Information on EC 3.6.5.1 - heterotrimeric G-protein GTPase

New: Word Map on EC 3.6.5.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Search Reference ID:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
3.6.5.1
-
RECOMMENDED NAME
GeneOntology No.
heterotrimeric G-protein GTPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + H2O = GDP + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
hydrolysis of phosphoric ester
phosphorous acid anhydride hydrolysis
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
NIL
-
-
SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (signalling)
This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-32-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
Aspergillus Emericella nidulans
-
-
Manually annotated by BRENDA team
cv. California wonder
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
genes gna 1-3 encoding the three subunits of the enzyme
Q05425 and Q05424 and Q9HFW7
UniProt
Manually annotated by BRENDA team
Neurospora crassa 74 A-OR23-1A
genes gna 1-3 encoding the three subunits of the enzyme
Q05425 and Q05424 and Q9HFW7
UniProt
Manually annotated by BRENDA team
Gsalpha
-
-
Manually annotated by BRENDA team
recombiant protein expressed in Escherichia coli
-
-
Manually annotated by BRENDA team
alpha subunit of transducin
-
-
Manually annotated by BRENDA team
alpha subunit of transducin
-
-
Manually annotated by BRENDA team
Gialpha1
-
-
Manually annotated by BRENDA team
Saccharomyces pombe
-
-
-
Manually annotated by BRENDA team
cv. King
-
-
Manually annotated by BRENDA team
recombinant protein expressed in baculovirus/Sf9 system, reconstituted in vesicles
-
-
Manually annotated by BRENDA team
Gi: the G protein that mediates inhibition of adenylate cyclase
-
-
Manually annotated by BRENDA team
GTPase that functions as a component of the rhodopsin-linked, light-activated phosphodiesterase system
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Al3+
-
exposure of the rye roots to Al3+ results in activation of GTPase, Al-induced secretion is inhibited by pertussis toxin
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
betagamma subunit of the hetreotrimeric G protein
GDP
-
competitive inhibition
Gpp(NH)p
-
competitive inhibition
Leu-Gly-Asn repeat-enriched protein
Pasteurella multocida toxin
-
deamidates glutamine-205 of G alphaI2 to glutamic acid, inhibits intrinsic GTPase activity, causes persistent activation of the G protein
-
pertussis toxin
phosducin
-
inhibits betagamma function in vitro
-
regulator of G protein signaling protein
Saccharomyces pombe
-
Gpa1 signaling suppressed by low stimulation
-
YM-254890
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AGS3 protein
-
G-protein signaling modulator 1, GPSM1, Human Genome Organization nomenclature
-
amyloid beta-peptide fragment (1-42)
-
stimulates GTPase activity
-
amyloid beta-peptide fragment (25-35)
-
stimulates GTPase activity
-
Axin protein
-
member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
Axin2 protein
-
member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
betagamma-subunit of transducin
-
from bovine retinal transducin and from rabbit liver, enhances activity of Goalpha
-
Carbachol
-
0.1 mM, in presence of regulator of G-protein signaling proteins such as RGS4, Gbeta5 with RGS6, RGS7, RGS9 or RGS11, but not carbachol alone
cell-surface receptors
-
of the seven-transmembrane-helix class, activated by catalyzing the exchange of GDP for GTP in the guanine nucleotide-binding site of the alpha-subunit
-
cholera toxin
CIVIAKLKANLM amide
-
peptide derived from glucagon-like peptide, residues 329-340, 0.001 mM, 186% of basal GTPase activity
CIVIAKLKANLMCKTDIKCRLAK amide
-
peptide derived from glucagon-like peptide, residues 329-351, 0.001 mM, 595% of basal GTPase activity
CKTDIKCRLAK amide
-
peptide derived from glucagon-like peptide, residues 341-351, 0.001 mM, 216% of basal GTPase activity
D-AKAP2 protein
-
-
-
EGL-10 protein
-
egg-laying defective protein 10
-
ethylene glycol
-
-
FlbA protein
-
-
-
G component
-
can bind GTP and can support light-dependent and GTP-dependent phosphodiesterase activation
-
gamma-subunit of cGMP phosphodiesterase
GRK1 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
GRK2 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
GRK3 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
GRK4 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
GRK5 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
GRK6 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
