Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.6.5.5 - dynamin GTPase and Organism(s) Rattus norvegicus and UniProt Accession P21575

for references in articles please use BRENDA:EC3.6.5.5
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Rattus norvegicus
UNIPROT: P21575
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
dynamin, dynamin-related protein 1, dynamin 2, d100, dynamin-2, dynamin 1, dynamin i, optic atrophy 1, dynamin-1, gtpase dynamin, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dynamin1
isoform
B-dynamin
-
-
-
-
D100
-
-
-
-
Dyn2ba
splice variant
Dyn2bb
splice variant
dynamin
dynamin 1
-
-
dynamin 2aa
Dynamin BREDNM19
-
-
-
-
dynamin GTPase
-
-
Dynamin UDNM
-
-
-
-
Dynamin, brain
-
-
-
-
Dynamin, testicular
-
-
-
-
dynamin-1 GTPase
-
-
dynamin-1-like protein
-
dynamin-2
dynamin-related protein 1
-
dynamin-retated GTPase Drp1
-
-
dynamin2
dynamin2 GTPase
-
dynamine-related GTPase
-
-
GTP phosphohydrolase
-
-
-
-
GTPase
-
-
-
-
GTPase dynamin
-
-
GTPase dynamin-related protein 1
-
-
guanine triphosphatase
-
-
-
-
guanosine 5'-triphosphatase
-
-
-
-
guanosine triphosphatase
-
-
-
-
mitofusin 1
-
-
phosphatase, guanosine tri-
-
-
-
-
ribosomal GTPase
-
-
-
-
Shibire protein
-
-
-
-
T-dynamin
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (vesicle-releasing)
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-32-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
ATP + H2O
ADP + phosphate
show the reaction diagram
-
dynamin also has ATPase activity
-
-
?
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
-
-
-
?
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Arc/Arg3.1
enhances dynamin polymerization and GTPase activity. The activity-regulated cytoskeleton-associated protein, Arc, is an immediate-early gene product implicated in various forms of synaptic plasticity. Arc promotes endocytosis of AMPA type glutamate receptors and regulates cytoskeletal assembly in neuronal dendrites. Bacterially-expressed His6-Arc facilitates the polymerization of Dyn2 and stimulates its GTPase activity under physiologic conditions (37°C and 100 mM NaCl). At lower ionic strength Arc also stabilizes preformed Dyn2 polymers against GTP-dependent disassembly, thereby prolonging assembly-dependent GTP hydrolysis catalyzed by Dyn2. Analysis of recombinant full-length mouse Arc and of His6-tagged fragments, including Arc-N (residues 1-227), Arc-C (residues 228-396), and Arc-(DELTA195-214). At physiologic ionic strength, Arc facilitates Dyn2 self-assembly but does not prevent GTP-dependent Dyn2 disassembly, which is expected to suppress rather than activate endocytosis
-
Ca2+
-
inhibits dynamin I GTPase activity after stimulation by phosphorylation or by phospholipids but not after stimulation a glutathione S-transferase-SH3 fusion protein containing the SH3-domain of phosphoinositide 3-kinase
dynasore
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Arc/Arg3.1
-
cardiolipin
stimulates Drp1, synergistically with mitochondrial fission factor
endogenouse rat brain vesicles
-
cooperative interactions between dynamin molecules are responsible for the apparent activation of GTPase observed
-
Grb2
-
stimulates
-
lipid tubule
-
stimulate GTPase activity
-
Mff-proteoliposome
lipid-stimulated GTPase activity
-
microtubules
-
mitochondrial fission factor
Mff, stimulates Drp1 independently of, but synergistically with cardiolipin
-
phosphatidylglycerol
-
stimulates
phosphatidylinositol
-
stimulates
phosphatidylserine
-
stimulates
phospholipase D
-
PLD function as a GTPase activating protein, GAP, through its phox homology domain, PX, which directly activates the GTPase domain of dynamin
-
Phospholipid
SH3 domains
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025 - 0.37
GTP
additional information
additional information
