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Information on EC 3.6.1.62 - 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase and Organism(s) Mus musculus and UniProt Accession Q9CYC6

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EC Tree
IUBMB Comments
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) . The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ .
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This record set is specific for:
Mus musculus
UNIPROT: Q9CYC6
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
nudt16, dcp1p, hdcp2, dcp2p, mrna decapping enzyme, nudt19, hnudt16, d10 protein, d10 decapping enzyme, nudt17, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
show the reaction diagram
m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
show the reaction diagram
regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
-
-
?
m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
show the reaction diagram
regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
embryonic fibroblast
Manually annotated by BRENDA team
Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult
Manually annotated by BRENDA team
Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult
Manually annotated by BRENDA team
Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult
Manually annotated by BRENDA team
highest expression level
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
no obvious phenotypic difference or differences in fertility, life span, or litter size are detected between the wild type animals and Dcp2b/b mice (mice containing a homozygous insertion of the beta-geo gene as Dcp2beta/beta)
physiological function
physiological function
Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DCP2_MOUSE
422
0
48380
Swiss-Prot
other Location (Reliability: 2)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Dcp2 expression is induced upon viral infection
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Song, M.G.; Li, Y.; Kiledjian, M.
Multiple mRNA decapping enzymes in mammalian cells
Mol. Cell.
40
423-432
2010
Homo sapiens (Q8IU60), Homo sapiens (Q96DE0), Homo sapiens, Mus musculus (Q6P3D0), Mus musculus (Q9CYC6), Mus musculus
Manually annotated by BRENDA team
Li, Y.; Dai, J.; Song, M.; Fitzgerald-Bocarsly, P.; Kiledjian, M.
Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7
Mol. Cell. Biol.
32
1164-1172
2012
Mus musculus (Q9CYC6)
Manually annotated by BRENDA team