GRK7 protein
-
member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
H component
-
MW 60000 Da, participates in the light-dependent activation of GTPase, G component requires the presence of H component for expression of GTPase activity
-
LARG protein
-
member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
LGN protein
-
G-protein signaling modulator 2, GPSM2, Human Genome Organization nomenclature
-
muscarinic acetylcholine receptors
-
receptor m1 activates, no activation by receptor m2
-
NDP kinase
-
can transfer the gamma-phosphate of ATP directly to GDP bound to the G protein, this phosphorylation results in the activation of the signal-coupling proteins
-
p115-RhoGEF protein
-
member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
Pasteurella multocida toxin
PDZ-RhoGEF protein
-
member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
phenylephrine
-
-
phospholipase C-beta1
-
activating protein for Gq/11, its physiologic regulator
-
phospholipase D
-
coincubation of enzyme with phospholipase D in equal amounts stimulates up to 35%
-
regulator of G protein signaling protein
Saccharomyces pombe
-
Gpa1 signaling potentiated by high stimulation
-
RGS protein
-
one RGS gene in the Capsicum genome that acts as a regulator of the G-protein signaling, idetification and cloning
-
RGS1 protein
RGS10 protein
-
member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS11 protein
-
member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS12 protein
-
member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS13 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS14 protein
RGS16 protein
RGS17 protein
-
member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS18 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS19 protein
-
member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS2 protein
RGS20 protein
-
member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS21 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS22 protein
-
-
-
RGS3 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS4
-
-
-
RGS4 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS5 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS6 protein
-
member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS7 protein
-
member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS8 protein
-
member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS9
-
-
-
RGS9 protein
-
member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
RGS9-1 protein
-
short splice variant of RGS9, in complex with type 5 G protein beta-subunit Gbeta5L, regulated by the membrane anchor R9AP
-
RGS9d protein
-
-
-
rhodopsin
SNX13 protein
-
member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
SNX14 protein
-
member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
SNX25 protein
-
member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
-
Sst2 protein
-
Sst2: supersensitivity to pheromone-2
-
tubulin
direct transfer of GTP
-
unidentified membrane factor
-
accelerate GTP hydrolysis by transducin
-
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0008 - 0.85
GTP
additional information
additional information
-
kinetics of 2'-/3'-O-N'-methylanthraniloyl-labeled GTP/GDP exchange for GmGalpha1-GmGalpha4, overview. GmGalpha1 and GmGalpha4 bind GTP more rapidly thanGmGalpha2 and GmGalpha3
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0018 - 21
GTP
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0003 - 0.0074
GDP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.722
-
recombinant GL2
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4
-
in presence of NH4Cl, NaCl, KCl
4.5
-
assay at
5
-
in presence of CuCl2, FeCl2, MnCl2, NiCl2
6
-
in presence of CaCl2, MgCl2
additional information
-
optimum pH-value depends on kation present
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20 - 25
-
assay at
30
-
assay at
60
-
activity assay
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22 - 24
-
activity assay
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
Go-alpha subunit
Manually annotated by BRENDA team
-
Jurkat leukemic T lymphocyte cell line, clone E6-1
Manually annotated by BRENDA team
-
Go-alpha subunit
Manually annotated by BRENDA team
-
light-dependent localizations of the transducin-alpha subunit Gtalpha
Manually annotated by BRENDA team
-
light-dependent localizations of the transducin-alpha subunit Gtalpha
Manually annotated by BRENDA team
-
Go-alpha subunit
Manually annotated by BRENDA team
-
only under intense illumination
