Information on EC 3.6.3.44 - xenobiotic-transporting ATPase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
3.6.3.44
-
RECOMMENDED NAME
GeneOntology No.
xenobiotic-transporting ATPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + xenobiotic/in = ADP + phosphate + xenobiotic/out
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
transmembrane transport
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-
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (xenobiotic-exporting)
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione---drug conjugates. Some also show some 'flippase' (phospholipid-translocating ATPase; EC 3.6.3.1) activity.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzymes AtrA and AtrB
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-
Manually annotated by BRENDA team
strain CCM8320
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-
Manually annotated by BRENDA team
strain CCM8270
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-
Manually annotated by BRENDA team
strain CCM8270
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
gene dMRP/CG6214
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain IL1403
Uniprot
Manually annotated by BRENDA team
strain NZ9000
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-
Manually annotated by BRENDA team
MRP6
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-
Manually annotated by BRENDA team
SMDR2, Egyptian isolate propagated in female Swiss Webster mice
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-
Manually annotated by BRENDA team
subsp. yingchengensis strain 10-22
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
strain F20
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-
Manually annotated by BRENDA team
strain F20
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl S-glutathione/in + ATP + H2O
2,4-dinitrophenyl S-glutathione/out + ADP + H2O
show the reaction diagram
-
-
-
?
3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide/in + ATP + H2O
3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
3alpha-sulfatolithocholyltaurine/in + ATP + H2O
3alpha-sulfatolithocholyltaurine/out + ADP + phosphate
show the reaction diagram
-
-
-
?
6-mercaptopurine/in + ATP + H2O
6-mercaptopurine/out + ADP + phosphate
show the reaction diagram
-
-
-
?
8-aza-ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in
8-aza-ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
show the reaction diagram
-
8-aza-ATP is a fairly good substrate of BmrA
-
-
?
8-azido-ATP + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
8-azido-ATP + H2O + xenobiotic/in
8-azido-ADP + phosphate + xenobiotic/out
show the reaction diagram
-
-
-
-
?
9-(2-phosphonylmethoxyethyl)adenine/in + ATP + H2O
9-(2-phosphonylmethoxyethyl)adenine/out + ADP + phosphate
show the reaction diagram
-
-
-
?
aflatoxin B1-epoxide-GSH conjugate/in + ATP + H2O
aflatoxin B1-epoxide-GSH conjugate/out + ADP + phosphate
show the reaction diagram
-
-
-
?
aflatoxin B1/in + ATP + H2O
aflatoxin B1/out + ADP + phosphate
show the reaction diagram
ATP + H2O
?
show the reaction diagram
-
-
-
-
?
ATP + H2O
ADP + phosphate
show the reaction diagram
ATP + H2O + 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane/in
ADP + phosphate + 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 17beta-estradiol 17-(beta-D-glucuronide)/in
ADP + phosphate + 17beta-estradiol 17-(beta-D-glucuronide)/out
show the reaction diagram
ATP + H2O + 17beta-glucuronosyl oestradiol/in
ADP + phosphate + 17beta-glucuronosyl oestradiol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 2',3'-dideoxycytidine/in
ADP + phosphate + 2',3'-dideoxycytidine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein/in
ADP + phosphate + 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 2',7'-bis-(2-carboxyethyl)-5,6-carboxylfluoresceinacetoxymethyl ester/in
ADP + phosphate + 2',7'-bis-(2-carboxyethyl)-5,6-carboxylfluoresceinacetoxymethyl ester/out
show the reaction diagram
YdaG/YdbA heterodimer
-
-
?
ATP + H2O + 2',7'-bis-(3-carboxyethyl)-5-carboxyfluorescein/in
ADP + phosphate + 2',7'-bis-(3-carboxyethyl)-5-carboxyfluorescein/out
show the reaction diagram
-
fluorescent substrate
-
-
?
ATP + H2O + 2',7'-bis-(3-carboxyethyl)-6-carboxyfluorescein/in
ADP + phosphate + 2',7'-bis-(3-carboxyethyl)-6-carboxyfluorescein/out
show the reaction diagram
-
fluorescent substrate
-
-
?
ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in
ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
show the reaction diagram
ATP + H2O + 2,5-dimethoxy-4-iodoamphetamine/in
ADP + phosphate + 2,5-dimethoxy-4-iodoamphetamine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 3,3'-dihexyloxacarbocyanine iodide/in
ADP + phosphate + 3,3'-dihexyloxacarbocyanine iodide/out
show the reaction diagram
ATP + H2O + 3,4-methylenedioxy-alpha-ethylphenethylamine/in
ADP + phosphate + 3,4-methylenedioxy-alpha-ethylphenethylamine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 4-(2-aminoethyl)benzenesulfonylfluoride/in
ADP + phosphate + 4-(2-aminoethyl)benzenesulfonylfluoride/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 4-aminohippuric acid/in
ADP + phosphate + 4-aminohippuric acid/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 4-N-(2'-methoxystyryl)-thiosemicarbazone/in
ADP + phosphate + 4-N-(2'-methoxystyryl)-thiosemicarbazone/out
show the reaction diagram
ATP + H2O + 4-nitroquinoline-1-oxide/in
ADP + phosphate + 4-nitroquinoline-1-oxide/out
show the reaction diagram
-
substrate for Snq2p
-
-
?
ATP + H2O + 5-(glutathione-S-yl)-N-methyl-alpha-methyldopamine/in
ADP + phosphate + 5-(glutathione-S-yl)-N-methyl-alpha-methyldopamine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 7-aminoactinomycin D/in
ADP + phosphate + 7-aminoactinomycin D/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + 9-hydroxyrisperidone/in
ADP + phosphate + 9-hydroxyrisperidone/out
show the reaction diagram
ATP + H2O + acitretin/in
ADP + phosphate + acitretin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + actinomycin D/in
ADP + phosphate + actinomycin D/out
show the reaction diagram
-
-
-
?
ATP + H2O + acyclovir/in
ADP + phosphate + acyclovir/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + adefovir/in
ADP + phosphate + adefovir/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + allopurinol/in
ADP + phosphate + allopurinol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + anisomycin/in
ADP + phosphate + anisomycin/out
show the reaction diagram
ATP + H2O + azole/in
ADP + phosphate + azole/out
show the reaction diagram
-
the ABC multidrug transporter Cdr1p plays a key role in azole resistance
-
-
?
ATP + H2O + beta-estradiol 17-beta-D-glucuronide/in
ADP + phosphate + beta-estradiol 17-beta-D-glucuronide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + beta-estradiol/in
ADP + phosphate + beta-estradiol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + bimatoprost/in
ADP + phosphate + bimatoprost/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + Bodipy-verapamil/in
ADP + phosphate + Bodipy-verapamil/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + bodipy-vinblastine/in
ADP + phosphate + bodipy-vinblastine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + buspirone/in
ADP + phosphate + buspirone/out
show the reaction diagram
ATP + H2O + C12E08/in
ADP + phosphate + C12E08/out
show the reaction diagram
-
-
-
?
ATP + H2O + caffeine/in
ADP + phosphate + caffeine/out
show the reaction diagram
-
Snq2p is a more functional transporter of caffeine than Pdr5p in yeast cells
-
-
?
