Information on EC 3.6.3.8 - Ca2+-transporting ATPase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.6.3.8
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RECOMMENDED NAME
GeneOntology No.
Ca2+-transporting ATPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2]
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
transmembrane transport
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (Ca2+-transporting)
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in yeast. The first and third transport one ion per ATP hydrolysed, whereas the second transports two ions. Ca2+ is transported from the cytosol [side 1] into the sarcoplasmic reticulum in muscle cells [side 2].
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene Afpmr1
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Manually annotated by BRENDA team
strain PS832, derived from strain 168
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
strains N2, daf-16(m26), and daf-2(e1370)III, gene pmr1
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-
Manually annotated by BRENDA team
crucian carp
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-
Manually annotated by BRENDA team
Dorytheutis plei
-
-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Homarus sp.
lobster
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-
Manually annotated by BRENDA team
gene PMR1
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-
Manually annotated by BRENDA team
burbot
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Manually annotated by BRENDA team
strain 7S
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-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Pigeon
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-
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
red swamp crayfish
SwissProt
Manually annotated by BRENDA team
from Vicia faba root nodules
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl phosphate + H2O + Ca2+/in
?
show the reaction diagram
-
-
-
-
?
acyl-carrier protein + H2O + Ca2+/in
?
show the reaction diagram
-
-
-
-
?
ADP + phosphate + Ca2+/in
ATP + H2O + Ca2+/out
show the reaction diagram
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-
-
r
ATP + H2O
ADP + phosphate
show the reaction diagram
ATP + H2O + 2 Ca2+[cytoplasm side]
ADP + phosphate + 2 Ca2+[lumen side]
show the reaction diagram
ATP + H2O + 2 Ca2+[side 1]
ADP + phosphate + 2 Ca2+[side 2]
show the reaction diagram
-
-
-
-
?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
show the reaction diagram
ATP + H2O + Ca2+/in
ADP + phosphate + Ca2+/out
show the reaction diagram
ATP + H2O + Ca2+/out
?
show the reaction diagram
ATP + H2O + Ca2+/out
ADP + phosphate + Ca2+/in
show the reaction diagram
ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
show the reaction diagram
ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
show the reaction diagram
ATP + H2O + Sr2+/in
ADP + phosphate + Sr2+/out
show the reaction diagram
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-
-
?
ATP + Sr2+/cis + H2O
ADP + phosphate + Sr2+/trans
show the reaction diagram
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-
-
-
?
CTP + H2O + Ca2+[side 1]
CDP + phosphate + Ca2+[side 2]
show the reaction diagram
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best substrate
-
-
?
GTP + H2O + Ca2+/in
GDP + phosphate + Ca2+/out
show the reaction diagram
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-
-
?
GTP + H2O + Ca2+[side 1]
GDP + phosphate + Ca2+[side 2]
show the reaction diagram
-
best substrate
-
-
?
ITP + H2O + Ca2+[side 1]
IDP + phosphate + Ca2+[side 2]
show the reaction diagram
-
best substrate
-
-
?
p-nitrophenyl phosphate + H2O + Ca2+/in
?
show the reaction diagram
-
-
-
-
?
UTP + H2O + Ca2+/in
UDP + phosphate + Ca2+/out
show the reaction diagram
UTP + H2O + Ca2+[side 1]
UDP + phosphate + Ca2+[side 2]
show the reaction diagram
-
best substrate
-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
-
?
ATP + H2O + 2 Ca2+[cytoplasm side]
ADP + phosphate + 2 Ca2+[lumen side]
show the reaction diagram
ATP + H2O + 2 Ca2+[side 1]
ADP + phosphate + 2 Ca2+[side 2]
show the reaction diagram
-
-
-
-
?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
show the reaction diagram
ATP + H2O + Ca2+/in
ADP + phosphate + Ca2+/out
show the reaction diagram
-
plasma-membrane Ca2+-ATPase is a calcium pump that exports Ca2+ from the cytosol to the extracellular environment of eukaryotic cells and thus maintain overall Ca2+ homoeostasis and provide local control of intracellular Ca2+ signalling
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-
?
ATP + H2O + Ca2+/out
?
show the reaction diagram
ATP + H2O + Ca2+/out
ADP + phosphate + Ca2+/in
show the reaction diagram
-
-
-
-
?
ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
show the reaction diagram
ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ba2+
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PMCA of neurons is electroneutral and exchanges 2 H+ for each Ca2+ or Ba2+ ion extruded
Calmodulin
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PMCA is dependent on Ca2+-calmodulin
K+
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slightly stimulates the dephosphorylation reaction
Na+
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when an outwardly directed Na+ gradient is imposed on the plasma membrane vesicles from the optic nerve, they accumulate Ca2+ in the absence of Mg2+ and/or ATP. Km for Na+ is 74 mM
Zn2+
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ER-type Ca2+-ATPases can transport, beside Ca2+, also Mn2+ and Zn2+ ions
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(12S,12aR)-3-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
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(1R,9aR)-9-[2-[(4-fluorobenzyl)oxy]ethyl]-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepine
-
(1S,6R,9aS)-3,6-dimethyloctahydro-3,9a-epidioxy-2-benzoxepin-1(1H)-yl phenylacetate
-
(1S,9aR)-1-methoxy-3-methyl-9-[2-(phenylperoxy)ethyl]octahydro-3,9a-epidioxy-2-benzoxepine
-
(1S,9aR)-1-methoxy-3-methyl-9-[2-(prop-2-en-1-yloxy)ethyl]octahydro-3,9a-epidioxy-2-benzoxepine
-
(1S,9aR)-9-[2-(benzyloxy)ethyl]-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepine
-
(1S,9aS)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepine
-
(1S,9aS)-1-[2-(benzyloxy)ethyl]-1,3,9-trimethyloctahydro-3,9a-epidioxy-2-benzoxepine
-
(2Z)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide
-
-
(3R,5aS,6R,8aS,12aS)-11-benzyl-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3,6-dimethyl-11-(2-methylbutyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3,6-dimethyl-11-(2-phenylethyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3,6-dimethyl-11-(3-phenylpropyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3,6-dimethyl-11-(4-methylbenzyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3,6-dimethyl-11-pentyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3-butyl-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3-ethyl-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-3-[3-(4-chlorophenyl)propyl]-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-6-methyl-3-(3-phenylpropyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,12aS)-6-methyl-3-propyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,9R,12aR)-3,9-dibutyl-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,9R,12aR)-9-butyl-3-ethyl-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,9R,12aR)-9-butyl-3-[3-(4-chlorophenyl)propyl]-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,9R,12aR)-9-butyl-6-methyl-3-(4-phenylbutyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
-
(3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3R,6R,9R,12R,12aR)-6,9-dimethyl-10-(2,2,2-trifluoroethyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-9-ol
-
(3R,6R,9S,12R,12aR)-10-ethoxy-6,9-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-9-ol
-
(3R,6R,9S,12R,12aR)-6,9-dimethyl-10-(2,2,2-trifluoroethyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-9-ol
-
(3R,6R,9S,12R,12aR)-6,9-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,10-diol
-
(3S,5aR,6S,8aR,9R,12S,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl N-[(2-methylpropoxy)carbonyl]-b-alaninate
-
(3S,5aS,6R,8aS,12aS)-6-methyl-3-(2-methylpropyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3S,5aS,6R,8aS,12aS)-6-methyl-3-(2-phenylethyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3S,5aS,6R,8aS,9R,12aR)-9-butyl-6-methyl-3-(2-phenylethyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(3S,6R,12R,12aS)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(4-chlorophenyl)(pyridin-2-yl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanol
-
-
(4-chlorophenyl)[4-([[3-(4-[3-[(7-chloroquinolin-4-yl)amino]propyl]piperazin-1-yl)propyl]amino]methyl)phenyl]methanone
-
-
(4aS)-3,3-diethylhexahydro-6H-[1,2,4]trioxino[6,5-j]isochromen-6-one
-
(4aS)-3,3-dimethylhexahydro-6H-[1,2,4]trioxino[6,5-j]isochromen-6-one
-
(4aS)-hexahydro-6H-[1,2,4]trioxino[6,5-j]isochromen-6-one