Manually annotated by BRENDA team
-
Go-alpha subunit
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
taste receptor cells
Manually annotated by BRENDA team
-
Go-alpha subunit
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
outer rod segment membrane
Manually annotated by BRENDA team
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heteropentamer
heterotrimer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lipoprotein
phosphoprotein
-
phosphorylation of Galpha subunits is an important modification that regulates their function. Galpha12 is a substrate for phosphorylation by protein kinase C. Endogenous Ga12 in human platelets is phosphorylated within the first 50 N-terminal amino acid residues in response to PMA, thrombin and the TXA2 receptor agonist U46619. Phosphorylated Galpha12 loses its affinity for Gbetagamma, and the association with Gbetagamma reciprocally inhibits the phosphorylation of Ga12 by protein kinase C. Endogenous Galpha13 in platelets is phosphorylated in response to PMA, although not in vitro. PKC-mediated phosphorylation of Ga13 in cell might require additional factors
side-chain modification
additional information
-
Galpha12 and Galpha13 are not myristoylated because they lack a glycine residue as the second amino acid residue
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Galphao-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036, method screening, hanging-drop vapour-diffusion method, mixing of 0.0015 ml of 25 mg/ml protein solution containing 20 mM Tris-HCl pH 7.5, 2 mM MgCl2, 150 mM NaCl, 2 mM DTT, with 0.0015 ml of reservoir solution containing 20% PEG 4000, 100 mM HEPES sodium salt, pH 7.5, and equilibration against 0.3 ml of reservoir solution, 8-10 days, 22C, X-ray diffraction structure determination and analysis at 2.0 A resolution, model fitting and refinement
-
crystal structure of mutant K180P-Galphai1 bound to a GTP analog
-
RGS4 complexed with Gialpha1-Mg2+-GDP-AlF4
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20C, Tris-HCl buffer, pH 7.8, 10 mM MgCl2, 50% v/v glycerol
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
purified from Sulfolobus solfataricus
-
recombinant His6-tagged truncation enzyme mutants GalphaoDELTA21 and GalphaoDELTA109 from Escherichia coli strain M15 by nickel affinity chromatography, for the first followed by anion exchange chromatography and gel filtration
-
the alpha subunit of Gq family G proteins, GL1alpha(G14alpha), GL2alpha(G11alpha) and Gqalpha are expressed with G proteins beta1 and gamma2 subunits in insect cells using a baculovirus system. The trimeric forms of G proteins, GL1(GL1alphabetagamma), GL2(GL2alphabetagamma) and Gq(Gqalphabetagamma) are solubilized and purified
-
using a Ni-NTA column
-
using Ni-NTA His-binding affinity chromatography and a Mono Q column
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloning of heterotrimeric G proteins, DNA and amino acid sequence determination and analysis
-
cloning of the complete heterotrimeric G-protein repertoire in the Capsicum annuum genome which consists of one Galpha, one Gbeta and three Ggamma genes, phylogenetic analysis, DNA and amino acid sequence determination and analysis, real time quantitative PCR tissue-specific enzyme expression analysis, transgenic expression of Gbeta, Ggamma1-3 genes, from pSAT5-DEST-cEYFP-C1 destination vectors containing cEYFP at the N-terminal end via Agrobacterium tumefaciens strain GV3101 transformation, in Nicotiana tabaccum leaves, co-expression of RGS protein
-
expressed in HEK-293T cells; Galpha subunit is subcloned into pcDNA3.1+
-
expression in Escherichia coli
-
Expression of the N-terminally His6-tagged mutant Galphai/q chimeric gene, in which the native N-terminus of Galphaq is replaced with that of Galphai1, the gene also posseses a TEV cleavage site, amino acids 1-28 of rat Galphai1, a linker of Arg and Ser, and the 37-359 amino acid region of mouse Galphaq, expression of recombinant wild-type Galphaq and Galphaq mutant Q209E in Mus musculus Galphaq/11-deficient embryonic fibroblasts, Swiss3T3 cells, expression of alpha subunit cDNAs of heterotrimeric GTPases, Gs, Gi-2, G13 and G11 in human 293T cells
-
genes gna 1-3 encoding the three subunits of the enzyme, transfection of Neurospora crassa with mutant enzymes
Q05425 and Q05424 and Q9HFW7
Gtalpha and GtalphaR238E for expression in Escherichia coli strains DH5alpha and BL21(DE3)
-
into pcDNA3.1 vector for transfection of HEK-293 cells
-
