Information on EC 3.6.3.37 - guanine-transporting ATPase

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The expected taxonomic range for this enzyme is: Drosophila melanogaster

EC NUMBER
COMMENTARY hide
3.6.3.37
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RECOMMENDED NAME
GeneOntology No.
guanine-transporting ATPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + guanine/out = ADP + phosphate + guanine/in
show the reaction diagram
ABC-type (ATP-binding cassette) ATPase. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports guanine and tryptophan (it contains a single ATP-binding site)
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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transmembrane transport
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (guanine-importing)
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A eukaryotic enzyme that imports guanine and tryptophan (it contains a single ATP-binding site).
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + guanine/out
ADP + phosphate + guanine/in
show the reaction diagram
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-
-
-
?
ATP + H2O + tryptophan/out
ADP + phosphate + tryptophan/in
show the reaction diagram
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-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + guanine/out
ADP + phosphate + guanine/in
show the reaction diagram
-
-
-
-
?
ATP + H2O + tryptophan/out
ADP + phosphate + tryptophan/in
show the reaction diagram
-
-
-
-
?
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
integral, protein products encoded by the white and brown genes
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Manually annotated by BRENDA team
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloning of the brown gene
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cloning of the scarlet gene
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F590G
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major decrease in red eye color pigments, guanine transport affected
G243S
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major decrease in red and brown eye color pigments, guanine and tryptophan transport affected
G589E
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major decrease in red eye color pigments, guanine transport affected
H298N
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major decrease in red and brown eye color pigments, guanine and tryptophan transport affected