Information on EC 3.6.2.1 - adenylylsulfatase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.6.2.1
-
RECOMMENDED NAME
GeneOntology No.
adenylylsulfatase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
adenylyl sulfate + H2O = AMP + sulfate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of sulfuric acid anhydride
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
Sulfur metabolism
-
SYSTEMATIC NAME
IUBMB Comments
adenylyl-sulfate sulfohydrolase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
adenosine 5'-phosphosulphate sulphotransferase
-
-
-
-
adenosine 5-phosphosulfate sulfohydrolase
-
-
-
-
APS sulfohydrolase
-
-
-
-
APSST
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37289-36-4
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenosine 5'-phosphosulphate + H2O
adenosine 3',5'-diphosphate + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
-
-
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
-
-
-
?
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
-
adenosine
-
-
adenosine 2'-monophosphate
-
-
adenosine 3'-monophosphate
-
-
ethoxy-formic anhydride
-
-
Fe2+
-
-
-
p-mercuribenzoate
-
-
Rose bengal
-
photo-oxidation
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.04
-
adenosine 5'-phosphosulfate
-
-
0.05
-
adenosine 5'-phosphosulfate
-
-
0.95
-
adenosine 5'-phosphosulfate
-
-
9
-
adenosine 5'-phosphosulfate
-
-
0.14
-
ATP
-
-
0.4
-
bis(4-nitrophenyl)phosphate
-
-
0.14
-
phosphate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.014
0.049
-
different substrates and concentrations
6
-
-
-
42.2
-
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5
6
-
ATP or phosphate as substrate
5.4
-
-
-
6
-
-
adenosine 5'-phosphosulfate as substrate
7
-
-
bis(4-nitrophenyl)phosphate as substrate
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
53000
-
-
SDS-PAGE
56000
-
-
gel filtration
68000
-
-
SDS-PAGE
69000
-
-
gel filtration
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8.5
-
-
10-15% loss of activity above
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0
-
-
stable for 30 h
additional information
-
-
stable for several months
additional information
-
-
at pH 6.6 stable for several months
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pharmacology
-
biological sulfation process