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Reference on EC 3.6.4.13 - RNA helicase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kyono, K.; Miyashiro, M.; Taguchi, I.
Characterization of ATPase activity of a hepatitis C virus NS3 helicase domain, and analysis involving mercuric reagents
J. Biochem.
134
505-511
2003
Hepacivirus C
Manually annotated by BRENDA team
Yon, C.; Teramoto, T.; Mueller, N.; Phelan, J.; Ganesh, V.K.; Murthy, K.H.; Padmanabhan, R.
Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase
J. Biol. Chem.
280
27412-27419
2005
Dengue virus type 2
Manually annotated by BRENDA team
Ivanov, K.A.; Ziebuhr, J.
Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5-triphosphatase activities
J. Virol.
78
7833-7838
2004
Human coronavirus 229E (P0C6X1), Human coronavirus 229E
Manually annotated by BRENDA team
Xu, T.; Sampath, A.; Chao, A.; Wen, D.; Nanao, M.; Chene, P.; Vasudevan Subhash, G.; Lescar, J.
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A
J. Virol.
79
10278-10288
2005
Dengue virus
Manually annotated by BRENDA team
Wang, X.; Lee, W.M.; Watanabe, T.; Schwartz, M.; Janda, M.; Ahlquist, P.
Brome mosaic virus 1a nucleoside triphosphatase/helicase domain plays crucial roles in recruiting RNA replication templates
J. Virol.
79
13747-13758
2005
Brome mosaic virus
Manually annotated by BRENDA team
Yamashita, T.; Unno, H.; Mori, Y.; Tani, H.; Moriishi, K.; Takamizawa, A.; Agoh, M.; Tsukihara, T.; Matsuura, Y.
Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 A
Virology
373
426-436
2008
Japanese encephalitis virus (P27395), Japanese encephalitis virus
Manually annotated by BRENDA team
De Colibus, L.; Speroni, S.; Coutard, B.; Forrester, N.L.; Gould, E.; Canard, B.; Mattevi, A.
Purification and crystallization of Kokobera virus helicase.
Acta Crystallogr. Sect. F
63
193-195
2007
Kokobera virus
Manually annotated by BRENDA team
Rodamilans, B.; Montoya, G.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain
Acta Crystallogr. Sect. F
63
283-286
2007
Homo sapiens (O00571), Homo sapiens
Manually annotated by BRENDA team
Rudolph, M.G.; Wittmann, J.G.; Klostermeier, D.
Crystallization and preliminary characterization of the Thermus thermophilus RNA helicase Hera C-terminal domain
Acta Crystallogr. Sect. F
65
248-252
2009
Thermus thermophilus
Manually annotated by BRENDA team
Diges, C.M.; Uhlenbeck, O.C.
Escherichia coli DbpA is a 3' -> 5' RNA helicase
Biochemistry
31; 44
7903-7911
2005
Escherichia coli
Manually annotated by BRENDA team
Yang, Q.; Jankowsky, E.
ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1
Biochemistry
44
13591-13601
2005
Saccharomyces cerevisiae (P06634), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Abdelhaleem, M.
RNA helicases: regulators of differentiation
Clin. Biochem.
38
499-503
2005
Homo sapiens (O00571), Homo sapiens (O15523), Homo sapiens (Q9NQI0), Homo sapiens (Q9UHL0), Homo sapiens, Mus musculus (Q501J6), Mus musculus (Q61656), Mus musculus (Q9QY15), Rattus norvegicus (Q9QY16)
Manually annotated by BRENDA team
Frick, D.N.
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target
Curr. Issues Mol. Biol.
9
1-20
2007
Hepacivirus C
Manually annotated by BRENDA team
Cordin, O.; Tanner, N.K.; Doere, M.; Linder, P.; Banroques, J.
The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity
EMBO J.
23
2478-2487
2004
Saccharomyces cerevisiae (P06634), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Luo, D.; Xu, T.; Watson, R.P.; Scherer-Becker, D.; Sampath, A.; Jahnke, W.; Yeong, S.S.; Wang, C.H.; Lim, S.P.; Strongin, A.; Vasudevan, S.G.; Lescar, J.
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein
EMBO J.
27
3209-3219
2008
Dengue virus
Manually annotated by BRENDA team
Lopez-Camarillo, C.; de la Luz Garca-Hernandez, M.; Marchat, L.A.; Luna-Arias, J.P.; Hernandez de la Cruz, O.; Mendoza, L.; Orozco, E.
Entamoeba histolytica EhDEAD1 is a conserved DEAD-box RNA helicase with ATPase and ATP-dependent RNA unwinding activities
Gene
15
19-31
2008
Entamoeba histolytica
Manually annotated by BRENDA team
Lee, C.G.; Hurwitz, J.