-
(5S,6R,9R,10S,12R,12aS)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-5-ol
-
(6'R,12'S,12a'R)-3',6'-dimethyl-3',4',5',5a',6',7',8',8a'-octahydrospiro[cyclopent-3-ene-1,9'-[1,2,11,13]tetraoxa[3,12]epoxy[1,2]dioxepino[4,3-i]isochromen]-10'-one
-
(6'R,12'S,12a'R)-3',6'-dimethyloctahydrospiro[1,3-dioxolane-2,9'-[3,12]epoxy[1,2]dioxepino[4,3-i]isochromen]-10'-one
-
(6R,10R,12R,12aR)-3,6-dimethyl-9-methylidenedecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl hydroperoxide
-
(6R,10R,12R,12aR)-3,6-dimethyloctahydrospiro[3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,2'-oxiran]-10-ol
-
(6R,10R,12R,12aR)-3,6-dimethyloctahydrospiro[3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,2'-oxiran]-10-yl hydroperoxide
-
(6R,10S,12R,12aR)-3,6-dimethyl-9-methylidenedecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
-
(6R,12aS)-11-(4-chlorobenzyl)-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-11-acetyl-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-11-benzyl-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-3,6-dimethyl-11-(2-phenylethyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-3,6-dimethyl-11-(3-phenylpropyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-3,6-dimethyl-11-(pyridin-2-ylmethyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-3,6-dimethyl-11-(thiophen-2-yl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12aS)-3,6-dimethyl-11-pentyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one
-
(6R,12R,12aR)-3,6-dimethyl-9-methylidenedecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl hydroperoxide
-
(6R,12R,12aS)-3-butyl-6-methyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,12R,12aS)-3-ethyl-6-methyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,12R,12aS)-3-[3-(4-chlorophenyl)propyl]-6-methyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,12R,12aS)-6-methyl-3-(2-methylpropyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,12R,12aS)-6-methyl-3-(4-phenylbutyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,12R,12aS)-6-methyl-3-propyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,12S,12aS)-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,12S,12aS)-3-ethyl-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,12S,12aS)-6-methyl-3-(4-phenylbutyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,12S,12aS)-6-methyl-3-propyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,8aR,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,8aR,9R,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,8aR,9R,12S,12aR)-9-bromo-9-(bromomethyl)-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,8aS,9S,10R,12R,12aR)-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,10-diol
-
(6R,8aS,9Z,12S,12aR)-9-ethylidene-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9aS)-3,6-dimethyloctahydro-3,9a-epidioxy-2-benzoxepine
-
(6R,9R,12R,12aR)-10-(tert-butylperoxy)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-10-ethoxy-3,6-dimethyl-9-propyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-10-ethoxy-9-ethyl-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
-
(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-3,6-dimethyl-9-(3-phenylpropyl)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-3,6-dimethyl-9-pentyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-3,6-dimethyl-9-propyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-3,6-dimethyloctahydrospiro[3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,2'-oxiran]-10-yl hydroperoxide
-
(6R,9R,12R,12aR)-9-butyl-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12R,12aR)-9-ethyl-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-3,4,4',5,5',5a,6,7,8,8a-decahydrospiro[3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,3'-pyrazol]-10-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-(2-methylpropyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-(2-phenylethyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-(3-phenylpropyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-(4-phenylbutyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-(prop-2-en-1-yl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-(propan-2-yl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-3,6-dimethyl-9-pentyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-9-butyl-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-9-butyl-6-methyl-3-(4-phenylbutyl)octahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-9-ethyl-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-9-hexyl-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9R,12S,12aR)-9-[3-(4-chlorophenyl)propyl]-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9S,10R,12R,12aR)-3,6-dimethyloctahydrospiro[3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,2'-oxiran]-10-yl hydroperoxide
-
(6R,9S,11aR)-3,6,9-trimethyloctahydro-3H-3,11-epoxyfuro[3,4-j][1,2]benzodioxepine
-
(6R,9S,12R,12aR)-9-bromo-3,6,9-trimethyl-N-phenyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine
-
(6R,9S,12R,12aR)-9-bromo-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6R,9S,12S,12aR)-9-[(1E)-but-1-en-1-yl]-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6R,9S,12S,12aR)-9-[(2E)-but-2-en-1-yl]-3,6-dimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
-
(6S,7S,10S,12aS)-10-ethoxy-7-fluoro-3,6,7-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(6S,7S,10S,12R,12aS)-10-ethoxy-3,6-dimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-7-ol
-
(6S,9R,10S,12aS)-10-ethoxy-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-7(3H)-one
-
(6S,9R,10S,12aS)-10-ethoxy-7,7-difluoro-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
-
(7R,12aR)-7,10-dimethyldodecahydro-2H-10,13-epoxy[1,2]dioxepino[4,3-i]pyrano[2,3-c]isochromene
-
(N-((3-chlorophenyl)(4-(pyrrolidin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline
-
NF1058, inhibits the enzyme SERCA1 stabilizing an E2 state that can still be phosphorylated with phosphate
1,1'-methanediyldinaphthalen-2-ol
-
-
1,3-dibromo-2,4,6-tri(methylisothiouronium)benzene
-
micromolar inhibitor of SERCA
1,5-bis(4-methoxyphenyl)-6,7-dioxabicyclo[3.2.2]nonane
-
1,5-diphenyl-3,6,7-trioxabicyclo[3.2.2]nonane
-
1-(naphthalen-1-ylmethyl)naphthalen-2-ol
-
-
1-[(4-chlorophenyl)(phenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1H-1,2,4-triazole
-
-
1-[(4-chlorophenyl)(phenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1H-imidazole
-
-
1-[(6R)-3,3,6-trimethyloctahydro-9aH-1,2-benzodioxepin-9a-yl]ethanone
-
2,2',2''-methanetriyltris(4-tert-butylphenol)
-
-
2,2'-methanediylbis(4-tert-butylphenol)
-
-
2,3-bis[(2-hydroxyethyl)sulfanyl]naphthalene-1,4-dione
-
-
2,4-di-tert-butyl-6-(1-phenylethyl)phenol
-
-
2,4-di-tert-butyl-6-[1-(4-methoxyphenyl)ethyl]phenol
-
-
2,5-bis(2-methylpropyl)phenol
-
-
2,5-bis(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
-
-
2,5-di(tert-butyl)-1,4-benzohydroquinone
-
-
2,5-di(tert-butyl)hydroquinone
-
micromolar inhibitor of SERCA, inhibits Ca2+ binding and catalytic activation
2,5-di-tert-butyl-1,4-dihydroxybenzene
2,5-di-tert-butylhydroquinone
-
-
2,6-di-tert-butyl-4-[1-(4-methoxyphenyl)ethyl]phenol
-
-
2-(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
-
-
2-(dimethylamino)ethyl 4-(2-oxo-2-[[(3S,5aR,6S,8aR,9R,12S,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]ethyl)benzoate
-
2-(dimethylamino)ethyl 4-[([2-[(1S,9aR)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepin-9(1H)-yl]ethyl]peroxy)methyl]benzoate
-
2-cyclooctylbenzene-1,4-diol
-
-
2-phenyl-1,2-benzoselenazol-3(2H)-one
-
-
2-[(1R,9aR)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepin-9(1H)-yl]ethyl diethylcarbamate
-
2-[(1R,9aR)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepin-9(1H)-yl]ethyl diphenylcarbamate
-
2-[(1S,9aS)-1,3,9-trimethyloctahydro-3,9a-epidioxy-2-benzoxepin-1(1H)-yl]ethanol
-
2-[(1S,9aS)-1,3-dimethyloctahydro-3,9a-epidioxy-2-benzoxepin-1(1H)-yl]ethanol
-
2-[(1S,9aS)-3,9-dimethyloctahydro-3,9a-epidioxy-2-benzoxepin-1(1H)-yl]ethanol
-
2-[(cyclopropylcarbonyl)amino]-4,5-dimethylthiophene-3-carboxamide
-
-
3-(1,1-diphenylethyl)cyclopentanol
-
-
3-[(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]propan-1-ol
-
4,4'-butane-2,2-diylbis(2-methylphenol)
-
-
4,4'-butane-2,3-diyldiphenol
-
-
4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid
-
-
4,4'-propane-2,2-diylbis(2,6-dimethylphenol)
-
-
4,5-dibenzylbenzene-1,2-diol
-
-
4,5-dimethyl-2-([[5-methyl-2-(propan-2-yl)phenoxy]acetyl]amino)thiophene-3-carboxamide
-
-
4-(2-[2-[(1S,9aR)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepin-9(1H)-yl]ethoxy]ethyl)pyridine