ATP + H2O + calcein acetoxymethylester/in
ADP + phosphate + calcein acetoxymethylester/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + calcein/in
ADP + phosphate + calcein/out
show the reaction diagram
ATP + H2O + cAMP/in
ADP + phosphate + cAMP/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + carboxydichlorofluorescein/in
ADP + phosphate + carboxydichlorofluorescein/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cefazolin/in
ADP + phosphate + cefazolin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cefmetazole/in
ADP + phosphate + cefmetazole/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cefotaxime/in
ADP + phosphate + cefotaxime/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + ceftizoxime/in
ADP + phosphate + ceftizoxime/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + celecoxib/in
ADP + phosphate + celecoxib/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cGMP/in
ADP + phosphate + cGMP/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + chenodeoxycholylglycine/in
ADP + phosphate + chenodeoxycholylglycine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + chenodeoxycholyltaurine/in
ADP + phosphate + chenodeoxycholyltaurine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + chlorpromazine/in
ADP + phosphate + chlorpromazine/out
show the reaction diagram
ATP + H2O + cholate/in
ADP + phosphate + cholate/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cholesterol/in
ADP + phosphate + cholesterol/out
show the reaction diagram
ATP + H2O + cholylglycine/in
ADP + phosphate + cholylglycine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cholytaurine/in
ADP + phosphate + cholytaurine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + citalopram/in
ADP + phosphate + citalopram/out
show the reaction diagram
ATP + H2O + clotrimazole/in
ADP + phosphate + clotrimazole/out
show the reaction diagram
ATP + H2O + colchicine/in
ADP + phosphate + colchicine/out
show the reaction diagram
ATP + H2O + corticosterone/in
ADP + phosphate + corticosterone/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cyclic guanosine monophosphate/in
ADP + phosphate + cyclic guanosine monophosphate/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cyclobenzaprine/in
ADP + phosphate + cyclobenzaprine/out
show the reaction diagram
ATP + H2O + cycloheximide /in
ADP + phosphate + cycloheximide /out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cycloheximide/in
ADP + phosphate + cycloheximide/out
show the reaction diagram
ATP + H2O + cyclosporin A/in
ADP + phosphate + cyclosporin A/out
show the reaction diagram
ATP + H2O + cyclosporine A/in
ADP + phosphate + cyclosporine A/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + cytarabine/in
ADP + phosphate + cytarabine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + darunavir/in
ADP + phosphate + darunavir/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + daunomycin/in
ADP + phosphate + daunomycin/out
show the reaction diagram
ATP + H2O + daunorubicin/in
ADP + phosphate + daunorubicin/out
show the reaction diagram
ATP + H2O + dehydroepiandrosterone sulfate/in
ADP + phosphate + dehydroepiandrosterone sulfate/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + dehydroepiandrosterone-3-sulfate/in
ADP + phosphate + dehydroepiandrosterone-3-sulfate/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + deoxycholylglycine/in
ADP + phosphate + deoxycholylglycine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + deoxycorticosterone/in
ADP + phosphate + deoxycorticosterone/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + dexamethasone/in
ADP + phosphate + dexamethasone/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + diazepam/in
ADP + phosphate + diazepam/out
show the reaction diagram
ATP + H2O + diclofenac/in
ADP + phosphate + diclofenac/out
show the reaction diagram
-
substrate of BCRP, but not of P-gp and MDR1
-
-
?
ATP + H2O + digoxin/in
ADP + phosphate + digoxin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + diltiazem/in
ADP + phosphate + diltiazem/out
show the reaction diagram
ATP + H2O + dipyridamole/in
ADP + phosphate + dipyridamole/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + docetaxel/in
ADP + phosphate + docetaxel/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + dodecyloctaglycol/in
ADP + phosphate + dodecyloctaglycol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + doxorubicin/in
ADP + phosphate + doxorubicin/out
show the reaction diagram
ATP + H2O + E217betaG/in
ADP + phosphate + E217betaG/out
show the reaction diagram
-
MRP3 preferentially transports E217betaG with a medium affinity and a very high capacity, while MRP1 transports E217betaG with a higher affinity but with much lower capacity
-
-
?
