Information on EC 3.6.2.2 - phosphoadenylylsulfatase

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The expected taxonomic range for this enzyme is: Eutheria

EC NUMBER
COMMENTARY
3.6.2.2
-
RECOMMENDED NAME
GeneOntology No.
phosphoadenylylsulfatase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + sulfate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of sulfuric ester anhydride
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Sulfur metabolism
-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate sulfohydrolase
Requires Mn2+.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3-phosphoadenosine 5-phosphosulfate sulfatase
-
-
-
-
3-phosphoadenylyl sulfatase
-
-
-
-
PAPS sulfatase
-
-
-
-
PAPS sulfohydrolase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37289-37-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + H2O
adenosine 3',5'-bisphosphate + SO42-
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + H2O
adenosine 3',5'-bisphosphate + SO42-
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + H2O
adenosine 3',5'-bisphosphate + SO42-
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + H2O
adenosine 3',5'-bisphosphate + SO42-
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Co2+
-
-
Mg2+
-
-
Mn2+
-
-
Ni2+
-
-
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
3'-phosphoadenosine 5'-phosphate
-
0.2 mM
ADP
-
0.1 mM
AMP
-
0.1 mM
ATP
-
0.1 mM
BAL
-
bronchoalveolar lavage, 0.1 mM
Co2+
-
0.2 mM
cysteine
-
-
glutathione
-
-
Hg2+
-
0.2 mM
Mg2+
-
0.2 mM
Mn2+
-
0.2 mM
Pb2+
-
0.2 mM
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.017
-
3'-phosphoadenylylsulfate
-
-
0.045
-
3'-phosphoadenylylsulfate
-
[35S]
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
-
520 units/mg, 1 unit of enzyme is 2000 counts of [35S]sulfate/100 s
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6
-
-
addition of Tris acetate buffer
9.4
-
-
addition of 0.1M glycine-glycylglycine-NaOH
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
enzyme activity is higher in placenta and fetal or newborn livers than in adult liver
Manually annotated by BRENDA team
-
enzyme activity is higher in placenta and fetal or newborn livers than in adult liver
Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
frozen conditions, 4 weeks
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE