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Information on EC 3.6.5.6 - tubulin GTPase
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3.6.5.6 tubulin GTPaseIUBMB Comments
An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
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Word Map
- 3.6.5.6
- polymerization
- actin
- cytoskeleton
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mitotic
- spindle
-
microtubule-associated
- taxol
- centrosome
- paclitaxel
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nucleation
- tau
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disassembly
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antiproliferative
- heterodimers
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antimitotic
- nerve
- vinblastine
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interphase
-
isotypes
- nocodazole
- microtubular
-
neurite
- gtpases
- pole
-
axonemal
- vimentin
-
polymerized
- neurofilament
- kinesins
- cortical
- gdp
- cytokine
- cilia
- myosin
- dynein
-
lattice
-
metaphase
- map2
-
microfilaments
-
taxanes
-
anaphase
- urchin
-
multipolar
-
catastrophe
- vincristine
- kinetochore
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microtubule-based
- nestin
- flagella
- docetaxel
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
tubulin, gamma-tubulin, cell division protein, tubg1, tubulin homolog ftsz, tubulin gtpase, btubb, atypical gtpase, orf156, tubulin ftsz, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
GTP phosphohydrolase
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GTPase
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guanine triphosphatase
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guanosine 5'-triphosphatase
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guanosine triphosphatase
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ribosomal GTPase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoric ester hydrolysis
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SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (microtubule-releasing)
An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
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CAS REGISTRY NUMBER
COMMENTARY
9059-32-9
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K+
K+ ion at the GTP binding site allows the positioning of one water molecule that interacts with catalytic residues D235 and D238, K+ ion stabilizes dimer (molecular dynamics simulations)
Na+
Na+ destabilizes the dimer and does not allow the positioning of the catalytic water molecule (molecular dynamics simulations)
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin.
Acquired Immunodeficiency Syndrome
Detection of natural autoantibodies in the serum of anti-HIV-positive individuals.
Acquired Immunodeficiency Syndrome
Incorporation of (14C) leucine into protein and tubulin by brain slices from young and old mice.
Acquired Immunodeficiency Syndrome
Mechanism of defective natural killer cell activity in patients with AIDS is associated with defective distribution of tubulin.
Adenocarcinoma
Customized Adjuvant Chemotherapy Based on Biomarker Examination May Improve Survival of Patients Completely Resected for Non-small-cell Lung Cancer.
Adenocarcinoma
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
Adenocarcinoma
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma.
Adenocarcinoma
Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.
Adenocarcinoma
Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells.
Adenocarcinoma
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.
Adenocarcinoma
Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation.
Adenocarcinoma of Lung
Ampelopsin-sodium induces apoptosis in human lung adenocarcinoma cell lines by promoting tubulin polymerization in vitro.
Adenocarcinoma of Lung
betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer.
Adenocarcinoma of Lung
Effect of taxol on vinblastine sulfate-induced crystallization of tubulin.
Adenocarcinoma of Lung
Linobiflavonoid inhibits human lung adenocarcinoma A549 cells: effect on tubulin protein.
Adenoma, Pleomorphic
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Adenomatous Polyposis Coli
Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity.
Adenomatous Polyposis Coli
Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1.
Adenomatous Polyposis Coli
Microtubule self-organization via protein-RNA network crosstalk.
AIDS-Related Complex
Detection of natural autoantibodies in the serum of anti-HIV-positive individuals.
Albinism, Oculocutaneous
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Alzheimer Disease
Acute decrease in alkaline phosphatase after brain injury: A potential mechanism for tauopathy.
Alzheimer Disease
Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.
Alzheimer Disease
Analysis of microtubule-associated protein tau glycation in paired helical filaments.
Alzheimer Disease
Antigenic characteristics of neurofibrillary tangles in progressive supranuclear palsy.
Alzheimer Disease
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Alzheimer Disease
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.
Alzheimer Disease
Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease.
Alzheimer Disease
Change in the cytoskeletal system in fibroblasts from patients with familial Alzheimer's disease.
Alzheimer Disease
Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients. I. Decrease in NF-L and NF-M message.
Alzheimer Disease
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Alzheimer Disease
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Alzheimer Disease
Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases.
Alzheimer Disease
Exchangeable GTP binding site of the beta-subunit of brain tubulin in Alzheimer disease.
Alzheimer Disease
Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau.
Alzheimer Disease
High level of aspartic acid-bond isomerization during the synthesis of an N-linked tau glycopeptide.
Alzheimer Disease
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy.
Alzheimer Disease
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
Alzheimer Disease
Incorporation of (14C) leucine into protein and tubulin by brain slices from young and old mice.
Alzheimer Disease
Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis.
Alzheimer Disease
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Alzheimer Disease
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Alzheimer Disease
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Alzheimer Disease
Real-Time Tau Protein Detection by Sandwich-Based Piezoelectric Biosensing: Exploring Tubulin as a Mass Enhancer.
Alzheimer Disease
Reduced proteins in temporal cortex in Alzheimer's disease: an electrophoretic study.
Alzheimer Disease
Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease.
Alzheimer Disease
Reductions in soluble brain proteins in older subjects with Down's syndrome.
Alzheimer Disease
Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.
Alzheimer Disease
Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.
Alzheimer Disease
Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases.
Alzheimer Disease
Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.
Alzheimer Disease
[The pathogenesis of Alzheimer's disease: the effect of aluminum ions on the cytoskeletal protein tubulin]
Ameloblastoma
?TAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion.
Amyotrophic Lateral Sclerosis
Assessing the role of TUBA4A gene in frontotemporal degeneration.
Amyotrophic Lateral Sclerosis
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Amyotrophic Lateral Sclerosis
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Amyotrophic Lateral Sclerosis
Kennedy's disease: a triplet repeat disorder or a motor neuron disease?
Amyotrophic Lateral Sclerosis
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Anemia
Isolation, characterization and sequence of a cDNA encoding gamma-tubulin protein from the fern Anemia phyllitidis L. Sw.
Anemia
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
Anemia, Iron-Deficiency
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
Anthrax
Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-? Signaling.
Aortic Valve Stenosis
Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading.
Arrhythmias, Cardiac
Tubulin polymerization modifies cardiac sodium channel expression and gating.
Arthritis
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Arthritis, Rheumatoid
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Arthritis, Rheumatoid
In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis.
Asthenozoospermia
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Asthenozoospermia
Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Asthma
Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.
Asthma
Neural autoantibodies in patients with neurological symptoms and histories of chemical/mold exposures.
Asthma
Neurokinin 1 receptor promotes rat airway smooth muscle cell migration in asthmatic airway remodelling by enhancing tubulin expression.
Astrocytoma
Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
Astrocytoma
Anti-neoplastic agent thymoquinone induces degradation of ? and ? tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.
Astrocytoma
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Astrocytoma
Cell-cycle specific cytotoxicity mediated by stizophyllin (2 alpha,3 beta,12 beta-trihydroxypregna-4,7,16-trien-20-one), a novel electrophilic pregnane isolated from Stizophyllum riparium.
Astrocytoma
Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.
Astrocytoma
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Astrocytoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Ataxia
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Ataxia
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Ataxia Telangiectasia
ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells.
Atherosclerosis
Pentoxifylline administration changes protein expression profile of coronary artery disease patients.
Bardet-Biedl Syndrome
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Bardet-Biedl Syndrome
Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Bardet-Biedl Syndrome
Protein profile of Dabry's sturgeon (Acipenser dabryanus) spermatozoa and relationship to sperm quality.
Bile Duct Neoplasms
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Blister
Disruption of microtubules in vivo by vincristine induces large membrane complexes and other cytoplasmic abnormalities in megakaryocytes and platelets of normal rats like those in human and Wistar Furth rat hereditary macrothrombocytopenias.
Blister
Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells.
Blister
Myosin IIB and F-Actin Control Apical Vacuolar Morphology and Histamine-Induced Trafficking of H,K-ATPase-Containing Tubulovesicles in Gastric Parietal Cells.
Blister
Nocodazole and taxol affect subcellular compartments but not secretory activity of GH3B6 prolactin cells.
Blister
Rapid and transient reorganization of the cytoskeleton in GH3B6 cells during short-term exposure to thyroliberin.
Blister
Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner.
Blister
Surface blebbing and cytoskeletal changes induced in vitro by toxin B from Clostridium difficile: an immunochemical and ultrastructural study.
Brain Diseases
Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy.
Brain Diseases
Effect of experimental colchicine encephalopathy on brain protein synthesis and tubulin metabolism.
Brain Diseases
Mutation of Ser172 in Yeast ? Tubulin Induces Defects in Microtubule Dynamics and Cell Division.
Brain Diseases
Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrP(Sc).
Brain Diseases
Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Brain Injuries, Traumatic
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Brain Ischemia
Immunohistochemical investigation of ischemic and postischemic damage after bilateral carotid occlusion in gerbils.
Brain Ischemia
Immunohistochemical investigation of regional cerebral ischemia in the gerbil: occlusion of the posterior communicating artery.
Brain Neoplasms
Investigation of structural requirements of anticancer activity at the paclitaxel/tubulin binding site using CoMFA and CoMSIA.
Breast Neoplasms
1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure.
Breast Neoplasms
15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.
Breast Neoplasms
3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells.
Breast Neoplasms
4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.
Breast Neoplasms
9-Arylimino noscapinoids as potent tubulin binding anticancer agent: chemical synthesis and cellular evaluation against breast tumour cells.
Breast Neoplasms
?-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.
Breast Neoplasms
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
Breast Neoplasms
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Breast Neoplasms
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and ?-III tubulin mediated tumor drug resistance in vitro.
Breast Neoplasms
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Breast Neoplasms
Antiproliferative mechanism of action of the novel taxane cabazitaxel as compared with the parent compound docetaxel in MCF7 breast cancer cells.
Breast Neoplasms
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Breast Neoplasms
Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis.
Breast Neoplasms
Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.
Breast Neoplasms
Association of ABCB1, ? tubulin I, and III with multidrug resistance of MCF7/DOC subline from breast cancer cell line MCF7.
Breast Neoplasms
Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells.
Breast Neoplasms
Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14.
Breast Neoplasms
BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy.
Breast Neoplasms
Characterization of the pharmacokinetics of a liposomal formulation of eribulin mesylate (E7389) in mice.
Breast Neoplasms
Clinical analysis of 21-gene recurrence score test in hormone receptor-positive early-stage breast cancer.
Breast Neoplasms
Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule.
Breast Neoplasms
CoMFA and docking studies of 2-phenylindole derivatives with anticancer activity.
Breast Neoplasms
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Breast Neoplasms
CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK.
Breast Neoplasms
Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines.
Breast Neoplasms
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Breast Neoplasms
Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.
Breast Neoplasms
Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization.
Breast Neoplasms
Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers.
Breast Neoplasms
Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer.
Breast Neoplasms
Effect of an aryl chloroethyl urea on tubulin and vimentin syntheses in a human breast cancer cell line.
Breast Neoplasms
Effect of CH-35, a novel anti-tumor colchicine analogue, on breast cancer cells overexpressing the ?III isotype of tubulin.
Breast Neoplasms
Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer.
Breast Neoplasms
Effects of tubulin-inhibiting agents in human lung and breast cancer cell lines with different multidrug resistance phenotypes.
Breast Neoplasms
Electrochemical approach for monitoring the effect of anti tubulin drugs on breast cancer cells based on silicon nanograss electrodes.
Breast Neoplasms
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Breast Neoplasms
Eribulin in the Management of Advanced Breast Cancer: Implications of Current Research Findings.
Breast Neoplasms
Ferulin C triggers potent PAK1 and p21-mediated anti-tumor effects in breast cancer by inhibiting Tubulin polymerization in vitro and in vivo.
Breast Neoplasms
G-1 inhibits breast cancer cell growth via targeting colchicine-binding site of tubulin to interfere with microtubule assembly.
Breast Neoplasms
Gallic acid based steroidal phenstatin analogues for selective targeting of breast cancer cells through inhibiting tubulin polymerization.
Breast Neoplasms
Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance.
Breast Neoplasms
Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of ?-tubulin.
Breast Neoplasms
Identification by mass spectrometry of a new alpha-tubulin isotype expressed in human breast and lung carcinoma cell lines.
Breast Neoplasms
Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors.
Breast Neoplasms
In silico design of novel tubulin binding 9-arylimino derivatives of noscapine, their chemical synthesis and cellular activity as potent anticancer agents against breast cancer.
Breast Neoplasms
In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes.
Breast Neoplasms
Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase.
Breast Neoplasms
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.
Breast Neoplasms
Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.
Breast Neoplasms
Kinesin-1 translocation: Surprising differences between bovine brain and MCF7-derived microtubules.
Breast Neoplasms
Lead identification of conformationally restricted ?-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects.
Breast Neoplasms
Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells.
Breast Neoplasms
Long non-coding RNA Tubulin Alpha 4B (TUBA4B) inhibited breast cancer proliferation and invasion by directly targeting miR-19.
Breast Neoplasms
MCF7 microtubules: Cancer microtubules with relatively slow and stable dynamic in vitro.
Breast Neoplasms
Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cells.
Breast Neoplasms
Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
Breast Neoplasms
Methyl 5-[(1H-indol-3-yl)selanyl]-1H-benzoimidazol-2-ylcarbamate (M-24), a novel tubulin inhibitor, causes G2/M arrest and cell apoptosis by disrupting tubulin polymerization in human cervical and breast cancer cells.
Breast Neoplasms
Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells.
Breast Neoplasms
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.
Breast Neoplasms
Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer.
Breast Neoplasms
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Breast Neoplasms
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Breast Neoplasms
Novel mutations involving ?I-, ?IIA-, or ?IVB-tubulin isotypes with functional resemblance to ?III-tubulin in breast cancer.
Breast Neoplasms
Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model.
Breast Neoplasms
Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-?B inhibition.
Breast Neoplasms
Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability.
Breast Neoplasms
Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo.
Breast Neoplasms
Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer.
Breast Neoplasms
Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
Breast Neoplasms
Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents.
Breast Neoplasms
Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol.
Breast Neoplasms
Self-assembled supramolecular nanomicelles from a bile acid-docetaxel conjugate are highly tolerable with improved therapeutic efficacy.
Breast Neoplasms
Septin cooperation with tubulin polyglutamylation contributes to cancer cell adaptation to taxanes.
Breast Neoplasms
Septin filament coalignment with microtubules depends on SEPT9_i1 and tubulin polyglutamylation, and is an early feature of acquired cell resistance to paclitaxel.
Breast Neoplasms
Silencing of tubulin binding cofactor C modifies microtubule dynamics and cell cycle distribution and enhances sensitivity to gemcitabine in breast cancer cells.
Breast Neoplasms
SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
Breast Neoplasms
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
Breast Neoplasms
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Breast Neoplasms
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.
Breast Neoplasms
Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization.
Breast Neoplasms
Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine.
Breast Neoplasms
Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.
Breast Neoplasms
Synthesis and biological evaluation of 1,1-dichloro-2,3-diarylcyclopropanes as antitubulin and anti-breast cancer agents.
Breast Neoplasms
Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway.
Breast Neoplasms
Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
Breast Neoplasms
Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors.
Breast Neoplasms
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Breast Neoplasms
Synthesis and in Vitro Bioactivity of Polyunsaturated Fatty Acid Conjugates of Combretastatin A-4.
Breast Neoplasms
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
Breast Neoplasms
Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.
Breast Neoplasms
Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation.
Breast Neoplasms
Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer.
Breast Neoplasms
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly.
Breast Neoplasms
TITAN: phase III study of doxorubicin/cyclophosphamide followed by ixabepilone or paclitaxel in early-stage triple-negative breast cancer.
Breast Neoplasms
Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.
Breast Neoplasms
Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24.
Breast Neoplasms
Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.
Breast Neoplasms
Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.
Breast Neoplasms
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Breast Neoplasms
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study.
Breast Neoplasms
Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.
Breast Neoplasms
Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy.
Breast Neoplasms
Vinorelbine-induced neurotoxicity in patients with advanced breast cancer pretreated with paclitaxel--a phase II study.
Breast Neoplasms
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Breast Neoplasms
[Expression of alpha-tubulin and gamma-tubulin in premalignant lesion and carcinoma of breast and the significance thereof]
Breast Neoplasms
[F-actin aggregates and aberrations of cytoskeletal organization of microfilaments and microtubules in human breast carcinoma cells]
Bronchiolitis Obliterans
Circulating exosomes with lung self-antigens as a biomarker for chronic lung allograft dysfunction: A retrospective analysis.
Bulbo-Spinal Atrophy, X-Linked
Kennedy's disease: a triplet repeat disorder or a motor neuron disease?
Burkholderia Infections
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia.
Burkitt Lymphoma
Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.
Burkitt Lymphoma
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
Carcinogenesis
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Carcinogenesis
Cadmium-induced multistep transformation of cultured Indian muntjac skin fibroblasts.
Carcinogenesis
Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation.