-
4-(7-methyloctyl)phenol
-
-
4-([2-[(1R,9aR)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepin-9(1H)-yl]ethoxy]methyl)pyrimidine
-
4-([[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]methyl)benzoic acid
-
5-chloro-N-(3,5-dimethoxyphenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-methoxybenzamide
-
-
6-amino-2-(hex-1-yn-1-yl)-9H-purin-9-yl-beta-D-N-ethylribofuranoic amide
-
-
6-tert-butyl-2,3-dihydro-1H-inden-5-ol
-
-
6-[(3R,5aS,6R,8aS,12aS)-3,6-dimethyl-10-oxodecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-11(12H)-yl]hexanoic acid
-
7-chloro-4-(piperazin-1-yl)quinoline
-
-
A23187
-
Ca2+ ionophore
amyloid beta-peptide
-
the addition of amyloid beta-peptide to normal brain decreases the PMCA activity resulting in the same Ca2+ dependency as that seen in Alzheimer's disease brain, whereas the addition of amyloid beta-peptide to Alzheimer's disease brain has no effect on PMCA activity, in the absence of cholesterol, the level of inhibition of cerebrum PMCA is 60%, but levels of inhibition decreases with increasing concentrations of cholesterol
-
amyloid beta-peptide 1-40
-
-
amyloid beta-peptide 25-35
biphenyl-2,5-diol
-
-
bis(maltolato)oxovanadium(IV)
-
-
bis(N-hydroxylamidoiminodiacetato)vanadium(IV)
-
-
bupivacaine
-
inhibition by bupivacaine is not competitive with respect to the specific transport and catalytic sites of the enzyme
Ca2+
-
above 0.1 mM, Ca2+-dependent ATPase
Calmidazolium
-
-
calmodulin antagonist compound 48/80
-
inhibits phosphatase activity
carboxyeosin
-
blocker of PMCA
clotrimazole
-
-
cyclopiazonic acid
D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol
-
-
-
detergent C12E8
-
inhibition of mutant D813A/D818A
eosin
potent inhibitor
eosin Y
-
auto-inhibited Ca2+-ATPases are particularly sensitive to inhibition by eosin Y
erythrosin B
erythrosine B
-
-
ethyl 3-[(3S,5aS,6R,8aS,12aS)-6-methyl-10-oxooctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-3(4H)-yl]propanoate
-
ethyl 3-[(3S,5aS,6R,8aS,9R,12aR)-9-butyl-6-methyl-10-oxooctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-3(4H)-yl]propanoate
-
ethyl 3-[(6R,12R,12aS)-6-methyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-3(4H)-yl]propanoate
-
ethyl 3-[(6R,12S,12aS)-6-methyl-10-oxooctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-3(4H)-yl]propanoate
-
ethyl 3-[(6R,9R,12S,12aR)-9-butyl-6-methyl-10-oxooctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-3(4H)-yl]propanoate
-
ethyl [[(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]acetate
-
Hg2+
-
0.25 mM, 50% inhibition
hydroxylamine
-
the enzyme is sensitive to treatment with hydroxylamine
iononphore A 23187
-
-
lidocaine
-
inhibition by lidocaine is not competitive with respect to the specific transport and catalytic sites of the enzyme
methyl 2-methyl-3-[[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]propanoate
-
methyl 2-methyl-3-[[(6R,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]propanoate
-
methyl 2-methyl-3-[[(6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]propanoate
-
methyl 2-[[(6R,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]propanoate
-
methyl 2-[[(6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]propanoate
-
methyl 3-[[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]butanoate
-
methyl 3-[[(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]propanoate
-
methyl 4-(2-oxo-2-[[(3S,5aR,6S,8aR,9R,12S,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]ethyl)benzoate
-
methyl 4-([[(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]methyl)benzoate
-
methyl 4-[[(6R,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy]butanoate
-
methyl [(4-tert-butylbenzoyl)amino]acetate
-
-
N,N-dimethylalkylamine N-oxide
-
slight stimulation at low concentrations, inhibition at higher concentrations, maximal inhibition for the homologue with the alkyl chain length n=16
-
N-((3-chlorophenyl)(4-((4-(7-chloroquinolin-4-yl)piperazin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline
-
NF1442
N-4-(azido-2-nitrophenyl)-2-aminoethylsulfonate
-
-
N-alkyl-N,N-dimethylamine-N-oxide
-
CnNO with n = 10-20, stimulate at low concentrations and inhibit at high concentrations dependent on the compound alkyl chain length, overview, inhibition occurs due to compound-induced lipid bilayer structure perturbation in the ATPase annular region