A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction.
J. Biol. Chem.
267
4398-4407
1992
Homo sapiens
Manually annotated by BRENDA team
Shuman S.
Vaccinia virus RNA helicase. Directionality and substrate specificity
J. Biol. Chem.
268
11798-11802
1993
Vaccinia virus
Manually annotated by BRENDA team
Flores-Rozas, H.; Hurwitz, J.
Characterization of a new RNA helicase from nuclear extracts of HeLa cells which translocates in the 5' to 3' direction.
J. Biol. Chem.
268
21372-21383
1993
Homo sapiens
Manually annotated by BRENDA team
Rogers, G.W.Jr.; Lima, W.F.; Merrick, W.C.
Further characterization of the helicase activity of eIF4A. Substrate specificity
J. Biol. Chem.
276
12598-12608
2001
Oryctolagus cuniculus (P29562)
Manually annotated by BRENDA team
Gutti, R.K.; Tsai-Morris, C.H.; Dufau, M.L.
Gonadotropin-regulated testicular helicase (DDX25), an essential regulator of spermatogenesis, prevents testicular germ cell apoptosis
J. Biol. Chem.
283
17055-17064
2008
Homo sapiens (Q9UHL0)
Manually annotated by BRENDA team
Bernstein, J.; Patterson, D.N.; Wilson, G.M.; Toth, E.A.
Characterization of the essential activities of Saccharomyces cerevisiae Mtr4p, a 3'->5' helicase partner of the nuclear exosome
J. Biol. Chem.
283
4930-4942
2008
Saccharomyces cerevisiae (P47047), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Serebrov, V.; Beran, R.K.; Pyle, A.M.
Establishing a mechanistic basis for the large kinetic steps of the NS3 helicase.
J. Biol. Chem.
284
2512-2521
2009
Hepacivirus C (P26663), Hepacivirus C
Manually annotated by BRENDA team
Leshchiner, A.D.; Solovyev, A.G.; Morozov, S.Y.; Kalinina, N.O.
A minimal region in the NTPase/helicase domain of the TGBp1 plant virus movement protein is responsible for ATPase activity and cooperative RNA binding
J. Gen. Virol.
87
3087-3095
2006
potato virus X, Poa semilatent virus
Manually annotated by BRENDA team
Talavera, M.A.; Matthews, E.E.; Eliason, W.K.; Sagi, I.; Wang, J.; Henn, A.; De La Cruz, E.M.
Hydrodynamic characterization of the DEAD-box RNA helicase DbpA
J. Mol. Biol.
355
697-707
2005
Escherichia coli
Manually annotated by BRENDA team
Henn, A.; Cao, W.; Hackney, D.D.; De La Cruz, E.M.
The ATPase cycle mechanism of the DEAD-box rRNA helicase, DbpA
J. Mol. Biol.
377
193-205
2008
Escherichia coli
Manually annotated by BRENDA team
Belon, C.A.; Frick, D.N.
Fuel specificity of the hepatitis C virus NS3 helicase
J. Mol. Biol.
388
851-864
2009
Hepacivirus C
Manually annotated by BRENDA team
Gross, C.H.; Shuman, S.
The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication
J. Virol.
72
4729-4736
1998
Vaccinia virus
Manually annotated by BRENDA team
Wu, J.; Bera, A.K.; Kuhn, R.J.; Smith, J.L.
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing
J. Virol.
79
10268-10277
2005
Yellow fever virus (P03314), Yellow fever virus
Manually annotated by BRENDA team
Imamura, O.; Saiki, K.; Tani, T.; Ohshima, Y.; Sugawara, M.; Furuichi. Y.
Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8
Nucleic Acids Res.
26
2063-2068
1998
Homo sapiens (O60231), Homo sapiens
Manually annotated by BRENDA team
Vlineva, T.; Yang, J.; Silvennoinen, O.
Characterization of RNA helicase A as component of STAT6-dependent enhanceosome
Nucleic Acids Res.
34
3938-3946
2006
Homo sapiens
Manually annotated by BRENDA team
Singh, M.; Srivastava, K.K.; Bhattacharya, S.M.
Molecular cloning and characterization of a novel immunoreactive ATPase/RNA helicase in human filarial parasite Brugia malayi
Parasitol. Res.
104
753-761
2009
Brugia malayi, Brugia malayi (EF409381)
Manually annotated by BRENDA team
Li, S.C.; Chung, M.C.; Chen, C.S.
Cloning and characterization of a DEAD box RNA helicase from the viable seedlings of aged mung bean
Plant Mol. Biol.
47
761-770
2001
Vigna radiata var. radiata (Q9M6R6), Vigna radiata var. radiata
Manually annotated by BRENDA team
Noble, C.G.; Song, H.
MLN51 stimulates the RNA-helicase activity of eIF4AIII
PLoS One
21
e303
2007
Homo sapiens (P38919)
Manually annotated by BRENDA team
Wen, G.; Xue, J.; Shen, Y.; Zhang, C.; Pan, Z.
Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase
Virus Res.
141
63-70
2009
Classical swine fever virus, Classical swine fever virus (Q9YS30), Classical swine fever virus CSFV (Q9YS30)
Manually annotated by BRENDA team
Lescar, J.; Luo, D.; Xu, T.; Sampath, A.; Lim, S.P.; Canard, B.; Vasudevan, S.G.
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target
Antiviral Res.
80
94-101
2008
Dengue virus
Manually annotated by BRENDA team
Borowski, P.; Heising, M.V.; Miranda, I.B.; Liao, C.L.; Choe, J.; Baier, A.
Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI)
Biochem. Pharmacol.
76
28-38
2008
Hepacivirus C
Manually annotated by BRENDA team
Mukovnya, A.V.; Tunitskaya, V.L.; Khandazhinskaya, A.L.; Golubeva, N.A.; Zakirova, N.F.; Ivanov, A.V.; Kukhanova, M.K.; Kochetkov, S.N.
Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors
Biochemistry (Moscow)
73
660-668
2008
Hepacivirus C
Manually annotated by BRENDA team
Hartjen, P.; Medom, B.K.; Reinholz, M.; Borowski, P.; Baier, A.
Regulation of the biochemical function of motif VI of HCV NTPase/helicase by the conserved Phe-loop
Biochimie
91
252-260
2009
Hepacivirus C (P27958), Hepacivirus C
Manually annotated by BRENDA team
Schnettler, E.; de Vries, W.; Hemmes, H.; Haasnoot, J.; Kormelink, R.; Goldbach, R.; Berkhout, B.
The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat
EMBO Rep.
10
258-263
2009
Rice hoja blanca tenuivirus (Q67897), Rice hoja blanca tenuivirus, Rice hoja blanca tenuivirus RHBV (Q67897)
Manually annotated by BRENDA team
Wang, C.C.; Huang, Z.S.; Chiang, P.L.; Chen, C.T.; Wu, H.N.
Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein
FEBS Lett.
583
691-696
2009
Dengue virus, Dengue virus PL046
Manually annotated by BRENDA team
Beran, R.K.; Pyle, A.M.
Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase
J. Biol. Chem.
283
29929-29937
2008
Hepacivirus C
Manually annotated by BRENDA team
Worrall, J.A.; Howe, F.S.; McKay, A.R.; Robinson, C.V.; Luisi, B.F.
Allosteric activation of the ATPase activity of the Escherichia coli RhlB RNA helicase
J. Biol. Chem.
283
5567-5576
2008
Escherichia coli
Manually annotated by BRENDA team
Beran, R.K.; Lindenbach, B.D.; Pyle, A.M.
The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase
J. Virol.
83
3268-3275
2009
Hepacivirus C, Hepacivirus C (Q9WPH5)
Manually annotated by BRENDA team
Theissen, B.; Karow, A.R.; Koehler, J.; Gubaev, A.; Klostermeier, D.
Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase
Proc. Natl. Acad. Sci. USA
105
548-553
2008
Bacillus subtilis
Manually annotated by BRENDA team
Feito, M.J.; Gomez-Gutierrez, J.; Ayora, S.; Alonso, J.C.; Peterson, D.; Gavilanes, F.
Insights into the oligomerization state-helicase activity relationship of West Nile virus NS3 NTPase/helicase
Virus Res.
135
166-174
2008
West Nile virus, West Nile virus WNV
Manually annotated by BRENDA team
Shimada, Y.; Fukuda, W.; Akada, Y.; Ishida, M.; Nakayama, J.; Imanaka, T.; Fujiwara, S.
Property of cold inducible DEAD-box RNA helicase in hyperthermophilic archaea
Biochem. Biophys. Res. Commun.
389
622-627
2009
Thermococcus kodakarensis
Manually annotated by BRENDA team
Tani, H.; Fujita, O.; Furuta, A.; Matsuda, Y.; Miyata, R.; Akimitsu, N.; Tanaka, J.; Tsuneda, S.; Sekiguchi, Y.; Noda, N.
Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro
Biochem. Biophys. Res. Commun.
393
131-136
2010
Hepacivirus C
Manually annotated by BRENDA team
Tang, W.; You, W.; Shi, F.; Qi, T.; Wang, L.; Djouder, Z.; Liu, W.; Zeng, X.
