Information on EC 3.6.2.1 - adenylylsulfatase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.6.2.1
-
RECOMMENDED NAME
GeneOntology No.
adenylylsulfatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenylyl sulfate + H2O = AMP + sulfate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of sulfuric acid anhydride
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
-
-
Sulfur metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
adenylyl-sulfate sulfohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37289-36-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenosine 5'-phosphosulphate + H2O
adenosine 3',5'-diphosphate + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
-
adenosine
-
-
adenosine 2'-monophosphate
-
-
adenosine 3'-monophosphate
-
-
AMP
-
-
Ca2+
-
-
Cu2+
-
-
diphosphate
-
-
ethoxy-formic anhydride
-
-
Fe2+
-
-
Hg2+
-
-
Mg2+
-
-
Mn2+
-
-
Ni2+
-
-
p-mercuribenzoate
-
-
Pb2+
-
-
phosphate
-
-
Rose bengal
-
photo-oxidation
UTP
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04 - 9
adenosine 5'-phosphosulfate
0.14
ATP
-
-
0.4
bis(4-nitrophenyl)phosphate
-
-
0.14
phosphate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.014 - 0.049
-
different substrates and concentrations
42.2
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 6
-
ATP or phosphate as substrate
5.4
-
-
6
-
adenosine 5'-phosphosulfate as substrate
7
-
bis(4-nitrophenyl)phosphate as substrate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
53000
-
SDS-PAGE
56000
-
gel filtration
68000
-
SDS-PAGE
69000
-
gel filtration
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.5
-
10-15% loss of activity above
289086
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0
-
stable for 30 h
additional information
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
-
biological sulfation process