ATP + H2O + edaravone glucuronide/in
ADP + phosphate + edaravone glucuronide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + epothilone B/in
ADP + phosphate + epothilone B/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + estradiol 17-beta-D-glucuronide/in
ADP + phosphate + estradiol 17-beta-D-glucuronide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + estradiol glucuronide/in
ADP + phosphate + estradiol glucuronid/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + estrone-3-sulfate/in
ADP + phosphate + estrone-3-sulfate/out
show the reaction diagram
ATP + H2O + ethanol/in
ADP + phosphate + ethanol/out
show the reaction diagram
ATP + H2O + ethidium bromide/in
ADP + phosphate + ethidium bromide/out
show the reaction diagram
ATP + H2O + etoposide/in
ADP + phosphate + etoposide/out
show the reaction diagram
ATP + H2O + fenbuconazole/in
ADP + phosphate + fenbuconazole/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + fexofenadine/in
ADP + phosphate + fexofenadine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + fluconazole/in
ADP + phosphate + fluconazole/out
show the reaction diagram
ATP + H2O + fluoroquinolone/in
ADP + phosphate + fluoroquinolone/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + fluoxetine/in
ADP + phosphate + fluoxetine/out
show the reaction diagram
ATP + H2O + fluvoxamine/in
ADP + phosphate + fluvoxamine/out
show the reaction diagram
ATP + H2O + folic acid/in
ADP + phosphate + folic acid/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + furosemide/in
ADP + phosphate + furosemide/out
show the reaction diagram
ATP + H2O + gemcitabine/in
ADP + phosphate + gemcitabine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + glaucine/in
ADP + phosphate + glaucine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + glutathione/in
ADP + phosphate + glutathione/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + GSH-conjugated 4-hydroxy-nonenal/in
ADP + phosphate + GSH-conjugated 4-hydroxy-nonenal/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + GSH-conjugated prostaglandin/in
ADP + phosphate + GSH-conjugated prostaglandin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + H33342/in
ADP + phosphate + H33342/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + Hoechst 33342/in
ADP + phosphate + Hoechst 33342/out
show the reaction diagram
ATP + H2O + hydrochlorothiazide/in
ADP + phosphate + hydrochlorothiazide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + hydroxyzine/in
ADP + phosphate + hydroxyzine/out
show the reaction diagram
ATP + H2O + indomethacin/in
ADP + phosphate + indomethacin/out
show the reaction diagram
ATP + H2O + itraconazole/in
ADP + phosphate + itraconazole/out
show the reaction diagram
ATP + H2O + ketoconazole/in
ADP + phosphate + ketoconazole/out
show the reaction diagram
ATP + H2O + latanoprost/in
ADP + phosphate + latanoprost/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + leucovorin/in
ADP + phosphate + leucovorin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + leukotriene B4/in
ADP + phosphate + leukotriene B4/out
show the reaction diagram
-
MRP4 only transports leukotriene B4 in the presence of glutathione
-
-
?
ATP + H2O + leukotriene C4/in
ADP + phosphate + leukotriene C4/out
show the reaction diagram
ATP + H2O + leukotriene C4/in
ADP + phosphate + LTC4/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + leukotriene E4/in
ADP + phosphate + leukotriene E4/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + Lipid A/in
ADP + phosphate + Lipid A/out
show the reaction diagram
-
native LmrA
-
-
?
ATP + H2O + loperamide/in
ADP + phosphate + loperamide/out
show the reaction diagram
ATP + H2O + loratadine/in
ADP + phosphate + loratadine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + lysophosphatidylinositol/in
ADP + phosphate + lysophosphatidylinositol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + malachite green/in
ADP + phosphate + malachite green/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + methotrexate/in
ADP + phosphate + methotrexate/out
show the reaction diagram
ATP + H2O + miconazole/in
ADP + phosphate + miconazole/out
show the reaction diagram
ATP + H2O + midazolam/in
ADP + phosphate + midazolam/out
show the reaction diagram
ATP + H2O + misoprostol/in
ADP + phosphate + misoprostol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + mitoxantrone/in
ADP + phosphate + mitoxantrone/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + monensin/in
ADP + phosphate + monensin/out
show the reaction diagram
-
affinity of verapamil to MDR1 is not affected by pH value. Protein concentration is inversely related to the maximum activation of ATPase activity achieved
-
-
?
ATP + H2O + monoglucuronosyl bilirubin/in
ADP + phosphate + monoglucuronosyl bilirubin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + N-(1-phenylcyclohexyl)-3-ethoxypropanamine/in
ADP + phosphate + N-(1-phenylcyclohexyl)-3-ethoxypropanamine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + N-(2'-deoxy-beta-D-ribofuranosyl)-5-cyclohexyl-1H-indole/in
?