Carcinogenesis
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Carcinogenesis
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Carcinogenesis
Identification of a novel transcript isoform of the TTLL12 gene in human cancers.
Carcinogenesis
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Carcinogenesis
Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance.
Carcinogenesis
STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro.
Carcinogenesis
The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol.
Carcinogenesis
Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells.
Carcinogenesis
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Carcinogenesis
Tubulin tyrosine ligase like 12, link to prostate cancer through tubulin post-translational modification and chromosome ploidy.
Carcinogenesis
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Carcinoma
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
Carcinoma
Acetylated Tubulin (AT) as a Prognostic Marker in Squamous Cell Carcinoma of the Head and Neck.
Carcinoma
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).
Carcinoma
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Carcinoma
Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe.
Carcinoma
Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors.
Carcinoma
Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
Carcinoma
Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression.
Carcinoma
Centrosomal abnormality is common in and a potential biomarker for bladder cancer.
Carcinoma
Delineating the interaction of combretastatin A-4 with ?? tubulin isotypes present in drug resistant human lung carcinoma using a molecular modeling approach.
Carcinoma
Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors.
Carcinoma
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Carcinoma
Exploring the interaction of Peloruside-A with drug resistant ??II and ??III tubulin isotypes in human ovarian carcinoma using a molecular modeling approach.
Carcinoma
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
Carcinoma
GAPD and tubulin are suitable internal controls for qPCR analysis of oral squamous cell carcinoma cell lines.
Carcinoma
Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions.
Carcinoma
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Carcinoma
Immunohistochemistry of the cytoskeleton of human prostatic epithelium. Evidence for disturbed organization in neoplasia.
Carcinoma
Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.
Carcinoma
Increased gamma-tubulin expression and P16INK4A promoter methylation occur together in preinvasive lesions and carcinomas of the breast.
Carcinoma
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Carcinoma
Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer.
Carcinoma
Modulation of endogenous beta-tubulin isotype expression as a result of human beta(III)cDNA transfection into prostate carcinoma cells.
Carcinoma
Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton.
Carcinoma
Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation.
Carcinoma
Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
Carcinoma
Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
Carcinoma
Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.
Carcinoma
Polyploidisation of metastatic colon carcinoma cells by microtubule and tubulin interacting drugs: effect on proteolytic activity and invasiveness.
Carcinoma
Pretreatment by tubulin agents decreases C-MYC induction in human colon carcinoma cell line HT29-D4.
Carcinoma
Resistance to the tubulin-binding agents in renal cell carcinoma: no mutations in the class I beta-tubulin gene but changes in tubulin isotype protein expression.
Carcinoma
Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.
Carcinoma
Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo.
Carcinoma
Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro.
Carcinoma
Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide.
Carcinoma
Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines.
Carcinoma
The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel.
Carcinoma
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Carcinoma
The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery.
Carcinoma
Theaflavins depolymerize microtubule network through tubulin binding and cause apoptosis of cervical carcinoma HeLa cells.
Carcinoma
Tubulin ?-6 chain is a stably expressed reference gene in archival samples of normal oral tissue and oral squamous cell carcinoma.
Carcinoma
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
Carcinoma
Tubulin Beta Chain, Filamin A Alpha Isoform 1, and Cytochrome b-c1 Complex Subunit 1 As Serological Diagnostic Biomarkers of Esophageal Squamous Cell Carcinoma: A Proteomics Study.
Carcinoma
Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents.
Carcinoma
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Carcinoma
[Conjugate of podophyllotoxin with chlorambucil: synthesis, biological testing and molecular modeling].
Carcinoma
[Expression of alpha-tubulin and gamma-tubulin in premalignant lesion and carcinoma of breast and the significance thereof]
Carcinoma, Basal Cell
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
Carcinoma, Basal Cell
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Carcinoma, Ductal
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Carcinoma, Ductal
Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.
Carcinoma, Ductal
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Carcinoma, Ductal
[Expression of alpha-tubulin and gamma-tubulin in premalignant lesion and carcinoma of breast and the significance thereof]
Carcinoma, Ehrlich Tumor
Assembly of nonneural microtubules in the absence of glycerol and microtubule-associated proteins.
Carcinoma, Ehrlich Tumor
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Comparison of tyrosine protein kinases in membrane fractions from mouse liver and Ehrlich ascites tumor.
Carcinoma, Ehrlich Tumor
In vitro formation of different tubulin polymers from purified tubulin of Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Interaction of triethyl lead chloride with microtubules in vitro and in mammalian cells.
Carcinoma, Embryonal
Complexes of gamma-tubulin with nonreceptor protein tyrosine kinases Src and Fyn in differentiating P19 embryonal carcinoma cells.
Carcinoma, Embryonal
Differential sorting of beta tubulin isotypes into colchicine-stable microtubules during neuronal and muscle differentiation of embryonal carcinoma cells.
Carcinoma, Embryonal
Effects of methylmercury on retinoic acid-induced neuroectodermal derivatives of embryonal carcinoma cells.
Carcinoma, Embryonal
Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase.
Carcinoma, Embryonal
The effects of methylmercury on the cytoskeleton of murine embryonal carcinoma cells.
Carcinoma, Hepatocellular
1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.
Carcinoma, Hepatocellular
A Chimeric Cetuximab-Functionalized Corona as a Potent Delivery System for Microtubule-Destabilizing Nanocomplexes to Hepatocellular Carcinoma Cells: A Focus on EGFR and Tubulin Intracellular Dynamics.
Carcinoma, Hepatocellular
A highly potent maytansinoid analogue and its use as a cytotoxic therapeutic agent in gold nanoparticles for the treatment of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer.
Carcinoma, Hepatocellular
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Carcinoma, Hepatocellular
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Identification of differentially expressed proteins between human hepatoma and normal liver cell lines by two-dimensional electrophoresis and liquid chromatography-ion trap mass spectrometry.
Carcinoma, Hepatocellular
MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Phenylazoxycyanide damages microtubular protein more than its reference antibiotic, calvatic acid.
Carcinoma, Hepatocellular
Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.
Carcinoma, Hepatocellular
Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect.
Carcinoma, Hepatocellular
Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
Carcinoma, Hepatocellular
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.
Carcinoma, Hepatocellular
Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Carcinoma, Hepatocellular
Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Carcinoma, Hepatocellular
Vacuole formation and cytokeratin rearrangement of hepatoma cells induced by teleocidin are not associated with down-regulation of protein kinase C.
Carcinoma, Intraductal, Noninfiltrating
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Carcinoma, Intraductal, Noninfiltrating
Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.
Carcinoma, Intraductal, Noninfiltrating
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Carcinoma, Large Cell
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Carcinoma, Lewis Lung
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Carcinoma, Non-Small-Cell Lung
Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
Carcinoma, Non-Small-Cell Lung
Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.
Carcinoma, Non-Small-Cell Lung
Expression of ERCC1 and class IIIbeta tubulin for predicting effect of carboplatin/paclitaxel in patients with advanced inoperable non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: Invitro and in vivo studies.
Carcinoma, Non-Small-Cell Lung
Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer.
Carcinoma, Non-Small-Cell Lung
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Carcinoma, Non-Small-Cell Lung
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Carcinoma, Non-Small-Cell Lung
Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
Carcinoma, Non-Small-Cell Lung
The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Tubulin inhibitors in non-small cell lung cancer: looking back and forward.
Carcinoma, Non-Small-Cell Lung
[Class III beta tubulin expression in nonsmall cell lung cancer]
Carcinoma, Ovarian Epithelial
Eribulin mesylate (halichondrin B analog E7389) in platinum-resistant and platinum-sensitive ovarian cancer: A 2-cohort, phase 2 study.
Carcinoma, Papillary
Overexpression of kalpha1 tubulin mRNA in thyroid anaplastic carcinoma.
Carcinoma, Renal Cell
Resistance to the tubulin-binding agents in renal cell carcinoma: no mutations in the class I beta-tubulin gene but changes in tubulin isotype protein expression.
Carcinoma, Renal Cell
The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery.
Carcinoma, Squamous Cell
Acetylated Tubulin (AT) as a Prognostic Marker in Squamous Cell Carcinoma of the Head and Neck.
Carcinoma, Squamous Cell
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Carcinoma, Squamous Cell
Beta-tubulin epitope expression in normal and malignant epithelial cells.
Carcinoma, Squamous Cell
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
Carcinoma, Squamous Cell
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
Carcinoma, Squamous Cell
Trafficking of beta2-adrenergic receptors: insulin and beta-agonists regulate internalization by distinct cytoskeletal pathways.
Carcinosarcoma
Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI.
Cardiomegaly
Cardiac hypertrophic and developmental regulation of the beta-tubulin multigene family.
Cardiomegaly
Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling.
Cardiomegaly
Role of microtubules in myocyte contractile dysfunction during cardiac hypertrophy in the rat.
Cardiomyopathies
Modulation of Ca(2+) signaling by microtubule disruption in rat ventricular myocytes and its dependence on the ruptured patch-clamp configuration.
Cardiomyopathies
Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy.
Cardiomyopathy, Dilated
Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy.
Cardiotoxicity
Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.
Cardiotoxicity
[Cardiac toxicity of cancer treatment regimes in children and adolescents: physiopathology, clinical data and the paediatric oncologist's point of view]
Cardiovascular Diseases
Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.
Cat-Scratch Disease
Use of the cell division protein FtsZ as a means of differentiating among Bartonella species.
Cataract
Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation.
Cervical Intraepithelial Neoplasia
Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions.
Chagas Disease
Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives.
Charcot-Marie-Tooth Disease
Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot-Marie-Tooth disease type 1.
Chediak-Higashi Syndrome
Tubulin tyrosinolation in human polymorphonuclear leukocytes: studies in normal subjects and in patients with the Chediak-Higashi syndrome.
Cholangiocarcinoma
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Cholangiocarcinoma
Tubulin ?-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.
Cholera
ADPRibosylation of chicken red cell tubulin and inhibition of microtubule self-assembly in vitro by the NAD(+)-dependent avian ADPRibosyl transferase.
Cholera
Changes of GTP binding proteins, not neurofilament-associated proteins, in the brain of the neurofilament-deficient quail, "Quiver".
Cholera
Cyclic AMP-independent stimulation of steroidogenesis in Y-1 adrenal tumor cells by antimitotic agents.
Cholera
Cytosolic G{alpha}s Acts as an Intracellular Messenger to Increase Microtubule Dynamics and Promote Neurite Outgrowth.
Cholera
Differential role of microtubules in the control of prostaglandin E2 and beta-adrenergic stimulation of cyclic AMP accumulation in the rat myometrium.
Cholera
Microtubule assembly in cultivated Greene melanoma cells is stimulated by dibutyryl adenosine 3':5'-cyclic monophosphate or cholera toxin.
Cholera
Microtubule protein ADP-ribosylation in vitro leads to assembly inhibition and rapid depolymerization.
Cholera
Natural flavonoid morin showed anti-bacterial activity against Vibrio cholera after binding with cell division protein FtsA near ATP binding site.
Cholestasis
Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat.
Chondroblastoma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Chondrosarcoma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Chondrosarcoma
Extraskeletal myxoid chondrosarcoma characterized by microtubular aggregates in the rough endoplasmic reticulum and tubulin immunoreactivity.
Chordoma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Chordoma
Microtubular aggregates in the rough endoplasmic reticulum of sacrococcygeal chordoma.
Chorea
Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments.
Ciliopathies
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Ciliopathies
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Ciliopathies
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Classical Lissencephalies and Subcortical Band Heterotopias
Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly.
Colitis
Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labeled internal standards.
Colonic Neoplasms
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy.
Colonic Neoplasms
?-III tubulin modulates the behavior of Snail overexpressed during the epithelial-to-mesenchymal transition in colon cancer cells.
Colonic Neoplasms
Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells.
Colonic Neoplasms
Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells.
Colonic Neoplasms
Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells.
Colonic Neoplasms
Discovery of oxyepiberberine as a novel tubulin polymerization inhibitor and an anti-colon cancer agent against LS-1034 cells.
Colonic Neoplasms
Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.
Colonic Neoplasms
Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway.
Colonic Neoplasms
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Colonic Neoplasms
Synthesis and biological evaluation of 7-methoxy-1-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-benzo[e]indazoles as new colchicine site inhibitors.
Colonic Neoplasms
Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents.
Colonic Neoplasms
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
Colonic Neoplasms
Tubulin inhibitory activity of a novel colchicine-binding compounds based on a dinaphthospiropyranran scaffold.
Colorectal Neoplasms
5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells.
Colorectal Neoplasms
CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
Colorectal Neoplasms
Identification alpha-2-HS-glycoprotein precursor and tubulin beta chain as serology diagnosis biomarker of colorectal cancer.
Colorectal Neoplasms
Inhibition of microtubule assembly and cytotoxic effect of graphene oxide on human colorectal carcinoma cell HCT116.
Colorectal Neoplasms
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 inhibits cell proliferation and invasion in human colorectal cancer.
Colorectal Neoplasms
Low expression of lncRNA TUBA4B promotes proliferation and inhibits apoptosis of colorectal cancer cells via regulating P15 and P16 expressions.
Colorectal Neoplasms
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage.
Colorectal Neoplasms
MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells.
Colorectal Neoplasms
Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells.
Colorectal Neoplasms
Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomas.
Colorectal Neoplasms
PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization.
Colorectal Neoplasms
PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells.
Colorectal Neoplasms
Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.
Colorectal Neoplasms
Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.
Colorectal Neoplasms
[BETA-III TUBULIN AS A POTENTIAL TARGET FOR BLOCKING INVASIVE GROWTH OF MALIGNANT EPITHELIAL TUMORS].
Cone Dystrophy
Novel TTLL5 Variants Associated with Cone-Rod Dystrophy and Early-Onset Severe Retinal Dystrophy.
Cone-Rod Dystrophies
Novel TTLL5 Variants Associated with Cone-Rod Dystrophy and Early-Onset Severe Retinal Dystrophy.
Confusion
Altered Loyalties of Neuronal Markers in Cultured Slices of Resected Human Brain Tissue.
Confusion
Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy.
Confusion
Variations of chromatin, tubulin and actin structures in primate oocytes arrested during in vitro maturation and fertilization-what is this telling us about the relationships between cytoskeletal and chromatin meiotic defects?
Congenital Abnormalities
Effects of sodium fluoride (NaF) on the cilia and microtubular system of Tetrahymena.
Contracture
Flow cytometric analysis of isolated adult cardiomyocytes: vinculin and tubulin fluorescence during metabolic inhibition and ischemia.
Contracture
[Isoproterenol induced changes of protein expression and myocardial ultrastructure]
Coronary Disease
Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) - study protocol for a randomised controlled trial.
Cough
Noscapine inhibits human prostate cancer progression and metastasis in a mouse model.
Cystic Fibrosis
Colchicine binding activity and tyrosyl tubulin ligase activity in normal and cystic fibrosis fibroblasts.
Cystic Fibrosis
Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of human patients.
Cystic Fibrosis
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens.
Cysticercosis
Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.
Cysts
A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.
Cysts
Actin and tubulin cytoskeletons in germlings of the oomycete fungus Phytophthora infestans.
Cysts
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Cysts
Expression of beta 1 tubulin (beta Tub56D) in Drosophila testis stem cells is regulated by a short upstream sequence while intron elements guide expression in somatic cells.
Cysts
Genesis of newt sperm axial fiber: cDNA cloning and expression of a 29 kDa protein, a major component of the axial fiber, during spermatogenesis.
Cysts
Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium.
Cysts
Mucin-histochemical and immunohistochemical profiles of epithelial cells of several types of hepatic cysts.
Cysts
Presence of a tubulin pool in the resting cyst of the hypotrich ciliate, Histriculus muscorum.
Decompression Sickness
Are the local adjustments of the relative spatial frequencies of the dynein arms and the beta-tubulin monomers involved in the regulation of the "9+2" axoneme?
Decompression Sickness
Detailed Per-residue Energetic Analysis Explains the Driving Force for Microtubule Disassembly.
Dehydration
Changes in DNA and microtubules during loss and re-establishment of desiccation tolerance in germinating Medicago truncatula seeds.
Dehydration
Dehydration and embedding temperatures affect the antigenic specificity of tubulin and immunolabeling by the protein A-colloidal gold technique.
Dehydration
Improved immunoelectron microscopic method for localizing cytoskeletal proteins in Lowicryl K4M embedded tissues.
Dementia
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Dementia, Vascular
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Demyelinating Diseases
A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.
Demyelinating Diseases
Axonal lesions and PDGF-enhanced remyelination in the rat corpus callosum after lysolecithin demyelination.
Demyelinating Diseases
Immunological myelin disruption does not alter expression of regeneration-associated genes in intact or axotomized rubrospinal neurons.
Demyelinating Diseases
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Dengue
Identification of a 48kDa tubulin or tubulin-like C6/36 mosquito cells protein that binds dengue virus 2 using mass spectrometry.