RNA helicase A acts as a bridging factor linking nuclear beta-actin with RNA polymerase II
Biochem. J.
420
421-428
2009
Homo sapiens
Manually annotated by BRENDA team
Hahn, D.; Beggs, J.D.
Brr2p RNA helicase with a split personality: insights into structure and function
Biochem. Soc. Trans.
38
1105-1109
2010
Homo sapiens
Manually annotated by BRENDA team
Sato, H.; Tsai-Morris, C.H.; Dufau, M.L.
Relevance of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) in the structural integrity of the chromatoid body during spermatogenesis
Biochim. Biophys. Acta
1803
534-543
2010
Mus musculus
Manually annotated by BRENDA team
Wang, H.; Gao, X.; Huang, Y.; Yang, J.; Liu, Z.R.
P68 RNA helicase is a nucleocytoplasmic shuttling protein
Cell Res.
19
1388-1400
2009
Mus musculus
Manually annotated by BRENDA team
Wilson, J.M.; Martinez-De Luna, R.I.; El Hodiri, H.M.; Smith, R.; King, M.W.; Mescher, A.L.; Neff, A.W.; Belecky-Adams, T.L.
RNA helicase Ddx39 is expressed in the developing central nervous system, limb, otic vesicle, branchial arches and facial mesenchyme of Xenopus laevis
Gene Expr. Patterns
10
44-52
2010
Xenopus laevis (Q7ZX48), Xenopus laevis
Manually annotated by BRENDA team
Shi, M.; Collett, M.; Loros, J.J.; Dunlap, J.C.
FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock
Genetics
184
351-361
2010
Neurospora sp.
Manually annotated by BRENDA team
Solana, J.; Romero, R.
SpolvlgA is a DDX3/PL10-related DEAD-box RNA helicase expressed in blastomeres and embryonic cells in planarian embryonic development
Int. J. Biol. Sci.
5
64-73
2009
Schmidtea polychroa (B9VSG1), Schmidtea polychroa
Manually annotated by BRENDA team
Collins, R.; Karlberg, T.; Lehtioe, L.; Schuetz, P.; van den Berg, S.; Dahlgren, L.G.; Hammarstroem, M.; Weigelt, J.; Schueler, H.
The DEXD/H-box RNA helicase DDX19 is regulated by an alpha-helical switch
J. Biol. Chem.
284
10296-10300
2009
Homo sapiens (Q9UMR2), Homo sapiens
Manually annotated by BRENDA team
Tsai-Morris, C.H.; Sheng, Y.; Gutti, R.; Li, J.; Pickel, J.; Dufau, M.L.
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis
J. Cell. Biochem.
109
1142-1147
2010
Mus musculus
Manually annotated by BRENDA team
Schuetz, P.; Wahlberg, E.; Karlberg, T.; Hammarstroem, M.; Collins, R.; Flores, A.; Schueler, H.
Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein
J. Mol. Biol.
400
768-782
2010
Homo sapiens (Q08211), Homo sapiens
Manually annotated by BRENDA team
Prakash, J.S.; Krishna, P.S.; Sirisha, K.; Kanesaki, Y.; Suzuki, I.; Shivaji, S.; Murata, N.
An RNA helicase, CrhR, regulates the low-temperature-inducible expression of heat-shock genes groES, groEL1 and groEL2 in Synechocystis sp. PCC 6803
Microbiology
156
442-451
2010
Synechocystis sp. PCC 6803
Manually annotated by BRENDA team
Minshall, N.; Kress, M.; Weil, D.; Standart, N.
Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly
Mol. Biol. Cell
20
2464-2472
2009
Homo sapiens (P26196), Homo sapiens
Manually annotated by BRENDA team
Bolinger, C.; Sharma, A.; Singh, D.; Yu, L.; Boris-Lawrie, K.
RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions
Nucleic Acids Res.
38
1686-1696
2010
Human immunodeficiency virus 1
Manually annotated by BRENDA team
Despins, S.; Issur, M.; Bougie, I.; Bisaillon, M.
Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase
Nucleic Acids Res.
38
5493-5506
2010
West Nile virus
Manually annotated by BRENDA team
Carter, C.L.; Lin, C.; Liu, C.Y.; Yang, L.; Liu, Z.R.
Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter
Oncogene
29
5427-5436
2010
Homo sapiens
Manually annotated by BRENDA team
Paul, E.; Kielbasinski, M.; Sedivy, J.M.; Murga-Zamalloa, C.; Khanna, H.; Klysik, J.E.
Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse
Transgenic Res.
19
691-701
2010
Mus musculus (Q80YD1), Mus musculus
Manually annotated by BRENDA team
Sireesha, K.; Radharani, B.; Krishna, P.S.; Sreedhar, N.; Subramanyam, R.; Mohanty, P.; Prakash, J.S.
RNA helicase, CrhR is indispensable for the energy redistribution and the regulation of photosystem stoichiometry at low temperature in Synechocystis sp. PCC6803
Biochim. Biophys. Acta
1817
1525-1536
2012
Synechocystis sp.
Manually annotated by BRENDA team
Yajima, M.; Wessel, G.M.
The DEAD-box RNA helicase Vasa functions in embryonic mitotic progression in the sea urchin
Development
138
2217-2222
2011
Lytechinus variegatus, Patiria miniata, Strongylocentrotus purpuratus
Manually annotated by BRENDA team
Xu, R.R.; Qi, S.D.; Lu, L.T.; Chen, C.T.; Wu, C.A.; Zheng, C.C.
A DExD/H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana
FEBS J.
278
2296-2306
2011
Arabidopsis thaliana
Manually annotated by BRENDA team
Hicks, L.D.; Warrier, I.; Raghavan, R.; Minnick, M.F.
Ribozyme stability, exon skipping, and a potential role for RNA helicase in group I intron splicing by Coxiella burnetii
J. Bacteriol.
193
5292-5299
2011
Coxiella burnetii (Q83DM8), Coxiella burnetii
Manually annotated by BRENDA team
Ranji, A.; Shkriabai, N.; Kvaratskhelia, M.; Musier-Forsyth, K.; Boris-Lawrie, K.
Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs
J. Biol. Chem.
286
5328-5337
2011
Homo sapiens
Manually annotated by BRENDA team
Choi, Y.J.; Lee, S.G.
The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export
J. Cell. Biochem.
113
985-996
2012
Homo sapiens, Homo sapiens (P17844)
Manually annotated by BRENDA team
Rowland, J.G.; Simon, W.J.; Prakash, J.S.; Slabas, A.R.
Proteomics reveals a role for the RNA helicase crhR in the modulation of multiple metabolic pathways during cold acclimation of Synechocystis sp. PCC6803
J. Proteome Res.
10
3674-3689
2011
Synechocystis sp.
Manually annotated by BRENDA team
Kar, A.; Fushimi, K.; Zhou, X.; Ray, P.; Shi, C.; Chen, X.; Liu, Z.; Chen, S.; Wu, J.Y.
RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5 splice site
Mol. Cell. Biol.
31
1812-1821
2011
Homo sapiens (P17844)
Manually annotated by BRENDA team
Booy, E.P.; Meier, M.; Okun, N.; Novakowski, S.K.; Xiong, S.; Stetefeld, J.; McKenna, S.A.
The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary
Nucleic Acids Res.
40
4110-4124
2012
Homo sapiens
Manually annotated by BRENDA team
Chi, W.; He, B.; Mao, J.; Li, Q.; Ma, J.; Ji, D.; Zou, M.; Zhang, L.
The function of RH22, a DEAD RNA helicase, in the biogenesis of the 50S ribosomal subunits of Arabidopsis chloroplasts
Plant Physiol.
158
693-707
2012
Arabidopsis thaliana
Manually annotated by BRENDA team
Salman-Dilgimen, A.; Hardy, P.; Dresser, A.; Chaconas, G.
HrpA, a Deah-Box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete
PLoS ONE
6
e22168
2011
Borreliella burgdorferi
Manually annotated by BRENDA team
Manojlovic, Z.; Stefanovic, B.
A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs
RNA
18
321-334
2012
Homo sapiens
Manually annotated by BRENDA team
Xing, L.; Niu, M.; Zhao, X.; Kleiman, L.
Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell
Biochim. Biophys. Acta
1840
2234-2243
2014
Homo sapiens (Q08211)
Manually annotated by BRENDA team
Chen, G.; Liu, C.H.; Zhou, L.; Krug, R.M.
Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein
Cell Host Microbe
15
484-493
2014
Homo sapiens (Q9NR30)
Manually annotated by BRENDA team
Hug, N.; Caceres, J.F.
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex
Cell Rep.
8
1845-1856
2014
Homo sapiens (Q14147), Homo sapiens
Manually annotated by BRENDA team
Leitao, A.L.; Costa, M.C.; Enguita, F.J.
Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
Int. J. Mol. Sci.
16
2269-2293
2015
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P21372), Saccharomyces cerevisiae (P47047), Dengue virus, Hepacivirus C, Neurospora crassa, Yellow fever virus, Homo sapiens (O95786), Homo sapiens (Q9UMR2), Murray Valley encephalitis virus (P05769), Kunjin virus (P14335), Japanese encephalitis virus (P27395)
Manually annotated by BRENDA team
Netterling, S.; Vaitkevicius, K.; Nord, S.; Johansson, J.
A Listeria monocytogenes RNA helicase essential for growth and ribosomal maturation at low temperatures uses its C terminus for appropriate interaction with the ribosome
J. Bacteriol.
194
4377-4385
2012
Listeria monocytogenes (Q8Y6G5), Listeria monocytogenes, Listeria monocytogenes EGDe (Q8Y6G5)
Manually annotated by BRENDA team
Guo, M.; Hundseth, K.; Ding, H.; Vidhyasagar, V.; Inoue, A.; Nguyen, C.H.; Zain, R.; Lee, J.S.; Wu, Y.
A distinct triplex DNA unwinding activity of ChlR1 helicase
J. Biol. Chem.
290
5174-5189
2015
Homo sapiens (Q96FC9), Homo sapiens
Manually annotated by BRENDA team
Fiorini, F.; Bagchi, D.; Le Hir, H.; Croquette, V.
Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities
Nat. Commun.
6
7581
2015
Homo sapiens (Q92900), Homo sapiens
Manually annotated by BRENDA team
Erkizan, H.V.; Schneider, J.A.; Sajwan, K.; Graham, G.T.; Griffin, B.; Chasovskikh, S.; Youbi, S.E.; Kallarakal, A.; Chruszcz, M.; Padmanabhan, R.; Casey, J.L.; Ueren, A.; Toretsky, J.A.
RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1
Nucleic Acids Res.
43
1069-1080
2015
Homo sapiens (Q08211)
Manually annotated by BRENDA team
Nicklas, S.; Okawa, S.; Hillje, A.L.; Gonzalez-Cano, L.; Del Sol, A.; Schwamborn, J.C.
The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs
Nucleic Acids Res.
43
2638-2654
2015
Mus musculus (P54823)
Manually annotated by BRENDA team
Zhang, X.; Zhao, X.; Feng, C.; Liu, N.; Feng, H.; Wang, X.; Mu, X.; Huang, L.; Kang, Z.
The cloning and characterization of a DEAD-Box RNA helicase from stress-responsive wheat
Physiol. Mol. Plant Pathol.
88
36-42
2014
Triticum aestivum (N0E6R8)
-
Manually annotated by BRENDA team
Asakura, Y.; Galarneau, E.; Watkins, K.P.; Barkan, A.; van Wijk, K.J.
Chloroplast RH3 DEAD box RNA helicases in maize and Arabidopsis function in splicing of specific group II introns and affect chloroplast ribosome biogenesis
Plant Physiol.
159
961-974
2012
Zea mays (A0A1D6GDY8), Zea mays, Arabidopsis thaliana (Q8L7S8)
Manually annotated by BRENDA team
Seo, M.; Seo, K.; Hwang, W.; Koo, H.J.; Hahm, J.H.; Yang, J.S.; Han, S.K.; Hwang, D.; Kim, S.; Jang, S.K.; Lee, Y.; Nam, H.G.; Lee, S.J.
RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans
Proc. Natl. Acad. Sci. USA
112
E4246-E4255
2015
Caenorhabditis elegans (Q18212), Caenorhabditis elegans
Manually annotated by BRENDA team
Zhang, X.; Nakashima, T.; Kakuta, Y.; Yao, M.; Tanaka, I.; Kimura, M.
Crystal structure of an archaeal Ski2p-like protein from Pyrococcus horikoshii OT3
Protein Sci.
17
136-145
2008
Pyrococcus horikoshii (O59025), Pyrococcus horikoshii OT-3 (O59025)
Manually annotated by BRENDA team
Tauchert, M.J.; Ficner, R.
Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum
Acta crystallogr. Sect. F
72
409-416
2016
Thermochaetoides thermophila (G0SBQ7), Thermochaetoides thermophila DSM 1495 (G0SBQ7)
Manually annotated by BRENDA team
Chen, X.; Wang, C.; Zhang, X.; Tian, T.; Zang, J.
Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP
Acta Crystallogr. Sect. F
74
704-709
2018
Staphylococcus aureus (Q99SH6), Staphylococcus aureus, Staphylococcus aureus ATCC 700699 (Q99SH6), Staphylococcus aureus Mu50 (Q99SH6)
Manually annotated by BRENDA team
Felisberto-Rodrigues, C.; Thomas, J.C.; McAndrew, C.; Le Bihan, Y.V.; Burke, R.; Workman, P.; van Montfort, R.L.M.
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release
Biochem. J.
476
2521-2543
2019
Homo sapiens (Q14562), Homo sapiens
Manually annotated by BRENDA team
Xie, Q.; Liu, J.; Shan, Y.; Wang, S.; Liu, F.
Substrate determinants for unwinding activity of the DExH/D-Box protein RNA helicase A
Biochemistry
57
6662-6668
2018
Homo sapiens (Q08211)
Manually annotated by BRENDA team
Moore, A.F.; Gentry, R.C.; Koculi, E.
DbpA is a region-specific RNA helicase
Biopolymers
107
e23001
2017
Escherichia coli (P21693)
Manually annotated by BRENDA team
Giraud, G.; Terrone, S.; Bourgeois, C.F.
Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation
BMB Rep.
51
613-622
2018
Drosophila melanogaster, Drosophila melanogaster (P19109), Homo sapiens (P17844), Homo sapiens (Q92841), Mus musculus (Q501J6), Mus musculus (Q61656)
Manually annotated by BRENDA team
Absmeier, E.; Santos, K.F.; Wahl, M.C.
Functions and regulation of the Brr2 RNA helicase during splicing
Cell Cycle
15
3362-3377
2016
Homo sapiens (O75643), Homo sapiens, Saccharomyces cerevisiae (P32639), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P32639)
Manually annotated by BRENDA team
Absmeier, E.; Becke, C.; Wollenhaupt, J.; Santos, K.F.; Wahl, M.C.
Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2
Cell Cycle
16
100-112
2017
Thermochaetoides thermophila (G0S0B9), Homo sapiens (O75643), Thermochaetoides thermophila IMI 039719 (G0S0B9), Thermochaetoides thermophila DSM 1495 (G0S0B9), Thermochaetoides thermophila CBS 144.50 (G0S0B9)
Manually annotated by BRENDA team
Tauchert, M.J.; Fourmann, J.B.; Luehrmann, R.; Ficner, R.
Structural insights into the mechanism of the DEAH-box RNA helicase Prp43
eLife
6
e21510
2017
Thermochaetoides thermophila (G0RY84), Thermochaetoides thermophila IMI 039719 (G0RY84), Thermochaetoides thermophila DSM 1495 (G0RY84), Thermochaetoides thermophila CBS 144.50 (G0RY84)
Manually annotated by BRENDA team
Conrad, K.S.; Hurley, J.M.; Widom, J.; Ringelberg, C.S.; Loros, J.J.; Dunlap, J.C.; Crane, B.R.
Structure of the frequency-interacting RNA helicase a protein interaction hub for the circadian clock
EMBO J.
35
1707-1719
2016
Neurospora crassa (Q1K502), Neurospora crassa, Neurospora crassa 74-OR23-1A (Q1K502), Neurospora crassa ATCC 24698 (Q1K502), Neurospora crassa CBS 708.71 (Q1K502), Neurospora crassa DSM 1257 (Q1K502), Neurospora crassa FGSC 987 (Q1K502)
Manually annotated by BRENDA team
Leone, S.; Baer, D.; Slabber, C.F.; Dalcher, D.; Santoro, R.
The RNA helicase DHX9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation
EMBO Rep.
18
1248-1262
2017
Mus musculus (O70133)
Manually annotated by BRENDA team
Cusumano, P.; Damulewicz, M.; Carbognin, E.; Caccin, L.; Puricella, A.; Specchia, V.; Bozzetti, M.P.; Costa, R.; Mazzotta, G.M.
The RNA helicase BELLE is involved in circadian rhythmicity and in transposons regulation in Drosophila melanogaster
Front. Physiol.
10
133
2019
Drosophila melanogaster (Q9VHP0), Drosophila melanogaster
Manually annotated by BRENDA team
Kim, S.; Corvaglia, A.R.; Leo, S.; Cheung, A.; Francois, P.
Characterization of RNA helicase CshA and its role in protecting mRNAs and small RNAs of Staphylococcus aureus strain Newman
Infect. Immun.
84
833-844
2016
Staphylococcus aureus (A0A0H3K9R1), Staphylococcus aureus (Q7A4G0), Staphylococcus aureus, Staphylococcus aureus N315 (Q7A4G0), Staphylococcus aureus Newman (A0A0H3K9R1)
Manually annotated by BRENDA team
Intile, P.J.; Balzer, G.J.; Wolfgang, M.C.; Yahr, T.L.
The RNA helicase DeaD stimulates ExsA translation to promote expression of the Pseudomonas aeruginosa type III secretion system
J. Bacteriol.
197
2664-2674
2015
Pseudomonas aeruginosa (Q9I003), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9I003), Pseudomonas aeruginosa 1C (Q9I003), Pseudomonas aeruginosa PRS 101 (Q9I003), Pseudomonas aeruginosa DSM 22644 (Q9I003), Pseudomonas aeruginosa CIP 104116 (Q9I003), Pseudomonas aeruginosa LMG 12228 (Q9I003), Pseudomonas aeruginosa JCM 14847 (Q9I003)
Manually annotated by BRENDA team
Hashemi, V.; Masjedi, A.; Hazhir-Karzar, B.; Tanomand, A.; Shotorbani, S.S.; Hojjat-Farsangi, M.; Ghalamfarsa, G.; Azizi, G.; Anvari, E.; Baradaran, B.; Jadidi-Niaragh, F.
The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer
J. Cell. Physiol.
234
5478-5487
2019
Homo sapiens (P17844), Homo sapiens
Manually annotated by BRENDA team
Iwatani-Yoshihara, M.; Ito, M.; Klein, M.G.; Yamamoto, T.; Yonemori, K.; Tanaka, T.; Miwa, M.; Morishita, D.; Endo, S.; Tjhen, R.; Qin, L.; Nakanishi, A.; Maezaki, H.; Kawamoto, T.
Discovery of allosteric inhibitors targeting the spliceosomal RNA helicase Brr2
J. Med. Chem.
60
5759-5771
2017
Homo sapiens (O75643)
Manually annotated by BRENDA team
Aryanpur, P.P.; Renner, D.M.; Rodela, E.; Mittelmeier, T.M.; Byrd, A.; Bolger, T.A.
The DEAD-box RNA helicase Ded1 has a role in the translational response to TORC1 inhibition
Mol. Biol. Cell
30
2171-2184
2019
Saccharomyces cerevisiae (P06634), Saccharomyces cerevisiae ATCC 204508 (P06634)
Manually annotated by BRENDA team
De, I.; Bessonov, S.; Hofele, R.; dos Santos, K.; Will, C.L.; Urlaub, H.; Luehrmann, R.; Pena, V.
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes
Nat. Struct. Mol. Biol.
22
138-144
2015
Homo sapiens (O60306), Homo sapiens
Manually annotated by BRENDA team
Gowravaram, M.; Bonneau, F.; Kanaan, J.; Maciej, V.D.; Fiorini, F.; Raj, S.; Croquette, V.; Le Hir, H.; Chakrabarti, S.
A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner
Nucleic Acids Res.
46
2648-2659
2018
Homo sapiens (Q92900)
Manually annotated by BRENDA team
Bobik, K.; McCray, T.N.; Ernest, B.; Fernandez, J.C.; Howell, K.A.; Lane, T.; Staton, M.; Burch-Smith, T.M.
The chloroplast RNA helicase ISE2 is required for multiple chloroplast RNA processing steps in Arabidopsis thaliana
Plant J.
91
114-131
2017
Arabidopsis thaliana (B9DFG3), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (B9DFG3)
Manually annotated by BRENDA team
Bennett, A.H.; ODonohue, M.F.; Gundry, S.R.; Chan, A.T.; Widrick, J.; Draper, I.; Chakraborty, A.; Zhou, Y.; Zon, L.I.; Gleizes, P.E.; Beggs, A.H.; Gupta, V.A.
RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes
PLoS Genet.
14
e1007226
2018
Danio rerio (Q6DRN0)
Manually annotated by BRENDA team
Liu, Y.; Tabata, D.; Imai, R.
A cold-inducible DEAD-Box RNA helicase from Arabidopsis thaliana regulates plant growth and development under low temperature
PLoS ONE
11
e0154040
2016
Arabidopsis thaliana (Q39189), Arabidopsis thaliana
Manually annotated by BRENDA team
Szappanos, D.; Tschismarov, R.; Perlot, T.; Westermayer, S.; Fischer, K.; Platanitis, E.; Kallinger, F.; Novatchkova, M.; Lassnig, C.; Mueller, M.; Sexl, V.; Bennett, K.L.; Foong-Sobis, M.; Penninger, J.M.; Decker, T.
The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity
PLoS Pathog.
14
e1007397
2018
Mus musculus (Q62167)
Manually annotated by BRENDA team
Giraud, C.; Hausmann, S.; Lemeille, S.; Prados, J.; Redder, P.; Linder, P.
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen Staphylococcus aureus
RNA Biol.
12
658-674
2015
Staphylococcus aureus (Q2FWH5), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FWH5)
Manually annotated by BRENDA team
Xu, L.; Wang, L.; Peng, J.; Li, F.; Wu, L.; Zhang, B.; Lv, M.; Zhang, J.; Gong, Q.; Zhang, R.; Zuo, X.; Zhang, Z.; Wu, J.; Tang, Y.; Shi, Y.
Insights into the structure of dimeric RNA helicase CsdA and indispensable role of its C-terminal regions
Structure
25
1795-1808.e5
2017
Escherichia coli (P0A9P6)
Manually annotated by BRENDA team