show the reaction diagram
-
nontransported substrate of P-glycoprotein
-
-
-
ATP + H2O + N-benzyl-2-nitro-1H-imidazole-1-acetamide/in
ADP + phosphate + N-benzyl-2-nitro-1H-imidazole-1-acetamide/out
show the reaction diagram
ATP + H2O + N-ethylmaleimide S-glutathione/in
ADP + phosphate + N-ethylmaleimide S-glutathione/out
show the reaction diagram
ATP + H2O + N-isopropyl-1,2-diphenylethylamine/in
ADP + phosphate + N-isopropyl-1,2-diphenylethylamine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + nicardipine/in
ADP + phosphate + nicardipine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + nifedipine/in
ADP + phosphate + nifedipine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + nortryptiline/in
ADP + phosphate + nortryptiline/out
show the reaction diagram
ATP + H2O + oligomycin/in
ADP + phosphate + oligomycin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + olmesartan/in
ADP + phosphate + olmesartan/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + p-methoxy-ethylamphetamine/in
ADP + phosphate + p-methoxy-ethylamphetamine/out
show the reaction diagram
ATP + H2O + paclitaxel/in
ADP + phosphate + paclitaxel/out
show the reaction diagram
ATP + H2O + para-methoxy-ethylamphetamine/in
ADP + phosphate + para-methoxy-ethylamphetamine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + paroxetine/in
ADP + phosphate + paroxetine/out
show the reaction diagram
ATP + H2O + phosphatidylcholine/in
ADP + phosphate + phosphatidylcholine/out
show the reaction diagram
-
-
-
?
ATP + H2O + pirarubicin/in
ADP + phosphate + pirarubicin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + prazosin/in
ADP + phosphate + prazosin/out
show the reaction diagram
ATP + H2O + prednisone/in
ADP + phosphate + prednisone/out
show the reaction diagram
ATP + H2O + probenecid/in
ADP + phosphate + probenecid/out
show the reaction diagram
ATP + H2O + progesterone/in
ADP + phosphate + progesterone/out
show the reaction diagram
ATP + H2O + propoxyphene/in
ADP + phosphate + propoxyphene/out
show the reaction diagram
ATP + H2O + prostaglandin A2/in
ADP + phosphate + prostaglandin A2/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + prostaglandin E1/in
ADP + phosphate + prostaglandin E1/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + prostaglandin E2/in
ADP + phosphate + prostaglandin E2/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + prostaglandin F2alpha/in
ADP + phosphate + prostaglandin F2alpha/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + puromycin/in
ADP + phosphate + puromycin/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + quinidine/in
ADP + phosphate + quinidine/out
show the reaction diagram
ATP + H2O + repaglinide/in
ADP + phosphate + repaglinide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + resazurine/in
ADP + phosphate + resazurine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + resorufine/in
ADP + phosphate + resorufine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + resveratrol disulfate/in
ADP + phosphate + resveratrol disulfate/out
show the reaction diagram
-
substrate of BCRP in vitro
-
-
?
ATP + H2O + resveratrol-3-glucuronide/in
ADP + phosphate + resveratrol-3-glucuronide/out
show the reaction diagram
-
substrate of Mrp3 and BCRP in vitro as sulfate
-
-
?
ATP + H2O + resveratrol/in
ADP + phosphate + resveratrol/out
show the reaction diagram
-
substrate of BCRP in vitro as sulfate
-
-
?
ATP + H2O + rhodamine 123 /in
ADP + phosphate + rhodamine 123 /out
show the reaction diagram
-
-
-
-
?
ATP + H2O + rhodamine 123/in
ADP + phosphate + rhodamine 123/out
show the reaction diagram
ATP + H2O + rhodamine 6-G/in
ADP + phosphate + rhodamine 6-G/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + rhodamine 6G/in
ADP + phosphate + rhodamine 6G/out
show the reaction diagram
ATP + H2O + rhodamine B/in
ADP + phosphate + rhodamine B/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + rifampicin/in
ADP + phosphate + rifampicin/out
show the reaction diagram
-
-
-
?
ATP + H2O + risperidone/in
ADP + phosphate + risperidone/out
show the reaction diagram
ATP + H2O + ritonavir/in
ADP + phosphate + ritonavir/out
show the reaction diagram
ATP + H2O + S-2,4-dinitrophenylglutathione/in
ADP + phosphate + S-2,4-dinitrophenylglutathione/out
show the reaction diagram
ATP + H2O + salmeterol/in
ADP + phosphate + salmeterol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + saquinavir/in
ADP + phosphate + saquinavir/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + sertraline/in
ADP + phosphate + sertraline/out
show the reaction diagram
ATP + H2O + SN-38/in
ADP + phosphate + SN-38/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + sphingosine-1-phosphate/in
ADP + phosphate + sphingosine-1-phosphate/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + talinolol/in
ADP + phosphate + talinolol/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + taurocholate/in
ADP + phosphate + taurocholate/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + telmisartan/in
ADP + phosphate + telmisartan/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + tenofovir/in
ADP + phosphate + tenofovir/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + tetramethylrhodamine/in
ADP + phosphate + tetramethylrhodamine/out
show the reaction diagram
-
better substrate than rhodamine 123, temperature dependence of the rate of tetramethylrosamine transport, the rate of drug transport may be dominated by partitioning of drug into the membrane bilayer
-
-
?
