisoapionate 4-phosphate + H2O = glycolate + 3-phospho-D-glycerate
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PATHWAY SOURCE
PATHWAYS
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