Information on EC 3.6.1.68 - geranyl diphosphate phosphohydrolase

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The expected taxonomic range for this enzyme is: Rosa hybrid cultivar

EC NUMBER
COMMENTARY hide
3.6.1.68
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RECOMMENDED NAME
GeneOntology No.
geranyl diphosphate phosphohydrolase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranyl diphosphate + H2O = geranyl phosphate + phosphate
show the reaction diagram
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
juvenile hormone III biosynthesis I
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SYSTEMATIC NAME
IUBMB Comments
geranyl-diphosphate phosphohydrolase
The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
compared with control, petals expressing a isoformNUDX1 RNAi construct have fewer monoterpenes. Amounts of other volatiles are unaffected. Transient expression in Nicotiana benthamiana leads to enzyme accumulation in leaves and accumulation of geraniol and geraniol glycosides
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
farnesyl diphosphate + H2O
farnesyl phosphate + phosphate
show the reaction diagram
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-
?
geranyl diphosphate + H2O
geranyl phosphate + phosphate
show the reaction diagram
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?
additional information
?
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very low activity with 8-oxo-dGTP and dGTP, substrates of Arabidospis thaliana Nudx1, EC 3.6.1.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00048
farnesyl diphosphate
pH not specified in the publication, temperature not specified in the publication
0.00014
geranyl diphosphate
pH not specified in the publication, temperature not specified in the publication
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6
very low activity below
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression levels in fully opened flower
Manually annotated by BRENDA team
additional information
little to no expression in stamens, sepals, or young leaves
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
16800
x * 16800, SDS-PAGE and calculated
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 16800, SDS-PAGE and calculated