ATP + H2O + tetramethylrosamine/in
ADP + phosphate + tetramethylrosamine/out
show the reaction diagram
ATP + H2O + thromboxane B2/in
ADP + phosphate + thromboxane B2/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + topotecan/in
ADP + phosphate + topotecan/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + trazodone/in
ADP + phosphate + trazodone/out
show the reaction diagram
ATP + H2O + Triton X-100/in
ADP + phosphate + Triton X-100/out
show the reaction diagram
ATP + H2O + Tween 80/in
ADP + phosphate + Tween 80/out
show the reaction diagram
ATP + H2O + urate/in
ADP + phosphate + urate/out
show the reaction diagram
ATP + H2O + ursodeoxycholylglycine/in
ADP + phosphate + ursodeoxycholylglycine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + ursodeoxycholyltaurine/in
ADP + phosphate + ursodeoxycholyltaurine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + valinomycin/in
ADP + phosphate + valinomycin/out
show the reaction diagram
ATP + H2O + verapamil/in
ADP + phosphate + verapamil/out
show the reaction diagram
ATP + H2O + vinblastine sulfate/in
ADP + phosphate + vinblastine sulfate/out
show the reaction diagram
-
-
-
?
ATP + H2O + vinblastine/in
ADP + phosphate + vinblastine/out
show the reaction diagram
ATP + H2O + vincristine sulfate/in
ADP + phosphate + vincristine sulfate/out
show the reaction diagram
-
-
-
?
ATP + H2O + vincristine/in
ADP + phosphate + vincristine/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + VP-16/in
ADP + phosphate + VP-16/out
show the reaction diagram
ATP + H2O + xenobiotic/in
ADP + phosphate + xenobiotic/out
show the reaction diagram
ATP + H2O + zolpidem/in
ADP + phosphate + zolpidem/out
show the reaction diagram
bacitracin/in + ATP + H2O
bacitracin/out + ADP + phosphate
show the reaction diagram
-
-
-
?
chloramphenicol/in + ATP + H2O
chloramphenicol/out + ADP + phosphate
show the reaction diagram
-
-
-
?
clotrimazole/in + ATP + H2O
clotrimazole/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
colchicine/in + ATP + H2O
colchicine/out + ADP + phosphate
show the reaction diagram
-
-
-
?
CTP + H2O
CDP + phosphate
show the reaction diagram
-
-
-
-
?
CTP + H2O + rhodamine 6G/in
CDP + phosphate + rhodamine 6G/out
show the reaction diagram
-
low CTPase activity
-
-
?
cyclo(D-Trp-D-Asp-L-Pro-D-Val-L-Leu)/in + ATP + H2O
cyclo(D-Trp-D-Asp-L-Pro-D-Val-L-Leu)/out + ADP + phosphate
show the reaction diagram
cysteinyl leukotriene C4/in + ATP + H2O
cysteinyl leukotriene C4/out + ADP + phosphate
show the reaction diagram
-
-
-
?
daunomycin/in + ATP + H2O
daunomycin/out + ADP + phosphate
show the reaction diagram
-
-
-
?
daunorubicin/in + ATP + H2O
daunorubicin/out + ADP + phosphate
show the reaction diagram
dexamethasone/in + ATP + H2O
dexamethasone/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
digoxin/in + ATP + H2O
digoxin/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
doxorubicin/in + ATP + H2O
doxorubicin/out + ADP + phosphate
show the reaction diagram
epsilon-ATP + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
erythromycin/in + ATP + H2O
erythromycin/out + ADP + phosphate
show the reaction diagram
estradiol 17-beta-D-glucuronide/in + ATP + H2O
estradiol 17-beta-D-glucuronide/out + ADP + phosphate
show the reaction diagram
ethidium bromide/in + ATP + H2O
ethidium bromide/out + ADP + phosphate
show the reaction diagram
-
-
-
?
etoposide/in + ATP + H2O
etoposide/out + ADP + phosphate
show the reaction diagram
glycocholate/in + ATP + H2O
glycocholate/out + ADP + phosphate
show the reaction diagram
-
-
-
?