Michaelis-Menten kinetics
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0079 - 0.024
GTP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.16
-
the specific rate of GTP hydrolysis of dynamin stimulated by the PLDs-PX
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
GTPase assay
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
-
GTPase assay at room temperature
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
dynamin-1, endocrine cell of the gastric mucosa
Manually annotated by BRENDA team
Dyn1 is a neuron-specific isoform
Manually annotated by BRENDA team
dynamin2 is ubiquitously expressed, while dynamin1 is restricted to the nervous system
Manually annotated by BRENDA team
invasive bladder cancer cell
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isozyme dynamin2 only
Manually annotated by BRENDA team
-
Drp1 assembles into large complexes at future scission sites on the inner mitochondrial membrane
Manually annotated by BRENDA team
-
Drp1 binds to mitochondrial outer membrane via Fis1
Manually annotated by BRENDA team
-
dynamin 2
Manually annotated by BRENDA team
-
hippocampal synapse
Manually annotated by BRENDA team
additional information
-
localization of dynamin 2 depends on its Pro-rich domain, immunohistochemic determination of dynamin 2 localization during mitosis, overview
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Dyn1 is a neuron-specific isoform involved in synaptic vesicle recycling
evolution
there are three dynamin isoforms in mammalian cells: dynamin1 (neuronal isoform), dynamin2 (ubiquitous isoform) and dynamin3 (a testis, lung and brain isoform). All the dynamin isoforms share similar domain structures aligned from N-terminus to C-terminus: a GTPase domain, a middle domain, a PH domain, a GTPase effector domain (GED) and PRD domain
malfunction
metabolism
-
GTPase dynamin is the founding member of a family of GTPases that have diverse roles in membrane-remodelling events throughout the cell
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DYN1_RAT
864
0
97295
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterotetramer
-
Dyn2 can interfere with Dyn2 mutants or Dyn1, Dyn2-Dyn1, Dyn2S45N-Dyn1 and Dyn2-Dyn1I690K heteromers are formed
homotetramer
-
-
tetramer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
Drp1 is specifically phosphorylated in mitosis by Cdk1/cyclin B on Ser-585
side-chain modification
-
dynamin I phosphorylation by protein kinase C and dephosphorylation by calcineurin serve as molecular switches to control nerve terminal vesicle recycling
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging-drop method, 1.9 A crystal structure of the nucleotide-free GTPase domain of dynamin 1
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K44A
dominant-negative dynamin mutant
Dyn2DELTAPRD
-
truncation mutant lacking the C-terminal proline-arginine-rich domain, PRD
Dyn2I684K
-
point mutation to render Dyn2 defective in oligomerization and self-assembly
Dyn2I684KDELTAPRD
-
point mutation to render Dyn2 defective in oligomerization and self-assembly
Dyn2S45N
-
point mutation to render Dyn2 defective in GTP binding
Dyn2S45N/I684K
-
point mutations to render Dyn2 defective in GTP binding and in oligomerization and self-assembly
I690K
-
mutant is assembly incompetent and inactive for endocytosis
K38A
-
dominant-negative mutant
K44E
-
dominant-negative form of dynamin
K694A
-
mutant of dynamin that increases the rate of endocytosis owing to impaired assembly into higher order structures
R59A
-
kcat is 1.5fold lower than wild-type value, KM is 5.2fold higher than wild-type value
R59K
-
kcat is 3fold lower than wild-type value, KM is 2fold higher than wild-type value
S126A
-
mutation in the potential recognition site for Cdk1/cyclin B
S136A
-
mutation in the potential recognition site for Cdk1/cyclin B
