Reference on EC 3.6.4.10 - non-chaperonin molecular chaperone ATPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lissin, N.M.; Venyaminov, S.Y.; Girshovich, A.S.
(Mg-ATP)-dependent self-assembly of molecular chaperone GroEL
Nature
348
339-342
1990
Escherichia coli
Sadis, S.; Hightower, L.E.
Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange
Biochemistry
31
9406-9412
1992
Bos taurus, Saccharomyces cerevisiae, Escherichia coli
Blond-Elguindi, S.; Fourie, A.M.; Sambrook, J.F.; Gething, M.J.H.
Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers
J. Biol. Chem.
268
12730-12735
1993
Bos taurus, Cricetulus griseus, Mus musculus
Wawrzynow, A.; Wojtkowiak, D.; Marszalek, J.; Banecki, B.; Jonsen, M.; Graves, B.; Georgopoulos, C.; Zylicz, M.
The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone
EMBO J.
14
1867-1877
1995
Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli
O'Brien, M.C.; McKay, D.B.
How potassium affects the activity of the molecular chaperone Hsc70 I. Potassium is required for optimal ATPase activity
J. Biol. Chem.
270
2247-2250
1995
Bos taurus, Escherichia coli
Wilbanks, S.M.; McKay, D.B.
How potassium affects the activity of the molecular chaperone Hsc70 II. Potassium binds specifically in the ATPase active site
J. Biol. Chem.
270
2251-2257
1995
Bos taurus
Jordan, R.; McMackens, R.
Modulation of the ATPase activity of the molecular chaperone DnaK by peptides and the DnaJ and GrpE heat shock proteins
J. Biol. Chem.
270
4563-4569
1995
Escherichia coli
Ha, J.H.; McKay, D.B.
Kinetics of nucleotide-induced changes in the tryptophan fluorescence of the molecular chaperone Hsc70 and its subfragments suggest the ATP-induced conformational change follows initial ATP binding
Biochemistry
34
11635-11644
1995
Bos taurus, Escherichia coli
Miernyk, J.A.; Hayman, G.T.
ATPase activity and molecular chaperone function of the stress70 proteins
Plant Physiol.
110
419-424
1996
Escherichia coli, Homo sapiens, Solanum lycopersicum, Zea mays
Sriram, M.; Osipiuk, J.; Freeman, B.C.; Morimoto, R.I.; Joachimiak, A.
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
Structure
5
403-414
1997
Bos taurus, Escherichia coli, Homo sapiens
Russell, R.; Jordan, R.; McMacken, R.
Kinetic characterization of the ATPase cycle of the DnaK molecular chaperone
Biochemistry
37
596-607
1998
Bos taurus, Escherichia coli
Slepenkov, S.; Witt, S.N.
Kinetics of the reactions of the Escherichia coli molecular chaperone DnaK with ATP: Evidence that a three-step reaction precedes ATP hydrolysis
Biochemistry
37
1015-1024
1998
Escherichia coli, Solanum lycopersicum, Zea mays
Li, X.; Su, R.T.C.; Hsu, H.; Sze, H.
The molecular chaperone calnexin associates with the vacuolar H+-ATPase from oat seedlings
Plant Cell
10
119-130
1998
Arabidopsis thaliana, Avena sativa, Saccharomyces cerevisiae
Muchowski, P.J.; Clark, J.I.
ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin
Proc. Natl. Acad. Sci. USA
95
1004-1009
1998
Homo sapiens, Mus musculus
Hiromura, M.; Yano, M.; Mori, H.; Inoue, M.; Kido, H.
Intrinsic ADP-ATP exchange activity is a novel function of the molecular chaperone, Hsp70
J. Biol. Chem.
273
5435-5438
1998
Bos taurus, Escherichia coli
Panaretou, B.; Prodromou, C.; Roe, S.M.; O'Brien, R.; Ladbury, J.E.; Piper, P.W.; Pearl, L.H.
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
EMBO J.
17
4829-4836
1998
Saccharomyces cerevisiae, Escherichia coli, Saccharomyces cerevisiae PP30
McClellan, A.J.; Endres, J.B.; Vogel, J.P.; Palazzi, D.; Rose, M.D.; Brodsky, J.L.
Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER
Mol. Biol.
9
3533-3545
1998
Bos taurus, Cricetulus griseus, Saccharomyces cerevisiae
Brodsky, J.L.
Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin. Modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions
Biochem. Pharmacol.
57
877-880
1999
Bos taurus, Saccharomyces cerevisiae, Rattus norvegicus
Chadli, A.; Ladjimi, M.M.; Baulieu, E.E.; Catelli, M.G.
Heat-induced oligomerization of the molecular chaperone Hsp90
J. Biol. Chem.
274
4133-4239
1999
Escherichia coli, Gallus sp., Neurospora crassa
Silberg, J.J.; Vickery, L.E.
Kinetic characterization of the ATPase cycle of the molecular chaperone Hsc66 from Escherichia coli
J. Biol. Chem.
275
7779-7786
2000
Escherichia coli
Li, J.; Sha, B.
Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1)
Acta Crystallogr. Sect. D
57
909-911
2001
Escherichia coli
Li, J.; Sha, B.
Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 nucleotide-binding domain 2 (NBD2)
Acta Crystallogr. Sect. D
58
1030-1031
2002
Escherichia coli
Rowlands, M.G.; Newbatt, Y.M.; Prodromou, C.; Pearl, L.H.; Workman, P.; Aherne, W.
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
Anal. Biochem.
327
176-183
2004
Saccharomyces cerevisiae
Sehorn, M.G.; Slepenkov, S.V.; Witt, S.N.
Characterization of two partially unfolded intermediates of the molecular chaperone DnaK at low pH
Biochemistry
41
8499-8507
2002
Escherichia coli
Buczynski, G.; Slepenkov, S.V.; Sehorn, M.G.; Witt, S.N.
Characterization of a lidless form of the molecular chaperone DnaK: deletion of the lid increases peptide on- and off-rate constants
J. Biol. Chem.
276
27231-27236
2001
Escherichia coli
Richter, K.; Reinstein, J.; Buchner, J.
N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle
J. Biol. Chem.
277
44905-44910
2002
Saccharomyces cerevisiae
Lotz, G.P.; Lin, H.; Harst, A.; Obermann, W.M.
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
J. Biol. Chem.
278
17228-17235
2003
Saccharomyces cerevisiae
Song, C.; Wang, Q.; Li, C.C.
ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity
J. Biol. Chem.
278
3648-3655
2003
Homo sapiens
Kim, D.Y.; Kim, K.K.
Crystal structure of ClpX molecular chaperone from Helicobacter pylori
J. Biol. Chem.
278
50664-50670
2003
Helicobacter pylori
Tupling, A.R.; Gramolini, A.O.; Duhamel, T.A.; Kondo, H.; Asahi, M.; Tsuchiya, S.C.; Borrelli, M.J.; Lepock, J.R.; Otsu, K.; Hori, M.; MacLennan, D.H.; Green, H.J.
HSP70 binds to the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1a) and prevents thermal inactivation
J. Biol. Chem.
279
52382-52389
2004
Homo sapiens, Rattus norvegicus
Grimminger, V.; Richter, K.; Imhof, A.; Buchner, J.; Walter, S.
The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104
J. Biol. Chem.
279
7378-7383
2004
Saccharomyces cerevisiae
Zeng, X.C.; Bhasin, S.; Wu, X.; Lee, J.G.; Maffi, S.; Nichols, C.J.; Lee, K.J.; Taylor, J.P.; Greene, L.E.; Eisenberg, E.
Hsp70 dynamics in vivo: effect of heat shock and protein aggregation
J. Cell Sci.
117
4991-5000
2004
Homo sapiens
Place, S.P.; Hofmann, G.E.
Temperature interactions of the molecular chaperone Hsc70 from the eurythermal marine goby Gillichthys mirabilis
J. Exp. Biol.
204
2675-2682
2001
Gillichthys mirabilis
Groemping, Y.; Klostermeier, D.; Herrmann, C.; Veit, T.; Seidel, R.; Reinstein, J.
Regulation of ATPase and chaperone cycle of DnaK from Thermus thermophilus by the nucleotide exchange factor GrpE
J. Mol. Biol.
305
1173-1183
2001
Thermus thermophilus
McLaughlin, S.H.; Ventouras, L.A.; Lobbezoo, B.; Jackson, S.E.
Independent ATPase activity of hsp90 subunits creates a flexible assembly platform
J. Mol. Biol.
344
813-826
2004
Homo sapiens
Zhang, Z.; Quick, M.K.; Kanelakis, K.C.; Gijzen, M.; Krishna, P.