GSH/in + ATP + H2O
GSH/out + ADP + phosphate
show the reaction diagram
-
-
-
?
GTP + H2O
GDP + phosphate
show the reaction diagram
GTP + H2O + doxorubicin/in
GDP + phosphate + doxorubicin/out
show the reaction diagram
highest efficiency
-
-
?
GTP + H2O + rhodamine 6G/in
GDP + phosphate + rhodamine 6G/out
show the reaction diagram
-
-
-
-
?
Hoechst 33342/in + ATP + H2O
Hoechst 33342/out + ADP + H2O
show the reaction diagram
-
i.e. 2-[2-(4-ethoxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazinyl)benzimidazole
-
?
leukotriene C4/in + ATP + H2O
leukotriene C4/out + ADP + phosphate
show the reaction diagram
leukotriene D4/in + ATP + H2O
leukotriene D4/out + ADP + phosphate
show the reaction diagram
leukotriene E4/in + ATP + H2O
leukotriene E4/out + ADP + phosphate
show the reaction diagram
-
-
-
?
methotrexate/in + ATP + H2O
methotrexate/out + ADP + phosphate
show the reaction diagram
-
-
-
?
N-(4',4'-azo-n-pentyl)-21-deoxy-ajamalinium/in + ATP + H2O
N-(4',4'-azo-n-pentyl)-21-deoxy-ajamalinium/out + ADP + phosphate
show the reaction diagram
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]selenochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate/in + ATP + H2O
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]thiochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
nicardipine/in + ATP + H2O
nicardipine/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
novobiocin/in + ATP + H2O
novobiocin/out + ADP + phosphate
show the reaction diagram
-
-
-
?
oleandomycin/in + ATP + H2O
oleandomycin/out + ADP + phosphate
show the reaction diagram
paclitaxel/in + ATP + H2O
paclitaxel/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
pentachlorophenol/in + ATP + H2O
pentachlorophenol/out + ADP + phosphate
show the reaction diagram
-
-
-
?
phenol/in + ATP + H2O
phenol/out + ADP + phosphate
show the reaction diagram
-
-
-
?
rhodamine 123/in + ATP + H2O
rhodamine 123/out + ADP + phosphate
show the reaction diagram
rhodamine B/in + ATP + H2O
rhodamine B/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O
S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate
show the reaction diagram
spiramycin/in + ATP + H2O
spiramycin/out + ADP + phosphate
show the reaction diagram
streptomycin/in + ATP + H2O
streptomycin/out + ADP + phosphate
show the reaction diagram
-
-
-
?
streptothricin/in + ATP + H2O
streptothricin/out + ADP + phosphate
show the reaction diagram
-
-
-
?
taxol/in + ATP + H2O
taxol/out + ADP + H2O
show the reaction diagram
-
weak activity
-
?
tetrachlorohydroquinone/in + ATP + H2O
tetrachlorohydroquinone/out + ADP + phosphate
show the reaction diagram
-
-
-
?
tetracyclin/in + ATP + H2O
tetracyclin/out + ATP + H2O
show the reaction diagram
tobramycin/in + ATP + H2O
tobramycin/out + ADP + phosphate
show the reaction diagram
-
-
-
?
UTP + H2O
UDP + phosphate
show the reaction diagram
UTP + H2O + rhodamine 6G/in
UDP + phosphate + rhodamine 6G/out
show the reaction diagram
-
low UTPase activity
-
-
?
valinomycin/in + ATP + H2O
valinomycin/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
verapamil/in + ATP + H2O
verapamil/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
vinblastine/in + ATP + H2O
vinblastine/out + ADP + H2O
show the reaction diagram
-
weak activity
-
?
vinblastine/in + ATP + H2O
vinblastine/out + ADP + phosphate
show the reaction diagram
-
-
-
-
?
vincristine/in + ATP + H2O
vincristine/out + ADP + phosphate
show the reaction diagram
additional information
?
-