Information on EC 3.6.2.1 - adenylylsulfatase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.6.2.1
-
RECOMMENDED NAME
GeneOntology No.
adenylylsulfatase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
adenylyl sulfate + H2O = AMP + sulfate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of sulfuric acid anhydride
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
-
-
Sulfur metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
adenylyl-sulfate sulfohydrolase
-
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
adenosine 5'-phosphosulphate sulphotransferase
-
-
-
-
adenosine 5-phosphosulfate sulfohydrolase
-
-
-
-
APS sulfohydrolase
-
-
-
-
APSST
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37289-36-4
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenosine 5'-phosphosulphate + H2O
adenosine 3',5'-diphosphate + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
-
-
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
-
adenosine
-
-
adenosine 2'-monophosphate
-
-
adenosine 3'-monophosphate
-
-
ADP
-
-
AMP
-
-
ATP
-
-
Ca2+
-
-
Cu2+
-
-
diphosphate
-
-
ethoxy-formic anhydride
-
-
Fe2+
-
-
GTP
-
-
Hg2+
-
-
ITP
-
-
Mg2+
-
-
Mn2+
-
-
Ni2+
-
-
p-mercuribenzoate
-
-
Pb2+
-
-
phosphate
-
-
Rose bengal
-
photo-oxidation
UTP
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.04
adenosine 5'-phosphosulfate
-
-
0.05
adenosine 5'-phosphosulfate
-
-
0.95
adenosine 5'-phosphosulfate
-
-
9
adenosine 5'-phosphosulfate
-
-
0.14
ATP
-
-
0.4
bis(4-nitrophenyl)phosphate
-
-
0.14
phosphate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.014 - 0.049
-
different substrates and concentrations
42.2
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 6
-
ATP or phosphate as substrate
5.4
-
-
6
-
adenosine 5'-phosphosulfate as substrate
7
-
bis(4-nitrophenyl)phosphate as substrate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
53000
-
SDS-PAGE
289087
56000
-
gel filtration
289087
68000
-
SDS-PAGE
289089
69000
-
gel filtration
289089
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8.5
-
10-15% loss of activity above
289086
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0
-
stable for 30 h
289087
additional information
-
stable for several months
289087
additional information
-
at pH 6.6 stable for several months
289090
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pharmacology
-
biological sulfation process