Characterization of a plant homolog of hop, a cochaperone of hsp90
Plant Physiol.
131
525-535
2003
Glycine max
Matambo, T.S.; Odunuga, O.O.; Boshoff, A.; Blatch, G.L.
Overproduction, purification, and characterization of the Plasmodium falciparum heat shock protein 70
Protein Expr. Purif.
33
214-222
2004
Plasmodium falciparum
Boshoff, A.; Hennessy, F.; Blatch, G.L.
The in vivo and in vitro characterization of DnaK from Agrobacterium tumefaciens RUOR
Protein Expr. Purif.
38
161-169
2004
Agrobacterium tumefaciens
Li, J.; Sha, B.
Crystal structure of the E. coli Hsp100 ClpB N-terminal domain
Structure
11
323-328
2003
Escherichia coli
Worrall, L.; Walkinshaw, M.D.
Crystallization and X-ray data analysis of the 10 kDa C-terminal lid subdomain from Caenorhabditis elegans Hsp70
Acta Crystallogr. Sect. F
62
938-943
2006
Caenorhabditis elegans
Sharp, S.; Workman, P.
Inhibitors of the HSP90 molecular chaperone: current status
Adv. Cancer Res.
95
323-348
2006
Homo sapiens
Deane, E.E.; Woo, N.Y.
Cloning and characterization of the hsp70 multigene family from silver sea bream: Modulated gene expression between warm and cold temperature acclimation
Biochem. Biophys. Res. Commun.
330
776-783
2005
Rhabdosargus sarba (Q596W8), Rhabdosargus sarba (Q596W9)
Wadhwa, R.; Takano, S.; Kaur, K.; Aida, S.; Yaguchi, T.; Kaul, Z.; Hirano, T.; Taira, K.; Kaul, S.C.
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60
Biochem. J.
391
185-190
2005
Homo sapiens
Li, J.; Wu, Y.; Qian, X.; Sha, B.
Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex
Biochem. J.
398
353-360
2006
Saccharomyces cerevisiae
Mosser, D.D.; Ho, S.; Glover, J.R.
Saccharomyces cerevisiae Hsp104 enhances the chaperone capacity of human cells and inhibits heat stress-induced proapoptotic signaling
Biochemistry
43
8107-8115
2004
Saccharomyces cerevisiae
Chesnokova, L.S.; Witt, S.N.
Switches, catapults, and chaperones: Steady-state kinetic analysis of Hsp70-substrate interactions. [Erratum to document cited in CA143:262085]
Biochemistry
44
13224
2005
Escherichia coli
-
Tanaka, N.; Nakao, S.; Chatellier, J.; Tani, Y.; Tada, T.; Kunugi, S.
Effect of the polypeptide binding on the thermodynamic stability of the substrate binding domain of the DnaK chaperone
Biochim. Biophys. Acta
1748
1-8
2005
Escherichia coli
Brough, P.A.; Barril, X.; Beswick, M.; Dymock, B.W.; Drysdale, M.J.; Wright, L.; Grant, K.; Massey, A.; Surgenor, A.; Workman, P.
3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone
Bioorg. Med. Chem. Lett.
15
5197-5201
2005
Homo sapiens
Zippay, M.L.; Place, S.P.; Hofmann, G.E.
The molecular chaperone Hsc70 from a eurythermal marine goby exhibits temperature insensitivity during luciferase refolding assays
Comp. Biochem. Physiol. A
138A
1-7
2004
Gillichthys mirabilis
Takle, H.; McLeod, A.; Andersen, O.
Cloning and characterization of the executioner caspases 3, 6, 7 and Hsp70 in hyperthermic Atlantic salmon (Salmo salar) embryos
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
144
188-198
2006
Salmo salar
Kourtidis, A.; Scouras, Z.G.
Analysis and characterization of the transcriptional unit of a new Mytilus galloprovincialis (Mollusca: Bivalvia) hsp70 gene
DNA Seq.
16
36-43
2005
Mytilus galloprovincialis
Moro, F.; Fernandez-Saiz, V.; Slutsky, O.; Azem, A.; Muga, A.
Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70. Role of the divergent C-terminal alpha-helical subdomain
FEBS J.
272
3184-3196
2005
Saccharomyces cerevisiae, Escherichia coli
Groemping, Y.; Seidel, R.; Reinstein, J.
Balance of ATPase stimulation and nucleotide exchange is not required for efficient refolding activity of the DnaK chaperone
FEBS Lett.
