Information on EC 3.6.3.38 - capsular-polysaccharide-transporting ATPase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.6.3.38
-
RECOMMENDED NAME
GeneOntology No.
capsular-polysaccharide-transporting ATPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + capsular polysaccharide/in = ADP + phosphate + capsular polysaccharide/out
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
-
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transmembrane transport
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (capsular-polysaccharide-exporting)
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme that exports capsular polysaccharide from Gram-negative bacteria.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain 3937
Swissprot
Manually annotated by BRENDA team
strain 3937
Swissprot
Manually annotated by BRENDA team
strain K1
-
-
Manually annotated by BRENDA team
strain K5 and K1
-
-
Manually annotated by BRENDA team
serotype 01
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + A-band polysaccharide/in
ADP + phosphate + A-band polysaccharide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + capsular polysaccharide/in
ADP + phosphate + capsular polysaccharide/out
show the reaction diagram
ATP + H2O + oligogalacturonide/in
ADP + phosphate + oligogalacturonide/out
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + A-band polysaccharide/in
ADP + phosphate + A-band polysaccharide/out
show the reaction diagram
-
-
-
-
?
ATP + H2O + capsular polysaccharide/in
ADP + phosphate + capsular polysaccharide/out
show the reaction diagram
additional information
?
-
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24600
-
CtrD, nucleotide sequence
24700
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BexA, nucleotide sequence
25000
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KpsT, nucleotide sequence
27400
-
RfbB, nucleotide sequence
29500
-
Wzm, nucleotide sequence
29800
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KpsM, nucleotide sequence
30000
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RfbA, nucleotide sequence
30100
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CtrC, nucleotide sequence
30200
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BexA, nucleotide sequence
30800
-
RfbB, SDS-PAGE
47200
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Wzt, nucleotide sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
KpsT, the ATP-binding component of enzyme, recombinant protein
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C163Y
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no suppression of the dominant negative phenotype
E150G
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still binds ATP
G84D
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alters regions of the protein thought to interact with KpsM, suppression of the dominant negative phenotype
G93E
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partially disrupts translocation of the capsule, suppression of the dominant negative phenotype
H181Y
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no suppression of the dominant negative phenotype
S126F
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alters regions of the protein thought to interact with KpsM, suppression of the dominant negative phenotype