Dengue
Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents.
Dermatitis, Allergic Contact
SAR modelling of complex phenomena: probing methodological limitations.
Dermoid Cyst
Centrioles, microtubules and microfilaments in activated mononuclear and multinucleate macrophages from rat peritoneum: electron-microscopic and immunofluorescence microscopic studies.
Diabetes Complications
Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats.
Diabetes Mellitus
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Diabetes Mellitus
Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats.
Diabetes Mellitus
Proteins of slow axonal transport in sciatic motoneurones of rats with streptozotocin-induced diabetes or galactosaemia.
Diabetes Mellitus
Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus.
Diabetes Mellitus
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Experimental
Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetic Ketoacidosis
Cardiac antibody production to self-antigens in children and adolescents during and following the correction of severe diabetic ketoacidosis.
Down Syndrome
Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease.
Dysarthria
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Dysautonomia, Familial
Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.
Dyskinesias
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Dyslipidemias
Associations between TUBB-WWOX SNPs, their haplotypes, gene-gene, and gene-environment interactions and dyslipidemia.
Dystonia
A novel TUBB4A mutation G96R identified in a patient with hypomyelinating leukodystrophy onset beyond adolescence.
Dystonia
Dystonin-A3 upregulation is responsible for maintenance of tubulin acetylation in a less severe dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI.
Echinococcosis
Recombinant ?- and ?-tubulin from Echinococcus granulosus: expression, purification and polymerization.
Ectromelia
Ectromelia virus induces tubulin cytoskeletal rearrangement in immune cells accompanied by a loss of the microtubule organizing center and increased ?-tubulin acetylation.
Endometrial Neoplasms
Expression of tubulin, p53, ki67, receptors for estrogen, and progesterone in endometrial cancer.
Endometrial Neoplasms
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.
Endometrial Neoplasms
Tubulin inhibitor AEZS 112 inhibits the growth of experimental human ovarian and endometrial cancers irrespective of caspase inhibition.
Endometriosis
Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization.
Epilepsy
A novel TUBG1 mutation with neurodevelopmental disorder caused by malformations of cortical development.
Epilepsy
Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin.
Epilepsy
Lissencephaly in an epilepsy cohort: Molecular, radiological and clinical aspects.
Epilepsy
Nestin-expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity.
Epilepsy
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
Epilepsy
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Epilepsy, Temporal Lobe
Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin.
Esophageal Neoplasms
PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts.
Esophageal Neoplasms
Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.
Esophageal Squamous Cell Carcinoma
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Tubulin Beta Chain, Filamin A Alpha Isoform 1, and Cytochrome b-c1 Complex Subunit 1 As Serological Diagnostic Biomarkers of Esophageal Squamous Cell Carcinoma: A Proteomics Study.
Familial Mediterranean Fever
Analysis of polymorphisms in the colchicine binding site of tubulin in colchicine-resistant familial Mediterranean fever patients.
Familial Primary Pulmonary Hypertension
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Fibroma
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions.
Fibrosarcoma
3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells.
Fibrosarcoma
Glycosylated podophyllotoxin congeners: loss of microtubule inhibition and permission of invasion in vitro.
Fibrosarcoma
New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
Frontotemporal Dementia
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Frontotemporal Dementia
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Frontotemporal Dementia
Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family.
Frontotemporal Dementia
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
Frontotemporal Dementia
The role of tau (MAPT) in frontotemporal dementia and related tauopathies.
Frontotemporal Dementia
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Frontotemporal Lobar Degeneration
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Frontotemporal Lobar Degeneration
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.
Gallbladder Neoplasms
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Gastroenteritis
Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particles.
Gastroenteritis, Transmissible, of Swine
Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particles.
Gastrointestinal Stromal Tumors
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.
Genetic Diseases, Inborn
A TUBB6 mutation is associated with autosomal dominant non-progressive congenital facial palsy, bilateral ptosis and velopharyngeal dysfunction.
Genetic Diseases, Inborn
An essential quality control mechanism at the eukaryotic Basal body prior to intraflagellar transport.
Giant Cell Tumor of Bone
Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
Giant Cell Tumors
Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
Glioblastoma
6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability.
Glioblastoma
Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
Glioblastoma
Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma.
Glioblastoma
Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.
Glioblastoma
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Glioblastoma
Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
Glioblastoma
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Glioblastoma
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
Glioblastoma
Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents.
Glioblastoma
Morphological and quantitative analysis on ?-tubulin modifications in glioblastoma cells.
Glioblastoma
Novel chalcones derivatives with potential antineoplastic activity investigated by docking and molecular dynamics simulations.
Glioblastoma
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Glioblastoma
Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling.
Glioblastoma
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Glioblastoma
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Glioblastoma
Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.
Glioblastoma
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin.
Glioblastoma
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Glioma
A novel cholchicine/gadolinium-loading tubulin self-assembly nanocarrier for MR imaging and chemotherapy of glioma.
Glioma
A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate biomarkers for glioma blood vessel formation.
Glioma
A tubulin binding peptide targets glioma cells disrupting their microtubules, blocking migration, and inducing apoptosis.
Glioma
AlphaB-crystallin phosphorylated at Ser-59 is localized in centrosomes and midbodies during mitosis.
Glioma
Biphasic regulation by dibutyryl cyclic AMP of tubulin and actin mRNA levels in neuroblastoma cells.
Glioma
Change of morphology and cytoskeletal protein gene expression during dibutyryl cAMP-induced differentiation in C6 glioma cells.
Glioma
Comparative study of microtubule inhibitors - Estramustine and natural podophyllotoxin conjugated PAMAM dendrimer on glioma cell proliferation.
Glioma
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Glioma
Differential expression of centrosomal proteins at different stages of human glioma.
Glioma
Effects of methylmercury and some metal ions on microtubule networks in mouse glioma cells and in vitro tubulin polymerization.
Glioma
Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
Glioma
Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA.
Glioma
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.
Glioma
Investigating the Structural Variability and Binding Modes of the Glioma Targeting NFL-TBS.40-63 Peptide on Tubulin.
Glioma
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
Glioma
Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption.
Glioma
Methylmercury-induced microtubule depolymerization leads to inhibition of tubulin synthesis.
Glioma
Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton.
Glioma
Proteins from morphologically differentiated neuroblastoma cells promote tubulin polymerization.
Glioma
Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes.
Glioma
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
Glioma
Tubulin microheterogeneity in neuroblastoma and glioma cell lines differs from that of the brain.
Glioma
Tubulin stimulates adenylyl cyclase activity in C6 glioma cells by bypassing the beta-adrenergic receptor: a potential mechanism of G protein activation.
Glioma
Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein.
Glioma
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Gout
Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.
Gout
Novel analogue of colchicine induces selective pro-death autophagy and necrosis in human cancer cells.
Granuloma
Asteroid bodies: products of unusual microtubule dynamics in monocyte-derived giant cells. An immunohistochemical study.
Granuloma
Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection.
Granulomatous Disease, Chronic
Studies in normal and chronic granulomatous disease neutrophils indicate a correlation of tubulin tyrosinolation with the cellular redox state.
Gray Platelet Syndrome
The organization of microtubules and microtubule coils in giant platelet disorders.
Guillain-Barre Syndrome
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Head and Neck Neoplasms
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Hearing Loss
Age-related changes in microtubules in the guinea pig organ of Corti. Tubulin isoform shifts with increasing age suggest changes in micromechanical properties of the sensory epithelium.
Heart Failure
Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy.
Heart Failure
Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling.
Heart Failure
Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure.
Heart Failure
Post-translational modifications of cardiac tubulin during chronic heart failure in the rat.
Heart Failure
The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.
Heart Failure
Tubulin polymerization modifies cardiac sodium channel expression and gating.
Helminthiasis
A review of chemotherapeutic approaches to the treatment of cryptosporidiosis.
Hemangiosarcoma
The radiation response of sarcomas by histologic subtypes: a review with special emphasis given to results achieved with razoxane.
Hematologic Neoplasms
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Hematologic Neoplasms
Microtubule changes in hematologic malignant cells treated with paclitaxel and comparison with vincristine cytotoxicity.
Hematologic Neoplasms
PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.
Hepatitis
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Hepatitis B
Autoantibodies and circulating immune complexes in sera from patients with hepatitis B virus-related chronic liver disease.
Hepatitis B
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Hepatitis C
Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.
Hepatitis C
Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Hepatitis, Chronic
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Herpes Simplex
Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin.
Herpes Simplex
Intracellular maturation and sorting of two herpes simplex virus type 1 glycoproteins. Immunogold staining of ultrathin cryosections.
Herpes Simplex
Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.
Herpes Zoster
Dietary cysteamine hydrochloride protects against oxidation, inflammation, and mucosal barrier disruption of broiler chickens challenged with Clostridium perfringens.
Herpes Zoster
Multiwalled carbon nanotubes induce altered morphology and loss of barrier function in human bronchial epithelium at noncytotoxic doses.
Herpes Zoster
Patterns of intercellular connectivity in the mammalian cumulus-oocyte complex.
Hirschsprung Disease
Calretinin, ? Tubulin Immunohistochemistry And Submucosal Nerve Trunks Morphology In Hirschsprung Disease: Possible Applications In Clinical Practice.
Huntington Disease
Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.
Huntington Disease
Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.
Huntington Disease
Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease.
Huntington Disease
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.
Huntington Disease
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.
Huntington Disease
The cytoskeleton of cultured skin fibroblasts from patients with Huntington's chorea.
Hydrocephalus
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Hypertension
Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects.
Hypertension
Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem.
Hypertension
Inhibition of flippase-like activity by tubulin regulates phosphatidylserine exposure in erythrocytes from hypertensive and diabetic patients.
Hypertension
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Hyperthyroidism
Effects of fetal thyroid states on RNA, DNA, and tubulin content in neonatal rat brain.
Hypoparathyroidism
Hypoparathyroidism, retardation, and dysmorphism syndrome: impaired early growth and increased susceptibility to severe infections due to hyposplenism and impaired polymorphonuclear cell functions.
Hypoparathyroidism
Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress.
Hypothyroidism
Hypothyroidism reduces the rate of slow component A (SCa) axonal transport and the amount of transported tubulin in the hyt/hyt mouse optic nerve.
Idiopathic Pulmonary Fibrosis
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Infarction, Middle Cerebral Artery
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infections
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Infections
Blue Native/SDS-PAGE and iTRAQ-Based Chloroplasts Proteomics Analysis of Nicotiana tabacum Leaves Infected with M Strain of Cucumber Mosaic Virus Reveals Several Proteins Involved in Chlorosis Symptoms.
Infections
Comparison between autoantibodies arising during Trypanosoma cruzi infection in mice and natural autoantibodies.
Infections
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Infections
Differential Proteome Analysis of Host Cells Infected with Porcine Circovirus Type 2.
Infections
Expression of both Arabidopsis ?-tubulin genes is essential for development of a functional syncytium induced by Heterodera schachtii.
Infections
Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection.
Infections
Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro.
Infections
Hepatitis C virus and alcohol: Same mitotic targets but different signaling pathways.
Infections
Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus.
Infections
Initiation of Hepatitis C Virus Infection Requires the Dynamic Microtubule Network: ROLE OF THE VIRAL NUCLEOCAPSID PROTEIN.
Infections
Internalization of Candida albicans and cytoskeletal organization in macrophages and fibroblasts treated with concanavalin A.
Infections
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infections
iTRAQ-based proteomic study of the effects of Spiroplasma eriocheiris on Chinese mitten crab Eriocheir sinensis hemocytes.
Infections
Legionella pneumophila invasion of MRC-5 cells induces tyrosine protein phosphorylation.
Infections
Localization and immunogenicity of tubulin in the filarial nematodes Brugia malayi and B. pahangi.
Infections
Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage.
Infections
Morphologic, immunohistochemical, immunologic, ultrastructural, and time-related study of herpes simplex virus type 1-infected cultured human fibroblasts.
Infections
Nuclear localizations of the herpes simplex virus type 1 tegument proteins VP13/14, vhs, and VP16 precede VP22-dependent microtubule reorganization and VP22 nuclear import.
Infections
Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.
Infections
Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.
Infections
Plasma phosphoproteome and differential plasma phosphoproteins with opisthorchis viverrini-related cholangiocarcinoma.
Infections
Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors.
Infections
Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.
Infections
Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum.
Infections
Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton.
Infections
Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination.
Infections
Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
Infections
The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidis.
Infections
Tropism and Induction of Cytokines in Human Embryonic-Stem Cells-Derived Neural Progenitors upon Inoculation with Highly- Pathogenic Avian H5N1 Influenza Virus.
Infections
Trypanosoma brucei: anti-tubulin antibodies specifically inhibit trypanosome growth in culture.
Infections
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
Infections
Verifying the stability of selected genes for normalization in Q PCR experiments of Spodoptera frugiperda cells during AcMNPV infection.
Infections
[Effect of wild-type p53 gene on the number and proteins of centrosome in leukemic K562 cells]
Infectious Mononucleosis
Antitubulin antibody in healthy adults and patients with infectious mononucleosis and its relationship to smooth muscle antibody (SMA).
Infertility
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans.
Infertility, Female
Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects.
Infertility, Male
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Infertility, Male
Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Infertility, Male
Tubulin cytoskeleton during microsporogenesis in the male-sterile genotype of Allium sativum and fertile Allium ampeloprasum L.
Influenza, Human
Mammalian Diaphanous-related formin-1 restricts early phases of influenza A/NWS/33 virus (H1N1) infection in LLC-MK2 cells by affecting cytoskeleton dynamics.
Intellectual Disability
A novel TUBG1 mutation with neurodevelopmental disorder caused by malformations of cortical development.
Intellectual Disability
Clinical variability of TUBB-associated disorders: Diagnosis through reanalysis.
Intellectual Disability
Overlapping phenotype comprising Kenny-Caffey type 2 and Sanjad-Sakati syndromes: The first case report.
Intellectual Disability
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Intervertebral Disc Degeneration
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Intestinal Neoplasms
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines.
Intestinal Volvulus
Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude.
Ischemic Attack, Transient
Immunoelectron microscopic study of tubulin and microtubule-associated proteins after transient cerebral ischemia in gerbils.
Keratosis, Actinic
Tirbanibulin Ointment 1% as a Novel Treatment for Actinic Keratosis: Phase 1 and 2 Results.
Kidney Neoplasms
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Labyrinth Diseases
TUNEL-positive labeling in mouse inner ear caused by tubulin immunization is not apoptosis.
Leiomyosarcoma
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Leishmaniasis
Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum.
Leishmaniasis, Visceral
Antiactin and antitubulin antibodies in canine visceral leishmaniasis.
Leishmaniasis, Visceral
Identification of immune complex antigens in sera of Indian kala-azar patients.
Leukemia
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells.
Leukemia
Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype.
Leukemia
Antiproliferative activity and mechanism of action of DZ-3358, a novel pyrimidinyl pyrazole derivative.
Leukemia
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.
Leukemia
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Leukemia
Cell surface tubulin in leukemic cells: molecular structure, surface binding, turnover, cell cycle expression, and origin.
Leukemia
Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis.
Leukemia
Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity.
Leukemia
Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site.
Leukemia
Design and synthesis of novel 5-(4-chlorophenyl)furan derivatives with inhibitory activity on tubulin polymerization.
Leukemia
Effects of extremely low frequency magnetic fields on NGF induced neuronal differentiation of PC12 cells.
Leukemia
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein.
Leukemia
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Leukemia
Establishment and characterization of embryonic stem-like cells from porcine somatic cell nuclear transfer blastocysts.
Leukemia
Estimation of changes in tubulin induced with etoposide in human leukemia cells line K-562 by immunofluorescence microscope.
Leukemia
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Leukemia
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Leukemia
Increase in the chemically-induced differentiation of human leukemia cell lines by tubulin disruptors.
Leukemia
Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.
Leukemia
Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro.
Leukemia
MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.
Leukemia
MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells.
Leukemia
MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
Leukemia
Mutations of oncoprotein 18/stathmin identify tubulin-directed regulatory activities distinct from tubulin association.
Leukemia
Op18/stathmin mediates multiple region-specific tubulin and microtubule-regulating activities.
Leukemia
Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells.
Leukemia
Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization.
Leukemia
Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B.
Leukemia
Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
Leukemia
Syntheses of 5a'-homo-vinblastine and congeners designed to establish structural determinants for isolation of atropisomers.
Leukemia
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine.
Leukemia
Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.
Leukemia
Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer agents.
Leukemia
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.
Leukemia
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.
Leukemia
Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues.
Leukemia
The influence of etoposide on the distribution of tubulin in human leukemia cell line HL-60.
Leukemia
Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
Leukemia
[The cytoskeleton reorganization and differentiation of HL-60 and K-562 human leukemia cell lines]
Leukemia, Lymphocytic, Chronic, B-Cell
Human lymphocyte tubulin. Purification and characterization in normal and leukemic cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.