579
5713-5717
2005
Thermus thermophilus
Brunt, S.A.; Silver, J.C.
Molecular cloning and characterization of two different cDNAs encoding the molecular chaperone Hsp90 in the oomycete Achlya ambisexualis
Fungal Genet. Biol.
41
239-252
2004
Achlya ambisexualis
Yamashita, M.; Hirayoshi, K.; Nagata, K.
Characterization of multiple members of the HSP70 family in platyfish culture cells: molecular evolution of stress protein HSP70 in vertebrates
Gene
336
207-218
2004
Xiphophorus maculatus (Q8UWM8), Xiphophorus maculatus (Q8UWM9), Xiphophorus maculatus (Q8UWN0)
Cheng, Q.; Hallmann, A.; Edwards, L.; Miller, S.M.
Characterization of a heat-shock-inducible hsp70 gene of the green alga Volvox carteri
Gene
371
112-120
2006
Volvox carteri
Ravaux, J.; Toullec, J.Y.; Leger, N.; Lopez, P.; Gaill, F.; Shillito, B.
First hsp70 from two hydrothermal vent shrimps, Mirocaris fortunata and Rimicaris exoculata: Characterization and sequence analysis
Gene
386
162-172
2006
Mirocaris fortunata (A1XQQ5), Mirocaris fortunata, Rimicaris exoculata (A1XQQ6), Rimicaris exoculata
Newton-Howes, J.; Heath, D.D.; Shoemaker, C.B.; Grant, W.N.
Characterisation and expression of an Hsp70 gene from Parastrongyloides trichosuri
Int. J. Parasitol.
36
467-474
2006
Parastrongyloides trichosuri
Boesl, B.; Grimminger, V.; Walter, S.
Substrate binding to the molecular chaperone Hsp104 and its regulation by nucleotides
J. Biol. Chem.
280
38170-38176
2005
Saccharomyces cerevisiae
Swain, J.F.; Schulz, E.G.; Gierasch, L.M.
Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states
J. Biol. Chem.
281
1605-1611
2006
Escherichia coli
Andersson, F.I.; Blakytny, R.; Kirstein, J.; Turgay, K.; Bukau, B.; Mogk, A.; Clarke, A.K.
Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity
J. Biol. Chem.
281
5468-5475
2006
Synechococcus elongatus
Wegele, H.; Wandinger, S.K.; Schmid, A.B.; Reinstein, J.; Buchner, J.
Substrate transfer from the chaperone Hsp70 to Hsp90
J. Mol. Biol.
356
802-811
2006
Homo sapiens
Targosz, A.; Pierzchalski, P.; Krawiec, A.; Szczyrk, U.; Brzozowski, T.; Konturek, S.J.; Pawlik, W.W.
Helicobacter pylori inhibits expression of heat shock protein 70 (HSP70) in human epithelial cell line. Importance of Cag A protein
J. Physiol. Pharmacol.
57
265-278
2006
Homo sapiens
Sjoegren, L.L.; MacDonald, T.M.; Sutinen, S.; Clarke, A.K.
Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content
Plant Physiol.
136
4114-4126
2004
Arabidopsis thaliana
Chang, L.; Bertelsen, E.B.; Wisen, S.; Larsen, E.M.; Zuiderweg, E.R.; Gestwicki, J.E.
High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK
Anal. Biochem.
372
167-176
2008
Escherichia coli
Nagy, M.; Akoev, V.; Zolkiewski, M.
Domain stability in the AAA+ ATPase ClpB from Escherichia coli
Arch. Biochem. Biophys.
453
63-69
2006
Escherichia coli
Mao, Y.; Deng, A.; Qu, N.; Wu, X.
ATPase domain of Hsp70 exhibits intrinsic ATP-ADP exchange activity
Biochemistry (Moscow)
71
1222-1229
2006
Bos taurus
Hawkins, T.A.; Haramis, A.; Etard, C.; Prodromou, C.; Vaughan, C.K.; Ashworth, R.; Ray, S.; Behra, M.; Holder, N.; Talbot, W.S.; Pearl, L.H.; Strahle, U.; Wilson, S.W.
The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis
Development
135
1147-1156
2008
Danio rerio
Weitzmann, A.; Baldes, C.; Dudek, J.; Zimmermann, R.
The heat shock protein 70 molecular chaperone network in the pancreatic endoplasmic reticulum - a quantitative approach
FEBS J.
274
5175-5187
2007
Canis lupus familiaris
Loovers, H.M.; Guinan, E.; Jones, G.W.
Importance of Hsp70 ATPase domain in yeast prion propagation
Genetics
175
621-630
2007
Saccharomyces cerevisiae
Boshoff, A.; Stephens, L.L.; Blatch, G.L.
The Agrobacterium tumefaciens DnaK: ATPase cycle, oligomeric state and chaperone properties
Int. J. Biochem. Cell Biol.
40
804-812
2008
Agrobacterium tumefaciens
Sugimoto, S.; Yoshida, H.; Mizunoe, Y.; Tsuruno, K.; Nakayama, J.; Sonomoto, K.
Structural and functional conversion of molecular chaperone ClpB from the gram-positive halophilic lactic acid bacterium Tetragenococcus halophilus mediated by ATP and stress
J. Bacteriol.
188
8070-8078
2006
Tetragenococcus halophilus
McLaughlin, S.H.; Sobott, F.; Yao, Z.P.; Zhang, W.; Nielsen, P.R.; Grossmann, J.G.; Laue, E.D.; Robinson, C.V.; Jackson, S.E.
The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
J. Mol. Biol.
356
746-758
2006
Homo sapiens
Schaupp, A.; Marcinowski, M.; Grimminger, V.; Boesl, B.; Walter, S.
Processing of proteins by the molecular chaperone Hsp104
J. Mol. Biol.
370
674-686
2007
Saccharomyces cerevisiae
Lee, S.; Choi, J.M.; Tsai, F.T.
Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB
Mol. Cell
25
261-271
2007
Thermus thermophilus
Doyle, S.M.; Shorter, J.; Zolkiewski, M.; Hoskins, J.R.; Lindquist, S.; Wickner, S.
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity
Nat. Struct. Mol. Biol.
14
114-122
2007
Saccharomyces cerevisiae, Escherichia coli
Colombo, G.; Morra, G.; Meli, M.; Verkhivker, G.
Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution
Proc. Natl. Acad. Sci. USA
105
7976-7981
2008
Homo sapiens
Saji, H.; Iizuka, R.; Yoshida, T.; Abe, T.; Kidokoro, S.; Ishii, N.; Yohda, M.
Role of the IXI/V motif in oligomer assembly and function of StHsp14.0, a small heat shock protein from the acidothermophilic archaeon, Sulfolobus tokodaii strain 7
Proteins
71
771-782
2008
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
Needham, P.G.; Masison, D.C.
Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities
Arch. Biochem. Biophys.
478
167-174
2008
Saccharomyces cerevisiae
Watanabe, Y.H.; Nakazaki, Y.; Suno, R.; Yoshida, M.
Stability of the two wings of the coiled-coil domain of ClpB chaperone is critical for its disaggregation activity
Biochem. J.
421
71-77
2009
Thermus thermophilus
Sugimoto, S.; Saruwatari, K.; Higashi, C.; Tsuruno, K.; Matsumoto, S.; Nakayama, J.; Sonomoto, K.
In vivo and in vitro complementation study comparing the function of DnaK chaperone systems from halophilic lactic acid bacterium Tetragenococcus halophilus and Escherichia coli
Biosci. Biotechnol. Biochem.
72
811-822
2008
Escherichia coli, Tetragenococcus halophilus (Q93R27), Tetragenococcus halophilus JCM 5888 (Q93R27)
Polier, S.; Dragovic, Z.; Hartl, F.U.; Bracher, A.
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding
Cell
133
1068-1079
2008
Saccharomyces cerevisiae
Graf, C.; Stankiewicz, M.; Kramer, G.; Mayer, M.P.
Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine
EMBO J.
28
602-613
2009
Escherichia coli
Karradt, A.; Sobanski, J.; Mattow, J.; Lockau, W.; Baier, K.
NblA, a key protein of phycobilisome degradation, interacts with ClpC, a HSP100 chaperone partner of a cyanobacterial Clp protease
J. Biol. Chem.
283
32394-32403
2008
Nostoc sp. PCC 7120 = FACHB-418 (Q8YST5)
Werbeck, N.D.; Schlee, S.; Reinstein, J.
Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB
J. Mol. Biol.
378
178-190
2008
Thermus thermophilus
Onuoha, S.C.; Coulstock, E.T.; Grossmann, J.G.; Jackson, S.E.