S585A
-
exogenous expression of unphosphorylated mutant S585A leads to reduced mitotic mitochondrial fragmentation
S71A
-
mutation in the potential recognition site for Cdk1/cyclin B
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant C-terminally His6-tagged isozyme Dyn1 from Sf9 cells by nickel affinity chromatography and dialysis
glutathione S-transferase-fused proteins are purified from Escherichia coli strain BL21 using glutathione-Sepharose, full-length dynamin is purified from rat brain
-
recombinant C-terminally His6-tagged isozyme Dyn2 from Sf9 cells by nickel affinity chromatography and dialysis
recombinant C-terminally His6-tagged isozyme Dyn3 from Sf9 cells by nickel affinity chromatography and dialysis
recombinant His-Drp1 proteins are purified by metal-chelating resin and further purified by ion exchange chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in a fibroblastoid cell line and in embryonic stem cells
gene Dnm1, recombinant expression of C-terminally His6-tagged isozyme Dyn1 in Spodoptera frugiperda Sf9 cells
adenovirus expressing the dynamin mutant K44A is constructed
-
expressed in a fibroblastoid cell line and in embryonic stem cells
expressed in HEK-293 cells
-
expressed in HeLa cells
expression of dynamin II in Tn5 cells
-
expression of GFP-tagged or V5/His-tagged wild-type and K44A mutant dynamin 2aa in HeLa cells
-
gene DNM2, enzyme expression analysis, recombinant expression of GFP-tagged isozyme dynamin2 in human T24 cells
gene Dnm2, recombinant expression of C-terminally His6-tagged isozyme Dyn2 in Spodoptera frugiperda Sf9 cells
gene Dnm3, recombinant expression of C-terminally His6-tagged isozyme Dyn3 in Spodoptera frugiperda Sf9 cells
gene DNMTL1, recombinant expression of the splice variants of Drp1 in Escherichia coli strain BL21 Star (DE3)
into the pFLAG-CMV-2 vector, five functional dynamin domains, GTPase, Middle, pleckstrin homology, GTPase effector and proline rich, are subcloned into pGEX-4T2
-
the cDNA of rat Drp1 is subcloned into pEGFP-N1 and p3xFLAG-CMV-10 for transfection of HeLa cells, and in pET28a for expression in Escherichia coli
-
the vectors pcDNA3.1 and pADT3T7tet are used, recombinant adenoviruses are produced in HEK293-Cre cells
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, J.P.; Sim, A.T.R.; Robinson, P.J.
Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization
Science
265
970-973
1994
Rattus norvegicus
Manually annotated by BRENDA team
Rasmussen, R.K.; Rusak, J.; Price, G.; Robinson, P.J.; Simpson, R.J.; Dorow, D.S.
Mixed-lineage kinase 2-SH2 domain binds dynamin and greatly enhances activation of GTPase by phospholipid
Biochem. J.
335
119-124
1998
Ovis aries, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Oh, P.; McIntosh, D.P.; Schnitzer, J.E.
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium
J. Cell Biol.
141
101-114
1998
Rattus norvegicus
Manually annotated by BRENDA team
Tuma, P.L.; Stachniak, M.C.; Collins, C.A.
Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles
J. Biol. Chem.
268
17240-17246
1993
Rattus norvegicus
Manually annotated by BRENDA team
Tuma, P.L.; Collins, C.A.
Activation of dynamin GTPase is a result of positive cooperativity
J. Biol. Chem.
269
30842-30847
1994
Rattus norvegicus
Manually annotated by BRENDA team
Liu, J.P.; Zhang, Q.X.; Baldwin, G.; Robinson, P.J.
Calcium binds dynamin I and inhibits its GTPase activity
J. Neurochem.
66
2074-2081
1996
Rattus norvegicus
Manually annotated by BRENDA team
Fish, K.N.; Schmid, S.L.; Damke, H.
Evidence that dynamin-2 functions as a signal-transducing GTPase
J. Cell Biol.
150
145-154
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Gout, I.; Dhand, R.; Hiles, I.D.; Fry, M.J.; Panayotou, G; Das, P.; Truong, O.; Totty, N.F.; Hsuan, J.; Booker, G.W.; Campbell, I.D.; Waterfield, M.D.
: The GTPase dynamin binds to and is activated by a subset of SH3 domains
Cell
75
25-36
1993
Rattus norvegicus
Manually annotated by BRENDA team
Maeda, K.; Nakata, T.; Noda, Y.; Sato-Yoshitake, R.; Hirokawa, N.
Interaction of dynamin with microtubules: its structure and GTPase activity investigated by using highly purified dynamin
Mol. Biol. Cell
3
1181-1194
1992
Rattus norvegicus
Manually annotated by BRENDA team
Warnock, D.E.; Schmid, S.L.
Dynamin GTPase, a force-generating molecular switch
Bioessays
18
885-893
1996
Drosophila sp. (in: flies), Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Warnock, D.E.; Baba, T.; Schmidt, S.L.
Ubiquitously expressed dynamin-II has a higher intrinsic GTPase activity and a greater propensity for self-assembly than neuronal dynamin-I
Mol. Biol. Cell
8
2553-2562
1997
Rattus norvegicus
Manually annotated by BRENDA team
Jiang, S.; Avraham, H.K.; Kim, T.A.; Rogers, R.A.; Avraham, S.
Receptor-type PTP-NP inhibition of dynamin-1 GTPase activity is associated with neuronal depolarization
Cell. Signal.
18
1439-1446
2006
Rattus norvegicus
Manually annotated by BRENDA team
McNiven, M.A.; Baldassarre, M.; Buccione, R.
The role of dynamin in the assembly and function of podosomes and invadopodia
Front. Biosci.
9
1944-1953
2004
Rattus norvegicus
Manually annotated by BRENDA team
Zanner, R.; Gratzl, M.; Prinz, C.
Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells
J. Cell Sci.
117
2369-2376
2004
Rattus norvegicus (P21575), Rattus norvegicus (P39052)
Manually annotated by BRENDA team
Zhu, J.; Zhou, K.; Hao, J.J.; Liu, J.; Smith, N.; Zhan, X.
Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits
J. Cell Sci.
118
807-817
2005
Rattus norvegicus
Manually annotated by BRENDA team
Bruzzaniti, A.; Neff, L.; Sanjay, A.; Horne, W.C.; De Camilli, P.; Baron, R.
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity
Mol. Biol. Cell
16
3301-3313
2005
Rattus norvegicus
Manually annotated by BRENDA team
Roux, A.; Uyhazi, K.; Frost, A.; De Camilli, P.
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
Nature
441
528-531
2006
Rattus norvegicus
Manually annotated by BRENDA team
Reubold, T.F.; Eschenburg, S.; Becker, A.; Leonard, M.; Schmid, S.L.; Vallee, R.B.; Kull, F.J.; Manstein, D.J.
Crystal structure of the GTPase domain of rat dynamin 1
Proc. Natl. Acad. Sci. USA
102
13093-13098
2005
Rattus norvegicus
Manually annotated by BRENDA team
Lee, C.S.; Kim, I.S.; Park, J.B.; Lee, M.N.; Lee, H.Y.; Suh, P.G.; Ryu, S.H.
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis
Nat. Cell Biol.
8
477-484
2006
Rattus norvegicus
Manually annotated by BRENDA team
Barsoum, M.J.; Yuan, H.; Gerencser, A.A.; Liot, G.; Kushnareva, Y.; Graeber, S.; Kovacs, I.; Lee, W.D.; Waggoner, J.; Cui, J.; White, A.D.; Bossy, B.; Martinou, J.C.; Youle, R.J.; Lipton, S.A.; Ellisman, M.H.; Perkins, G.A.; Bossy-Wetzel, E.
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
EMBO J.
25
3900-3911
2006
Rattus norvegicus
Manually annotated by BRENDA team
Sever, S.; Skoch, J.; Newmyer, S.; Ramachandran, R.; Ko, D.; McKee, M.; Bouley, R.; Ausiello, D.; Hyman, B.T.; Bacskai, B.J.
Physical and functional connection between auxilin and dynamin during endocytosis
EMBO J.
25
4163-4174
2006
Rattus norvegicus
Manually annotated by BRENDA team
Soulet, F.; Schmid, S.L.; Damke, H.
Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2
Exp. Cell Res.
312
3539-3545
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Taguchi, N.; Ishihara, N.; Jofuku, A.; Oka, T.; Mihara, K.
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
J. Biol. Chem.
282
11521-11529
2007
Rattus norvegicus
Manually annotated by BRENDA team
Newton, A.J.; Kirchhausen, T.; Murthy, V.N.
Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis
Proc. Natl. Acad. Sci. USA
103
17955-17960
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hamao, K.; Morita, M.; Hosoya, H.
New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells
Exp. Cell Res.
315
1336-1345
2009
Rattus norvegicus (P39052)
Manually annotated by BRENDA team
Murphy, J.E.; Vohra, R.S.; Dunn, S.; Holloway, Z.G.; Monaco, A.P.; Homer-Vanniasinkam, S.; Walker, J.H.; Ponnambalam, S.
Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2
J. Cell Sci.
121
2136-2147
2008
Rattus norvegicus (P39052)
Manually annotated by BRENDA team
Xu, A.J.; Kuramasu, A.; Maeda, K.; Kinoshita, K.; Takayanagi, S.; Fukushima, Y.; Watanabe, T.; Yanagisawa, T.; Sukegawa, J.; Yanai, K.
Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent
J. Neurochem.
107
208-217
2008
Rattus norvegicus
Manually annotated by BRENDA team
Liu, Y.W.; Surka, M.C.; Schroeter, T.; Lukiyanchuk, V.; Schmid, S.L.
Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells
Mol. Biol. Cell
19
5347-5359
2008
Rattus norvegicus (P21575), Rattus norvegicus (P39052), Rattus norvegicus (Q08877), Homo sapiens (Q05193)
Manually annotated by BRENDA team
Rappoport, J.Z.; Heyman, K.P.; Kemal, S.; Simon, S.M.
Dynamics of dynamin during clathrin mediated endocytosis in PC12 cells
PLoS ONE
3
e2416
2008
Rattus norvegicus (P21575), Rattus norvegicus (P39052)
Manually annotated by BRENDA team
Ishida, N.; Nakamura, Y.; Tanabe, K.; Li, S.A.; Takei, K.
Dynamin 2 associates with microtubules at mitosis and regulates cell cycle progression
Cell Struct. Funct.
36
145-154
2011
Rattus norvegicus
Manually annotated by BRENDA team
Ferguson, S.M.; De Camilli, P.
Dynamin, a membrane-remodelling GTPase
Nat. Rev. Mol. Cell Biol.
13
75-88
2012
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Zhang, Y.; Nolan, M.; Yamada, H.; Watanabe, M.; Nasu, Y.; Takei, K.; Takeda, T.
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells
Biochem. Biophys. Res. Commun.
480
409-414
2016
Rattus norvegicus (P39052), Homo sapiens (P50570), Homo sapiens
Manually annotated by BRENDA team
Byers, C.E.; Barylko, B.; Ross, J.A.; Southworth, D.R.; James, N.G.; Taylor, C.A.; Wang, L.; Collins, K.A.; Estrada, A.; Waung, M.; Tassin, T.C.; Huber, K.M.; Jameson, D.M.; Albanesi, J.P.
Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1
Biochim. Biophys. Acta
1850
1310-1318
2015
Rattus norvegicus (P21575), Rattus norvegicus (P39052), Rattus norvegicus (Q08877)
Manually annotated by BRENDA team
Macdonald, P.J.; Francy, C.A.; Stepanyants, N.; Lehman, L.; Baglio, A.; Mears, J.A.; Qi, X.; Ramachandran, R.
Distinct splice variants of dynamin-related protein 1 differentially utilize mitochondrial fission factor as an effector of cooperative GTPase activity
J. Biol. Chem.
291
493-507
2016
Homo sapiens (O00429), Rattus norvegicus (O35303)
Manually annotated by BRENDA team