the enzyme gamma subunit is located adjacent to the M2-M6-M9 pocket of the alpha subunit at the transmembrane-extracellular interface. During the E1 to E2 transition, there is no relative change in distance between the alpha and gamma subunits but there is a relative change in distance between the beta and gamma subunits
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ATP phosphohydrolase (Na+/K+-exchanging)
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.