Structural studies on the co-chaperone Hop and its complexes with Hsp90
J. Mol. Biol.
379
732-744
2008
Homo sapiens
Bhattacharya, A.; Kurochkin, A.V.; Yip, G.N.; Zhang, Y.; Bertelsen, E.B.; Zuiderweg, E.R.
Allostery in Hsp70 chaperones is transduced by subdomain rotations
J. Mol. Biol.
388
475-490
2009
Thermus thermophilus
Southworth, D.R.; Agard, D.A.
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle
Mol. Cell
32
631-640
2008
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Xu, Z.; Page, R.C.; Gomes, M.M.; Kohli, E.; Nix, J.C.; Herr, A.B.; Patterson, C.; Misra, S.
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
Nat. Struct. Mol. Biol.
15
1309-1317
2008
Homo sapiens
Hessling, M.; Richter, K.; Buchner, J.
Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90
Nat. Struct. Mol. Biol.
16
287-293
2009
Saccharomyces cerevisiae
Bertelsen, E.B.; Chang, L.; Gestwicki, J.E.; Zuiderweg, E.R.
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate
Proc. Natl. Acad. Sci. USA
106
8471-8476
2009
Escherichia coli
Nagy, M.; Wu, H.C.; Liu, Z.; Kedzierska-Mieszkowska, S.; Zolkiewski, M.
Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB
Protein Sci.
18
287-293
2009
Escherichia coli
Neckers, L.; Mollapour, M.; Tsutsumi, S.
The complex dance of the molecular chaperone Hsp90
Trends Biochem. Sci.
34
223-226
2009
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Wisniewska, M.; Karlberg, T.; Lehtioe, L.; Johansson, I.; Kotenyova, T.; Moche, M.; Schueler, H.
Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B, and HSPA5/BiP/GRP78
PLoS ONE
5
e8625
2010
Homo sapiens
Taldone, T.; Sun, W.; Chiosis, G.
Discovery and development of heat shock protein 90 inhibitors
Bioorg. Med. Chem.
17
2225-2235
2009
Saccharomyces cerevisiae, Homo sapiens
Janin, Y.L.
ATPase inhibitors of heat-shock protein 90, second season
Drug Discov. Today
15
342-353
2010
Homo sapiens
Cho, H.J.; Gee, H.Y.; Baek, K.H.; Ko, S.K.; Park, J.M.; Lee, H.; Kim, N.D.; Lee, M.G.; Shin, I.
A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator
J. Am. Chem. Soc.
133
20267-20276
2011
Homo sapiens
Gao, X.C.; Zhou, C.J.; Zhou, Z.R.; Wu, M.; Cao, C.Y.; Hu, H.Y.
The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation
J. Biol. Chem.
287
6044-6052
2012
Homo sapiens
Liu, Y.; Gierasch, L.; Bahar, I.
Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs
PLoS Comput. Biol.
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e1000931
2010
Homo sapiens
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Ngansop, F.; Li, H.; Zolkiewska, A.; Zolkiewski, M.
Biochemical characterization of the apicoplast-targeted AAA+ ATPase ClpB from Plasmodium falciparum
Biochem. Biophys. Res. Commun.
439
191-195
2013
Plasmodium falciparum (Q8IB03), Plasmodium falciparum
Aguado, A.; Fernandez-Higuero, J.A.; Cabrera, Y.; Moro, F.; Muga, A.
ClpB dynamics is driven by its ATPase cycle and regulated by the DnaK system and substrate proteins
Biochem. J.
466
561-570
2015
Plasmodium falciparum (Q8IB03)
Araujo, T.L.; Borges, J.C.; Ramos, C.H.; Meyer-Fernandes, J.R.; Oliveira Junior, R.S.; Pascutti, P.G.; Foguel, D.; Palhano, F.L.
Conformational changes in human Hsp70 induced by high hydrostatic pressure produce oligomers with ATPase activity but without chaperone activity
Biochemistry
53
2884-2889
2014
Homo sapiens
Flores-Perez, U.; Jarvis, P.
Molecular chaperone involvement in chloroplast protein import
Biochim. Biophys. Acta
1833
332-340
2013
Physcomitrium patens, Physcomitrium patens (D2XNF3), Physcomitrium patens (D2XNF4), Pisum sativum, Arabidopsis thaliana (P22953), Arabidopsis thaliana (P22954)
Hu, Y.H.; Dang, W.; Zhang, M.; Sun, L.
Japanese flounder (Paralichthys olivaceus) Hsp70: adjuvant effect and its dependence on the intrinsic ATPase activity
Fish Shellfish Immunol.
33
829-834
2012
Paralichthys olivaceus (O93240), Paralichthys olivaceus
Yokoyama, Y.; Ohtaki, A.; Jantan, I.; Yohda, M.; Nakamoto, H.
Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity
J. Biochem.
157
161-168
2015
Schizosaccharomyces pombe, Synechococcus elongatus, Synechococcus elongatus PCC 7942
Cai, K.; Frederick, R.O.; Kim, J.H.; Reinen, N.M.; Tonelli, M.; Markley, J.L.
Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU)
J. Biol. Chem.
288
28755-28770
2013
Homo sapiens
Yamamoto, S.; Subedi, G.P.; Hanashima, S.; Satoh, T.; Otaka, M.; Wakui, H.; Sawada, K.; Yokota, S.; Yamaguchi, Y.; Kubota, H.; Itoh, H.
ATPase activity and ATP-dependent conformational change in the co-chaperone HSP70/HSP90-organizing protein (HOP)
J. Biol. Chem.
289
9880-9886
2014
Sus scrofa, Sus scrofa (O02705)
Yamasaki, T.; Oohata, Y.; Nakamura, T.; Watanabe, Y.H.
Analysis of the cooperative ATPase cycle of the AAA+ chaperone ClpB from Thermus thermophilus by using ordered heterohexamers with an alternating subunit arrangement
J. Biol. Chem.
290
9789-9800
2015
Thermus thermophilus (Q9RA63), Thermus thermophilus
Blamowska, M.; Neupert, W.; Hell, K.
Biogenesis of the mitochondrial Hsp70 chaperone
J. Cell Biol.
199
125-135
2012
Saccharomyces cerevisiae
Singh, M.; Shah, V.; Tatu, U.
A novel C-terminal homologue of Aha1 co-chaperone binds to heat shock protein 90 and stimulates its ATPase activity in Entamoeba histolytica
J. Mol. Biol.
426
1786-1798
2014
Entamoeba histolytica (Q5KTW9), Entamoeba histolytica, Entamoeba histolytica HM-1: IMSS (Q5KTW9)
Bartolini, M.; Wainer, I.W.; Bertucci, C.; Andrisano, V.
The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90
J. Pharm. Biomed. Anal.
73
77-81
2013
Homo sapiens
Tyc, J.; Klingbeil, M.M.; Lukes, J.
Mitochondrial heat shock protein machinery hsp70/hsp40 is indispensable for proper mitochondrial DNA maintenance and replication
mBio
6
e02425-14
2015
Trypanosoma brucei
General, I.J.; Liu, Y.; Blackburn, M.E.; Mao, W.; Gierasch, L.M.; Bahar, I.
ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones
PLoS Comput. Biol.
10
e1003624
2014
Escherichia coli
Dores-Silva, P.R.; Barbosa, L.R.; Ramos, C.H.; Borges, J.C.
Human mitochondrial Hsp70 (mortalin): shedding light on ATPase activity, interaction with adenosine nucleotides, solution structure and domain organization
PLoS ONE
10
e0117170
2015
Homo sapiens (P38646), Homo sapiens
Liu, S.; Wang, J.; Cong, B.; Huang, X.; Chen, K.; Zhang, P.
Characterization and expression analysis of a mitochondrial heat-shock protein 70 gene from the Antarctic moss Pohlia nutans
Polar Biol.
37
1145-1155
2014
Pohlia nutans
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AhYoung, A.P.; Koehl, A.; Cascio, D.; Egea, P.F.
Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design
Protein Sci.
24
1508-1520
2015
Plasmodium falciparum, Plasmodium falciparum (A0A0L7LXM6)
Dhara, A.; Hussain, M.; Datta, D.; Kumar, M.
Insights to the assembly of a functionally active leptospiral ClpP1P2 protease complex along with its ATPase chaperone ClpX
ACS Omega
4
12880-12895
2019
Leptospira interrogans (Q72SG5), Leptospira interrogans, Leptospira interrogans Fiocruz L1-130 (Q72SG5)
Ranaweera, C.B.; Glaza, P.; Yang, T.; Zolkiewski, M.
Interaction of substrate-mimicking peptides with the AAA+ ATPase ClpB from Escherichia coli
Arch. Biochem. Biophys.
655
12-17
2018
Escherichia coli
Pearl, L.
Review The HSP90 molecular chaperone - an enigmatic ATPase
Biopolymers
105
594-607
2016
Homo sapiens (P07900 and P08238)
Krajewska, J.; Arent, Z.; Wieckowski, D.; Zolkiewski, M.; Kedzierska-Mieszkowska, S.
Immunoreactivity of the AAA+ chaperone ClpB from Leptospira interrogans with sera from Leptospira-infected animals
BMC Microbiol.
16
151
2016
Leptospira interrogans
Deville, C.; Franke, K.; Mogk, A.; Bukau, B.; Saibil, H.R.
Two-step activation mechanism of the ClpB disaggregase for sequential substrate threading by the main ATPase motor
Cell Rep.
27
3433-3446.e4
2019
Escherichia coli (P63284)
Tripathi, P.; Parijat, P.; Patel, V.K.; Batra, J.K.
The amino-terminal domain of Mycobacterium tuberculosis ClpB protein plays a crucial role in its substrate disaggregation activity
FEBS Open Bio
8
1669-1690
2018
Mycobacterium tuberculosis
Rotanova, T.V.; Andrianova, A.G.; Kudzhaev, A.M.; Li, M.; Botos, I.; Wlodawer, A.; Gustchina, A.
New insights into structural and functional relationships between LonA proteases and ClpB chaperones
FEBS Open Bio
9
1536-1551
2019
Escherichia coli (P63284), Thermus thermophilus (Q9RA63)
Johnston, D.M.; Miot, M.; Hoskins, J.R.; Wickner, S.; Doyle, S.M.
Substrate discrimination by ClpB and Hsp104
Front. Mol. Biosci.
4
36
2017
Saccharomyces cerevisiae, Thermus thermophilus (Q9RA63)
Krajewska, J.; Arent, Z.; Zolkiewski, M.; K?dzierska-Mieszkowska, S.
Isolation and identification of putative protein substrates of the AAA+ molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans
Int. J. Mol. Sci.
19
E1234
2018
Leptospira interrogans, Leptospira interrogans B42
Yokoyama, Y.; Ohtaki, A.; Jantan, I.; Yohda, M.; Nakamoto, H.
Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity
J. Biochem.
157
161-168
2015
Schizosaccharomyces pombe, Synechococcus elongatus, Synechococcus elongatus PCC 7942
Xu, M.; Marsh, H.; Sevier, C.
A conserved cysteine within the ATPase domain of the endoplasmic reticulum chaperone BiP is necessary for a complete complement of BiP activities
J. Mol. Biol.
428
4168-4184
2016
Saccharomyces cerevisiae
Cabrera, Y.; Dublang, L.; Fernandez-Higuero, J.; Albesa-Jove, D.; Lucas, M.; Viguera, A.; Guerin, M.; Vilar, J.; Muga, A.; Moro, F.
Regulation of human Hsc70 ATPase and chaperone activities by Apg2 role of the acidic subdomain
J. Mol. Biol.
431
444-461
2019
Homo sapiens
Dutkiewicz, R.; Nowak, M.; Craig, E.; Marszalek, J.
Fe-S cluster Hsp70 chaperones the ATPase cycle and protein interactions
Methods Enzymol.
595
161-184
2017
Saccharomyces cerevisiae
Schulze, A.; Beliu, G.; Helmerich, D.; Schubert, J.; Pearl, L.; Prodromou, C.; Neuweiler, H.
Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism
Nat. Chem. Biol.
12
628-635
2016
Saccharomyces cerevisiae (P02829), Saccharomyces cerevisiae
Goloubinoff, P.; Sassi, A.S.; Fauvet, B.; Barducci, A.; De Los Rios, P.
Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins
Nat. Chem. Biol.
14
388-395
2018
Escherichia coli
Mercier, R.; Wolmarans, A.; Schubert, J.; Neuweiler, H.; Johnson, J.; LaPointe, P.
The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
Nat. Commun.
10
1273
2019
Saccharomyces cerevisiae
Krajewska, J.; Modrak-Wojcik, A.; Arent, Z.J.; Wieckowski, D.; Zolkiewski, M.; Bzowska, A.; Kedzierska-Mieszkowska, S.
Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans
PLoS ONE
12
e0181118
2017
Escherichia coli, Leptospira interrogans
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