N-[(6R,9R,12R,12aR)-9-bromo-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]pyridin-2-amine
-
N-[(6R,9S,12R,12aR)-9-bromo-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]-1,3-thiazol-2-amine
-
N-[(6R,9S,12R,12aR)-9-bromo-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]pyridin-2-amine
-
neuraminidase
-
-
-
Ni2+
-
1 mM, 28% inhibition
orthovanadate
palytoxin
-
the inhibition process exhibits the following characteristics: the degree of inhibition is dependent on membrane protein concentration, no protection is observed when the ATP concentration is raised, dependence on Ca2+ concentration with a decreased maximum catalytic rate, and it occurrs in the absence of Ca2+ ionophoric activity
PCMB
Pigeon
-
-
peptide C28
-
peptide C28 is a peptide that prevents activation of PMCA by calmodulin
-
phosphatidylcholine
-
native PMCA from erythrocytes in mixed micelles of phosphatidylcholine-detergent has 30% of its maximal activity, while the recombinant PMCA enzyme is nearly inactive, increasing the phosphatidylcholine content of the micelles does not increase the activity of recombinant PMCA but the activity in the presence of phosphatidylcholine improves by partially removing the detergent
phospholamban
pyridine-2,6-dicarboxylatodioxovanadium
-
-
ruthenium red
-
slight inhibition
rutin arachidonate
-
-
rutin erucate
-
-
-
rutin linoleate
-
-
rutin linolenate
-
-
-
rutin oleate
-
-
-
rutin palmitate
-
-
-
rutin stearate
-
-
-
sarcolipin
-
-
Sodium vanadate
-
slight inhibition
tert-butyl [(1E)-1-([2-[(1S,9aR)-1-methoxy-3-methyloctahydro-3,9a-epidioxy-2-benzoxepin-9(1H)-yl]ethyl]peroxy)ethylidene]carbamate
-
tert-butylhydroquinone
-
-
tetrabromobisphenol A
-
can inhibit SERCA at low concentrations (IC50, 0.0004-0.0012 mM)
thapsigargin
Trifluoperazine
-
-
vanadate
[(dihydroindenyl)oxy]acetic acid
-
DIOA
[3-[(6R,9R,12S,12aR)-9-butyl-6-methyl-10-oxooctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-3(4H)-yl]propyl]phenylphosphinous chloride
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calcineurin
-
Pmr1p is positively controlled by the calmodulin and calcineurin complex in the presence of an elevated Ca2+ level
-
calcium-bound calmodulin
-
in the resting state, the plant plasma-membrane Ca2+-ATPase is autoinhibited by binding of its N-terminal tail to two major intracellular loops. Activation requires the binding of calcium-bound calmodulin to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain
-
Calmodulin
calpain
G-actin
-
when purified enzyme is incubated with increasing concentrations of G-actin, an increase in the rate of ATP hydrolysis is observed
-
HSP70
-
chaperone system can bind to enzyme and, depending on the severity of heat stress, protect the enzyme's function by stabilizing the nucleotide binding domain
-
N,N-dimethylalkylamine N-oxide
-
slight stimulation at low concentrations, inhibition at higher concentrations
-
N-alkyl-N,N-dimethylamine-N-oxide
-
CnNO with n = 10-20, stimulate at low concentrations and inhibit at high concentrations dependent on the compound alkyl chain length, overview
phosphatidylinositol 4-monophosphate
-
433% stimulation of activity at 1 mM
phosphatidylinositol bisphosphate
phosphatidylserine
valinomycin
-
the rate of Ca2+ uptake is stimulated by a inside-negative potential induced in the presence of valinomycin
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000021 - 0.1
ATP
0.000013 - 0.02
Ca2+
0.00071 - 0.0013
Ca2+/cis
0.015 - 0.035
Sr2+
0.000037
UTP
-
enzyme from liver
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.5 - 130
ATP
9.5 - 149
Ca2+
additional information
additional information
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000023 - 0.000045
thapsigargin
additional information
additional information
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.007
(2Z)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide
Plasmodium falciparum
-
at pH 7.5 and 25C
0.152
(4-chlorophenyl)(pyridin-2-yl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanol
Oryctolagus cuniculus
-
in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37C
0.022 - 0.029
(4-chlorophenyl)[4-([[3-(4-[3-[(7-chloroquinolin-4-yl)amino]propyl]piperazin-1-yl)propyl]amino]methyl)phenyl]methanone
0.0013
(N-((3-chlorophenyl)(4-(pyrrolidin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline
Oryctolagus cuniculus
-
in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37C
0.015
1,1'-methanediyldinaphthalen-2-ol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0273
1-(naphthalen-1-ylmethyl)naphthalen-2-ol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.032
1-[(4-chlorophenyl)(phenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1H-1,2,4-triazole
Oryctolagus cuniculus
-
in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37C
0.057
1-[(4-chlorophenyl)(phenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1H-imidazole
Oryctolagus cuniculus
-
in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37C
0.0213
2,2',2''-methanetriyltris(4-tert-butylphenol)
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0118
2,2'-methanediylbis(4-tert-butylphenol)
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.001
2,3-bis[(2-hydroxyethyl)sulfanyl]naphthalene-1,4-dione
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0338
2,4-di-tert-butyl-6-(1-phenylethyl)phenol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0353
2,4-di-tert-butyl-6-[1-(4-methoxyphenyl)ethyl]phenol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0188
2,5-bis(2-methylpropyl)phenol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0094
2,5-bis(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.065
2,5-di(tert-butyl)-1,4-benzohydroquinone
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0454
2,6-di-tert-butyl-4-[1-(4-methoxyphenyl)ethyl]phenol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0202
2-(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0115
2-cyclooctylbenzene-1,4-diol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.001
2-phenyl-1,2-benzoselenazol-3(2H)-one
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0031
2-[(cyclopropylcarbonyl)amino]-4,5-dimethylthiophene-3-carboxamide
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0497
3-(1,1-diphenylethyl)cyclopentanol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0393
4,4'-butane-2,2-diylbis(2-methylphenol)
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0283
4,4'-butane-2,3-diyldiphenol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0195
4,4'-propane-2,2-diylbis(2,6-dimethylphenol)
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0238
4,5-dibenzylbenzene-1,2-diol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0011
4,5-dimethyl-2-([[5-methyl-2-(propan-2-yl)phenoxy]acetyl]amino)thiophene-3-carboxamide
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0172
4-(7-methyloctyl)phenol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.003
5-chloro-N-(3,5-dimethoxyphenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-methoxybenzamide
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0085
6-amino-2-(hex-1-yn-1-yl)-9H-purin-9-yl-beta-D-N-ethylribofuranoic amide
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0281
6-tert-butyl-2,3-dihydro-1H-inden-5-ol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.0025
amyloid beta-peptide 25-35
Sus scrofa
P23220
-
-
0.00229
biphenyl-2,5-diol
Oryctolagus cuniculus
-
In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
0.04
bis(maltolato)oxovanadium(IV)
Oryctolagus cuniculus
-
in 25 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 0.05 mM CaCl2, at 25C
0.325
bis(N-hydroxylamidoiminodiacetato)vanadium(IV)
Oryctolagus cuniculus
-
in 25 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 0.05 mM CaCl2, at 25C
35
clotrimazole
Oryctolagus cuniculus
-
IC50 about 0.035 mM, in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37C
0.00016 - 0.0004
cyclopiazonic acid
0.0036
eosin
Solanum lycopersicum
Q42883
in 1 mM EGTA, 130 mM NaCl, 3 mM MgCl2, at 37C
0.0012
methyl [(4-tert-butylbenzoyl)amino]acetate
Plasmodium falciparum
-
at pH 7.5 and 25C
0.0008
N-((3-chlorophenyl)(4-((4-(7-chloroquinolin-4-yl)piperazin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline
Oryctolagus cuniculus
-
in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37C
0.0004
palytoxin
Oryctolagus cuniculus
-
in 20 mM MOPS, pH 7.0, 80 mM KC1, 5 mM MgCl2, 0.5 mM EGTA, 0.55 mM CaC12, at 25C
0.025
pyridine-2,6-dicarboxylatodioxovanadium
Oryctolagu