Leukemia, Lymphocytic, Chronic, B-Cell
Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
Leukemia, Lymphoid
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.
Leukemia, Lymphoid
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Leukemia, Lymphoid
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine.
Leukemia, Lymphoid
Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature.
Leukemia, Myeloid
Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.
Leukemia, Myeloid, Acute
Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
Leukemia, Myeloid, Acute
MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation.
Leukemia, Myeloid, Acute
Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin.
Leukemia, Myeloid, Acute
Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation.
Lewy Body Disease
The presence of tau distinguishes Lewy bodies of diffuse Lewy body disease from those of idiopathic Parkinson disease.
Lipidoses
A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis.
Lissencephaly
A case of TUBA1A mutation presenting with lissencephaly and Hirschsprung disease.
Lissencephaly
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Lissencephaly
In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.
Lissencephaly
Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).
Lissencephaly
Lissencephaly in an epilepsy cohort: Molecular, radiological and clinical aspects.
Lissencephaly
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Lissencephaly
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Lissencephaly
Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures.
Lissencephaly
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.
Lissencephaly
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
Lissencephaly
TUBA1A mutation-associated lissencephaly: case report and review of the literature.
Lissencephaly
Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects.
Lissencephaly
Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1.
Liver Cirrhosis
Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat.
Liver Cirrhosis, Biliary
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Liver Diseases
Autoantibodies and circulating immune complexes in sera from patients with hepatitis B virus-related chronic liver disease.
Liver Diseases
Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease.
Liver Diseases, Alcoholic
Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease.
Liver Neoplasms
An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent.
Liver Neoplasms
COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma.
Liver Neoplasms
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Liver Neoplasms
Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
Liver Neoplasms
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma.
Liver Neoplasms
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Liver Neoplasms
Mitochondrial-targeted prodrug cancer therapy using a rhodamine B labeled fluorinated docetaxel.
Liver Neoplasms
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Liver Neoplasms
Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.
Liver Neoplasms
Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer.
Lung Diseases
Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity.
Lung Neoplasms
5-Demethylnobiletin promotes the formation of polymerized tubulin, leads to G2/M phase arrest and induces autophagy via JNK activation in human lung cancer cells.
Lung Neoplasms
Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
Lung Neoplasms
Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.
Lung Neoplasms
Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis.
Lung Neoplasms
Cytotoxicity, in silico predictions and molecular studies for androstane heterocycle compounds revealed potential antitumor agent against lung cancer cells.
Lung Neoplasms
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Lung Neoplasms
Design, synthesis and biological evaluation of imidazopyridine-propenone conjugates as potent tubulin inhibitors.
Lung Neoplasms
Drug resistance to paclitaxel is not only associated with ABCB1 mRNA expression but also with drug accumulation in intracellular compartments in human lung cancer cell lines.
Lung Neoplasms
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin.
Lung Neoplasms
Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer.
Lung Neoplasms
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Lung Neoplasms
Eribulin mesilate, a halichondrin B analogue, in the treatment of breast cancer.
Lung Neoplasms
Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.
Lung Neoplasms
Expression of ERCC1 and class IIIbeta tubulin for predicting effect of carboplatin/paclitaxel in patients with advanced inoperable non-small cell lung cancer.
Lung Neoplasms
Genome-wide cDNA microarray screening of genes related to survival in patients after curative resection of non-small cell lung cancer.
Lung Neoplasms
Identification by mass spectrometry of a new alpha-tubulin isotype expressed in human breast and lung carcinoma cell lines.
Lung Neoplasms
Imetelstat (a telomerase antagonist) exerts off?target effects on the cytoskeleton.
Lung Neoplasms
Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line.
Lung Neoplasms
Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung cancer cell lines.
Lung Neoplasms
Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: Invitro and in vivo studies.
Lung Neoplasms
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 Suppresses Proliferation and Induces Apoptosis in Non-Small-Cell Lung Cancer.
Lung Neoplasms
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Lung Neoplasms
Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity.
Lung Neoplasms
Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer.
Lung Neoplasms
P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model.
Lung Neoplasms
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Lung Neoplasms
Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model.
Lung Neoplasms
Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer.
Lung Neoplasms
Randomized phase II study of ixabepilone or paclitaxel plus carboplatin in patients with non-small-cell lung cancer prospectively stratified by beta-3 tubulin status.
Lung Neoplasms
Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines.
Lung Neoplasms
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Lung Neoplasms
Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization.
Lung Neoplasms
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
Lung Neoplasms
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
Lung Neoplasms
The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance.
Lung Neoplasms
The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer.
Lung Neoplasms
Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization.
Lupus Erythematosus, Systemic
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Lupus Nephritis
Pathogenic autoantibodies from patients with lupus nephritis cause reduced tyrosine phosphorylation of podocyte proteins, including tubulin.
Lymphatic Metastasis
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Lymphoma
Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature.
Lymphoma
Cytosine arabinoside, vinblastine, 5-fluorouracil and 2-aminoanthracene testing in the in vitro micronucleus assay with L5178Y mouse lymphoma cells at Sanofi Aventis, with different cytotoxicity measurements, in support of the draft OECD Test Guideline on In Vitro Mammalian Cell Micronucleus Test.
Lymphoma
Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene tested in MNvit in the absence of cytokinesis block using TK6 cells at AstraZeneca UK, in support of OECD draft Test Guideline 487.
Lymphoma
MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
Lymphoma
Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice.
Lymphoma
Purification and characterization of tubulin from parental and vincristine-resistant HOB1 lymphoma cells.
Lymphoma, B-Cell
LncRNA MEG3 inhibits proliferation and promotes apoptosis of synovial cells in rats with knee osteoarthritis by regulating PTEN.
Lymphoma, B-Cell
Molecular targets for the management of gastrointestinal cancer using melatonin, a natural endogenous body hormone.
Malaria
An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization.
Malaria
Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites.
Malaria
Combination Assays and Molecular Docking Can Identify Binding Sites of Anti-Microtubule Drugs on Plasmodium falciparum tubulin.
Malaria
Comparative Gene Expression Profiling of P. falciparum Malaria Parasites Exposed to Three Different Histone Deacetylase Inhibitors.
Malaria
The tubulin genes of the human malaria parasite Plasmodium falciparum, their chromosomal location and sequence analysis of the alpha-tubulin II gene.
Malaria, Cerebral
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India.
Malformations of Cortical Development
A novel TUBG1 mutation with neurodevelopmental disorder caused by malformations of cortical development.
Malformations of Cortical Development
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Malformations of Cortical Development
Brain malformations and mutations in ?- and ?-tubulin genes: a review of the literature and description of two new cases.
Malformations of Cortical Development
Cerebral palsy and seizures in a child with tubulinopathy pattern dysgenesis and focal cortical dysplasia.
Malformations of Cortical Development
Investigation of the most common clinical and imaging findings and the role of Tubulin genes in the etiology Of malformations of cortical development.
Malformations of Cortical Development
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Malformations of Cortical Development
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Malformations of Cortical Development
Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly.
Malformations of Cortical Development
Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development.
Malformations of Cortical Development
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.
Malformations of Cortical Development
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
Malformations of Cortical Development
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Malformations of Cortical Development
Tubulin genes and malformations of cortical development.
Malformations of Cortical Development
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development.
Malformations of Cortical Development, Group II
Epilepsy in Tubulinopathy: Personal Series and Literature Review.
Malformations of Cortical Development, Group II
Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5.
Malnutrition
Malnutrition increases insoluble-to-soluble tubulin ratio and in vitro incorporation of 32ATP in rat cerebral cortex.
Medulloblastoma
Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
Medulloblastoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Melanoma
3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.
Melanoma
An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1.
Melanoma
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Melanoma
Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
Melanoma
Cytoplasmic microtubules in two different mouse melanoma cell lines: a qualitative and quantitative analysis using confocal laser scanning microscopy and computer-assisted image analysis.
Melanoma
Cytoskeletal tubulin competes with actin to increase deformability of metastatic melanoma cells.
Melanoma
Evaluation of tubulin ?-3 as a novel senescence-associated gene in melanocytic malignant transformation.
Melanoma
Exploring the Influence of the Aromaticity on the Anticancer and Antivascular Activities of Organoplatinum(II) Complexes.
Melanoma
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Melanoma
Gold(I)-NHC complexes of antitumoral diarylimidazoles: structures, cellular uptake routes and anticancer activities.
Melanoma
Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity.
Melanoma
Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo.
Melanoma
New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.
Melanoma
Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis.
Melanoma
Postembedding immunogold electron microscopy for S100, tubulin, and cytoskeletal proteins in an amelanotic malignant melanoma.
Melanoma
RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness.
Melanoma
Requirement of calcium ions for cell degeneration with a toxin (vibriolysin) from Vibrio parahaemolyticus.
Melanoma
Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents.
Melanoma
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
Melanoma
Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma.
Melanoma
Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma.
Melanoma
The Tubulin Inhibitor VERU-111 in Combination With Vemurafenib Provides an Effective Treatment of Vemurafenib-Resistant A375 Melanoma.
Melanoma, Experimental
A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach.
Melanoma, Experimental
Cellular uptake and tubulin binding properties of four Vinca alkaloids.
Melanoma, Experimental
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.
Melanoma, Experimental
Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours.
Melanoma, Experimental
Structure-activity relationships of indole compounds derived from combretastatin A4: synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents.
Melanoma, Experimental
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.
Melanoma, Experimental
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
Melanoma, Experimental
Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives.
Melanoma, Experimental
Synthesis of biologically active taxol analogues with modified phenylisoserine side chains.
Melanoma, Experimental
YoshixolTR inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death.
Memory Disorders
Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein/presenilin 1 (APP/PS1) mice.
Memory Disorders
Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits.
Meningeal Carcinomatosis
Pathology of brain parenchyma in meningeal carcinomatosis; immunohistochemical study with astroprotein (GFAP) and tubulin.
Meningeal Carcinomatosis
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Mesothelioma
Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.
Mesothelioma
Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells.
Mesothelioma, Malignant
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Mesothelioma, Malignant
Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23.
Microcephaly
Bi-allelic Pathogenic Variants in TUBGCP2 Cause Microcephaly and Lissencephaly Spectrum Disorders.
Microcephaly
Case reports: novel TUBG1 mutations with milder neurodevelopmental presentations.
Microcephaly
Clinical variability of TUBB-associated disorders: Diagnosis through reanalysis.
Microcephaly
De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy.
Microcephaly
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Microcephaly
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Microcephaly
Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly.
Microcephaly
Overlapping phenotype comprising Kenny-Caffey type 2 and Sanjad-Sakati syndromes: The first case report.
Microcephaly
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
Microcephaly
Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1.
microtubule-severing atpase deficiency
Graded Control of Microtubule Severing by Tubulin Glutamylation.
Mobius Syndrome
An exome sequencing study of Moebius syndrome including atypical cases reveals an individual with CFEOM3A and a TUBB3 mutation.
Motor Neuron Disease
A missense mutation in Tbce causes progressive motor neuronopathy in mice.
Motor Neuron Disease
AAV9-Stathmin1 gene delivery improves disease phenotype in an intermediate mouse model of Spinal Muscular Atrophy.
Mouth Neoplasms
?- and ?-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
Movement Disorders
MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons.
Movement Disorders
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Multiple Myeloma
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.
Multiple Myeloma
Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities.
Multiple Myeloma
Ricolinostat, the First Selective Histone Deacetylase 6 Inhibitor, in Combination with Bortezomib and Dexamethasone for Relapsed or Refractory Multiple Myeloma.
Multiple Myeloma
Targeting the 'garbage-bin' to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU.
Multiple Sclerosis
A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.
Multiple Sclerosis
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Multiple Sclerosis
Axon cytoskeleton proteins specifically modulate oligodendrocyte growth and differentiation in vitro.
Multiple Sclerosis
Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain.
Multiple Sclerosis
Cerebrospinal fluid antibodies to tubulin are elevated in the patients with multiple sclerosis.
Multiple Sclerosis
Comparative study of natural autoantibodies in the serum and cerebrospinal fluid of normal individuals and patients with multiple sclerosis and other neurological diseases.
Multiple Sclerosis
Serum antibodies against central nervous system proteins in human demyelinating disease.
Multiple Sclerosis
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Multiple Sclerosis
[Lesion mechanism dependent, differential changes in neurofilaments and microtubules: a pathological and experimental study]
Multiple System Atrophy
?-III Tubulin Fragments Inhibit ?-Synuclein Accumulation in Models of Multiple System Atrophy.
Multiple System Atrophy
Binding of neuronal ?-synuclein to ?-III tubulin and accumulation in a model of multiple system atrophy.
Multiple System Atrophy
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, {beta}-amyloid and {alpha}-synuclein.
Multiple System Atrophy
Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion.
Multiple System Atrophy
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments.
Multiple System Atrophy
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Muscle Hypotonia
[Reorganization of the tubulin and vimentin components of the cytoskeleton as affected by the action of hypotonia on L cells]
Muscular Atrophy
Effect of an Adipose-Derived Stem Cell and Nerve Growth Factor-Incorporated Hydrogel on Recovery of Erectile Function in a Rat Model of Cavernous Nerve Injury.
Muscular Atrophy
The decrease of the cytoskeleton tubulin follows the decrease of the associating molecular chaperone alphaB-crystallin in unloaded soleus muscle atrophy without stretch.
Muscular Diseases
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Muscular Dystrophies
Distribution of cytoskeletal elements in cultured skin fibroblasts of patients with Duchenne's muscular dystrophy.
Muscular Dystrophy, Facioscapulohumeral
Identification of a novel beta-tubulin subfamily with one member (TUBB4Q) located near the telomere of chromosome region 4q35.
Myelodysplastic Syndromes
Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
Nasopharyngeal Carcinoma
Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri.
Nasopharyngeal Carcinoma
Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma.
Nasopharyngeal Neoplasms
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Nematode Infections
Expression of both Arabidopsis ?-tubulin genes is essential for development of a functional syncytium induced by Heterodera schachtii.
Neoplasm Metastasis
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Neoplasm Metastasis
Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis.
Neoplasm Metastasis
Differential expression of glu-tubulin in relation to mammary gland disease.
Neoplasm Metastasis
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Neoplasm Metastasis
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Neoplasm Metastasis
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Neoplasm Metastasis
Induction of 18A2/mts1 gene expression and its effects on metastasis and cell cycle control.
Neoplasm Metastasis
Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours.
Neoplasm Metastasis
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Novel Molecular Targets for the Therapy of Castration-Resistant Prostate Cancer.
Neoplasm Metastasis
Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis.
Neoplasm Metastasis
Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins.
Neoplasm Metastasis
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6.
Neoplasm Metastasis
PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells.
Neoplasm Metastasis
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Neoplasm Metastasis
Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
Neoplasm Metastasis
Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma.
Neoplasm Metastasis
Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
Neoplasm Metastasis
Tubulin cofactor a functions as a novel positive regulator of ccRCC progression, invasion and metastasis.
Neoplasm Metastasis
Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells - A critical role of Cdk1 in mitotic entry.
Neoplasm Metastasis
Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.
Neoplasm Metastasis
Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma.
Neoplasms
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells.
Neoplasms
(E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction.
Neoplasms
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.
Neoplasms
10-(2-oxo-2-Phenylethylidene)-10H-anthracen-9-ones as Highly Active Antimicrotubule Agents: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization.
Neoplasms
10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Neoplasms
11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.
Neoplasms
2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines.
Neoplasms
2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
Neoplasms
2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients.
Neoplasms
3-(Iodoacetamido)-benzoylurea: a novel cancericidal tubulin ligand that inhibits microtubule polymerization, phosphorylates bcl-2, and induces apoptosis in tumor cells.
Neoplasms
3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
Neoplasms
?- and ?-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
Neoplasms
?-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell.
Neoplasms
?-Taxilin Interacts with Sorting Nexin 4 and Participates in the Recycling Pathway of Transferrin Receptor.
Neoplasms
?-tubulin as a signal-transducing molecule and meshwork with therapeutic potential.
Neoplasms
?III-Tubulin is required for interphase microtubule dynamics in untransformed human mammary epithelial cells.
Neoplasms
A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
Neoplasms
A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
Neoplasms
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Neoplasms
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
Neoplasms
A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy.
Neoplasms
A drug repositioning success: The repositioned therapeutic applications and mechanisms of action of thalidomide.
Neoplasms
A highly potent maytansinoid analogue and its use as a cytotoxic therapeutic agent in gold nanoparticles for the treatment of hepatocellular carcinoma.
Neoplasms
A method for determination of dimethyl benzoylphenyl urea (BPU) in human plasma by using LC/UV.
Neoplasms
A new C,N-cyclometalated osmium(ii) arene anticancer scaffold with a handle for functionalization and antioxidative properties.
Neoplasms
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.
Neoplasms
A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe.
Neoplasms
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
Neoplasms
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.
Neoplasms
A novel candidate compound with urethane structure for anticancer drug development.
Neoplasms
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Neoplasms
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells
Neoplasms
A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis.
Neoplasms
A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics.
Neoplasms
A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
Neoplasms
A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells.
Neoplasms
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
Neoplasms
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Neoplasms
A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment.
Neoplasms
A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors.
Neoplasms
A phase 2 study of epothilone B analog BMS-247550 (NSC 710428) in patients with relapsed aggressive non-Hodgkin lymphomas.
Neoplasms
A phase I study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 21 days every 28 days in pediatric patients with solid tumors.
Neoplasms
A phase I study of paclitaxel, estramustine phosphate and vinorelbine (Pacl-E-Vin) in advanced malignancies: triple tubulin targeting.
Neoplasms
A phase I-II study of the histone deacetylase inhibitor vorinostat plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in locally advanced breast cancer.
Neoplasms
A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma.
Neoplasms
A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group study.
Neoplasms
A rapid and sensitive method for determination of dimethyl benzoylphenyl urea in human plasma by using LC/MS/MS.
Neoplasms
A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin.
Neoplasms
A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability.
Neoplasms
A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity.
Neoplasms
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and ?-III tubulin mediated tumor drug resistance in vitro.
Neoplasms
A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization.
Neoplasms
A study of the cross-resistance of vincristine and vindesine in reinduction therapy for acute lymphocytic leukemia in relapse. A report for Children's Cancer Study Group.
Neoplasms
A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy.
Neoplasms
A Theoretical Study on the Biophysical Mechanisms by Which Tumor Treating Fields Affect Tumor Cells during Mitosis.
Neoplasms
A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules.
Neoplasms
Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice.
Neoplasms
Acetonitrile-assisted enzymatic digestion can facilitate the bottom-up identification of proteins of cancer origin.
Neoplasms
Activated carbon/Brønsted acid-promoted aerobic benzylic oxidation under "on-water" condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors.
Neoplasms
Affinity Purification and Characterization of Functional Tubulin from Cell Suspension Cultures of Arabidopsis and Tobacco.
Neoplasms
Alterations in vascular architecture and permeability following OXi4503 treatment.
Neoplasms
Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
Neoplasms
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.
Neoplasms
An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance.
Neoplasms
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Neoplasms
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Neoplasms
Analysis of Tubulin Alpha-1A/1B C-Terminal Tail Post-translational Poly-glutamylation Reveals Novel Modification Sites.
Neoplasms
Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.
Neoplasms
Anti-neoplastic agent thymoquinone induces degradation of ? and ? tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.
Neoplasms
Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains.
Neoplasms
Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
Neoplasms
Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma.
Neoplasms
Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids.
Neoplasms
Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene.
Neoplasms
Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
Neoplasms
Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
Neoplasms
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
Neoplasms
Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.
Neoplasms
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Neoplasms
Antiproliferative Activity of 8-methoxy Ciprofloxacin-Hydrozone/Acylhydrazone Scaffolds.
Neoplasms
Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells.
Neoplasms
Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells.
Neoplasms
Antitumor activity of tricyclic pyrone analogs, a new synthetic class of microtubule de-stabilizing agents, in the murine EMT-6 mammary tumor cell line in vitro.
Neoplasms
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Neoplasms
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.
Neoplasms
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Neoplasms
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Neoplasms
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
Neoplasms
Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer.
Neoplasms
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.
Neoplasms
Antitumor effect of the vascular-disrupting agent ZD6126 in a murine renal cell carcinoma model.
Neoplasms
Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
Neoplasms
Application of GA-MLR for QSAR modeling of the arylthioindole class of tubulin polymerization inhibitors as anticancer agents.
Neoplasms
Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.
Neoplasms
Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide.
Neoplasms
Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
Neoplasms
Assembly of nonneural microtubules in the absence of glycerol and microtubule-associated proteins.
Neoplasms
Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy.
Neoplasms
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Neoplasms
Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.
Neoplasms
ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect.
Neoplasms
Attachment and invasion of high- and low-metastatic clones of RCT sarcoma in a three-dimensional culture system.
Neoplasms
Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity.
Neoplasms
Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of ?-catenin pathway.
Neoplasms
B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities.
Neoplasms
BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy.
Neoplasms
beta(III)-tubulin at the invasive margin of colorectal cancer: possible link to invasion.
Neoplasms
BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability.
Neoplasms
betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer.
Neoplasms
Bioelectrical impedimetric sensor for single cell analysis based on nanoroughened quartz substrate; suitable for cancer therapeutic purposes.
Neoplasms
Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor.
Neoplasms
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.
Neoplasms
Biological evaluation on different human cancer cell lines of novel colchicine analogs.
Neoplasms
Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.
Neoplasms
Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
Neoplasms
Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.
Neoplasms
Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.
Neoplasms
BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy.
Neoplasms
Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents.
Neoplasms
Breast cancer cells evade paclitaxel-induced cell death by developing resistance to dasatinib.
Neoplasms
BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
Neoplasms
Butterfly Structure: A Privileged Scaffold Targeting Tubulin-Colchicine Binding Site.
Neoplasms
CA-1H, a novel oxazole bearing analogue of combretastatin A-4, disrupts the tumor vasculatures and inhibits the tumor growth via inhibiting tubulin polymerization.
Neoplasms
Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics.
Neoplasms
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Neoplasms
Caulerpenyne binding to tubulin: structural modifications by a non conventional pharmacological agent.
Neoplasms
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.
Neoplasms
Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens.
Neoplasms
Cellular Effects of Curcumin on Plasmodium falciparum Include Disruption of Microtubules.
Neoplasms
Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: type II estrogen binding sites and tubulin.
Neoplasms
Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression.
Neoplasms
Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
Neoplasms
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Neoplasms
Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.
Neoplasms
Characterization of Ceap-11 and Ceap-16, two novel splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell proliferation.
Neoplasms
Chemical targeting of GAPDH moonlighting function in cancer cells reveals its role in tubulin regulation.
Neoplasms
Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1.
Neoplasms
Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy.
Neoplasms
Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro.
Neoplasms
Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
Neoplasms
Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
Neoplasms
Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action.
Neoplasms
Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl)indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors.
Neoplasms
Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.
Neoplasms
Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.
Neoplasms
Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization.
Neoplasms
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
Neoplasms
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.
Neoplasms
Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
Neoplasms
Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer.
Neoplasms
Comparison of beta-tubulin mRNA and protein levels in 12 human cancer cell lines.
Neoplasms
Comparison of tyrosine protein kinases in membrane fractions from mouse liver and Ehrlich ascites tumor.
Neoplasms
Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.
Neoplasms
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Neoplasms
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Neoplasms
Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
Neoplasms
Constitutive production of 92-kDa gelatinase B can be suppressed by alterations in cell shape.
Neoplasms
Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents.
Neoplasms
Copper(I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-?-noscapine from natural ?-noscapine.
Neoplasms
Correlation of tubulin-binding and antitumor activities of podophyllotoxin analogs.
Neoplasms
CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.
Neoplasms
CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo.
Neoplasms
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy.
Neoplasms
Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis.
Neoplasms
CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells.
Neoplasms
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
Neoplasms
Cytoskeleton and motility: an immunohistological and computer simulation analysis of melanocytic skin tumors.
Neoplasms
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Neoplasms
Cytotoxic activity of the histone deacetylase inhibitor panobinostat (LBH589) in anaplastic thyroid cancer in vitro and in vivo.
Neoplasms
Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles.
Neoplasms
Delineating the interaction of combretastatin A-4 with ?? tubulin isotypes present in drug resistant human lung carcinoma using a molecular modeling approach.
Neoplasms
Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines.
Neoplasms
Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells.
Neoplasms
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Neoplasms
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.
Neoplasms
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.
Neoplasms
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
Neoplasms
Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.
Neoplasms
Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors.
Neoplasms
Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors.
Neoplasms
Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors.
Neoplasms
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Neoplasms
Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
Neoplasms
Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.
Neoplasms
Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
Neoplasms
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.
Neoplasms
Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
Neoplasms
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.
Neoplasms
Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site.
Neoplasms
Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
Neoplasms
Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.
Neoplasms
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Neoplasms
Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
Neoplasms
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.
Neoplasms
Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo.
Neoplasms
Design, Synthesis, and Biological Evaluation of the First Podophyllotoxin Analogues as Potential Vascular-Disrupting Agents.
Neoplasms
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Neoplasms
Design, Synthesis, and in?vitro Evaluation of Tubulin-Targeting Dibenzothiazines with Antiproliferative Activity as a Novel Heterocycle Building Block.
Neoplasms
Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents.
Neoplasms
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Neoplasms
Design, Synthesis, in vitro and in vivo Evaluation of (Z)-3,4,5-Trimethoxystyryl Benzenesulfonamides/Sulfonates as Highly Potent Tubulin Polymerization Inhibitors.
Neoplasms
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.
Neoplasms
Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells.
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Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics.
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Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
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Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy.
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Development of a novel class of tubulin inhibitors with promising anticancer activities.
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Development of a novel in vitro human tissue-based angiogenesis assay to evaluate the effect of antiangiogenic drugs.
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Development of a novel near-infrared fluorescent theranostic combretastain A-4 analogue, YK-5-252, to target triple negative breast cancer.
Neoplasms
Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.
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Development of novel derivatives of stilbene and macrocyclic compounds as potent of anti-microtubule factors.
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Development of Taccalonolide AJ-Hydroxypropyl-?-Cyclodextrin Inclusion Complexes for Treatment of Clear Cell Renal-Cell Carcinoma.
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Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance.
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Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
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Dietary cysteamine hydrochloride protects against oxidation, inflammation, and mucosal barrier disruption of broiler chickens challenged with Clostridium perfringens.
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Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
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Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
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Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the ?T5 loop.
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Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.
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Discover 4?-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
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Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.
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Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.
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Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
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Discovery of 3-(((9H-purin-6-yl)amino)methyl)-4,6-dimethylpyridin-2(1H)-one derivatives as novel tubulin polymerization inhibitors for treatment of cancer.
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Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties.
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Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy.
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Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy.
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Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.
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Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.
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Discovery of CYT997: a structurally novel orally active microtubule targeting agent.
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Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities.
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Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.
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Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment.
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Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity.
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Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
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Discovery of novel tubulin inhibitors targeting taxanes site by virtual screening, molecular dynamic simulation, and biological evaluation.
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Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
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Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
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Discovery of oxyepiberberine as a novel tubulin polymerization inhibitor and an anti-colon cancer agent against LS-1034 cells.
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Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.
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Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
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Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.
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Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe.
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Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine.
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Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
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Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1? Mediated Cancer Cell Viability and Vascularization.
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Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer.
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Dual-Fluorescence Isogenic High-Content Screening for MUC16/CA125 Selective Agents.
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Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
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Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance.
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DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells.
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Eaton's reagent-mediated domino ?-cationic arylations of aromatic carboxylic acids to Iasi-red polymethoxylated polycyclic aromatic hydrocarbons: products with unprecedented biological activities as tubulin polymerization inhibitors.
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EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
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Effect of TTLL12 on tubulin tyrosine nitration as a novel target for screening anticancer drugs in vitro.
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Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
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Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells.
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Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.
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Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer.
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Effects of novel and conventional anti-cancer agents on human endothelial permeability: influence of tumour secreted factors.
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Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
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Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks.
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Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).
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Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins.
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Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma.
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Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo.
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Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference.
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Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
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Enhancing major histocompatibility complex class I antigen presentation by targeting antigen to centrosomes.
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Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
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Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells.
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ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1.
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Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer.
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Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats.
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Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo.
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Ethyl-2-amino-pyrrole-3-carboxylates are novel potent anticancer agents that affect tubulin polymerization, induce G2/M cell-cycle arrest, and effectively inhibit soft tissue cancer cell growth in vitro.
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Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds.
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Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy.
Neoplasms
Evaluation of epothilone B analog in advanced soft tissue sarcoma: a phase II study of the phase II consortium.
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Evaluation of glycosylated docetaxel-encapsulated liposomes prepared by remote loading under solubility gradient.
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Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects.
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Evidence for microtubule target engagement in tumors of patients receiving ixabepilone.
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Evolution of the Systems Pharmacokinetics-Pharmacodynamics Model for Antibody-Drug Conjugates to Characterize Tumor Heterogeneity and In Vivo Bystander Effect.
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Evolving Approaches to Metastatic Breast Cancer Patients Pre-treated with Anthracycline and Taxane.
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Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
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Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells.
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Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Neoplasms
Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.
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Expression of ?V-Tubulin in Secretory Cells of the Fallopian Tube Epithelium Marks Cellular Atypia.
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Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line.
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Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone.
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Expression of class III beta tubulin in cervical cancer patients administered preoperative radiochemotherapy: correlation with response to treatment and clinical outcome.
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Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.
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Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody.
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Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Neoplasms
Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression.
Neoplasms
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Neoplasms
Expression of tubulin, p53, ki67, receptors for estrogen, and progesterone in endometrial cancer.
Neoplasms
Expression profiling of tubulin isotypes and microtubule-interacting proteins using real-time polymerase chain reaction.
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Extraskeletal myxoid chondrosarcoma characterized by microtubular aggregates in the rough endoplasmic reticulum and tubulin immunoreactivity.
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FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression.
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Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
Neoplasms
Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
Neoplasms
Fluorine Substituted Proline Enhances the Tubulin Binding Potential of a Tetrapeptide at the GTP Binding Pocket Causing the Inhibition of Microtubule Motility and an Antimitotic Effect.
Neoplasms
From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides.
Neoplasms
From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor.
Neoplasms
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
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Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
Neoplasms
Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas.
Neoplasms
Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes.
Neoplasms
Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance.
Neoplasms
Genome-wide cDNA microarray screening of genes related to survival in patients after curative resection of non-small cell lung cancer.
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Giant cell glioblastoma and pleomorphic xanthoastrocytoma show different immunohistochemical profiles for neuronal antigens and p53 but share reactivity for class III beta-tubulin.
Neoplasms
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
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Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA.
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Glyceraldehyde-3-phosphate dehydrogenase is a microtubule binding protein in a human colon tumor cell line.
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Gold(I) Biscarbene Complexes Derived from Vascular-Disrupting Combretastatin A-4 Address Different Targets and Show Antimetastatic Potential.
Neoplasms
Gold(I)-NHC complexes of antitumoral diarylimidazoles: structures, cellular uptake routes and anticancer activities.
Neoplasms
Halichondrin B amide acts as tubulin binding agent to exhibit anti-tumor efficacy in hematologic cancers.
Neoplasms
Heterogeneous and homogeneous nucleation of Taxol crystals in aqueous solutions and gels: effect of tubulin proteins.
Neoplasms
HIC1 and RassF1A Methylation Attenuates Tubulin Expression and Cell Stiffness in Cancer.
Neoplasms
High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.
Neoplasms
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Neoplasms
Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions.
Neoplasms
Hybridized quinoline derivatives as anticancer agents: Design, Synthesis, biological evaluation and molecular docking.
Neoplasms
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity.
Neoplasms
Identification and Characterization of an Intermediate Taxol Binding Site Within Microtubule Nanopores and a Mechanism for Tubulin Isotype Binding Selectivity.
Neoplasms
Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity.
Neoplasms
Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation.
Neoplasms
Identification of a novel transcript isoform of the TTLL12 gene in human cancers.
Neoplasms
Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
Neoplasms
Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53.
Neoplasms
Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells.
Neoplasms
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Neoplasms
Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors.
Neoplasms
Identification of potent virtual leads and ADME prediction of isoxazolidine podophyllotoxin derivatives as topoisomerase II and tubulin inhibitors.
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Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
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Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.
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Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
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Implications of Nanoscale Based Drug Delivery Systems in Delivery and Targeting Tubulin Binding Agent, Noscapine in Cancer Cells.
Neoplasms
In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting ?-Tubulin Isotypes: A Search for a Selective and Specific ?-III Tubulin Ligand.
Neoplasms
In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(iv) complex.
Neoplasms
In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin.
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In vitro formation of different tubulin polymers from purified tubulin of Ehrlich ascites tumor cells.
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In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes.
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In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.
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Increased gamma-tubulin expression and P16INK4A promoter methylation occur together in preinvasive lesions and carcinomas of the breast.
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Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells.
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Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy.
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Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.
Neoplasms
Indomethacin derivatives as tubulin stabilizers to inhibit cancer cell proliferation.
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Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones.
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Induction of microtubule hyper stabilization and robust G2 /M arrest by N-4-CN in human breast carcinoma MDA-MB-231 cells.
Neoplasms
Induction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydes.
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Influence of guanine nucleotides on vincristine binding in tumor cytosols and purified tubulin: evidence for an inhibitor of vincristine binding.
Neoplasms
Influence of hormones and hormone metabolites on the growth of schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.
Neoplasms
Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.
Neoplasms
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Neoplasms
Integrated Analysis Reveals That Long Non-Coding RNA TUBA4B Can Be Used as a Prognostic Biomarker in Various Cancers.
Neoplasms
Integration of NMR studies, computational predictions, and in vitro assays in the search of marine diterpenes with antitumor activity.
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Interaction between cisplatin-treated macrophages and Dalton's lymphoma cells in vitro.
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Interaction of A? peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells.
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Interaction of microtubule depolymerizing agent indanocine with different human ?? tubulin isotypes.
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Interaction of triethyl lead chloride with microtubules in vitro and in mammalian cells.
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Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation.
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Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells.
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Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression.
Neoplasms
Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties.
Neoplasms
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.
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IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents.
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Isolation of a taxol-resistant Leishmania donovani promastigote mutant that exhibits a multidrug-resistant phenotype.
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Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1).
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JWA enhances As(2)O (3)-induced tubulin polymerization and apoptosis via p38 in HeLa and MCF-7 cells.
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Kinetic stabilization of microtubule dynamics by indanocine perturbs EB1 localization, induces defects in cell polarity and inhibits migration of MDA-MB-231 cells.
Neoplasms
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 inhibits cell proliferation and invasion in human colorectal cancer.
Neoplasms
Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment.
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LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b.
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Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
Neoplasms
Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent n12-aza-epothilone (azathilone).
Neoplasms
MALDI in-source decay of high mass protein isoforms: application to alpha- and beta-tubulin variants.
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Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
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Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature.
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Mechanism of action of ixabepilone and its interactions with the ?III-tubulin isotype.
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Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.
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Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro.
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Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation.
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Mechanisms of multidrug resistance: the potential role of microtubule-stabilizing agents.
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Mechanisms of Tubulin Binding Ligands to Target Cancer Cells: Updates on Their Therapeutic Potential and Clinical Trials.
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Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.
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Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes.
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Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours.
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Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.
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Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents.
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Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
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Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.
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Microtubular aggregates in the rough endoplasmic reticulum of sacrococcygeal chordoma.
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Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.
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Microtubule binding and disruption and induction of premature senescence by disorazole C(1).
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Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
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Microtubule network and microtubule-associated proteins in leukemic T lymphocytes.
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Microtubule polymerase and processive plus-end tracking functions originate from distinct features within TOG domain arrays.
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Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing Agents.
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Microtubule-disrupting chemotherapeutics result in enhanced proteasome-mediated degradation and disappearance of tubulin in neural cells.
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Microtubule-targetable fluorescent probe: site-specific detection and super-resolution imaging of ultratrace tubulin in microtubules of living cancer cells.
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Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.
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Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth.
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Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.
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MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
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Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.
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Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M ?I-tubulin mutations causing paclitaxel resistance in cancer cells.
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Molecular insight of isotypes specific ?-tubulin interaction of tubulin heterodimer with noscapinoids.
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Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets.
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Morphological and quantitative analysis on ?-tubulin modifications in glioblastoma cells.
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MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
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MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
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MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation.
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Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.
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N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.
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N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.
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N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as a novel tubulin ligand against human cancer.
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N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide: A novel reversible antimitotic agent inhibiting cancer cell motility.
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N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
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Nakiterpiosin targets tubulin and triggers mitotic catastrophe in human cancer cells.
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New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
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New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.
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New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities.
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New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.
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New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
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Nitric oxide-dependent cytoskeletal changes and inhibition of endothelial cell migration contribute to the suppression of angiogenesis by RAD50 gene transfer.
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NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
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Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.
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Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice.
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Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.
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Novel mutations involving ?I-, ?IIA-, or ?IVB-tubulin isotypes with functional resemblance to ?III-tubulin in breast cancer.
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Novel nicotinoyl pyrazoline derivates bearing N-methyl indole moiety as antitumor agents: Design, synthesis and evaluation.
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Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells.
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Novel Podophyllotoxin Derivatives as Potential Tubulin Inhibitors: Design, Synthesis and Anti-proliferative Activity Evaluation.
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Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents.
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Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function.
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Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity.
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Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents.
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NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.
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Nuclear gamma-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
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Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site.
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Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
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Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells.
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Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.
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Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation.
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Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer.
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Over-Expression of ?II-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.
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Overexpression of a hexa-histidine and T7 peptide-tagged human ribonucleotide reductase small subunit, R2 in Escherichia coli and the generation of human R2 antibodies.
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Overexpression of class III beta tubulin and amplified HER2 gene predict good response to paclitaxel and trastuzumab therapy.
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Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
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Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure?Activity Relations of New Inhibitors of HDAC and/or Tubulin Function.
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Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals.
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p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells.
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Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
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Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of {beta}-tubulin (Asp26Glu) and less stable microtubules.
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Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
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Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-?B inhibition.
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Pathology of brain parenchyma in meningeal carcinomatosis; immunohistochemical study with astroprotein (GFAP) and tubulin.
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PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.
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Perturbation of microtubule polymerization by quercetin through tubulin binding: a novel mechanism of its antiproliferative activity.
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Pharmacokinetics, pharmacodynamics and metabolism of a novel anticancer agent for prostate cancer.
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Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6.
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Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study.
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Phase I and pharmacokinetic trial of the novel taxane BMS-184476 administered as a 1-hour intravenous infusion in combination with cisplatin every 21 days.
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Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors.
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Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks.
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Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses.
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Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer.
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Phase II Multicenter Trial of Oral Quisinostat, a Histone Deacetylase Inhibitor, in Patients with Previously Treated Stage IB-IVA Mycosis Fungoides/Sézary Syndrome.
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Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. Model for prospective evaluation of neurotoxicity.
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Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
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Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model.
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Pictorial Imaging-Histopathology Correlation in a Rabbit with Hepatic VX2 Tumor Treated by Transarterial Vascular Disrupting Agent Administration.
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Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance.
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Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling.
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PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).
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Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.
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PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.
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PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells.
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Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.
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Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
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Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance.
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Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines.
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Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy.
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Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503.
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Prediction of new chromene-based inhibitors of tubulin using structure-based virtual screening and molecular dynamics simulation methods.
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Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.
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Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.
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Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.
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Proteomic alteration of a thermo?sensitive male sterility SP2S in rapeseed (Brassica napus) in response to mild temperature stress
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Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation.
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Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin.
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Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives.
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Quantitative Proteomics Reveals a Novel Role of Karyopherin Alpha 2 in Cell Migration through the Regulation of Vimentin-pErk Protein Complex Levels in Lung Cancer.
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Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues.
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Randomized phase II study of ixabepilone or paclitaxel plus carboplatin in patients with non-small-cell lung cancer prospectively stratified by beta-3 tubulin status.
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Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.
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RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes.
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Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents.
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Recent advances in heterocyclic tubulin inhibitors targeting the colchicine binding site.
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Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.
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Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
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Recent Developments in Oxazole Derivatives as Anticancer Agents: Review on Synthetic Strategies, Mechanism of Action and SAR studies.
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Recent Developments of Target Based Coumarin Derivatives as Potential Anticancer Agents.
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Recent progress in structure activity relationship and mechanistic studies of taxol analogues.
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Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy.
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Regioselective suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
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Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin a-1.
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Regulation of Tubulin Expression by Micro-RNAs: Implications for Drug Resistance.
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Relationship between lipophilicity and inhibitory activity against cancer cell growth of nine kinds of alk(en)yl trisulfides with different side chains.
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Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples.
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Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.
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Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel.
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Reverse micelles-in-microspheres with sustained release of water-soluble combretastatin A4 phosphate for S180 tumor treatment.
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Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics.
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Revisiting microtubule targeting agents: ?-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics.
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Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
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Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents.
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RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers.
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S-(4-Methoxyphenyl)-4-methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent.
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S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.
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Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum.
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Screening Anti-Cancer Drugs against Tubulin using Catch-and-Release Electrospray Ionization Mass Spectrometry.
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Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.
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Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation.
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Selective enhancement of vincristine cytotoxicity in multidrug-resistant tumor cells by dilantin (phenytoin)
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Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.
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Selenium nanoparticles as new strategy to potentiate ?? T cell anti-tumor cytotoxicity through upregulation of tubulin-? acetylation.
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Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
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Septin cooperation with tubulin polyglutamylation contributes to cancer cell adaptation to taxanes.
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Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead.
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Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.
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Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis.
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Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-?B/COX2 signal pathway in breast cancer cell.
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Simplified Pretubulysin Derivatives and Their Biological Effects on Cancer Cells.
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SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines.
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Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner.
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Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells.
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Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy.
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SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
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Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors.
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STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro.
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Strategy for developing transgenic assays for screening antineoplastic drugs that affect tubulin polymerization.
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Structural basis for drug resistance conferred by ?-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B.
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Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays.
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Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
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Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.
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Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action.
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Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.
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Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
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Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors.
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Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
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Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.
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Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity.
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Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
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Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.
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Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.
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Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
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Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells.
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Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin.
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Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.
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Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol.
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Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti?tubulin tetrahydrothieno[2,3?c]pyridine derivative and a peptide nucleic acid targeting miR?221?3p.
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Synergistic interaction of N-3-Br-benzyl-noscapine and docetaxel abrogates oncogenic potential of breast cancer cells.
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Syntheses, quantum mechanical modeling, biomolecular interaction and in vitro anticancer - Tubulin activity of thiosemicarbazones.
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Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
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Synthesis and anticancer activities of new Benzothiadiazinyl Hydrazinecarboxamides and Anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones.
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Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization.
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Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3',4',5'-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis.
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Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity.
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Synthesis and bioevaluation of new vascular-targeting and anti-angiogenic thieno[2,3-d]pyrimidin-4(3H)-ones.
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Synthesis and biological activities of high affinity taxane-based fluorescent probes.
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Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin.
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Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine.
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Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer.
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Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhibitors.
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Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.
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Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
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Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.
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Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
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Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents.
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Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
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Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents.
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Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.
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Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.
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Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents.
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Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs.
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Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.
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Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.
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Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.
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Synthesis and biological evaluation of benzo[b]furo[3,4-e][1,4]diazepin-1-one derivatives as anti-cancer agents.
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Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin.
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Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3?,4?,5?-trimethoxybenzoyl)-6-methoxyindole (OXi8006).
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Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.
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Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold.
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Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
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Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.
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Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors.
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Synthesis and Biological Evaluation of RGD?Cryptophycin Conjugates for Targeted Drug Delivery.
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Synthesis and biological evaluation of structurally diverse ?-conformationally restricted chalcones and related analogues.
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Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.
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Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.
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Synthesis and cellular uptake of p-[(123) I]-phenyl-amino-thiazole ((123) I-PAT) as a potential agent for targeting tubulin polymerization in tumors.
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Synthesis and characterisation of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features.
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Synthesis and Characterization of a Theranostic Vascular Disrupting Agent for In Vivo MR Imaging.
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Synthesis and cytostatic properties of polyfunctionalized furanoallocolchicinoids.
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Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.
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Synthesis and evaluation of alpha-hydroxymethylated conjugated nitroalkenes for their anticancer activity: inhibition of cell proliferation by targeting microtubules.
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Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.
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Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.
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Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.
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Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization.
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Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents.
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Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
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Synthesis and Structure-Activity Relationships of N-Methyl-5,6,7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents.
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Synthesis of (-)-Dactylolide and 13-Desmethylene-(-)-dactylolide and Their Effects on Tubulin.
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Synthesis of ?,?-Unsaturated Carbonyl-Based Compounds, Oxime and Oxime Ether Analogs as Potential Anticancer Agents for Overcoming Cancer Multidrug Resistance by Modulation of Efflux Pumps in Tumor Cells.
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Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.
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Synthesis of Combretastatin A-4 and 3'-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of Their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression.
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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
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Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.
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Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents.
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Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors.
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Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors.
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Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.
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Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
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Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors.
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Synthesis, biological evaluation and molecular docking studies of aminochalcone derivatives as potential anticancer agents by targeting tubulin colchicine binding site.
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Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors.
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Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position.
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Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives.
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Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.
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Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.
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Synthesis, Molecular Targets, and Antitumor Activities of Substituted Tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and Nanogels for Drug Delivery.
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Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel.
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Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins.
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Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma.
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Target identification of a novel unsymmetrical 1,3,4-oxadiazole derivative with antiproliferative properties.
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Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates.
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Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment.
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Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth.
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Targets and pathways involved in the antitumor activity of citral and its stereo-isomers.
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Tau and PTEN status as predictive markers for response to trastuzumab and paclitaxel in patients with HER2-positive breast cancer.
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Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
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Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies.
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Taxane- and epothilone-based chemotherapy: from molecule cargo cytoskeletal logistics to management of castration-resistant prostate carcinoma.
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Thalidomide as a multi-template for development of biologically active compounds.
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The ?-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells.
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The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol.
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The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
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The Bat Flower: A Source of Microtubule-Destabilizing and -Stabilizing Compounds with Synergistic Antiproliferative Actions.
Neoplasms
The betaII isotype of tubulin is present in the cell nuclei of a variety of cancers.
Neoplasms
The clinical development of new mitotic inhibitors that stabilize the microtubule.
Neoplasms
The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins.
Neoplasms
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in ?-tubulin.
Neoplasms
The design, synthesis and evaluation of selenium-containing 4-anilinoquinazoline hybrids as anticancer agents and a study of their mechanism.
Neoplasms
The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
Neoplasms
The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression.
Neoplasms
The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.
Neoplasms
The in vitro porcine brain tubulin assembly assay: effects of a genotoxic carcinogen (aflatoxin B1), eight tumor promoters and nine miscellaneous substances.
Neoplasms
The Interference of Selected Cytotoxic Alkaloids with the Cytoskeleton: An Insight into Their Modes of Action.
Neoplasms
The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells.
Neoplasms
The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin.
Neoplasms
The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1? Activation.
Neoplasms
The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo.
Neoplasms
The Potential of Combining Tubulin-Targeting Anticancer Therapeutics and Immune Therapy.
Neoplasms
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Neoplasms
The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.
Neoplasms
The role of shear stress and altered tissue properties on endothelial to mesenchymal transformation and tumor-endothelial cell interaction.
Neoplasms
The role of tubulin in the steroidogenic response of murine adrenal and rat Leydig cells.
Neoplasms
The roles of cys124 and ser239 in the functional properties of human betaIII tubulin.
Neoplasms
The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells.
Neoplasms
The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors.
Neoplasms
The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-alpha production with antitumor activity.
Neoplasms
The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer.
Neoplasms
The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
Neoplasms
The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Neoplasms
Thiophene derivative-loaded nanoparticles mediate anticancer activity through the inhibition of kinases and microtubule assembly.
Neoplasms
Three steps to cancer: how phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer.
Neoplasms
Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids.
Neoplasms
Three-dimensional structured illumination microscopy using Lukosz bound apodization reduces pixel negativity at no resolution cost.
Neoplasms
Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance.
Neoplasms
Topoisomerases and tubulin inhibitors: a promising combination for cancer treatment.
Neoplasms
Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.
Neoplasms
Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity.
Neoplasms
Toward docking-based virtual screening for discovering antitubulin agents by targeting taxane and colchicine binding sites.
Neoplasms
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.
Neoplasms
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction.
Neoplasms
TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827.
Neoplasms
Transformation-resistant mos revertant is unable to activate MAP kinase kinase in response to v-mos or v-raf.
Neoplasms
Triazole tethered C5-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies.
Neoplasms
Tricyclic pyrone analogs: a new class of microtubule-disrupting anticancer drugs effective against murine leukemia cells in vitro.
Neoplasms
Tricyclic pyrone analogs: a new synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro and the growth of solid tumors in vivo.
Neoplasms
TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.
Neoplasms
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Neoplasms
Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs.
Neoplasms
Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.
Neoplasms
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Neoplasms
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
Neoplasms
Tubulin heterogeneity regulates functions and dynamics of microtubules and plays a role in the development of drug resistance in cancer.
Neoplasms
Tubulin inhibitor AEZS 112 inhibits the growth of experimental human ovarian and endometrial cancers irrespective of caspase inhibition.
Neoplasms
Tubulin inhibitors as novel anticancer agents: an overview on patents (2013-2018).
Neoplasms
Tubulin Maytansine Site Binding Ligands and Their Applications as MTAs and ADCs for Cancer Therapy.
Neoplasms
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin.
Neoplasms
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Neoplasms
Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.
Neoplasms
Tubulin's response to external electric fields by molecular dynamics simulations.
Neoplasms
Tubulin-associated proteins: Aurora and Polo-like kinases as therapeutic targets in cancer.
Neoplasms
Tubulin: A Target for Antineoplastic Drugs into the Cancer Cells but also in the Peripheral Nervous System.
Neoplasms
Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival.
Neoplasms
Understanding the Basis of Drug Resistance of the Mutants of ??-Tubulin Dimer via Molecular Dynamics Simulations.
Neoplasms
Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.
Neoplasms
Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins.
Neoplasms
Vascular targeting in pancreatic cancer: the novel tubulin-binding agent ZD6126 reveals antitumor activity in primary and metastatic tumor models.
Neoplasms
Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma.
Neoplasms
VDAC upregulation and ?TAT1?mediated ??tubulin acetylation contribute to tanespimycin?induced apoptosis in Calu?1 cells.
Neoplasms
Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins.
Neoplasms
Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.
Neoplasms
Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells.
Neoplasms
Viriditoxin Stabilizes Microtubule Polymers in SK-OV-3 Cells and Exhibits Antimitotic and Antimetastatic Potential.
Neoplasms
Virtual and experimental high throughput screening of substituted hydrazones on ?-Tubulin polymerization.
Neoplasms
Vitamin K3 chloro derivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis, and inhibits aggresome formation in hepatocellular carcinoma cells.
Neoplasms
Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity.
Neoplasms
Voltage dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin.
Neoplasms
Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells.
Neoplasms
Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response.
Neoplasms
X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors.
Neoplasms
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Neoplasms
YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance.
Neoplasms
YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.
Neoplasms
Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads.
Neoplasms
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Neoplasms
[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.
Neoplasms
[BETA-III TUBULIN AS A POTENTIAL TARGET FOR BLOCKING INVASIVE GROWTH OF MALIGNANT EPITHELIAL TUMORS].
Neoplasms, Experimental
New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)car bamates.
Neoplasms, Neuroepithelial
Expression of tubulin beta II in neuroepithelial tumors: reflection of architectural changes in the developing human brain.
Neoplasms, Neuroepithelial
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
Nervous System Diseases
Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis.
Nervous System Diseases
Epileptogenic Brain Malformations and Mutations in Tubulin Genes: A Case Report and Review of the Literature.
Nervous System Diseases
Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth.
Nervous System Diseases
G protein-coupled receptor kinases are associated with Alzheimer's disease pathology.
Nervous System Diseases
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, {beta}-amyloid and {alpha}-synuclein.
Nervous System Diseases
TAPping into the treasures of tubulin using novel protein production methods.
Nervous System Diseases
The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.
Nervous System Diseases
The expression of tubb2b undergoes a developmental transition in murine cortical neurons.
Nervous System Diseases
TUBB Variants Underlying Different Phenotypes Result in Altered Vesicle Trafficking and Microtubule Dynamics.
Nervous System Neoplasms
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Neuralgia
Interaction of transient receptor potential vanilloid 4 with annexin A2 and tubulin beta 5.
Neuroaxonal Dystrophies
Cytoskeletal changes and ubiquitin expression in dystrophic axons of Seitelberger's disease.
Neuroblastoma
1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination.
Neuroblastoma
Adriamycin promotes neurite outgrowth in the "neurite-minus" N1A-103 mouse neuroblastoma cell line.
Neuroblastoma
Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples.
Neuroblastoma
Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells.
Neuroblastoma
Analysis of tubulin proteins and peptides in neuronal and non-neuronal tissues using immobilized pH gradients.
Neuroblastoma
Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization.
Neuroblastoma
Biphasic regulation by dibutyryl cyclic AMP of tubulin and actin mRNA levels in neuroblastoma cells.
Neuroblastoma
CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies.
Neuroblastoma
Centrosome overduplication induced by rotenone treatment affects the cellular distribution of p53 tumor suppressor protein in the neuroblastoma B65 cell line.
Neuroblastoma
Changes in intracellular organization of tubulin and actin in N-18 neuroblastoma cells during the process of axon extension induced by serum deprivation.
Neuroblastoma
Changes in microtubule-associated tau protein in human neuroblastoma cells after phencyclidine.
Neuroblastoma
Changes in some cytoskeletal proteins during neuroblastoma cell differentiation.
Neuroblastoma
Characterization and intracellular distribution of microtubule-associated protein 2 in differentiating human neuroblastoma cells.
Neuroblastoma
Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.
Neuroblastoma
Clathrin-mediated endocytosis of m3 muscarinic receptors. Roles for Gbetagamma and tubulin.
Neuroblastoma
Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro.
Neuroblastoma
Compartments of tubulin and tubulin-like proteins in differentiating neubroblastoma cells.
Neuroblastoma
Control of isotubulin expression during neuronal differentiation of mouse neuroblastoma and teratocarcinoma cell lines.
Neuroblastoma
Control of tubulin and actin synthesis and assembly during differentiation of neuroblastoma cells.
Neuroblastoma
D-glucose induces microtubular changes in C1300 neuroblastoma cell line through the incorporation of 3-nitro-L-tyrosine into tubulin.
Neuroblastoma
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Neuroblastoma
Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells.
Neuroblastoma
Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Effects of insulin and insulin-like growth factors on neurofilament mRNA and tubulin mRNA content in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Ganglioside GM1 alters neuronal morphology by modulating the association of MAP2 with microtubules and actin filaments.
Neuroblastoma
High molecular weight tau distribution and microtubule stability in neuroblastoma N115 cells.
Neuroblastoma
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.
Neuroblastoma
Interactions of ? tubulin isotypes with glutathione in differentiated neuroblastoma cells subject to oxidative stress.
Neuroblastoma
Localization of the neurofilament protein in neuroblastoma cells by immunofluorescent staining.
Neuroblastoma
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
Neuroblastoma
Mapping the Mechanome-A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression.
Neuroblastoma
Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells.
Neuroblastoma
Modification of tubulin by tyrosylation in cells and extracts and its effect on assembly in vitro.
Neuroblastoma
Nerve growth factor modulates tubulin transcript levels in pheochromocytoma PC12 cells.
Neuroblastoma
Neuritogenesis in mouse NB2a/d1 neuroblastoma cells: triggering by calcium influx and involvement of actin and tubulin dynamics.
Neuroblastoma
Proteins from morphologically differentiated neuroblastoma cells promote tubulin polymerization.
Neuroblastoma
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Neuroblastoma
Purification of tubulin from neuroblastoma cells: absence of covalently bound phosphate in tubulin from normal and morphologically differentiated cells.
Neuroblastoma
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues.
Neuroblastoma
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain.
Neuroblastoma
Reversible in vitro polymerization of tubulin from a cultured cell line (rat glial cell clone C6).
Neuroblastoma
RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.
Neuroblastoma
SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome.
Neuroblastoma
Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation.
Neuroblastoma
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.
Neuroblastoma
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.
Neuroblastoma
The expression of tubulin and various enzyme activities during neuroblastoma differentiation.
Neuroblastoma
The intracellular organization of actin and tubulin in cultured C-1300 mouse neuroblastoma cells (clone NB41A3).
Neuroblastoma
The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma.
Neuroblastoma
Tubulin constancy during morphological differentiation of mouse neuroblastoma cells.
Neuroblastoma
Tubulin microheterogeneity in neuroblastoma and glioma cell lines differs from that of the brain.
Neuroblastoma
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-?1 (ADAP1).
Neuroblastoma
Two-dimensional gel electrophoresis of human brain proteins. II. Specific proteins and brain subfractions.
Neuroblastoma
Ultrastructure of multiple microtubule initiation sites in mouse neuroblastoma cells.
Neurocysticercosis
Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35-55 in cerebral spinal fluid.
Neurodegenerative Diseases
A homozygous canonical splice acceptor site mutation in PRUNE1 is responsible for a rare childhood neurodegenerative disease in Manitoba Cree families.
Neurodegenerative Diseases
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Neurodegenerative Diseases
Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons.
Neurodegenerative Diseases
Analysis of Tubulin Alpha-1A/1B C-Terminal Tail Post-translational Poly-glutamylation Reveals Novel Modification Sites.
Neurodegenerative Diseases
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Neurodegenerative Diseases
Cholesterol derivatives induce dephosphorylation of the histone deacetylases Rpd3/HDAC1 to upregulate autophagy.
Neurodegenerative Diseases
Infantile Neurodegenerative Disorder Associated with Mutations in TBCD, an Essential Gene in the Tubulin Heterodimer Assembly Pathway.
Neurodegenerative Diseases
Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway.
Neurodegenerative Diseases
Insights into the interaction dynamics between volatile anesthetics and tubulin through computational molecular modelling.
Neurodegenerative Diseases
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Neurodegenerative Diseases
Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.
Neurodegenerative Diseases
Microtubule acetylation: A reading key to neural physiology and degeneration.
Neurodegenerative Diseases
Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.
Neurodegenerative Diseases
Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases.
Neurodegenerative Diseases
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Neurodegenerative Diseases
Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease.
Neurodegenerative Diseases
Shared and Distinct Patterns of Oligodendroglial Response in ?-Synucleinopathies and Tauopathies.
Neurodegenerative Diseases
Targeting the interface of the pathological complex of ?-synuclein and TPPP/p25.
Neurodegenerative Diseases
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases.
Neurodegenerative Diseases
The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders.
Neurodegenerative Diseases
The ins and outs of tubulin acetylation: More than just a post-translational modification?
Neurodegenerative Diseases
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Neurodegenerative Diseases
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments.
Neurodegenerative Diseases
Tubulin glutamylation: a skeleton key for neurodegenerative diseases.
Neuroectodermal Tumors, Primitive
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
Neuroinflammatory Diseases
Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin.
Neuroma
Both positive and negative factors regulate gene expression following chronic facial nerve resection.
Nevus
Evaluation of tubulin ?-3 as a novel senescence-associated gene in melanocytic malignant transformation.
Nevus
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Nevus, Pigmented
BAP1-inactivated melanocytic tumors show prominent centrosome amplification and associated loss of primary cilia.
Nevus, Pigmented
Tubulin expression in melanocytic skin tumors. An immunohistochemical study.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Ocular Motility Disorders
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Onchocerciasis
Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude.
Optic Nerve Injuries
Increased tubulin messenger RNA in the frog retina after optic nerve transection.
Optic Nerve Injuries
Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.
Optic Nerve Injuries
Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish.
Optic Neuritis
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Osteoarthritis
Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning.
Osteoarthritis
Profiling of Endogenous Peptides in Human Synovial Fluid by NanoLC-MS: Method Validation and Peptide Identification.
Osteochondroma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Osteomalacia
Aluminium induced osteomalacia and encephalopathy--an aberration of the tubulin assembly into microtubules (MTs) by Al3+?
Osteoporosis
Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology.
Osteosarcoma
Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms.
Osteosarcoma
Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma.
Osteosarcoma
The Interference of Selected Cytotoxic Alkaloids with the Cytoskeleton: An Insight into Their Modes of Action.
Osteosarcoma
Tubulin polymerization promoting protein 1 (TPPP1) increases ?-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells.
Ovarian Neoplasms
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.
Ovarian Neoplasms
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition.
Ovarian Neoplasms
Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine.
Ovarian Neoplasms
Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients.
Ovarian Neoplasms
Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition.
Ovarian Neoplasms
Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive - Based, natural product lead optimization approach.
Ovarian Neoplasms
Design, synthesis and biological evaluation of bridged epothilone D analogues.
Ovarian Neoplasms
Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer.
Ovarian Neoplasms
Knockout of vasohibin-2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer.
Ovarian Neoplasms
Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells.
Ovarian Neoplasms
MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27.
Ovarian Neoplasms
No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin.
Ovarian Neoplasms
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Ovarian Neoplasms
Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma.
Ovarian Neoplasms
P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane.
Ovarian Neoplasms
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Ovarian Neoplasms
Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole.
Ovarian Neoplasms
Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel.
Ovarian Neoplasms
SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells.
Ovarian Neoplasms
Stathmin and tubulin expression and survival of ovarian cancer patients receiving platinum treatment with and without paclitaxel.
Ovarian Neoplasms
The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization.
Ovarian Neoplasms
Tubulin Beta 2C Chain (TBB2C), a Potential Marker of Ovarian Cancer, an Insight from Ovarian Cancer Proteome Profile.
Ovarian Neoplasms
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
Pancreatic Neoplasms
A phase 2 study of oral MKC-1, an inhibitor of importin-?, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.
Pancreatic Neoplasms
Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents.
Pancreatic Neoplasms
Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells.
Pancreatic Neoplasms
Nanoformulation design and therapeutic potential of a novel tubulin inhibitor in pancreatic cancer.
Pancreatic Neoplasms
YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.
Pancreatitis, Acute Necrotizing
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Pantothenate Kinase-Associated Neurodegeneration
Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.
Paralysis
Antigenic characteristics of neurofibrillary tangles in progressive supranuclear palsy.
Paralysis
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Parasitemia
Induction of high levels of IgG autoantibodies in mice infected with Plasmodium chabaudi.
Parasitemia
Induction of protective immune response in mice by a DNA vaccine encoding Trypanosoma evansi beta tubulin gene.
Parasitic Diseases
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.
Parkinson Disease
Age-dependent accumulation of oligomeric SNCA/?-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Parkinson Disease
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Parkinson Disease
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Parkinson Disease
Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson's disease.
Parkinson Disease
G protein-coupled receptor kinases are associated with Alzheimer's disease pathology.
Parkinson Disease
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, {beta}-amyloid and {alpha}-synuclein.
Parkinson Disease
Irreversible incorporation of L-dopa into the C-terminus of ?-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon.
Parkinson Disease
Microtubule acetylation: A reading key to neural physiology and degeneration.
Parkinson Disease
Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.
Parkinson Disease
Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration.
Parkinson Disease
Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
Parkinson Disease
Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Parkinsonian Disorders
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Parkinsonian Disorders
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Parkinsonian Disorders
Docosahexaenoic acid protection in a rotenone induced Parkinson's model: Prevention of tubulin and synaptophysin loss, but no association with mitochondrial function.
Parkinsonian Disorders
The role of tau (MAPT) in frontotemporal dementia and related tauopathies.
Periodontal Diseases
A conserved Ala320 in the FtsZ of Porphyromonas gingivalis is important for cell division.
Peripheral Nervous System Diseases
cis-diamminedichloroplatinum (II) (cisplatin) alters microtubule assembly dynamics.
Peripheral Nervous System Diseases
Design, synthesis and anticancer evaluation of novel series of Indibulin analogues.
Peripheral Nervous System Diseases
Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy.
Peripheral Nervous System Diseases
Lack of neurotoxicity of the vascular targeting agent ZD6126 following repeated i.v. dosing in the rat.
Peripheral Nervous System Diseases
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.
Peripheral Nervous System Diseases
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.
Peripheral Nervous System Diseases
Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.
Peripheral Nervous System Diseases
TRPV1-tubulin complex: involvement of membrane tubulin in the regulation of chemotherapy-induced peripheral neuropathy.
Persistent Hyperplastic Primary Vitreous
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Phenylketonurias
Experimental phenylketonuria: replacement of carboxyl terminal tyrosine by phenylalanine in infant rat brain tubulin.
Pheochromocytoma
A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).
Pheochromocytoma
Charge variants of tubulin, tubulin S, membrane-bound and palmitoylated tubulin from brain and pheochromocytoma cells.
Pheochromocytoma
Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
Pheochromocytoma
I-387, a Novel Antimitotic Indole, Displays a Potent In vitro and In vivo Antitumor Activity with Less Neurotoxicity.
Pheochromocytoma
Nerve growth factor modulates tubulin transcript levels in pheochromocytoma PC12 cells.
Pheochromocytoma
Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of tau proteins.
Pheochromocytoma
Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease.
Pheochromocytoma
The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities.
Pheochromocytoma
Tubulin isotype usage in vivo: a unique spatial distribution of the minor neuronal-specific beta-tubulin isotype in pheochromocytoma cells.
Photosensitivity Disorders
Effects of Visible-Light Irradiation of Protoporphyrin?IX on the Self-Assembly of Tubulin Heterodimers.
Pituitary Neoplasms
Neuronal differentiation and expression of neural epitopes in pituitary adenomas.
Plant Diseases
Combretastatin A-4 and Derivatives: Potential Fungicides Targeting Fungal Tubulin.
Plasmacytoma
Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.
Polycystic Kidney Diseases
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.
Polycystic Kidney Diseases
Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice.
Polycystic Kidney, Autosomal Dominant
Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice.
Polycystic Kidney, Autosomal Recessive
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.
Polymicrogyria
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Polymicrogyria
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Polymicrogyria
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Polymicrogyria
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Polymicrogyria
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.
Polymicrogyria
TUBA1A mutation-associated lissencephaly: case report and review of the literature.
Polymicrogyria
Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects.
Polyneuropathies
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Anti-alpha- and beta-tubulin IgM antibodies in dysimmune neuropathies.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Porcine Reproductive and Respiratory Syndrome
Porcine reproductive and respiratory syndrome virus envelope (E) protein interacts with tubulin.
Pre-Eclampsia
Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas.
Pre-Eclampsia
Differential proteomic analysis of highly purified placental cytotrophoblasts in preeclampsia demonstrates a state of increased oxidative stress and reduced cytotrophoblast antioxidant defense.
Pre-Eclampsia
Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Primary Graft Dysfunction
Chronic Lung Allograft Dysfunction: Immune Responses Induced by Circulating Exosomes with Lung-Associated Self-Antigens.
Prion Diseases
Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrP(Sc).
Prolactinoma
Immunofluorescence demonstration of tubulin and actin in estrogen-induced rat prolactinoma cells in vitro. Alteration of their distribution after bromocriptine, colchicine and cytochalasin B treatments.
Prostatic Hyperplasia
Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.
Prostatic Neoplasms
(Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells.
Prostatic Neoplasms
2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
Prostatic Neoplasms
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer.
Prostatic Neoplasms
A Phase II study of Paclitaxel and Vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: Double Tubulin Targeting.
Prostatic Neoplasms
Activation of membrane androgen receptors potentiates the antiproliferative effects of paclitaxel on human prostate cancer cells.
Prostatic Neoplasms
Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors.
Prostatic Neoplasms
Design, synthesis and biological evaluation of bridged epothilone D analogues.
Prostatic Neoplasms
Diethylstilbestrol and docetaxel: a Phase II study of tubulin active agents in patients with metastatic, androgen-independent prostate cancer.
Prostatic Neoplasms
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.
Prostatic Neoplasms
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Prostatic Neoplasms
Enzyme-responsive polymeric micelles of cabazitaxel for prostate cancer targeted therapy.
Prostatic Neoplasms
Epothilones: tubulin polymerization as a novel target for prostate cancer therapy.
Prostatic Neoplasms
Estrogen effects on tubulin expression and taxane mediated cytotoxicity in prostate cancer cells.
Prostatic Neoplasms
Estrogen receptor ? and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy.
Prostatic Neoplasms
Histone Deacetylase Inhibitor Potentiates Anticancer Effect of Docetaxel via Modulation of Bcl-2 Family Proteins and Tubulin in Hormone Refractory Prostate Cancer Cells.
Prostatic Neoplasms
KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.
Prostatic Neoplasms
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo.
Prostatic Neoplasms
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Prostatic Neoplasms
Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis.
Prostatic Neoplasms
Posttranscriptional regulation of T-type Ca(2+) channel expression by interleukin-6 in prostate cancer cells.
Prostatic Neoplasms
Regulation of microtubule, apoptosis, and cell cycle-related genes by taxotere in prostate cancer cells analyzed by microarray.
Prostatic Neoplasms
Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol.
Prostatic Neoplasms
Self-Catalyzed Assembly of Peptide Scaffolded Nanozyme as a Dynamic Biosensing System.
Prostatic Neoplasms
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Prostatic Neoplasms
Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents.
Prostatic Neoplasms
Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
Prostatic Neoplasms
Synthesis of 2-anilinopyridyl-triazole conjugates as antimitotic agents.
Prostatic Neoplasms
The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance.
Prostatic Neoplasms
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
Prostatic Neoplasms
The role of clusterin in prostate cancer: treatment resistance and potential as a therapeutic target.
Prostatic Neoplasms
Tubulin tyrosine ligase like 12, link to prostate cancer through tubulin post-translational modification and chromosome ploidy.
Prostatic Neoplasms
Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer.
Prostatic Neoplasms
Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
Prostatic Neoplasms
[Synergic effects of the combination of VEGF-targeted shRNA and taxol on human prostate cancer DU145 both in vitro and in vivo]
Prostatic Neoplasms, Castration-Resistant
Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na+ /K+ -ATPase internalization and tubulin acetylation.
Proteinuria
Modulation of cytoskeletal organization of podocytes during the course of aminonucleoside nephrosis in rats.
Psoriasis
Immunofluorescence of the tubulin system in human skin fibroblasts in Werner's syndrome, Kaposi sarcoma, and psoriasis.
Pulmonary Arterial Hypertension
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Purpura, Thrombocytopenic, Idiopathic
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).
Reflex, Abnormal
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Reperfusion Injury
Expression of tubulin folding cofactor B in mouse hepatic ischemia-reperfusion injury.
Retinal Degeneration
Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.
Retinal Degeneration
Correction: Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.
Retinal Degeneration
Distribution of microtubules in cultured RPE cells from normal and dystrophic RCS rats.
Retinal Degeneration
Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.
Retinitis Pigmentosa
ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation.
Retinitis Pigmentosa
Crystal structure of the actin binding domain of the cyclase-associated protein.
Retinoblastoma
Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression.
Retinopathy of Prematurity
Pharmacological Interventions for Vascular Targeting in Retinopathy of Prematurity: An Experimental Study.
Rhabdomyosarcoma
The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo.
Rhabdomyosarcoma, Alveolar
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.
Rotavirus Infections
Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton.
Rotavirus Infections
Sequestration of free tubulin molecules by the viral protein NSP2 induces microtubule depolymerization during rotavirus infection.
Sarcoidosis
Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis.
Sarcoma
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
Sarcoma
Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells.
Sarcoma
Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Sarcoma
Systemic inflammation response index (SIRI) as a predictive factor for overall survival in advanced soft tissue sarcoma treated with eribulin.
Sarcoma 180
Antitumor agents. II: Regio- and stereospecific syntheses of 1-beta-alkyl-1-desoxypodophyllotoxin derivatives and biological activity.
Sarcoma, Avian
Organization of pp60src and selected cytoskeletal proteins within adhesion plaques and junctions of Rous sarcoma virus-transformed rat cells.
Sarcoma, Avian
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues.
Sarcoma, Avian
Temperature-sensitive changes in surface modulating assemblies of fibroblasts transformed by mutants of Rous sarcoma virus.
Sarcoma, Kaposi
Immunofluorescence of the tubulin system in human skin fibroblasts in Werner's syndrome, Kaposi sarcoma, and psoriasis.
Sarcoma, Synovial
The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.
Schizencephaly
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Scleroderma, Systemic
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Seizures
Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus.
Seizures
De novo pathogenic variant in TUBB2A presenting with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay.
Seizures
Effect of qingyangshen on hippocampal alpha- and beta-tubulin gene expression during kainic acid induced epileptogenesis.
Severe Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Sleep Apnea Syndromes
Neural autoantibodies in patients with neurological symptoms and histories of chemical/mold exposures.
Sleep Deprivation
Sleep deprivation-induced protein changes in basal forebrain: Implications for synaptic plasticity.
Small Cell Lung Carcinoma
Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung cancer cell lines.
Spinal Cord Injuries
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Spondylitis, Ankylosing
Genome-wide DNA methylation analysis in ankylosing spondylitis identifies HLA-B*27 dependent and independent DNA methylation changes in whole blood.
Squamous Cell Carcinoma of Head and Neck
?- and ?-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
Squamous Cell Carcinoma of Head and Neck
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
Squamous Cell Carcinoma of Head and Neck
GAPD and tubulin are suitable internal controls for qPCR analysis of oral squamous cell carcinoma cell lines.
Squamous Cell Carcinoma of Head and Neck
The effects of PC-Spes on chemosensitive and chemoresistant head and neck cancer cells and primary mucosal keratinocytes.
Squamous Cell Carcinoma of Head and Neck
Tubulin ?-6 chain is a stably expressed reference gene in archival samples of normal oral tissue and oral squamous cell carcinoma.
Starvation
An estimation of the soluble tubulin content in Tetrahymena cells of normal and of size-altered phenotype.
Starvation
Evaluation and validation of experimental condition-specific reference genes for normalization of gene expression in Asia II-I Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae).
Starvation
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.
Starvation
Reference Gene Validation for Quantitative PCR Under Various Biotic and Abiotic Stress Conditions in Toxoptera citricida (Hemiptera, Aphidiae).
Starvation
Selection of housekeeping genes and demonstration of RNAi in cotton leafhopper, Amrasca biguttula biguttula (Ishida).
Stomach Neoplasms
Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells.
Stomach Neoplasms
Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
Stomach Neoplasms
Deacetylisovaltratum disrupts microtubule dynamics and causes G2/M-phase arrest in human gastric cancer cells in vitro.
Stomach Neoplasms
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Stomach Neoplasms
Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line.
Stomach Neoplasms
Elevated TUBA1A Might Indicate the Clinical Outcomes of Patients with Gastric Cancer, Being Associated with the Infiltration of Macrophages in the Tumor Immune Microenvironment.
Stomach Neoplasms
Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization.
Stomach Neoplasms
Identification of tubulin beta chain, thymosin beta-4-like protein 3, and cytochrome b-c1 complex subunit 1 as serological diagnostic biomarkers of gastric cancer.
Stomach Neoplasms
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.
Stroke
Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) - study protocol for a randomised controlled trial.
Stroke
Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation.
Stroke
Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex.
Stroke
Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits.
Supranuclear Palsy, Progressive
Antigenic characteristics of neurofibrillary tangles in progressive supranuclear palsy.
Supranuclear Palsy, Progressive
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Synucleinopathies
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Synucleinopathies
Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models.
Synucleinopathies
Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis.
Synucleinopathies
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies.
Synucleinopathies
Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Tachycardia
Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy.
Tauopathies
Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics.
Tauopathies
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Tauopathies
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy.
Tauopathies
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
Tauopathies
Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies.
Tauopathies
Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings.
Teratocarcinoma
Actin and tubulin in teratocarcinoma cells. Amount and intracellular organization upon cytodifferentiation.
Teratocarcinoma
Control of isotubulin expression during neuronal differentiation of mouse neuroblastoma and teratocarcinoma cell lines.
Teratoma
GRO? regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.
Teratoma
Transfection with pax6 Gene of Mouse Embryonic Stem Cells and Subsequent Cell Cloning Induced Retinal Neuron Progenitors, Including Retinal Ganglion Cell-Like Cells, in vitro.
Tetanus
Buoyant density gradient fractionation and flow cytometric analysis of embryonic rat cortical neurons and progenitor cells.
Thrombocytopenia
?-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia.
Thrombocytopenia
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
Thrombocytopenia
Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform.
Thrombocytosis
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
Thrombocytosis
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
Thrombosis
Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thymoma
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Thymoma
Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Thyroid Carcinoma, Anaplastic
Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines.
Thyroid Neoplasms
Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cells.
Tinea
A Molecular Epidemiological Survey of Clinically Important Dermatophytes in Iran Based on Specific RFLP Profiles of Beta-tubulin Gene.
Tinea
Clinical evaluation of ?-tubulin real-time PCR for rapid diagnosis of dermatophytosis, a comparison with mycological methods.
Tourette Syndrome
Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments.
Tremor
Developmental consequences of mutations in the 84B alpha-tubulin gene of Drosophila melanogaster.
Trench Fever
Use of the cell division protein FtsZ as a means of differentiating among Bartonella species.
Triple Negative Breast Neoplasms
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Triple Negative Breast Neoplasms
HDAC6 inhibition enhances the anti-tumor effect of eribulin through tubulin acetylation in triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
Neoadjuvant Docetaxel/Cyclophosphamide in Triple-negative Breast Cancer: Predictive Value of Class III-? Tubulin and Non-basal Subtype.
Triple Negative Breast Neoplasms
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Triple Negative Breast Neoplasms
Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
Trypanosomiasis
Antibodies that recognize alpha- and beta-tubulin inhibit in vitro growth of the fish parasite Trypanosoma danilewskyi, Laveran and Mesnil, 1904.
Trypanosomiasis
Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro.
Trypanosomiasis, African
An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome.
Trypanosomiasis, African
Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents.
Tuberculosis
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.
Tuberculosis
Computational studies of the properties and activities of selected trisubstituted benzimidazoles as potential antitubercular drugs inhibiting MTB-FtsZ polymerization.
Tuberculosis
Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
Tuberculosis
Functional analysis of TPM domain containing Rv2345 of Mycobacterium tuberculosis identifies its phosphatase activity.
Tuberculosis
Identification of a novel steroid derivative, NSC12983, as a paclitaxel-like tubulin assembly promoter by 3-D virtual screening.
Tuberculosis
In vitro polymerization of Mycobacterium leprae FtsZ OR Mycobacterium tuberculosis FtsZ is revived or abolished, respectively, by reciprocal mutation of a single residue.
Tuberculosis
Molecular dynamics analysis of the effects of GTP, GDP, and benzimidazole derivative on structural dynamics of a cell division protein FtsZ from Mycobacterium tuberculosis.
Tuberculosis
MtFtsX a predicted membrane domain of ABC transporter complex MtFtsEX of Mycobacterium tuberculosis interacts with the cell division protein MtFtsZ.
Tuberculosis
Mycobacterium tuberculosis cell division protein, FtsE, is an ATPase in dimeric form.
Tuberculosis
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Uremia
[The physiopathologic bases of the neurotoxicity of phosphorus chelating agents containing soluble aluminum salts in patients with renal insufficiency]
Urinary Bladder Neoplasms
Anticancer sulfonamide hybrids that inhibit bladder cancer cells growth and migration as tubulin polymerisation inhibitors.
Uterine Cervical Neoplasms
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and ?-III tubulin mediated tumor drug resistance in vitro.
Uterine Cervical Neoplasms
Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: evidence of distinct binding sites for these agents in tubulin.
Uterine Cervical Neoplasms
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Uterine Cervical Neoplasms
Expression of class III beta tubulin in cervical cancer patients administered preoperative radiochemotherapy: correlation with response to treatment and clinical outcome.
Uterine Cervical Neoplasms
Innervation of cervical carcinoma is mediated by cancer-derived exosomes.
Uterine Cervical Neoplasms
NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine - site.
Uterine Cervical Neoplasms
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.
Uterine Cervical Neoplasms
Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes.
Uterine Cervical Neoplasms
Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization.
Uterine Cervical Neoplasms
Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.
Uterine Neoplasms
An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines.
Uterine Neoplasms
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Uterine Neoplasms
SQ1274, a novel microtubule inhibitor, inhibits ovarian and uterine cancer cell growth.
Vaccinia
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
Vascular System Injuries
Investigation into the role of Stmn2 in vascular smooth muscle phenotype transformation during vascular injury via RNA sequencing and experimental validation.
Vascular System Injuries
Lesion complexity determines arterial drug distribution after local drug delivery.
Vesicular Stomatitis
An alternative fixation-processing method for preembedding ultrastructural immunocytochemistry of cytoplasmic antigens: the GBS (glutaraldehyde-borohydride-saponin) procedure.
Vesicular Stomatitis
Interaction between tubulin and the viral matrix protein of vesicular stomatitis virus: possible implications in the viral cytopathic effect.
Vesicular Stomatitis
NH2-terminal acidic region of the phosphoprotein of vesicular stomatitis virus can be functionally replaced by tubulin.
Vesicular Stomatitis
Stimulation of vesicular stomatitis virus in vitro RNA synthesis by microtubule-associated proteins.
Vesicular Stomatitis
Tubulin: a factor necessary for the synthesis of both Sendai virus and vesicular stomatitis virus RNAs.
Virus Diseases
Chronic Lung Allograft Dysfunction: Immune Responses Induced by Circulating Exosomes with Lung-Associated Self-Antigens.
Virus Diseases
Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways.
Virus Diseases
Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.
Virus Diseases
Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples.
Waldenstrom Macroglobulinemia
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
Waldenstrom Macroglobulinemia
Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities.
Werner Syndrome
Immunofluorescence of the tubulin system in human skin fibroblasts in Werner's syndrome, Kaposi sarcoma, and psoriasis.
Whooping Cough
ADPRibosylation of chicken red cell tubulin and inhibition of microtubule self-assembly in vitro by the NAD(+)-dependent avian ADPRibosyl transferase.
Whooping Cough
Changes of GTP binding proteins, not neurofilament-associated proteins, in the brain of the neurofilament-deficient quail, "Quiver".
Whooping Cough
Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.
Whooping Cough
Microtubule protein ADP-ribosylation in vitro leads to assembly inhibition and rapid depolymerization.
Whooping Cough
Studies of signal transduction in the respiratory burst-associated stimulation of fMet-Leu-Phe-induced tubulin tyrosinolation and phorbol 12-myristate 13-acetate-induced posttranslational incorporation of tyrosine into multiple proteins in activated neutrophils and HL-60 cells.
Wilms Tumor
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Wiskott-Aldrich Syndrome
Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.
Yellow Fever
Testis-specific expression of the beta2 tubulin promoter of Aedes aegypti and its application as a genetic sex-separation marker.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). FTSZ1_METJA
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
364
0
38924
Swiss-Prot
-
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
can polimerize in vitro, analysis of the dimer
additional information
-
can polimerize in vitro, analysis of the dimer
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
protonation of the GTP gamma-phosphate, simulating low pH, excludes both monovalent cations and the catalytic water molecule from the GTP binding site and stabilizes the dimer
699587
additional information
-
protonation of the GTP gamma-phosphate, simulating low pH, excludes both monovalent cations and the catalytic water molecule from the GTP binding site and stabilizes the dimer
699587
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mendieta, J.; Rico, A.I.; Lopez-Vinas, E.; Vicente, M.; Mingorance, J.; Gomez-Puertas, P.
Structural and functional model for ionic (K(+)/Na(+)) and pH dependence of GTPase activity and polymerization of FtsZ, the prokaryotic ortholog of tubulin
J. Mol. Biol.
390
17-25
2009
Methanocaldococcus jannaschii (Q57816), Methanocaldococcus jannaschii
brenda
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Release 2023.1 (January 2023)
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