Information on EC 3.6.1.20 - 5'-acylphosphoadenosine hydrolase

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The expected taxonomic range for this enzyme is: Sus scrofa

EC NUMBER
COMMENTARY hide
3.6.1.20
-
RECOMMENDED NAME
GeneOntology No.
5'-acylphosphoadenosine hydrolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5'-acylphosphoadenosine + H2O = AMP + a carboxylate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphorous acid anhydride hydrolysis
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Purine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
5'-acylphosphoadenosine acylhydrolase
Also acts on inosine and uridine compounds.
CAS REGISTRY NUMBER
COMMENTARY hide
37289-31-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5'-acylphosphoadenosine + H2O
AMP + carboxylate
show the reaction diagram
-
-
-
-
?
acetyl adenylate + H2O
acetic acid + AMP
show the reaction diagram
-
-
-
-
?
benzoyl adenylate + H2O
benzoic acid + AMP
show the reaction diagram
-
-
-
-
?
hippuryl adenylate + H2O
hippuric acid + AMP
show the reaction diagram
-
-
-
-
?
inosine 5'-phosphobutyrate + H2O
butyric acid + IMP
show the reaction diagram
-
-
-
-
?
n-butyryl adenylate + H2O
n-butanoic acid + AMP
show the reaction diagram
-
-
-
-
?
uridine 5'-phosphobutyrate + H2O
butyric acid + UMP
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5'-acylphosphoadenosine + H2O
AMP + carboxylate
show the reaction diagram
-
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
adenylic acid
-
50 mM causes 20% inhibition
iodoacetate
-
inhibitory above 10 mM
p-chloromercuribenzoate
-
inhibitory above 0.1 mM
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.6
-
in 0.1 M potassium phosphate
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-18°C, stable for months, 30% loss of activity by frequent freezing and thawing within 2 month
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE