Any feedback?
Information on EC 3.6.5.5 - dynamin GTPase
for references in articles please use BRENDA:EC3.6.5.5Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.6.5.5 dynamin GTPaseIUBMB Comments
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Specify your search results
Word Map
- 3.6.5.5
-
endocytosis
- gtpases
-
endocytic
- clathrin
- actin
- synaptic
-
clathrin-mediated
- endosomes
-
dominant-negative
-
clathrin-coated
-
mitofusins
- cytoskeleton
- dynasore
- pi
- tubule
-
scission
-
mitophagy
-
constrict
- microtubule
- transferrin
-
receptor-mediated
- adaptor
- synapses
-
presynaptic
- myopathy
- rab5
- pink1
-
caveolae
-
brachytherapy
-
gtp-binding
- src
-
mechanochemical
-
clathrin-independent
- eps15
- caveolin-1
-
macropinocytosis
- parkin
- charcot-marie-tooth
-
cristae
-
pleckstrin
-
invagination
- arf6
- agriculture
- arrestins
- medicine
-
pten-induced
-
n-wasp
-
dosimetric
- cortactin
-
dose-volume
- grb2
- beta-arrestins
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
dynamin, dynamin-related protein 1, dynamin 2, d100, dynamin-2, dynamin 1, dynamin i, optic atrophy 1, dynamin-1, gtpase dynamin, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
B-dynamin
-
-
-
-
D100
-
-
-
-
Dynamin BREDNM19
-
-
-
-
Dynamin UDNM
-
-
-
-
Dynamin, brain
-
-
-
-
Dynamin, testicular
-
-
-
-
GTP phosphohydrolase
-
-
-
-
GTPase
-
-
-
-
guanine triphosphatase
-
-
-
-
guanosine 5'-triphosphatase
-
-
-
-
guanosine triphosphatase
-
-
-
-
phosphatase, guanosine tri-
-
-
-
-
ribosomal GTPase
-
-
-
-
Shibire protein
-
-
-
-
T-dynamin
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (vesicle-releasing)
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9059-32-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
the recombinant GTPase-GTPase effector domain fusion protein of human Drp1 shows GTPase activity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ionomycin
a calcium ionophore, causes rapid mitochondrial accumulation of actin filaments followed by Drp1 accumulation at the fission site, and increases fission rate
Mff protein
mitocjondrial protein Mff alone causes only a slight increase in Drp1 GTPase activity at the concentrations tested, while the combination of Mff and actin filaments causes a substantial increase in Drp1 activity, far beyond the additive effects of either Mff or actin alone
-
mitochondrial fission factor
Mff, stimulates Drp1 independently of, but synergistically with cardiolipin
-
additional information
interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
-
actin
actin filaments bind purified Drp1 and increase GTPase activity in a manner that is synergistic with the mitochondrial protein Mff, suggesting a role for direct Drp1/actin interaction
actin
actin filaments increase Drp1's GTPase activity eith a 3.5fold increase. The assembly of filaments of actin is the signal to Drp1 to accumulate on mitochondria and for fission
cardiolipin
Drp1 binding to anionic lipids such as cardiolipin increases its GTPase activity
cardiolipin
stimulates Drp1, synergistically with mitochondrial fission factor
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Adenocarcinoma
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Adenocarcinoma
SNPs in candidate genes MX dynamin-like GTPase and chemokine (C-C motif) receptor-5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep.
Adenocarcinoma of Lung
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Adenocarcinoma of Lung
Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1.
Adenocarcinoma of Lung
Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas.
Adenocarcinoma of Lung
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Adenoviridae Infections
Dynamin2 S-nitrosylation regulates adenovirus type 5 infection of epithelial cells.
Adenoviridae Infections
Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2.
Albuminuria
Sertraline Reduces Albuminuria by Interfering with Caveolae-Mediated Endocytosis through Glomerular Endothelial and Epithelial Cells.
Alzheimer Disease
Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.
Alzheimer Disease
Blocking GSK3?-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease.
Alzheimer Disease
Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models.
Alzheimer Disease
Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease.
Alzheimer Disease
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
Alzheimer Disease
Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism.
Alzheimer Disease
DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
Alzheimer Disease
Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells.
Alzheimer Disease
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Alzheimer Disease
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.
Alzheimer Disease
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients.
Alzheimer Disease
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Alzheimer Disease
Impaired Mitochondrial Dynamics and Abnormal Interaction of Amyloid Beta with Mitochondrial Protein Drp1 in Neurons from Patients with Alzheimer's Disease: Implications for Neuronal Damage.
Alzheimer Disease
Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons.
Alzheimer Disease
Mitochondrial dysfunction, mitophagy, and role of dynamin-related protein 1 in Alzheimer's disease.
Alzheimer Disease
Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease.
Alzheimer Disease
Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis.
Alzheimer Disease
No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Alzheimer Disease
Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases.
Alzheimer Disease
Reduced Dynamin-related Protein 1 Protects Against Phosphorylated Tau-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease.
Alzheimer Disease
Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Alzheimer Disease
S-Nitrosylation of Critical Protein Thiols Mediates Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases.
Alzheimer Disease
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
Alzheimer Disease
[Recent advances in the study of synaptic endocytosis key protein: Dynamin].
Amyotrophic Lateral Sclerosis
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Amyotrophic Lateral Sclerosis
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amyotrophic Lateral Sclerosis
The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation.
Anaphylaxis
The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis.
Anthrax
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process.
Arrhythmias, Cardiac
Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
Arthritis, Rheumatoid
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Asthma
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Ataxia
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Ataxia
Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons.
Atherosclerosis
Vav GEF regulates CD36-mediated macrophage foam cell formation via calcium and dynamin-dependent processes.
Blindness
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Blindness
Variation in OPA1 does not explain the incomplete penetrance of Leber hereditary optic neuropathy.
Bone Resorption
Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
Bone Resorption
The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts.
Botulism
Dynamin inhibition blocks botulinum neurotoxin type-A endocytosis in neurons and delays botulism.
Brain Diseases
A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy.
Brain Diseases
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
Brain Diseases
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.
Brain Diseases
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Brain Diseases
Clinical Assessments and EEG Analyses of Encephalopathies Associated With Dynamin-1 Mutation.
Brain Diseases
Clinical-genetic features and peculiar muscle histopathology in infantile DNM1L-related mitochondrial epileptic encephalopathy.
Brain Diseases
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Brain Diseases
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Brain Diseases
De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy.
Brain Diseases
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
Brain Diseases
Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis.
Brain Diseases
Insights into dynamin-associated disorders through analysis of equivalent mutations in the yeast dynamin Vps1.
Brain Diseases
Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila.
Brain Diseases
Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.
Brain Diseases
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Brain Diseases
RNAi-Based Gene Therapy Rescues Developmental and Epileptic Encephalopathy in a Genetic Mouse Model.
Brain Diseases
[Analysis of DNM1L gene variant in a case of fatal encephalopathy caused by mitochondrial peroxidase division deficiency].
Brain Diseases
[DNM1L gene variant caused encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1: three cases report and literature review].
Brain Injuries
Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1-Drp1 pathway.
Brain Injuries
Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury.
Brain Injuries
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Brain Injuries
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Brain Injuries
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
Brain Injuries
Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats.
Brain Injuries
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.
Brain Ischemia
Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1.
Brain Ischemia
Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Brain Ischemia
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Brain Ischemia
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Brain Ischemia
Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury.
Brain Neoplasms
Hippocampal Dosimetry and the Necessity of Hippocampal-Sparing in Gamma Knife Stereotactic Radiosurgery for Extensive Brain Metastases.
Breast Neoplasms
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
Breast Neoplasms
Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.
Breast Neoplasms
Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death.
Breast Neoplasms
Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells.
Breast Neoplasms
Epstein-Barr virus latent membrane protein-2A alters mitochondrial dynamics promoting cellular migration mediated by Notch signaling pathway.
Breast Neoplasms
Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.
Breast Neoplasms
Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells.
Breast Neoplasms
Functional regulation of oestrogen receptor pathway by the dynein light chain 1.
Breast Neoplasms
Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.
Breast Neoplasms
Illuminating Superoxide Anion and pH Enhancements in Apoptosis of Breast Cancer Cells Induced by Mitochondrial Hyperfusion Using a New Two-Photon Fluorescence Probe.
Breast Neoplasms
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Breast Neoplasms
Investigation of cellular uptake mechanism of functionalised gold nanoparticles into breast cancer using SERS.
Breast Neoplasms
Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells.
Breast Neoplasms
Mitochondrial dynamics regulates migration and invasion of breast cancer cells.
Breast Neoplasms
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.
Breast Neoplasms
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells.
Carcinogenesis
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Carcinogenesis
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.
Carcinogenesis
Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells.
Carcinogenesis
Expression of dynamin immunoreactivity in experimental pancreatic tumors induced in rat by mancozeb-nitrosomethylurea.
Carcinogenesis
Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma.
Carcinogenesis
Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis.
Carcinogenesis
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma.
Carcinogenesis
The expression and prognostic significance of Drp1 in lung cancer: A bioinformatics analysis and immunohistochemistry.
Carcinoma
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Carcinoma
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Carcinoma
Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner.
Carcinoma, Hepatocellular
Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway.
Carcinoma, Hepatocellular
DNM3 Attenuates Hepatocellular Carcinoma Growth by Activating P53.
Carcinoma, Hepatocellular
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Carcinoma, Hepatocellular
Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production.
Carcinoma, Hepatocellular
Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis.
Carcinoma, Hepatocellular
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Dynasore potentiates c-Met inhibitors against hepatocellular carcinoma through destabilizing c-Met.
Carcinoma, Hepatocellular
Glucocorticoid Modulation of Mitochondrial Function in Hepatoma Cells Requires the Mitochondrial Fission Protein Drp1.
Carcinoma, Hepatocellular
Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells.
Carcinoma, Hepatocellular
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways.
Carcinoma, Hepatocellular
The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles.
Carcinoma, Hepatocellular
The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.
Carcinoma, Non-Small-Cell Lung
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Carcinoma, Pancreatic Ductal
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma.
Carcinoma, Squamous Cell
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Cardiomegaly
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Cardiomegaly
Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats.
Cardiomegaly
Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.
Cardiomyopathies
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
Cardiomyopathies
Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects.
Cardiomyopathies
Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.
Cardiomyopathies
Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.
Cardiomyopathies
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction.
Cardiomyopathies
LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy.
Cardiomyopathies
The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.
Cardiomyopathy, Dilated
Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.
Cardiomyopathy, Dilated
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.
Cardiovascular Diseases
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Cardiovascular Diseases
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes.
Cerebral Infarction
YiQiFuMai Powder Injection Protects against Ischemic Stroke via Inhibiting Neuronal Apoptosis and PKC
Cervical Intraepithelial Neoplasia
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Charcot-Marie-Tooth Disease
Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
Charcot-Marie-Tooth Disease
Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.
Charcot-Marie-Tooth Disease
Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.
Charcot-Marie-Tooth Disease
Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.
Charcot-Marie-Tooth Disease
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation.
Charcot-Marie-Tooth Disease
Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
Charcot-Marie-Tooth Disease
The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.
Charcot-Marie-Tooth Disease
Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
Charcot-Marie-Tooth Disease
[Non-fortuitous dynamin II mutation-related association: Neutropenia and Charcot-Marie-Tooth disease.]
Chlamydia Infections
Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth.
Cholangiocarcinoma
Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines.
Cholera
Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum.
Cholera
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.
Cholera
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts.
Cholera
Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.
Cholera
Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells.
Ciliary Motility Disorders
Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.
Ciliary Motility Disorders
Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1.
Coinfection
Infectious pancreatic necrosis virus inhibits infectious hematopoietic necrosis virus at the early stage of infection in a time dependent manner during Co-infection in Chinook salmon embryo cell lines.
Colitis
Perturbed Mitochondrial Dynamics Is a Novel Feature of Colitis That Can Be Targeted to Lessen Disease.
Colonic Neoplasms
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis.
Colonic Neoplasms
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Colonic Neoplasms
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Colorectal Neoplasms
HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.
Coma
Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis.
Contracture
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation.
COVID-19
Multi-omics analysis of respiratory specimen characterizes baseline molecular determinants associated with SARS-CoV-2 outcome.
Cysts
Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila.
Cysts
Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
Cysts
PsVPS1, a Dynamin-Related Protein, Is Involved in Cyst Germination and Soybean Infection of Phytophthora sojae.
Cytomegalovirus Infections
Dynamin Is Required for Efficient Cytomegalovirus Maturation and Envelopment.
Cytomegalovirus Infections
NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.
Deafness
The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.
Dementia
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
Dementia
Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.
Dementia
Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.
Demyelinating Diseases
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.
Diabetes Mellitus
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Diabetes Mellitus, Type 1
Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats.
Diabetes Mellitus, Type 2
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Diabetic Nephropathies
Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy.
Diabetic Retinopathy
Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy.
Diffuse Axonal Injury
Dynamin and reverse-mode sodium calcium exchanger blockade confers neuroprotection from diffuse axonal injury.
Diphtheria
Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor.
Diphtheria
Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin.
Drug Resistant Epilepsy
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
Drug Resistant Epilepsy
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.
Drug Resistant Epilepsy
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Drug Resistant Epilepsy
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
dynamin gtpase deficiency
Clathrin- and dynamin-dependent endocytosis limits canonical NF-?B signaling triggered by lymphotoxin ? receptor.
dynamin gtpase deficiency
DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries.
dynamin gtpase deficiency
Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling.
dynamin gtpase deficiency
Dynamin deficiency causes insulin secretion failure and hyperglycemia.
dynamin gtpase deficiency
Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice.
dynamin gtpase deficiency
Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy.
dynamin gtpase deficiency
Dynamin-Related Protein 1 Deficiency Leads to Receptor-Interacting Protein Kinase 3-Mediated Necroptotic Neurodegeneration.
dynamin gtpase deficiency
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Dysarthria
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Dystonia
De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus.
Dystonia
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Encephalitis
Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis.
Encephalitis, Japanese
Japanese encephalitis virus enters rat neuroblastoma cells via a pH-dependent, dynamin and caveola-mediated endocytosis pathway.
Endometrial Neoplasms
Drp1 mediates high glucose-induced mitochondrial dysfunction and epithelial-mesenchymal transition in endometrial cancer cells.
Ephemeral Fever
Bovine ephemeral fever virus uses a clathrin-mediated and dynamin 2-dependent endocytosis pathway that requires Rab5 and Rab7 as well as microtubules.
Ephemeral Fever
Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF-?B pathways as well as Cox-2-mediated PGE2 /EP receptor signalling to enhance clathrin-mediated virus endocytosis.
Epilepsy
A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.
Epilepsy
De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy.
Epilepsy
De-novo mutations in patients with chronic ultra-refractory epilepsy with onset after age five years.
Epilepsy
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
Epilepsy
Mdivi-1 Protects Epileptic Hippocampal Neurons from Apoptosis via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress in Vitro.
Epilepsy
[Expression of dynamin-1 and phosphor-dynamin-1 in the hippocampus of children and rats with mesial temporal lobe epilepsy].
Epilepsy, Temporal Lobe
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
Epilepsy, Temporal Lobe
[Expression of dynamin-1 and phosphor-dynamin-1 in the hippocampus of children and rats with mesial temporal lobe epilepsy].
Epileptic Syndromes
De novo DNM1L mutation associated with mitochondrial epilepsy syndrome with fever sensitivity.
Esophageal Neoplasms
Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics.
Feline Infectious Peritonitis
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Gaucher Disease
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Glaucoma
DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.
Glaucoma
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan.
Glaucoma, Open-Angle
No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations.
Glaucoma, Open-Angle
The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma.
Glioblastoma
Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
Glioblastoma
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells.
Glioblastoma
Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.
Glioma
A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression.
Glioma
Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics.
Glioma
Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA.
Glioma
Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.
Glomerulonephritis
Sertraline Reduces Albuminuria by Interfering with Caveolae-Mediated Endocytosis through Glomerular Endothelial and Epithelial Cells.
Glucose Intolerance
Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis.
Heart Arrest
Inhibition of dynamin-related protein 1 has neuroprotective effect comparable with therapeutic hypothermia in a rat model of cardiac arrest.
Heart Arrest
Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model.
Heart Arrest
Therapeutic hypothermia attenuates global cerebral reperfusion-induced mitochondrial damage by suppressing dynamin-related protein 1 activation and mitochondria-mediated apoptosis in a cardiac arrest rat model.
Heart Failure
Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.
Heart Failure
Dynamin-2 mediates heart failure by modulating Ca(2+)-dependent cardiomyocyte apoptosis.
Heart Failure
OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability.
Heart Failure
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.
Heart Failure
Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure.
Hepatitis B
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.
Hepatitis B
The large GTPase dynamin is required for hepatitis B virus protein secretion from hepatocytes.
Hepatitis E
Hepatitis E Virus enters liver cells through a Dynamin-2, Clathrin and membrane cholesterol dependent pathway.
Herpes Simplex
Cellular internalization of green fluorescent protein fused with herpes simplex virus protein VP22 via a lipid raft-mediated endocytic pathway independent of caveolae and Rho family GTPases but dependent on dynamin and Arf6.
Herpes Simplex
Herpes Simplex Virus 1 Can Enter Dynamin 1 and 2 Double-Knockout Fibroblasts.
Herpes Simplex
Hsv-1 Endocytic Entry into a Human Oligodendrocytic Cell Line is Mediated by Clathrin and Dynamin but Not Caveolin.
Herpes Simplex
{alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2.
Herpes Zoster
Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.
HIV Infections
HIV infection is influenced by dynamin at 3 independent points in the viral life cycle.
HIV Infections
Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry.
HIV Infections
TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function.
Huntington Disease
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Huntington Disease
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
Huntington Disease
S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease.
Hyperglycemia
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Hyperglycemia
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Hyperinsulinism
Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons.
Hyperinsulinism
Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress.
Hypertension
Correlation between the expression of Drp1 in vascular endothelial cells and inflammatory factors in hypertension rats.
Hypertension
ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.
Hypertension, Pulmonary
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Hypertension, Pulmonary
Reactive oxygen species effect PASMCs apoptosis via regulation of dynamin-related protein 1 in hypoxic pulmonary hypertension.
Hypothyroidism
A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism.
Hypothyroidism
Hypothyroidism after 3-dimensional conformal radiotherapy and intensity modulated radiotherapy for head and neck cancers: Prospective data from two randomized controlled trials.
Infarction, Middle Cerebral Artery
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
Infarction, Middle Cerebral Artery
Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1-Drp1 pathway.
Infarction, Middle Cerebral Artery
Hyperglycemia Alters Mitochondrial Fission and Fusion Proteins in Mice Subjected to Cerebral Ischemia and Reperfusion.
Infarction, Middle Cerebral Artery
Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke.
Infarction, Middle Cerebral Artery
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Infections
A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells.
Infections
A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host.
Infections
A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection.
Infections
A plant RNA virus hijacks endocytic proteins to establish its infection in plants.
Infections
Association of chemokine-mediated block to HIV entry with coreceptor internalization.
Infections
Blockade of dengue virus entry into myeloid cells by endocytic inhibitors in the presence or absence of antibodies.
Infections
Bovine ephemeral fever virus uses a clathrin-mediated and dynamin 2-dependent endocytosis pathway that requires Rab5 and Rab7 as well as microtubules.
Infections
Bovine Parainfluenza Virus Type 3 (BPIV3) Enters HeLa Cells via Clathrin-Mediated Endocytosis in a Cholesterol- and Dynamin-Dependent Manner.
Infections
Caveolin-1 is involved in encephalomyocarditis virus replication in BHK-21 cells.
Infections
Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein.
Infections
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Infections
Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes.
Infections
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.
Infections
Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs).
Infections
Contribution of MX dynamin, oligoadenylate synthetase, and protein kinase R to anti-paramyxovirus activity of type 1 interferons in vitro.
Infections
DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans.
Infections
Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission.
Infections
Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification.
Infections
Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection.
Infections
Dynamin2 S-nitrosylation regulates adenovirus type 5 infection of epithelial cells.
Infections
Early stages of influenza virus entry into Mv-1 lung cells: involvement of dynamin.
Infections
Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events.
Infections
Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7.
Infections
Elevated endosomal pH in HeLa cells overexpressing mutant dynamin can affect infection by pH-sensitive viruses.
Infections
Endocytosis, Cytotoxicity, and Translocation of Shiga Toxin-2 Are Stimulated by Infection of Human Intestinal (HCT-8) Monolayers With an Hypervirulent E. coli O157:H7 Lacking stx2 Gene.
Infections
Entry of Challenge Virus Standard (CVS) -11 into N2a cells via a clathrin-mediated, cholesterol-, dynamin-, pH-dependent endocytic pathway.
Infections
Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
Infections
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity.
Infections
Experimental pathogenicity of viscerotropic and dermotropic isolates of Leishmania infantum from immunocompromised and immunocompetent patients in a murine model.
Infections
Formation of a stable mimic of ambient particulate matter containing viable infectious respiratory syncytial virus and its dry-deposition directly onto cell cultures.
Infections
Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation.
Infections
Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells.
Infections
Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence.
Infections
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.
Infections
HIV infection is influenced by dynamin at 3 independent points in the viral life cycle.
Infections
HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis.
Infections
Hsv-1 Endocytic Entry into a Human Oligodendrocytic Cell Line is Mediated by Clathrin and Dynamin but Not Caveolin.
Infections
Human Metapneumovirus Is Capable of Entering Cells by Fusion with Endosomal Membranes.
Infections
Human papillomavirus type 31 uses a caveolin 1- and dynamin 2-mediated entry pathway for infection of human keratinocytes.
Infections
Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent.
Infections
Infectious pancreatic necrosis virus inhibits infectious hematopoietic necrosis virus at the early stage of infection in a time dependent manner during Co-infection in Chinook salmon embryo cell lines.
Infections
Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus.
Infections
Interaction of human dynein light chain 1 (DYNLL1) with enterochelin esterase (Salmonella typhimurium) and protective antigen (Bacillus anthraci) might be the potential cause of human infection.
Infections
Interplay between Clathrin and Rab5 Controls the Early Phagocytic Trafficking and Intracellular Survival of Brucella abortus within HeLa cells.
Infections
Lymphocystis Disease Virus (Iridoviridae) Enters Flounder (Paralichthys olivaceus) Gill Cells via a Caveolae-Mediated Endocytosis Mechanism Facilitated by Viral Receptors.
Infections
Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy.
Infections
Mitogen-activated protein kinases are required for effective infection of human choroid plexus epithelial cells by Listeria monocytogenes.
Infections
Molecular identification and comparative transcriptional analysis of myxovirus resistance GTPase (Mx) gene in goose (Anser cygnoide) after H9N2 AIV infection.
Infections
Murine norovirus-1 cell entry is mediated through a non-clathrin, non-caveolae, dynamin and cholesterol dependent pathway.
Infections
Oncolytic H-1 Parvovirus Enters Cancer Cells through Clathrin-Mediated Endocytosis.
Infections
PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles.
Infections
Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.
Infections
Porcine sapovirus Cowden strain enters LLC-PK cells via clathrin- and cholesterol-dependent endocytosis with the requirement of dynamin II.
Infections
PsVPS1, a Dynamin-Related Protein, Is Involved in Cyst Germination and Soybean Infection of Phytophthora sojae.
Infections
Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body.
Infections
Rift Valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis.
Infections
Risk of infection according to the gamma globulin level in the 100 days following allogeneic stem cell transplantations.
Infections
Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection.
Infections
Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
Infections
The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus.
Infections
The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-?.
Infections
Transmembrane TNF-? Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy.
Infections
Transplant Energize Me Patient Outcome (TEMPO): A Quality Improvement Project that Maintains Functional Mobility in Pediatric Patients Admitted for Allogeneic Hematopoietic Cell Transplantation.
Infections
Uptake of Rabies Virus into Epithelial Cells by Clathrin-Mediated Endocytosis Depends upon Actin.
Infections
[Role of the adaptins, dynamin like GTP-ases and Rab proteins in metabolic disorders and various infections]
Infertility
Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.
Infertility
Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Influenza, Human
Early stages of influenza virus entry into Mv-1 lung cells: involvement of dynamin.
Influenza, Human
Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein.
Influenza, Human
Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.
Influenza, Human
Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop.
Influenza, Human
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Insulin Resistance
A multiscale study of the role of dynamin in the regulation of glucose uptake.
Insulin Resistance
Increased Dynamin-Related Protein 1-Dependent Mitochondrial Fission Contributes to High-Fat-Diet-Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts.
Insulin Resistance
Pharmacological inhibition of dynamin-related protein 1 attenuates skeletal muscle insulin resistance in obesity.
Insulinoma
A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic ?-Cells.
Iron Overload
Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection.
Ischemic Attack, Transient
Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice.
Ischemic Stroke
Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke.
Kidney Diseases
More expression, less function: cleaved dynamin in glomerular kidney disease.
Kidney Diseases
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.
Kidney Diseases
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Lennox Gastaut Syndrome
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
Leukemia
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Leukemia
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Leukemia, Myeloid
Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells.
Lewy Body Disease
Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.
Lewy Body Disease
Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.
Liver Cirrhosis
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
Low Tension Glaucoma
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan.
Lung Neoplasms
Bcl-2-enhanced efficacy of microtubule-targeting chemotherapy through Bim overexpression: implications for cancer treatment.
Lung Neoplasms
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Lung Neoplasms
Crosstalk between Akt/GSK3? signaling and dynamin-1 regulates clathrin-mediated endocytosis.
Lung Neoplasms
Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model.
Lung Neoplasms
Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET-GBR2-STAT3 Complex Formation.
Lung Neoplasms
Dynasore suppresses proliferation and induces apoptosis of the non-small-cell lung cancer cell line A549.
Lung Neoplasms
Effects of Dynamin-related Protein 1 Regulated Mitochondrial Dynamic Changes on Invasion and Metastasis of Lung Cancer Cells.
Lung Neoplasms
High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1.
Lung Neoplasms
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Lung Neoplasms
The expression and prognostic significance of Drp1 in lung cancer: A bioinformatics analysis and immunohistochemistry.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lupus Erythematosus, Systemic
Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Lymphatic Metastasis
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Lymphocytic Choriomeningitis
Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.
Lymphoma
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Lymphoma
Effects of biphasic and monophasic electrical stimulation on mitochondrial dynamics, cell apoptosis, and cell proliferation.
Lymphoma, B-Cell
Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice.
Lymphoma, B-Cell
Effects of biphasic and monophasic electrical stimulation on mitochondrial dynamics, cell apoptosis, and cell proliferation.
Lymphoma, B-Cell
Mitochondrial separation protein inhibitor inhibits cell apoptosis in rat lungs during intermittent hypoxia.
Lymphoma, B-Cell
T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway.
Megalencephaly
Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development.
Melanoma
Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas.
Memory Disorders
Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Memory Disorders
Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation.
Microcephaly
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.
Microcephaly
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Microcephaly
Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function.
Mitochondrial Diseases
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Mitochondrial Diseases
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Mitochondrial Diseases
DNM1L-Related Mitochondrial Fission Defects Presenting as Encephalopathy: A Case Report and Literature Review.
Mitochondrial Diseases
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Multiple Sclerosis
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Muscle Hypotonia
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Muscle Weakness
Clinical, Electrophysiology, and Pathology Features of Dynamin Centronuclear Myopathy: A Case Report and Review of Literature.
Muscle Weakness
Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness.
Muscular Atrophy
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Muscular Diseases
A novel dynamin-2 gene mutation associated with a late-onset centronuclear myopathy with necklace fibres.
Muscular Diseases
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
Muscular Diseases
Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset.
Muscular Diseases
Allele-Specific CRISPR/Cas9 Correction of a Heterozygous DNM2 Mutation Rescues Centronuclear Myopathy Cell Phenotypes.
Muscular Diseases
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.
Muscular Diseases
Impaired excitation-contraction coupling in muscle fibres from the dynamin2
Muscular Diseases
Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy.
Muscular Diseases
MRI in DNM2-related centronuclear myopathy: evidence for highly selective muscle involvement.
Muscular Diseases
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Muscular Diseases
Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations.
Muscular Diseases
Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice.
Myocardial Infarction
Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.
Myocardial Infarction
Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart.
Myocardial Infarction
Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction.
Myocardial Infarction
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Myocardial Ischemia
Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing.
Myocardial Ischemia
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
Myoclonus
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Myopathies, Structural, Congenital
A case of de novo dynamin 2-related centronuclear myopathy with electrical but not clinical myotonia.
Myopathies, Structural, Congenital
A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice.
Myopathies, Structural, Congenital
A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells.
Myopathies, Structural, Congenital
A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation.
Myopathies, Structural, Congenital
A novel dynamin-2 gene mutation associated with a late-onset centronuclear myopathy with necklace fibres.
Myopathies, Structural, Congenital
A novel mutation in the DNM2 gene impairs dynamin 2 localization in skeletal muscle of a patient with late onset centronuclear myopathy.
Myopathies, Structural, Congenital
A novel mutation in the dynamin 2 gene in a Charcot-Marie-Tooth type 2 patient: clinical and pathological findings.
Myopathies, Structural, Congenital
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
Myopathies, Structural, Congenital
Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset.
Myopathies, Structural, Congenital
Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2.
Myopathies, Structural, Congenital
Allele-Specific CRISPR/Cas9 Correction of a Heterozygous DNM2 Mutation Rescues Centronuclear Myopathy Cell Phenotypes.
Myopathies, Structural, Congenital
Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy.
Myopathies, Structural, Congenital
Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.
Myopathies, Structural, Congenital
BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin.
Myopathies, Structural, Congenital
Calcium homeostasis alterations in a mouse model of the Dynamin 2-related centronuclear myopathy.
Myopathies, Structural, Congenital
Centronuclear myopathies under attack: A plethora of therapeutic targets.
Myopathies, Structural, Congenital
Centronuclear myopathy related to dynamin 2 mutations: Clinical, morphological, muscle imaging and genetic features of an Italian cohort.
Myopathies, Structural, Congenital
Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
Myopathies, Structural, Congenital
Characterization of the muscle involvement in dynamin 2-related centronuclear myopathy.
Myopathies, Structural, Congenital
Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle.
Myopathies, Structural, Congenital
Clinical, Electrophysiology, and Pathology Features of Dynamin Centronuclear Myopathy: A Case Report and Review of Literature.
Myopathies, Structural, Congenital
Clinical, pathological, and genetic features of dynamin-2-related centronuclear myopathy in China.
Myopathies, Structural, Congenital
Clinicopathological features of centronuclear myopathy in Japanese populations harboring mutations in dynamin 2.
Myopathies, Structural, Congenital
Correlative SICM-FCM reveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations in dynamin.
Myopathies, Structural, Congenital
Defective membrane remodeling in neuromuscular diseases: insights from animal models.
Myopathies, Structural, Congenital
Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers.
Myopathies, Structural, Congenital
Different in vivo impacts of dynamin 2 mutations implicated in Charcot-Marie-Tooth neuropathy or centronuclear myopathy.
Myopathies, Structural, Congenital
Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.
Myopathies, Structural, Congenital
Dynamin 2 mutants linked to centronuclear myopathies form abnormally stable polymers.
Myopathies, Structural, Congenital
Dynamin 2 mutations cause sporadic centronuclear myopathy with neonatal onset.
Myopathies, Structural, Congenital
Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination.
Myopathies, Structural, Congenital
Dynamin 2-related centronuclear myopathy: clinical, histological and genetic aspects of further patients and review of the literature.
Myopathies, Structural, Congenital
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
Myopathies, Structural, Congenital
Dynamin-2 Function and Dysfunction Along the Secretory Pathway.
Myopathies, Structural, Congenital
Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation.
Myopathies, Structural, Congenital
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.
Myopathies, Structural, Congenital
Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy.
Myopathies, Structural, Congenital
Histopathologic changes in the extraocular muscle in centronuclear myopathy with a Dynamin 2 mutation.
Myopathies, Structural, Congenital
Impaired excitation-contraction coupling in muscle fibres from the dynamin2
Myopathies, Structural, Congenital
Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness.
Myopathies, Structural, Congenital
Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy.
Myopathies, Structural, Congenital
Mice with muscle-specific deletion of Bin1 recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes.
Myopathies, Structural, Congenital
Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy.
Myopathies, Structural, Congenital
Mitochondrial alterations in dynamin 2-related centronuclear myopathy.
Myopathies, Structural, Congenital
MRI in DNM2-related centronuclear myopathy: evidence for highly selective muscle involvement.
Myopathies, Structural, Congenital
Multi-omics comparisons of different forms of centronuclear myopathies and the effects of several therapeutic strategies.
Myopathies, Structural, Congenital
Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves.
Myopathies, Structural, Congenital
Mutant BIN1-Dynamin 2 complexes dysregulate membrane remodeling in the pathogenesis of centronuclear myopathy.
Myopathies, Structural, Congenital
Mutation Spectrum in the Large GTPase Dynamin 2, and Genotype-Phenotype Correlation in Autosomal Dominant Centronuclear Myopathy.
Myopathies, Structural, Congenital
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
Myopathies, Structural, Congenital
Mutations in dynamin 2 cause dominant centronuclear myopathy.
Myopathies, Structural, Congenital
Myopathic (not neuropathic) electrophysiological abnormalities in dynamin 2-related centronuclear myopathy.
Myopathies, Structural, Congenital
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Myopathies, Structural, Congenital
Novel molecular diagnostic approaches for X-linked centronuclear (myotubular) myopathy reveal intronic mutations.
Myopathies, Structural, Congenital
Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model.
Myopathies, Structural, Congenital
Oligomerization of dynamin superfamily proteins in health and disease.
Myopathies, Structural, Congenital
Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.
Myopathies, Structural, Congenital
Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations.
Myopathies, Structural, Congenital
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation.
Myopathies, Structural, Congenital
Phenotypic variability in a large Czech family with a Dynamin 2-associated Charcot-Marie-Tooth neuropathy.
Myopathies, Structural, Congenital
Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to dynamin.
Myopathies, Structural, Congenital
Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy.
Myopathies, Structural, Congenital
Reducing dynamin 2 expression rescues X-linked centronuclear myopathy.
Myopathies, Structural, Congenital
Satellite cells deficiency and defective regeneration in dynamin 2-related centronuclear myopathy.
Myopathies, Structural, Congenital
Sporadic centronuclear myopathy with muscle pseudohypertrophy, neutropenia, and necklace fibers due to a DNM2 mutation.
Myopathies, Structural, Congenital
Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
Myopathies, Structural, Congenital
The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.
Myopathies, Structural, Congenital
The intragenic microRNA miR199A1 in the dynamin 2 gene contributes to the pathology of X-linked centronuclear myopathy.
Myopathies, Structural, Congenital
Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
Myopathies, Structural, Congenital
Zebrafish as a Model to Investigate Dynamin 2-Related Diseases.
Myopathies, Structural, Congenital
[Mutations in dynamin 2 cause dominant centronuclear myopathy.]
Myopathies, Structural, Congenital
[Recent advances in the study of synaptic endocytosis key protein: Dynamin].
Myopathy, Central Core
MRI in DNM2-related centronuclear myopathy: evidence for highly selective muscle involvement.
Myotonia
A case of de novo dynamin 2-related centronuclear myopathy with electrical but not clinical myotonia.
nadh:ubiquinone reductase (h+-translocating) deficiency
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.
Nasopharyngeal Carcinoma
Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.
Neoplasm Metastasis
A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells.
Neoplasm Metastasis
Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.
Neoplasm Metastasis
Alteration of nuclear protein profiling for NIH-3T3 cells exposed to H?O?.
Neoplasm Metastasis
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Neoplasm Metastasis
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.
Neoplasm Metastasis
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Neoplasm Metastasis
Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis.
Neoplasm Metastasis
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Neoplasm Metastasis
Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein.
Neoplasm Metastasis
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Neoplasm Metastasis
Effects of Dynamin-related Protein 1 Regulated Mitochondrial Dynamic Changes on Invasion and Metastasis of Lung Cancer Cells.
Neoplasm Metastasis
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.
Neoplasm Metastasis
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Neoplasm Metastasis
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Neoplasm Metastasis
Mitochondrial dynamics regulates migration and invasion of breast cancer cells.
Neoplasms
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
Neoplasms
A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target.
Neoplasms
Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.
Neoplasms
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Neoplasms
CEACAM6 is a prognostic biomarker and potential therapeutic target for gastric carcinoma.
Neoplasms
Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression.
Neoplasms
Construction of a recombinant eukaryotic expression vector containing DNM3 gene and its expression in colon cancer cells.
Neoplasms
Correlation between intensity modulated radiotherapy and bone marrow suppression in breast cancer.
Neoplasms
Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis.
Neoplasms
Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission.
Neoplasms
Development of the "Day 100 Talk": Addressing existing communication gaps during the early cancer treatment period in childhood cancer.
Neoplasms
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.
Neoplasms
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Neoplasms
Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study.
Neoplasms
Dosimetry, efficacy, and safety of three-dimensional printing noncoplanar template-assisted and CT-guided 125I seed implantation for recurrent retroperitoneal lymphatic metastasis after external beam radiotherapy.
Neoplasms
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Neoplasms
DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.
Neoplasms
Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance.
Neoplasms
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Neoplasms
Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1.
Neoplasms
Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET-GBR2-STAT3 Complex Formation.
Neoplasms
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
Neoplasms
Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production.
Neoplasms
Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis.
Neoplasms
Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.
Neoplasms
Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.
Neoplasms
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Neoplasms
Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.
Neoplasms
Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death.
Neoplasms
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Neoplasms
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells.
Neoplasms
Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.
Neoplasms
Efficacy and safety of CT-guided high-dose-rate interstitial brachytherapy in primary and secondary malignancies of the pancreas.
Neoplasms
Efficacy and safety of percutaneous computed tomography-guided high-dose-rate interstitial brachytherapy in treatment of oligometastatic lymph node metastases of retroperitoneal space.
Neoplasms
EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway.
Neoplasms
Expression of dynamin immunoreactivity in experimental pancreatic tumors induced in rat by mancozeb-nitrosomethylurea.
Neoplasms
Expression profiling of osteosarcoma cells transfected with MDR1 and NEO genes: regulation of cell adhesion, apoptosis, and tumor suppression-related genes.
Neoplasms
Feasibility and acceptability of the "Day 100 Talk": An interdisciplinary communication intervention during the first six months of childhood cancer treatment.
Neoplasms
Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts.
Neoplasms
Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells.
Neoplasms
Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells.
Neoplasms
Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
Neoplasms
HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy.
Neoplasms
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Neoplasms
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma.
Neoplasms
Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.
Neoplasms
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota.
Neoplasms
Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site.
Neoplasms
Isolation of polysaccharides from Dendrobium officinale leaves and anti-inflammatory activity in LPS-stimulated THP-1 cells.
Neoplasms
Label-Free Semiquantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics Analysis of Laryngeal/Hypopharyngeal Squamous Cell Carcinoma on Formalin-Fixed, Paraffin-Embedded Tissue Samples - a Pilot Study.
Neoplasms
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Neoplasms
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Neoplasms
Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer.
Neoplasms
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis.
Neoplasms
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Neoplasms
Methylation of an intronic region regulates miR-199a in testicular tumor malignancy.
Neoplasms
Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics.
Neoplasms
Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer.
Neoplasms
Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1.
Neoplasms
N'-[4-(dipropylamino)benzylidene]-2-hydroxybenzohydrazide is a dynamin GTPase inhibitor that suppresses cancer cell migration and invasion by inhibiting actin polymerization.
Neoplasms
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.
Neoplasms
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Neoplasms
Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions.
Neoplasms
Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.
Neoplasms
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Neoplasms
Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell.
Neoplasms
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma.
Neoplasms
Silencing Drp1 inhibits glioma cells proliferation and invasion by RHOA/ ROCK1 pathway.
Neoplasms
The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.
Neoplasms
The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy.
Neoplasms
The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target?
Neoplasms
TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation.
Neoplasms
[Effects of heme oxygenase-1/carbon monoxide pathway on the mitochondrial fusion in rat alveolar epithelial type II cells stimulated by lipopolysaccharide].
Nephrotic Syndrome
Drugs targeting dynamin can restore cytoskeleton and focal contact alterations of urinary podocytes derived from patients with nephrotic syndrome.
Nervous System Diseases
Clinical Assessments and EEG Analyses of Encephalopathies Associated With Dynamin-1 Mutation.
Nervous System Diseases
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Nervous System Diseases
DNM1L-Related Mitochondrial Fission Defects Presenting as Encephalopathy: A Case Report and Literature Review.
Nervous System Diseases
Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury.
Nervous System Diseases
OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database.
Nervous System Diseases
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Nervous System Diseases
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Nervous System Diseases
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
Nervous System Malformations
Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
Neuralgia
Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide Induced by Perineural Human Immunodeficiency Virus gp120 in Rats.
Neuroblastoma
Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons.
Neuroblastoma
Japanese encephalitis virus enters rat neuroblastoma cells via a pH-dependent, dynamin and caveola-mediated endocytosis pathway.
Neuroblastoma
Stabilization of Actin Bundles by a Dynamin 1/Cortactin Ring Complex Is Necessary for Growth Cone Filopodia.
Neurodegenerative Diseases
A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.
Neurodegenerative Diseases
Analysis of mitochondrial structure and function in the Drosophila larval musculature.
Neurodegenerative Diseases
Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.
Neurodegenerative Diseases
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Neurodegenerative Diseases
Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.
Neurodegenerative Diseases
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Neurodegenerative Diseases
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.
Neurodegenerative Diseases
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Neurodegenerative Diseases
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Neurodegenerative Diseases
Mdivi-1 pretreatment mitigates isoflurane-induced cognitive deficits in developmental rats.
Neurodegenerative Diseases
Mitochondrial fission in apoptosis, neurodegeneration and aging.
Neurodegenerative Diseases
Presynaptic loss of dynamin related protein 1 impairs synaptic vesicle release and recycling at the mouse calyx of held.
Neurodegenerative Diseases
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy.
Neurodegenerative Diseases
The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation.
Neuroinflammatory Diseases
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.
Neuromuscular Diseases
Defective membrane remodeling in neuromuscular diseases: insights from animal models.
Neuromuscular Diseases
Dynamin 2 (DNM2) as Cause of, and Modifier for, Human Neuromuscular Disease.
Neutropenia
Impact of Preemptive Therapy for Cytomegalovirus on Toxicities after Allogeneic Hematopoietic Cell Transplantation in Clinical Practice: A Retrospective Single-Center Cohort Study.
Neutropenia
[Non-fortuitous dynamin II mutation-related association: Neutropenia and Charcot-Marie-Tooth disease.]
Newcastle Disease
Newcastle Disease Virus Entry into Chicken Macrophages via a pH-Dependent, Dynamin and Caveola-Mediated Endocytic Pathway That Requires Rab5.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Obesity
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Obesity
Pharmacological inhibition of dynamin-related protein 1 attenuates skeletal muscle insulin resistance in obesity.
Obesity, Morbid
Distinct Adaptations of Mitochondrial Dynamics to Electrical Pulse Stimulation in Lean and Severely Obese Primary Myotubes.
Optic Atrophies, Hereditary
Concurrent AFG3L2 and SPG7 mutations associated with syndromic parkinsonism and optic atrophy with aberrant OPA1 processing and mitochondrial network fragmentation.
Optic Atrophy
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function.
Optic Atrophy
A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis.
Optic Atrophy
Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents.
Optic Atrophy
Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics.
Optic Atrophy
Allyl Methyl Sulfide Preserved Pressure Overload-Induced Heart Failure Via Modulation of Mitochondrial Function.
Optic Atrophy
Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Optic Atrophy
Bromodomain-containing protein 4 inhibitor JQ1 promotes melanoma cell apoptosis by regulating mitochondrial dynamics.
Optic Atrophy
Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fission.
Optic Atrophy
Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells.
Optic Atrophy
Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G-?B-Crystallin-Induced Desmin-Related Cardiomyopathy.
Optic Atrophy
Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress.
Optic Atrophy
Effects of clenbuterol administration on mitochondrial morphology and its regulatory proteins in rat skeletal muscle.
Optic Atrophy
Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis.
Optic Atrophy
Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).
Optic Atrophy
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Optic Atrophy
Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.
Optic Atrophy
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Optic Atrophy
Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder.
Optic Atrophy
Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission.
Optic Atrophy
Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury.
Optic Atrophy
OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling.
Optic Atrophy
Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins.
Optic Atrophy
Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery.
Optic Atrophy
Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.
Optic Atrophy
Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins.
Optic Atrophy
The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.
Optic Atrophy
The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells.
Optic Atrophy, Autosomal Dominant
2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function.
Optic Atrophy, Autosomal Dominant
A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis.
Optic Atrophy, Autosomal Dominant
A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family.
Optic Atrophy, Autosomal Dominant
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
Optic Atrophy, Autosomal Dominant
A novel 3q29 deletion associated with autism, intellectual disability, psychiatric disorders, and obesity.
Optic Atrophy, Autosomal Dominant
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function.
Optic Atrophy, Autosomal Dominant
A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders.
Optic Atrophy, Autosomal Dominant
A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis.
Optic Atrophy, Autosomal Dominant
A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family.
Optic Atrophy, Autosomal Dominant
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Optic Atrophy, Autosomal Dominant
Abscisic acid suppresses the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation.
Optic Atrophy, Autosomal Dominant
Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation.
Optic Atrophy, Autosomal Dominant
Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.
Optic Atrophy, Autosomal Dominant
Activation of protein kinase C-?/heme oxygenase-1 signaling pathway improves mitochondrial dynamics in lipopolysaccharide-activated NR8383 cells.
Optic Atrophy, Autosomal Dominant
Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells.
Optic Atrophy, Autosomal Dominant
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.
Optic Atrophy, Autosomal Dominant
Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics.
Optic Atrophy, Autosomal Dominant
Alu-element insertion in an OPA1 intron sequence associated with autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: Implication of oxidative stress and apoptosis.
Optic Atrophy, Autosomal Dominant
Analysis of mitochondrial structure and function in the Drosophila larval musculature.
Optic Atrophy, Autosomal Dominant
Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene.
Optic Atrophy, Autosomal Dominant
Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens.
Optic Atrophy, Autosomal Dominant
Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.
Optic Atrophy, Autosomal Dominant
Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress.
Optic Atrophy, Autosomal Dominant
Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens.
Optic Atrophy, Autosomal Dominant
Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Optic Atrophy, Autosomal Dominant
Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer's Disease in the Korean Population.
Optic Atrophy, Autosomal Dominant
Association of OPA1 Polymorphisms with NTG and HTG: A Meta-Analysis.
Optic Atrophy, Autosomal Dominant
Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells.
Optic Atrophy, Autosomal Dominant
Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2.
Optic Atrophy, Autosomal Dominant
Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.
Optic Atrophy, Autosomal Dominant
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria.
Optic Atrophy, Autosomal Dominant
Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing.
Optic Atrophy, Autosomal Dominant
C-Phycocyanin Ameliorates Mitochondrial Fission and Fusion Dynamics in Ischemic Cardiomyocyte Damage.
Optic Atrophy, Autosomal Dominant
Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury.
Optic Atrophy, Autosomal Dominant
Cardiac mitochondrial dynamics: miR-mediated regulation during cardiac injury.
Optic Atrophy, Autosomal Dominant
Cardiac-specific overexpression of thioredoxin 1 attenuates mitochondrial and myocardial dysfunction in septic mice.
Optic Atrophy, Autosomal Dominant
Changes in mitochondrial morphology and bioenergetics in human lymphoblastoid cells with four novel OPA1 mutations.
Optic Atrophy, Autosomal Dominant
Characterization of Ca2+ signalling in postnatal mouse retinal ganglion cells: involvement of OPA1 in Ca2+ clearance.
Optic Atrophy, Autosomal Dominant
Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue.
Optic Atrophy, Autosomal Dominant
Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China.
Optic Atrophy, Autosomal Dominant
Concurrent OPA1 mutation and chromosome 3q deletion leading to Behr syndrome: a case report.
Optic Atrophy, Autosomal Dominant
Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division.
Optic Atrophy, Autosomal Dominant
Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy.
Optic Atrophy, Autosomal Dominant
Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding.
Optic Atrophy, Autosomal Dominant
Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic.
Optic Atrophy, Autosomal Dominant
Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics.
Optic Atrophy, Autosomal Dominant
Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.
Optic Atrophy, Autosomal Dominant
Deficit of in vivo mitochondrial ATP production in OPA1-related dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism.
Optic Atrophy, Autosomal Dominant
Depletion of Mitofusin-2 Causes Mitochondrial Damage in Cisplatin-Induced Neuropathy.
Optic Atrophy, Autosomal Dominant
Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease.
Optic Atrophy, Autosomal Dominant
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1.
Optic Atrophy, Autosomal Dominant
Dietary fucoxanthin increases metabolic rate and upregulated mRNA expressions of the PGC-1alpha network, mitochondrial biogenesis and fusion genes in white adipose tissues of mice.
Optic Atrophy, Autosomal Dominant
Diluted serum from calorie-restricted animals promotes mitochondrial ?-cell adaptations and protect against glucolipotoxicity.
Optic Atrophy, Autosomal Dominant
Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects.
Optic Atrophy, Autosomal Dominant
Disturbed mitochondrial dynamics and neurodegenerative disorders.
Optic Atrophy, Autosomal Dominant
Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.
Optic Atrophy, Autosomal Dominant
Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage.
Optic Atrophy, Autosomal Dominant
Does Metformin Modulate Mitochondrial Dynamics and Function in Type 2 Diabetic Patients?
Optic Atrophy, Autosomal Dominant
Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1.
Optic Atrophy, Autosomal Dominant
Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.
Optic Atrophy, Autosomal Dominant
Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation.
Optic Atrophy, Autosomal Dominant
Downregulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.
Optic Atrophy, Autosomal Dominant
Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle.
Optic Atrophy, Autosomal Dominant
Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice.
Optic Atrophy, Autosomal Dominant
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Optic Atrophy, Autosomal Dominant
Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells.
Optic Atrophy, Autosomal Dominant
Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G-?B-Crystallin-Induced Desmin-Related Cardiomyopathy.
Optic Atrophy, Autosomal Dominant
Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer.
Optic Atrophy, Autosomal Dominant
Effect of mito-TEMPO, a mitochondria-targeted antioxidant, in rats with neuropathic pain.
Optic Atrophy, Autosomal Dominant
Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity.
Optic Atrophy, Autosomal Dominant
Effects of Al Exposure on Mitochondrial Dynamics in Rat Hippocampus.
Optic Atrophy, Autosomal Dominant
Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis.
Optic Atrophy, Autosomal Dominant
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
Optic Atrophy, Autosomal Dominant
Effects of voluntary wheel running on mitochondrial content and dynamics in rat skeletal muscle.
Optic Atrophy, Autosomal Dominant
Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle.
Optic Atrophy, Autosomal Dominant
Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.
Optic Atrophy, Autosomal Dominant
Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement.
Optic Atrophy, Autosomal Dominant
Exploring the effect of Gupi Xiaoji Prescription on hepatitis B virus-related liver cancer through network pharmacology and in vitro experiments.
Optic Atrophy, Autosomal Dominant
Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network.
Optic Atrophy, Autosomal Dominant
First Cases of Dominant Optic Atrophy in Saudi Arabia: Report of Two Novel OPA1 Mutations.
Optic Atrophy, Autosomal Dominant
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Optic Atrophy, Autosomal Dominant
Fourteen novel OPA1 mutations in autosomal dominant optic atrophy including two de novo mutations in sporadic optic atrophy.
Optic Atrophy, Autosomal Dominant
Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery.
Optic Atrophy, Autosomal Dominant
Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).
Optic Atrophy, Autosomal Dominant
Genomics combined with a protein informatics platform to assess a novel pathogenic variant c.1024 A>G (p.K342E) in OPA1 in a patient with autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast.
Optic Atrophy, Autosomal Dominant
Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina.
Optic Atrophy, Autosomal Dominant
Granulosa Cell and Oocyte Mitochondrial Abnormalities in a Mouse Model of Fragile X Primary Ovarian Insufficiency.
Optic Atrophy, Autosomal Dominant
H2O2 induces caveolin?1 degradation and impaired mitochondrial function in E11 podocytes.
Optic Atrophy, Autosomal Dominant
Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner.
Optic Atrophy, Autosomal Dominant
Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.
Optic Atrophy, Autosomal Dominant
Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.
Optic Atrophy, Autosomal Dominant
Huangqi-Danshen Decoction Ameliorates Adenine-Induced Chronic Kidney Disease by Modulating Mitochondrial Dynamics.
Optic Atrophy, Autosomal Dominant
Human muscular mitochondrial fusion in athletes during exercise.
Optic Atrophy, Autosomal Dominant
Human Ovarian Cancer Tissue Exhibits Increase of Mitochondrial Biogenesis and Cristae Remodeling.
Optic Atrophy, Autosomal Dominant
Human skeletal muscle fiber type-specific responses to sprint interval and moderate-intensity continuous exercise: acute and training-induced changes.
Optic Atrophy, Autosomal Dominant
Human skeletal muscle mRNAResponse to a single hypoxic exercise bout.
Optic Atrophy, Autosomal Dominant
Hyperglycemia Alters Mitochondrial Fission and Fusion Proteins in Mice Subjected to Cerebral Ischemia and Reperfusion.
Optic Atrophy, Autosomal Dominant
Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.
Optic Atrophy, Autosomal Dominant
Indomethacin impairs mitochondrial dynamics by activating the PKC?-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.
Optic Atrophy, Autosomal Dominant
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.
Optic Atrophy, Autosomal Dominant
Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes.
Optic Atrophy, Autosomal Dominant
Inner membrane fusion mediates spatial distribution of axonal mitochondria.
Optic Atrophy, Autosomal Dominant
Interval and continuous exercise overcome memory deficits related to ?-Amyloid accumulation through modulating mitochondrial dynamics.
Optic Atrophy, Autosomal Dominant
Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction.
Optic Atrophy, Autosomal Dominant
L-OPA1 regulates mitoflash biogenesis independently from membrane fusion.
Optic Atrophy, Autosomal Dominant
Leptin enhances glycolysis via OPA1-mediated mitochondrial fusion to promote mesenchymal stem cell survival.
Optic Atrophy, Autosomal Dominant
Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation.
Optic Atrophy, Autosomal Dominant
Levosimendan in rats decreases acute kidney injury after cardiopulmonary resuscitation by improving mitochondrial dysfunction.
Optic Atrophy, Autosomal Dominant
Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity.
Optic Atrophy, Autosomal Dominant
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.
Optic Atrophy, Autosomal Dominant
Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis.
Optic Atrophy, Autosomal Dominant
Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways.
Optic Atrophy, Autosomal Dominant
Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection.
Optic Atrophy, Autosomal Dominant
Meta-analysis of genotype-phenotype analysis of OPA1 mutations in autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
MICOS and the mitochondrial inner membrane morphology - when things get out of shape.
Optic Atrophy, Autosomal Dominant
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes.
Optic Atrophy, Autosomal Dominant
Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells.
Optic Atrophy, Autosomal Dominant
Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis.
Optic Atrophy, Autosomal Dominant
Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.
Optic Atrophy, Autosomal Dominant
Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage.
Optic Atrophy, Autosomal Dominant
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis.
Optic Atrophy, Autosomal Dominant
Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases.
Optic Atrophy, Autosomal Dominant
Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis.
Optic Atrophy, Autosomal Dominant
Mitochondrial dynamics: overview of molecular mechanisms.
Optic Atrophy, Autosomal Dominant
Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate.
Optic Atrophy, Autosomal Dominant
Mitochondrial fission in apoptosis, neurodegeneration and aging.
Optic Atrophy, Autosomal Dominant
Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes.
Optic Atrophy, Autosomal Dominant
Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling.
Optic Atrophy, Autosomal Dominant
Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way.
Optic Atrophy, Autosomal Dominant
Mitochondrial Membrane Dynamics-Functional Positioning of OPA1.
Optic Atrophy, Autosomal Dominant
Mitochondrial network structure homeostasis and cell death.
Optic Atrophy, Autosomal Dominant
Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.
Optic Atrophy, Autosomal Dominant
Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats.
Optic Atrophy, Autosomal Dominant
Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.
Optic Atrophy, Autosomal Dominant
Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder.
Optic Atrophy, Autosomal Dominant
Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy.
Optic Atrophy, Autosomal Dominant
Neural stem cell transplantation enhances mitochondrial biogenesis in a transgenic mouse model of Alzheimer's disease-like pathology.
Optic Atrophy, Autosomal Dominant
Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity.
Optic Atrophy, Autosomal Dominant
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.
Optic Atrophy, Autosomal Dominant
No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations.
Optic Atrophy, Autosomal Dominant
Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease.
Optic Atrophy, Autosomal Dominant
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Ontogeny of muscle bioenergetics in Adelie penguin chicks (Pygoscelis adeliae).
Optic Atrophy, Autosomal Dominant
OPA1 and mitochondrial solute carriers in bioenergetic metabolism.
Optic Atrophy, Autosomal Dominant
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.
Optic Atrophy, Autosomal Dominant
Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy.
Optic Atrophy, Autosomal Dominant
OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.
Optic Atrophy, Autosomal Dominant
OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.
Optic Atrophy, Autosomal Dominant
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation.
Optic Atrophy, Autosomal Dominant
OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma.
Optic Atrophy, Autosomal Dominant
OPA1 expression in the normal rat retina and optic nerve.
Optic Atrophy, Autosomal Dominant
OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability.
Optic Atrophy, Autosomal Dominant
OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases.
Optic Atrophy, Autosomal Dominant
OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange.
Optic Atrophy, Autosomal Dominant
Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control.
Optic Atrophy, Autosomal Dominant
OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling.
Optic Atrophy, Autosomal Dominant
OPA1 requires mitofusin 1 to promote mitochondrial fusion.
Optic Atrophy, Autosomal Dominant
OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.
Optic Atrophy, Autosomal Dominant
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells.
Optic Atrophy, Autosomal Dominant
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
Optic Atrophy, Autosomal Dominant
OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion.
Optic Atrophy, Autosomal Dominant
OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology.
Optic Atrophy, Autosomal Dominant
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Optic Atrophy, Autosomal Dominant
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.
Optic Atrophy, Autosomal Dominant
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
Optic Atrophy, Autosomal Dominant
Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria.
Optic Atrophy, Autosomal Dominant
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.
Optic Atrophy, Autosomal Dominant
Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts.
Optic Atrophy, Autosomal Dominant
Optic atrophy plus phenotype due to mutations in the OPA1 gene: Two more Italian families.
Optic Atrophy, Autosomal Dominant
Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction.
Optic Atrophy, Autosomal Dominant
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Optic Atrophy, Autosomal Dominant
Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure.
Optic Atrophy, Autosomal Dominant
Oxidized LDL Causes Endothelial Apoptosis by Inhibiting Mitochondrial Fusion and Mitochondria Autophagy.
Optic Atrophy, Autosomal Dominant
PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels.
Optic Atrophy, Autosomal Dominant
PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction.
Optic Atrophy, Autosomal Dominant
Phenoxythiophene sulfonamide compound B355252 protects neuronal cells against glutamate-induced excitotoxicity by attenuating mitochondrial fission and the nuclear translocation of AIF.
Optic Atrophy, Autosomal Dominant
Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins.
Optic Atrophy, Autosomal Dominant
Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery.
Optic Atrophy, Autosomal Dominant
Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells.
Optic Atrophy, Autosomal Dominant
Polymorphism Analysis of GSTM1 and OPA1 Genes in Greek Patients with Primary Open-angle Glaucoma.
Optic Atrophy, Autosomal Dominant
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology.
Optic Atrophy, Autosomal Dominant
Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function.
Optic Atrophy, Autosomal Dominant
Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex.
Optic Atrophy, Autosomal Dominant
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.
Optic Atrophy, Autosomal Dominant
Protective effect of hyperoside against renal ischemia-reperfusion injury via modulating mitochondrial fission, oxidative stress, and apoptosis.
Optic Atrophy, Autosomal Dominant
Protective Effect of Optic Atrophy 1 on Cardiomyocyte Oxidative Stress: Roles of Mitophagy, Mitochondrial Fission, and MAPK/ERK Signaling.
Optic Atrophy, Autosomal Dominant
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Optic Atrophy, Autosomal Dominant
Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy.
Optic Atrophy, Autosomal Dominant
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes NRF2-Independent Mitochondrial Fusion through CXCR4/PSMB5-Mediated Drp1 Degradation in Endothelial Cells.
Optic Atrophy, Autosomal Dominant
Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion.
Optic Atrophy, Autosomal Dominant
Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.
Optic Atrophy, Autosomal Dominant
Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome.
Optic Atrophy, Autosomal Dominant
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1.
Optic Atrophy, Autosomal Dominant
Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells.
Optic Atrophy, Autosomal Dominant
Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion.
Optic Atrophy, Autosomal Dominant
Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function.
Optic Atrophy, Autosomal Dominant
Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration.
Optic Atrophy, Autosomal Dominant
Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression.
Optic Atrophy, Autosomal Dominant
RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity.
Optic Atrophy, Autosomal Dominant
Role of Pd(II)-chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics.
Optic Atrophy, Autosomal Dominant
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
Optic Atrophy, Autosomal Dominant
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
Optic Atrophy, Autosomal Dominant
Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest.
Optic Atrophy, Autosomal Dominant
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs.
Optic Atrophy, Autosomal Dominant
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.
Optic Atrophy, Autosomal Dominant
Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion.
Optic Atrophy, Autosomal Dominant
Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.
Optic Atrophy, Autosomal Dominant
Silver Nanoparticle Exposure Causes Pulmonary Structural Damage and Mitochondrial Dynamic Imbalance in the Rat: Protective Effects of Sodium Selenite.
Optic Atrophy, Autosomal Dominant
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
Optic Atrophy, Autosomal Dominant
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway.
Optic Atrophy, Autosomal Dominant
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Optic Atrophy, Autosomal Dominant
StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria.
Optic Atrophy, Autosomal Dominant
Stoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage.
Optic Atrophy, Autosomal Dominant
Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy.
Optic Atrophy, Autosomal Dominant
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Optic Atrophy, Autosomal Dominant
Structure, function, and regulation of mitofusin-2 in health and disease.
Optic Atrophy, Autosomal Dominant
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression.
Optic Atrophy, Autosomal Dominant
Tang Luo Ning, a Traditional Chinese Compound Prescription, Ameliorates Schwannopathy of Diabetic Peripheral Neuropathy Rats by Regulating Mitochondrial Dynamics In Vivo and In Vitro.
Optic Atrophy, Autosomal Dominant
Targeted next-generation sequencing extends the mutational spectrums for OPA1 mutations in Chinese families with optic atrophy.
Optic Atrophy, Autosomal Dominant
Testosterone induces up-regulation of mitochondrial gene expression in murine C2C12 skeletal muscle cells accompanied by an increase of nuclear respiratory factor-1 and its downstream effectors.
Optic Atrophy, Autosomal Dominant
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock.
Optic Atrophy, Autosomal Dominant
The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.
Optic Atrophy, Autosomal Dominant
The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells.
Optic Atrophy, Autosomal Dominant
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.
Optic Atrophy, Autosomal Dominant
The Differential DRP1 Phosphorylation and Mitochondrial Dynamics in the Regional Specific Astroglial Death Induced by Status Epilepticus.
Optic Atrophy, Autosomal Dominant
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
Optic Atrophy, Autosomal Dominant
The G401D mutation of OPA1 causes autosomal dominant optic atrophy and hearing loss in a Chinese family.
Optic Atrophy, Autosomal Dominant
The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.
Optic Atrophy, Autosomal Dominant
The mitochondrial inner membrane GTPase, Optic Atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.
Optic Atrophy, Autosomal Dominant
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Optic Atrophy, Autosomal Dominant
The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.
Optic Atrophy, Autosomal Dominant
The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma.
Optic Atrophy, Autosomal Dominant
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage.
Optic Atrophy, Autosomal Dominant
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.
Optic Atrophy, Autosomal Dominant
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan.
Optic Atrophy, Autosomal Dominant
The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy.
Optic Atrophy, Autosomal Dominant
The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.
Optic Atrophy, Autosomal Dominant
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
Optic Atrophy, Autosomal Dominant
The Short Variant of the Mitochondrial Dynamin OPA1 Maintains Mitochondrial Energetics and Cristae Structure.
Optic Atrophy, Autosomal Dominant
The vicious circle between mitochondrial oxidative stress and dynamic abnormality mediates triethylene glycol dimethacrylate-induced preodontoblast apoptosis.
Optic Atrophy, Autosomal Dominant
Therapeutic potential of targeting mitochondrial dynamics in cancer.
Optic Atrophy, Autosomal Dominant
Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice.
Optic Atrophy, Autosomal Dominant
Transient Contraction of Mitochondria Induces Depolarization through the Inner Membrane Dynamin OPA1.
Optic Atrophy, Autosomal Dominant
Triptolide induces toxicity in inner ear stem cells via promoting DNA damage.
Optic Atrophy, Autosomal Dominant
Ultrastructural Characterization of Flashing Mitochondria.
Optic Atrophy, Autosomal Dominant
Upregulation of OPA1 by carnosic acid is mediated through induction of IKK? ubiquitination by parkin and protects against neurotoxicity.
Optic Atrophy, Autosomal Dominant
Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening dependent apoptotic sensitivity in an induced pluripotent stem cell model.
Optic Atrophy, Autosomal Dominant
Variation in OPA1 does not explain the incomplete penetrance of Leber hereditary optic neuropathy.
Optic Atrophy, Autosomal Dominant
Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape.
Optic Atrophy, Autosomal Dominant
Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.
Optic Atrophy, Autosomal Dominant
[Effect of Sailuotong capsule on mitochondrial dynamics in focal cerebral ischemia/reperfusion rats].
Optic Atrophy, Autosomal Dominant
[Effects of electroacupuncture at "Zusanli"(ST36) on ultrastructure and mitochondrial dynamics of skeletal muscle in rats with spleen qi deficiency syndrome].
Optic Atrophy, Autosomal Dominant
[Effects of heme oxygenase-1/carbon monoxide pathway on the mitochondrial fusion in rat alveolar epithelial type II cells stimulated by lipopolysaccharide].
Optic Atrophy, Hereditary, Leber
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Optic Atrophy, Hereditary, Leber
Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2.
Optic Nerve Diseases
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Optic Nerve Diseases
Alu-element insertion in an OPA1 intron sequence associated with autosomal dominant optic atrophy.
Optic Nerve Diseases
Concurrent OPA1 mutation and chromosome 3q deletion leading to Behr syndrome: a case report.
Optic Nerve Diseases
Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.
Optic Nerve Diseases
Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy.
Optic Nerve Diseases
OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.
Optic Nerve Diseases
OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database.
Optic Nerve Diseases
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
Osteosarcoma
Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone.
Osteosarcoma
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells.
Ovarian Neoplasms
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Ovarian Neoplasms
Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel.
Ovarian Neoplasms
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Pancreatic Neoplasms
A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells.
Pancreatic Neoplasms
Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1.
Pancreatic Neoplasms
Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis.
Pancreatitis
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis.
Papillomavirus Infections
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Paralysis
Developmental stage- and tissue-specific expression of shibire, a Drosophila gene involved in endocytosis.
Paralysis
Dual function C-terminal domain of dynamin-1: modulation of self-assembly by interaction of the assembly site with SH3 domains.
Paralysis
Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling.
Paralysis
Unique biochemical and behavioral alterations in Drosophila shibire(ts1) mutants imply a conformational state affecting dynamin subcellular distribution and synaptic vesicle cycling.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Paraplegia
Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2.
Paraplegia
Atlastin-1, the dynamin-like GTPase responsible for spastic paraplegia SPG3A, remodels lipid membranes and may form tubules and vesicles in the endoplasmic reticulum.
Paraplegia
Mutations in the SPG3A gene encoding the GTPase atlastin interfere with vesicle trafficking in the ER/Golgi interface and Golgi morphogenesis.
Parkinson Disease
?-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.
Parkinson Disease
Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice.
Parkinson Disease
Alternative mitochondrial quality control mediated by extracellular release.
Parkinson Disease
Astrocytic dynamin-like protein 1 regulates neuronal protection against excitotoxicity in Parkinson disease.
Parkinson Disease
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
Parkinson Disease
Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease.
Parkinson Disease
Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells.
Parkinson Disease
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Parkinson Disease
Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson's disease.
Parkinson Disease
Inhibition of dynamin-related protein 1 ameliorates the mitochondrial ultrastructure via PINK1 and Parkin in the mice model of Parkinson's disease.
Parkinson Disease
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
Periodontitis
Crosstalk between reactive oxygen species and Dynamin-related protein 1 in periodontitis.
Peripheral Nervous System Diseases
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Peripheral Nervous System Diseases
Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-Tooth mutant.
Peripheral Nervous System Diseases
Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.
Peripheral Nervous System Diseases
Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy.
Peripheral Nervous System Diseases
Mitofusin 2 builds a bridge between ER and mitochondria.
Peripheral Nervous System Diseases
Protective effect of gliclazide on diabetic peripheral neuropathy through Drp-1 mediated-oxidative stress and apoptosis.
Peritonitis
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.
Peroxisomal Disorders
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Pheochromocytoma
Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms.
Pheochromocytoma
Sweeping model of dynamin activity. Visualization of coupling between exocytosis and endocytosis under an evanescent wave microscope with green fluorescent proteins.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: A role in apoptosis in prostate cancer cells.
Prostatic Neoplasms
The significance of dynamin 2 expression for prostate cancer progression, prognostication, and therapeutic targeting.
protein acetyllysine n-acetyltransferase deficiency
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
protein acetyllysine n-acetyltransferase deficiency
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Proteinuria
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Proteinuria
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
Proteinuria
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Psoriasis
Dynamin-related protein 1 expression correlates with psoriasis disease severity and regulates keratinocyte function.
Psoriasis
Uncoupling protein 2 and dynamin-related protein 1 mRNA expressions as genetic markers for plaque psoriasis.
Pulmonary Arterial Hypertension
ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Disease, Chronic Obstructive
Silencing FUNDC1 alleviates chronic obstructive pulmonary disease by inhibiting mitochondrial autophagy and bronchial epithelium cell apoptosis under hypoxic environment.
Rabies
A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.
Rabies
Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus.
Renal Insufficiency, Chronic
Increased dynamin expression precedes proteinuria in glomerular disease.
Renal Insufficiency, Chronic
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.
Reperfusion Injury
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Reperfusion Injury
Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission.
Reperfusion Injury
Erratum to: Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice.
Reperfusion Injury
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Reperfusion Injury
Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice.
Reperfusion Injury
PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury.
Reperfusion Injury
Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury.
Retinal Detachment
Inhibition of Mitochondrial Fission Preserves Photoreceptors after Retinal Detachment.
Rhinitis, Allergic
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Seizures
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Seizures
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Seizures
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
Seizures
Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy.
Seizures
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Seizures
Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I.
Seizures
Relationship between changes in mitochondrial function and hippocampal neuronal apoptosis after recurrent convulsion during developmental stage.
Sepsis
Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis.
Sleep Deprivation
Endocytosis at the Drosophila blood-brain barrier as a function for sleep.
Spasms, Infantile
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
Spastic Paraplegia, Hereditary
Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias.
Spastic Paraplegia, Hereditary
Targeted high-throughput sequencing identifies mutations in atlastin-1 as a cause of hereditary sensory neuropathy type I.
Spinal Cord Injuries
Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration.
Starvation
Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.
Starvation
MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria.
Starvation
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
Status Epilepticus
A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy.
Status Epilepticus
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
Status Epilepticus
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus.
Status Epilepticus
De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus.
Status Epilepticus
Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
Stomach Neoplasms
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Stroke
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
Stroke
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
Stroke
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Stroke
Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke.
Stroke
[Effects of uncoupling protein 2 overexpression on myocardial mitochondrial dynamics in sepsis rats].
Synucleinopathies
Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.
Tauopathies
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy.
Tetanus
Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis.
Thrombocytopenia
Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.
Thrombocytopenia
Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thyroid Cancer, Papillary
Dynamin 2 Is Correlated with Recurrence and Poor Prognosis of Papillary Thyroid Cancer.
Thyroid Neoplasms
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma.
Tuberculosis
Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-? dependant pexophagy mechanism to control redox levels in macrophages.
Typhoid Fever
Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells.
Urinary Bladder Neoplasms
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Urinary Bladder Neoplasms
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells.
Urinary Bladder Neoplasms
Serum and tissue profiling in bladder cancer combining protein and tissue arrays.
Uterine Cervical Neoplasms
Dose-Volume Histogram Parameters and Local Tumor Control in Magnetic Resonance Image-Guided Cervical Cancer Brachytherapy.
Uterine Cervical Neoplasms
Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells.
Uterine Cervical Neoplasms
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
Vaccinia
Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization.
Vascular Diseases
Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.
Vascular System Injuries
Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury.
Vesicular Stomatitis
Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF-?B pathways as well as Cox-2-mediated PGE2 /EP receptor signalling to enhance clathrin-mediated virus endocytosis.
Vesicular Stomatitis
Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network.
Vesicular Stomatitis
Receptor-mediated Moloney murine leukemia virus entry can occur independently of the clathrin-coated-pit-mediated endocytic pathway.
Vesicular Stomatitis
The matrix protein of Vesicular Stomatitis Virus binds dynamin for efficient viral assembly.
Virus Diseases
Cellular uptake and infection by canine parvovirus involves rapid dynamin-regulated clathrin-mediated endocytosis, followed by slower intracellular trafficking.
Virus Diseases
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
Virus Diseases
Dynein light chain 1 peptide inhibits human immunodeficiency virus infection in eukaryotic cells.
Virus Diseases
Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling.
Virus Diseases
Myxovirus resistance protein A activates type I IFN signaling pathway to inhibit zika virus replication.
Virus Diseases
Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.
Vision Disorders
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
Whooping Cough
Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.
Wiskott-Aldrich Syndrome
Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.
Wiskott-Aldrich Syndrome
Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes.
Wiskott-Aldrich Syndrome
Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells.
Wiskott-Aldrich Syndrome
Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.
Wiskott-Aldrich Syndrome
Syndapin isoforms participate in receptor-mediated endocytosis and actin organization.
Wiskott-Aldrich Syndrome
Syndapin oligomers interconnect the machineries for endocytic vesicle formation and actin polymerization.
Wiskott-Aldrich Syndrome
Transcriptional regulation of artemin is related to neurite outgrowth and actin polymerization in mature DRG neurons.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
steady-state GTPase activities of recombinant Drp1 GTPase-GTPase effector fusion protein
-
additional information
additional information
-
steady-state GTPase activities of recombinant Drp1 GTPase-GTPase effector fusion protein
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Drp1 is a cytosolic protein that translocates to the outer mitochondrial membrane
brenda
Drp1 is a cytosolic protein that translocates to the outer mitochondrial membrane
brenda
additional information
actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. Cytosolic Drp1 is recruited directly to fission sites immediately prior to fission. Progressive maturation of Drp1 oligomers on mitochondria through incorporation of smaller mitochondrially-bound Drp1 units. Maturation of a stable Drp1 oligomer does not forcibly lead to fission. Drp1 oligomers also translocate directionally along mitochondria. Drp1 is a cytosolic protein that translocates to the outer mitochondrial membrane
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
the enzyme is a member of the dynamin superfamily that comprises a family of conserved GTPases. Most dynamin superfamily members contain five conserved GTP-binding motifs (G1-5), similar to small Ras-like GTPases
malfunction
physiological function
additional information
malfunction
dysregulation of enzyme Drp1 is associated with abnormal mitochondrial dynamics and neuronal damage
malfunction
mutated Glu81 and Glu82 in the unique 16-residue insertion of the enzyme influence the activity significantly. Mutations of Gln34, Ser35, and Asp190 in the predicted assembly interface interfer with dimerization of the GTPase domain induced by a transition state analogue and lead to a loss of the lipid-stimulated GTPase activity
malfunction
suppression of either INF2 or myosin IIA causes an 50% decrease in fission rate, whereas Drp1 suppression or expression of the dominant-negative Drp1 K38A mutant cause near-complete inhibition. In addition, suppression of either INF2 or myosin IIA reduces mitochondrially-associated Drp1 puncta, with a moderate reduction of total Drp1 puncta (2.7fold for both INF2 and myosin IIA) and a larger reduction in high threshold puncta (6.7fold and 8.3fold, respectively). LatA treatment also causes a reduction in mitochondrially-associated Drp1 puncta, although the degree of high threshold reduction is not as great as for INF2 or myosin IIA suppression
physiological function
human dynamin-1-like protein is a GTP-driven molecular machine that segregates mitochondria and peroxisomes, catalytic mechanism involving dimerization of their GTPase domains, overview
physiological function
the mechano-enzyme dynamin-related protein 1 plays an important role in mitochondrial fission and is implicated in cell physiology
physiological function
distinct splice variants of dynamin-related protein 1 differentially utilize mitochondrial fission factor as an effector of cooperative GTPase activity
physiological function
mitochondrial fission is mediated by the dynamin-related GTPases Dnm1/Drp1 (yeast/mammals), which form spirals around constricted sites on mitochondria. Additional membrane-associated adaptor proteins (Fis1, Mdv1, Mff, and MiDs) are required to recruit these GTPases from the cytoplasm to the mitochondrial surface. Adaptors regulate mitochondrial dynamin assembly for membrane scission. An adaptor protein alters the architecture of a mitochondrial dynamin GTPase polymer in a manner that can facilitate membrane constriction and severing activity. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
physiological function
the large GTPase dynamin mediates membrane fission during clathrin-mediated endocytosis (CME). Dynamin GTPase Drp1 plays a critical role during mitochondrial fission, cytosolic Drp1 is recruited directly to fission sites immediately prior to fission. Progressive maturation of Drp1 oligomers on mitochondria through incorporation of smaller mitochondrially-bound Drp1 units. Maturation of a stable Drp1 oligomer does not forcibly lead to fission. Drp1 oligomers also translocate directionally along mitochondria. Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and fission factors such as actin filaments target productive oligomerization to fission sites. The assembly of filaments of actin is the signal to Drp1 for fission. Differential affinities of Drp1 oligomeric states for actin filaments
additional information
enzyme Drp1 shares structural and functional similarities with dynamin 1 with respect to domain organization, ability to self-assemble into spiral-like oligomers and GTP-cycle-dependent membrane scission. The enzyme has an additional unstructured region between the middle domain and GTPase effector domain
additional information
-
enzyme Drp1 shares structural and functional similarities with dynamin 1 with respect to domain organization, ability to self-assemble into spiral-like oligomers and GTP-cycle-dependent membrane scission. The enzyme has an additional unstructured region between the middle domain and GTPase effector domain
additional information
the GTPase domain of the enzyme is structurally related to that of dynamin and binds the nucleotide 5'-guanylyl-imidodiphosphate (GMP-PNP) via five highly conserved motifs, whereas the BSE folds into a pocket at the opposite side. Residues essential for the GTPase reaction are Lys38, Ser39 and Ser40 in the phosphate binding loop, Thr59 from switch I, Asp146 and Gly149 from switch II, Lys216 and Asp218 in the G4 element, as well as Asn246 in the G5 element. Conformational changes upon GTP-binding in the active site, and overall structure of the DNM1L GTPase-GED fusion protein, overview
additional information
-
the GTPase domain of the enzyme is structurally related to that of dynamin and binds the nucleotide 5'-guanylyl-imidodiphosphate (GMP-PNP) via five highly conserved motifs, whereas the BSE folds into a pocket at the opposite side. Residues essential for the GTPase reaction are Lys38, Ser39 and Ser40 in the phosphate binding loop, Thr59 from switch I, Asp146 and Gly149 from switch II, Lys216 and Asp218 in the G4 element, as well as Asn246 in the G5 element. Conformational changes upon GTP-binding in the active site, and overall structure of the DNM1L GTPase-GED fusion protein, overview
additional information
Drp1 isoforms exhibit differential GTPase activities, comparison of splice variants, overview. Human isozyme Drp1-short exhibits greater cooperative GTPase activities relative to rat Drp1-long
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). DNM1L_HUMAN
736
0
81877
Swiss-Prot
other Location (Reliability: 4)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PDB
SCOP
CATH
UNIPROT
ORGANISM
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40923
x * 40923, nucleotide-free GTPase-GTPase effector domain fusion protein of Drp1, mass spectrometry
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
x * 40923, nucleotide-free GTPase-GTPase effector domain fusion protein of Drp1, mass spectrometry
oligomer
in solution, Drp1 exists in a number of oligomeric states, including dimers, tetramers, and higher-order oligomers. Actin filaments can organize Drp1 into a productive oligomer
additional information
Drp1 isoforms exhibit differential oligomerization propensities in solution and distinct helical geometry on cardiolipin-containing membranes, analysis of Drp1-short, Drp1-A-only, and Drp1-B-only by gel filtration
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant dynamin-related protein 1 GTPase-GTPase effector domain fusion protein, sitting drop vapour diffusion method, mixing of 0.0004 ml of protein solution and reservoir solution, the latter containing 0.2 M lithium sulfate, 0.1 M Bis-Tris, pH 5.5, 25% v/v PEG 3350 or 0.1 M sodium citrate, pH 5.5, 20% PEG 3000, 20°C, X-ray diffraction structure determination and analysis at 2.67 A resolution
purified wild-type and mutants of DNM1L isoform 2, mixing of 0.001 ml of 1.2 mg/ml protein with 0.001 ml of reservoir solution containing 0.1 M sodium citrate pH 5, 27.5% PEG 3000, equilibration against 0.4 ml of reservoir solution, 3-5 days, for co-crystallization of the enzyme with a non-hydrolyzable GTP analogue the protein is incubated with 1 mM GMP-PNP and 4 mM MgCl2, and then purified by gel filtration, X-ray diffraction structure determination and analysis at 2.3 A resolution, molecular replacement using human dynamin-1 structure, PDB ID 3SNH
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K38A
additional information
additional information
Drp1-A-only (712 aa, 699 aax0413-aa A-insert) and Drp1-B-only (742 aa, 755 aa, 13-aa A-insert) are introduced in the Drp1-short isozyme. A- and B-insert sequences both suppress Drp1 GTPase activity, with the B-insert exerting the most dominant inhibitory effect on these interactions
additional information
partial shRNA suppression of endogenous Drp1 (gDrp-U2OS). GFP-Drp1 functionally compensates for endogenous Drp1 in these cells. gDrp-U2OS cells maintain 1.64fold total Drp1 levels compared to control U2OS cells, with 56% endogenous Drp1 and 44% GFP-Drp1. The fission rates of control U2OS and gDrp1-U2OS cells are statistically similar. A second clone displaying undetectable endogenous Drp1 levels and GFP-Drp1 levels about 3.5fold higher than control Drp1 levels shows similar mitochondrial fission frequency compared to control cells. By live-cell confocal microscopy, much of the GFP-Drp1 in gDrp-U2OS cells appears diffuse in the cytoplasm
additional information
the enzyme is cloned with Tom20 used as an N-terminal mitochondrial outer membrane anchor, or amino acids 131-155 of yeast Fis1 used as a C-terminal mitochondrial outer membrane anchor
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant N-terminally Strep-tagged Drp1 from Escherichia coli strain BL21 Star (DE3) by affinity chromatography, followed by tag cleavage by HRV3C protease, and gel filtration
recombinant N-terminally Strep-tagged Drp1 from Saccharomyces cerevisiae strain JSY9612 by affinity chromatography, followed by tag cleavage by PreScission protease, and dialysis
recombinant nucleotide-free GTPase-GTPase effector domain fusion protein of human Drp1, and wild-type and mutant full-length enzymes from Escherichia coli strain BL21(DE3)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene DNM1, recombinant expression of Drp1 containing an N-terminal PreScission protease cleavage site and a FLAG-One-Strep-tag (IBA) from plasmid pRS415-DNM1 in Saccharomyces cerevisiae strain JSY9612 lacking all fission proteins (MATa, can1, ade2, trp1, ura3, his3, leu2, pep4::HIS3, prb1::LEU2, bar1::HISG, lys2::GAL1/10-GAL4), coexpression with Saccharomyces cerevisiae mitochondrial fission 1 protein, Fis1 (UniProt ID P40515)
gene DNMTL1, recombinant expression of the splice variants of Drp1 in Escherichia coli strain BL21 Star (DE3)
recombinant expression of C-terminally His6-tagged wild-type and mutants of DNM1L isoform 2
recombinant expression of N-terminally Strep-tagged Drp1 with an HRV3C protease site from pET16b vector in Escherichia coli strain BL21 Star (DE3), stable recombinant expression of GFP-tagged DrpI in U2OS cells with partial shRNA suppression of endogenous Drp1 (gDrp-U2OS), GFP-Drp1 functionally compensates for endogenous Drp1 in these cells
recombinant expression of nucleotide-free GTPase-GTPase effector domain fusion protein of enzyme Drp1, and wild-type and mutant full-length enzymes in Escherichia coli strain BL21(DE3)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Klinglmayr, E.; Wenger, J.; Mayr, S.; Bossy-Wetzel, E.; Puehringer, S.
Purification, crystallization and X-ray diffraction analysis of human dynamin-related protein 1 GTPase-GED fusion protein
Acta Crystallogr. Sect. F
68
1217-1221
2012
Homo sapiens (O00429), Homo sapiens
brenda
Wenger, J.; Klinglmayr, E.; Froehlich, C.; Eibl, C.; Gimeno, A.; Hessenberger, M.; Puehringer, S.; Daumke, O.; Goettig, P.
Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses
PLoS ONE
8
e71835
2013
Homo sapiens (O00429), Homo sapiens
brenda
Ji, W.K.; Hatch, A.L.; Merrill, R.A.; Strack, S.; Higgs, H.N.
Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites
eLife
4
e11553
2015
Homo sapiens (O00429)
brenda
Macdonald, P.J.; Francy, C.A.; Stepanyants, N.; Lehman, L.; Baglio, A.; Mears, J.A.; Qi, X.; Ramachandran, R.
Distinct splice variants of dynamin-related protein 1 differentially utilize mitochondrial fission factor as an effector of cooperative GTPase activity
J. Biol. Chem.
291
493-507
2016
Homo sapiens (O00429), Rattus norvegicus (O35303)
brenda
Koirala, S.; Guo, Q.; Kalia, R.; Bui, H.T.; Eckert, D.M.; Frost, A.; Shaw, J.M.
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
Proc. Natl. Acad. Sci. USA
110
E1342-E1351
2013
Homo sapiens (O00429), Saccharomyces cerevisiae (P54861), Saccharomyces cerevisiae
brenda
EXTERNAL LINKS (specific for EC-Number 3.6.5.5)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