into the pT7-7 vector for expession in Escherichia coli JM109DE3 cells
-
into vector for expression in Escherichia coli
-
overexpression of heterotrimeric G-proteins Galphai1 and Galphai3 in Spodoptera frugiperda Sf 9 cell membranes using the baculovirus transfection method
-
pBRH Gtalpha transgenic construct containing the mouse Gtalpha genomic sequence flanked by the mouse opsin promoter fragment and the polyadenylation signal, EE-tagged
-
Rab1a is cloned from a mouse cardiac cDNA library, adenoviruses expressing FLAG-Rab1a are generated for infection of rat ventricular myocytes
-
recombinant expression of His6-tagged truncation enzyme mutants GalphaoDELTA21 and GalphaoDELTA109 in Escherichia coli strain M15
-
the alpha subunit of Gq family G proteins, GL1alpha(G14alpha), GL2alpha(G11alpha) and Gqalpha are expressed with G proteins beta1 and gamma2 subunits in insect cells using a baculovirus system. The trimeric forms of G proteins, GL1(GL1alphabetagamma), GL2(GL2alphabetagamma) and Gq(Gqalphabetagamma) are solubilized and purified
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CFP-TM-Galpha
-
consists of a cleavable signal peptide from human growth hormone, enhanced CFP, the amino-terminal amino acids of the rat mu-opioid receptor, including TM1 and intracellular loop1, and the human Galpha subunit
CFP-TM-Galphai3
-
C to G mutation at the -4 position to render them insensitive to PTX-mediated ADP-ribosylation
CFP-TM-GalphaoA
-
C to G mutation at the -4 position to render them insensitive to PTX-mediated ADP-ribosylation
CFP-TM-GalphaQ205L
-
active mutant
CFP-TM-Galphasq5
-
the five aminoacids normally found in the carboxyl terminus of Galphas, QYELL, are replaced with those normally found in the carboxy terminus of Galphaq, EYNLV
Q212L
site-directed mutagenesis,GTPase-deficient inactive mutant
R238E
-
mutant, reported to be a dominant-negative inhibitor of the rhodopsin-transducin-PDE visual system
S111N
-
mutation at carboxy-terminal end of helix alpha of helical domain, decreased nucleotide exchange kinetics, impaired adenylyl cyclase activation with GTPgammaS, but normal receptor and AlF4- activation
E92A/N93A
-
RGS14 mutant
E92A/N93A/R519F
-
RGS14 mutant
G202A
-
mutation of Galphai1 accelerates the rates of GTP hydrolysis and conformational change
G202A, K180P
-
mutations of Galphai1 accelerate the rates of GTP hydrolysis
GoLoco
-
RGS14 mutant
K180A
-
mutant of Galphai1, rate of GTP hydrolysis similar to wild-type
K180P
-
mutation of Galphai1 increases the rate of conformational change and decreases the rates of GTP hydrolysis
Myr-Pal-GoLoco
-
RGS14 mutant
Myr-Pal-GoLoco R519F
-
RGS14 mutant
R336L
-
RGS14 mutant
R519F
-
RGS14 mutant
RGS
-
RGS14 mutant
RID-GoLoco
-
RGS14 mutant
RID-GoLoco R336L
-
RGS14 mutant
RID-GoLoco R519F
-
RGS14 mutant
G208A
-
mutant of G alphaQ, unable to release G betagamma-subunits
GtalphaQ200L
-
GTPase-deficient mutant
I25A/E26A
-
mutant of G alphaQ, lost ability to bind the G betagamma-subunits
Q209E
-
increase of enzyme activity
Q209L
-
increase of enzyme activity
R183C
-
increase of enzyme activity
Rab1aN124I
-
guanine nucleotide binding-deficient mutant
Q204L
Q05425 and Q05424 and Q9HFW7
site-directed mutaggenesis
Q205L
Q05425 and Q05424 and Q9HFW7
site-directed mutaggenesis
Q208L
Q05425 and Q05424 and Q9HFW7
site-directed mutaggenesis
R179C
Q05425 and Q05424 and Q9HFW7
site-directed mutaggenesis
Q204L
Neurospora crassa 74 A-OR23-1A
-
site-directed mutaggenesis
-
Q205L
Neurospora crassa 74 A-OR23-1A
-
site-directed mutaggenesis
-
Q208L
Neurospora crassa 74 A-OR23-1A
-
site-directed mutaggenesis
-
R179C
Neurospora crassa 74 A-OR23-1A
-
site-directed mutaggenesis
-
Q209E
-
a Galphaq mutant, constructed for rasing of antibodies that specifically detect PMT-deaminated GTPase Galphaq
C351G
-
mutation of Gi1alpha or Gi3alpha, pertussis toxin-resistant mutant
C352G
-
mutation of Gi2alpha, pertussis toxin-resistant mutant
G223S
Saccharomyces pombe
-
blocked interaction with regulator of G-protein signaling protein
Q244L
Saccharomyces pombe
-
decreased GTPase activity
A26G
-
mutant, rate of poly(U)-directed poly(Phe) synthesis and the ribosome-dependent GTPase activity are decreased, the catalytic efficiency of the intrinsic SsEF-2 GTPase triggered by ethylene glycol is enhanced
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
mutants of transducin represent a major tool in designing potential therapeutical strategies for a group of visual diseases
medicine
Show AA Sequence (120 entries)
Please use the Sequence Search for a certain query.