Information on EC 3.6.1.44 - oligosaccharide-diphosphodolichol diphosphatase

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The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

EC NUMBER
COMMENTARY hide
3.6.1.44
-
RECOMMENDED NAME
GeneOntology No.
oligosaccharide-diphosphodolichol diphosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
oligosaccharide-diphosphodolichol + H2O = oligosaccharide phosphate + dolichyl phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of diphosphate bonds
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
oligosaccharide-diphosphodolichol phosphodolichohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
117698-28-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
oligosaccharide-diphosphodolichol + H2O
oligosaccharide phosphate + dolichyl phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
oligosaccharide-diphosphodolichol + H2O
oligosaccharide phosphate + dolichyl phosphate
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
150% activity compared to control, 10 mM
Mg2+
-
113% activity compared to control, 10 mM
Mn2+
-
149.5% activity compared to control, 10 mM
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bacitracin
-
80% inhibition at 10 mM
diphosphate
-
total inhibition at 10 mM
NAD+
-
total inhibition at 10 mM
phosphate
-
35% inhibition at 10 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Triton X-100
-
6fold increase at 0.5%
Triton X-114
-
7fold increase at 0.5%
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.5
-
no activity above pH 9.0
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30 - 35
-
no activity at 0°C
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.5
-
-
289083
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
preincubation for 10 min, half-life at 62°C 1 hour, activity lost after incubation at 70°C