Information on EC 3.6.3.53 - Ag+-exporting ATPase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
3.6.3.53
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RECOMMENDED NAME
GeneOntology No.
Ag+-exporting ATPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + Ag+/in = ADP + phosphate + Ag+/out
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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transmembrane transport
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (Ag+-exporting)
A P-type ATPase that exports Ag+ ions from pathogenic microorganisms as well as from some animal tissues.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
plasmid pKK1 specifies silver resistance
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Manually annotated by BRENDA team
gene is encoded by Ag+ resistance plasmid pMG101
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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mononesin, 0.01 mM, release transported Ag+ from the basolateral membrane vesicles
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0626
Ag+
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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enzyme of the heavy-metal resistance efflux P-type ATPase family. The enzyme has a conserved aspartyl residues that is phosphorylated during the enzyme cycle, the ATP-binding region, the Thr-Gly-Glu-Ser phosphatase determinant, the Cys-Pro-Cys in the predicted sixth transmembrane alpha-helical region, and the His-Pro in the large aspartyl kinase domain between the phosphorylation site and the ATP binding region
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene is encoded by Ag+ resistance plasmid pMG101
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
the gene is encoded by Ag+ resistance plasmid pMG101, the plasmid is transferred by conjugation to Escherichia coli, from which it is cloned
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